Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

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Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy

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Aquaporin-4 and Parkinson’s Disease

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Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies

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Identification of human α-synuclein specific single chain antibodies

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Parkinson's disease and related neurodegenerative synucleinopathies linked to progressive accumulations of synuclein aggregates in brain

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Alpha-Synuclein and Presynaptic Function: Implications for Parkinson's Disease

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Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin‐proteasome system, autophagy and aggresome formation

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Alpha-synuclein: between synaptic function and dysfunction.

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Midkine, a new neurotrophic factor, is present in glial cytoplasmic inclusions of multiple system atrophy brains

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Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates

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ALS ‐associated protein FIG4 is localized in P ick and L ewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases

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Alterations in Striatal microRNA-mRNA Networks Contribute to Neuroinflammation in Multiple System Atrophy

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Models of multiple system atrophy

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Mixed multiple system atrophy and progressive supranuclear palsy: a clinical and pathological report of one case

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Histone Deacetylase 6 and the Disease Mechanisms of α-Synucleinopathies

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Abnormal neuronal and glial argyrophilic fibrillary structures in the brain of an aged albino cynomolgus monkey ( Macaca fascicularis )

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Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy

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14-3-3 proteins in Lewy body-like hyaline inclusions in patients with sporadic amyotrophic lateral sclerosis

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Organization of the human synphilin-1 gene, a candidate for Parkinson's disease

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Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system

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Controversy: Is Parkinson's disease a single disease entity? Yes

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Multiple System Atrophy

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Prominent White Matter Involvement in Multiple System Atrophy of Cerebellar Type

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Pick's disease: α- and β-synuclein-immunoreactive Pick bodies in the dentate gyrus

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In Search of Effective Treatments Targeting α-Synuclein Toxicity in Synucleinopathies: Pros and Cons

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FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models

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Mapping of Rat Brain Using the Synuclein-1 Monoclonal Antibody Reveals Somatodendritic Expression of α-Synuclein in Populations of Neurons Homologous to those Vulnerable to Lewy Body Formation in Human Synucleopathies

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Tuft-shaped astrocytes in Lewy body disease

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Expression of β-synuclein in normal human astrocytes

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Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy

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Valosin‐containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease

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Immunohistochemical localization of NUB1, a synphilin-1-binding protein, in neurodegenerative disorders

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Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology

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S100A9 Alters the Pathway of Alpha-Synuclein Amyloid Aggregation

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α-Synuclein pathology from the body to the brain: so many seeds so close to the central soil

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Reciprocal accumulation of β-synuclein in α-synuclein lesions in multiple system atrophy

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Tunneling nanotubes: A novel pharmacological target for neurodegenerative diseases?

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Fatal attraction – The role of hypoxia when alpha-synuclein gets intimate with mitochondria

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Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson’s disease

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Does gut brain axis has an impact on Parkinson’s disease (PD)?

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Cytokines disrupt intracellular patterns of Parkinson's disease-associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells

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Immunoreactivity of myelin‐associated oligodendrocytic basic protein in Lewy bodies

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Ingenuity pathway analysis of α-synuclein predicts potential signaling pathways, network molecules, biological functions, and its role in neurological diseases

Suthar, S. K., & Lee, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1029682 · Cited by 21

The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology

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Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background

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Lewy Body Disorders

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Navigating through the complexities of synucleinopathies: Insights into pathogenesis, heterogeneity, and future perspectives

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MSA: From basic mechanisms to experimental therapeutics

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Models of Multiple System Atrophy

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Oligodendrocytes from neural stem cells express ??-synuclein: increased numbers from presenilin 1 deficient mice

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Products of Cu( ii )-catalyzed oxidation of α-synuclein fragments containing M 1 -D 2 and H 50 residues in the presence of hydrogen peroxide

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Progressive accumulation of ubiquitin and disappearance of α-synuclein epitope in multiple system atrophy-associated glial cytoplasmic inclusions: triple fluorescence study combined with Gallyas-Braak method

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Neurotransmitter amino acid in cerebrospinal fluid of patients with dementia with Lewy bodies

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Infectious Agents as Potential Drivers of α‐Synucleinopathies

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UCHL‐1 gene in multiple system atrophy: A haplotype tagging approach

Healy, D. G., Abou‐Sleiman, P. M., Quinn, N. P., Ahmadi, K. R., Ozawa, T., Kamm, C., Wüllner, U., Oertel, W. H., Bürk, K., Dupont, E., et al. (2005) · Movement Disorders · doi:10.1002/mds.20575 · Cited by 16

Role of the p62 Protein in the Formation of Neuropathological Cytoplasmic Inclusions

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How proteomics reveals potential biomarkers in brain diseases

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Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

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Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies

Kallunki, P., Sotty, F., Willén, K. I., Lubas, M., David, L., Ambjørn, M., Bergström, A., Vesterager, L. B., Malik, I., Nyegaard, S., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-024-00849-1 · Cited by 15

Spinocerebellar ataxia type 2 with glial cell cytoplasmic inclusions

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Effects of local reduction of endogenous α-synuclein using antisense oligonucleotides on the fibril-induced propagation of pathology through the neural network in wild-type mice

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The Therapeutic Potential of LRRK2 and α-Synuclein in Parkinson's Disease

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Diseases of movement and system degenerations

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Alpha-synuclein transgenic mice: Relevance to multiple system atrophy

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Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, 18F-SPAL-T-06 and 18F-C05-05

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Corneal confocal microscopy may help to distinguish Multiple System Atrophy from Parkinson’s disease

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Prolyl oligopeptidase inhibition reduces alpha‐synuclein aggregation in a cellular model of multiple system atrophy

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Interactions between S100A9 and Alpha-Synuclein: Insight from NMR Spectroscopy

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Serum levels of coenzyme Q in patients with Lewy body disease

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Genetic susceptibility and the occurrence of Parkinson's disease

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Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synuclein

Devi, S., Garg, D. K., & Bhat, R. (2023) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2023.140917 · Cited by 11

Presence of Extracellular Alpha-Synuclein Aggregates Trigger Astrocytic Degeneration Through Enhanced Membrane Rigidity and Deregulation of Store-Operated Calcium Entry (SOCE) into the Endoplasmic Reticulum

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Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy

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Impact of α-Synuclein Pathology on Aging

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Lewy bodies in Betz cells of the motor cortex in a patient with Parkinson's disease

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