Cited by 347Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and Signaling

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Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

Wakabayashi, K., Hayashi, Shintaro, Kakita, Akiyoshi, Yamada, Mitsunori, Toyoshima, Yasuko, Yoshimoto, Makoto, Takahashi, Hitoshi·1998·Acta Neuropathologica

DOI 10.1007/s004010050918

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Abstract

Recently, we have shown that the precursor of the non-Abeta component of Alzheimer's disease amyloid (NACP), also known as alpha-synuclein, is a major component of Lewy bodies (LBs) as well as neuronal and glial cytoplasmic inclusions in multiple system atrophy (MSA). To elucidate whether the accumulation of NACP is specific to LB disease and MSA, we further studied 83 autopsied cases with various neurological disorders, using anti-NACP antibodies. In LB disease, NACP immunoreactivity was present in all of the LBs and Lewy neurites in both the central and peripheral nervous systems, the pale bodies in the substantia nigra, and dystrophic neurites in the hippocampal CA2/3 region. Immunoelectron microscopy revealed that the reaction product was localized within filamentous structures and associated granular structures. In MSA, NACP immunoreactivity was found in the intracytoplasmic inclusions of both neuronal and oligodendroglial cells, neuronal intranuclear inclusions, and swollen neuronal processes. No NACP immunoreactivity was found in a variety of other neuronal or glial inclusions in other disorders, including Alzheimer's disease, Pick's disease, progressive supranuclear palsy, corticobasal degeneration, motor neuron disease and triplet-repeat diseases. These findings strongly suggest that the accumulation of NACP is a cytopathological feature common to LB disease and MSA.

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Authors: Wakabayashi, K., Hayashi, S., Kakita, A., Yamada, M., Toyoshima, Y., Yoshimoto, M., & Takahashi, H.
Affiliations: Brain Research Institute, Niigata University (JP)
Taisho Pharmaceutical (Japan) (JP)
ORCID: Wakabayashi, K.
Hayashi, Shintaro
Kakita, Akiyoshi
Yamada, Mitsunori
Toyoshima, Yasuko
Takahashi, Hitoshi
Venue: Acta Neuropathologica
Publisher: Springer Science and Business Media LLC
Published: 1998-11-01
Volume: 96
Issue: 5
Pages: 445-452
ISSN: 0001-6322 (ISSN-L)
1432-0533
DOI: 10.1007/s004010050918
OpenAlex: W2016816471
Cited by: 347
References: 52
Citations by year: 2026: 1 · 2025: 9 · 2024: 9 · 2023: 11 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 4 · 2017: 11 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 9
FWCI: 22.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Acta Neuropathologica (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: alpha-synuclein, Lewy bodies, multiple system atrophy, Lewy body disease, Lewy neurites, substantia nigra, dystrophic neurites, neuronal intranuclear inclusions, oligodendroglial inclusions, cytopathology, immunoreactivity, immunoelectron microscopy
MeSH terms: Humans, Immunohistochemistry, Nerve Degeneration, Nerve Tissue Proteins, Nervous System Diseases, Parkinson Disease, Microscopy, Immunoelectron, Lewy Bodies, Cellular Senescence, Multiple System Atrophy, Synucleins, alpha-Synuclein

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Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

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