Mitochondrial translocation of estrogen receptor Β affords resistance to oxidative insult-induced apoptosis and contributes to the pathogenesis of endometriosis
Abstract
Endometriosis is the major cause of female infertility and has been linked to the action of estrogen and estrogen receptor (ER). A new pool of ERβ locates within mitochondria, which regulates the endometriotic cell withstanding external insults, but its effect remains controversial. We hypothesize that mitochondrial estrogen receptor ERβ (mtERβ) is a pivotal regulator in estradiol-mediated cell protection leading to the endometriotic progression. We observed elevated levels of ERβ in the endometriotic tissues. A dramatic increase of ERβ in mitochondria (mtERβ) was found in the ectopic endometriotic tissues, or the estradiol-primed primary endometriotic cells. We analyzed the mtERβ-specific overexpressing clone (mtsERβ), which exhibited higher mitochondrial bioenergetics and lower reactive oxygen species (ROS) generation. The mtsERβ-overexpressed endometriotic cells displayed an enhanced migration phenotype, whereas significantly attenuated migration by mitochondrial respiratory inhibitor (oligomycin) or ERβ deficiency by shERβ. Further investigations revealed that ERβ directly modulated mitochondrial DNA (mtDNA) gene expression by interacting with mtDNA D-loop and polymerase γ. The mtsERβ afforded a resistance to oxidative insult-induced apoptosis through the induction of the ROS scavenger enzyme Mn-superoxide dismutase and anti-apoptotic protein Bcl-2. Collectively, the demonstration of mtERβ responses in restoration of mitochondrial bioenergetics and inhibition of mitochondria-dependent apoptotic events provides insight into the pathogenesis of endometriosis, suggesting ERβ-selective estrogen receptor modulator may serve as novel therapeutics of endometriosis in the future.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Higher ERβ expression in OE than AD lesions corroborates earlier reports.
“Higher ERβ expression in OE than AD lesions corroborates earlier reports (Liao et al., 2019).”
From Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium (2025) · cites this paper as Liao et al., 2019
17β-estradiol regulates multiple other aspects of mitochondrial function through ERs, including ROS generation, antioxidant defense, and Ca2+ handling.
“Moreover, 17β-estradiol also appears to regulate multiple other aspects of mitochondrial function through ERs, including ROS generation, antioxidant defense, and Ca2+ handling (126–131).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [127]
Cites
Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772 · see citing works
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm
Kurman, R. J., & Shih, I. (2011) · Human Pathology · doi:10.1016/j.humpath.2011.03.003 · Cited by 1,076 · see citing works
Keeney, P., Xie, J., Capaldi, R., & Bennett, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0984-06.2006 · Cited by 757 · see citing works
Mitochondrial localization of estrogen receptor β
Yang, S.-H., Liu, R., Perez, E., Wen, Y., Stevens, S. M., Valencia, T. G., Brun‐Zinkernagel, A., Prókai, L., Will, Y., Dykens, J. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306948101 · Cited by 501 · see citing works
Oxidative Stress and Endometriosis: A Systematic Review of the Literature
Scutiero, G., Iannone, P., Bernardi, G., Bonaccorsi, G., Spadaro, S., Volta, C. A., Greco, P., & Nappi, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7265238 · Cited by 436 · see citing works
Han, S. J., Jung, S. Y., Wu, S.-P., Hawkins, S. M., Park, M. J., Kyo, S., Qin, J., Lydon, J. P., Tsai, S. Y., Tsai, M.-J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.034 · Cited by 380 · see citing works
Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1
Xue, Q., Lin, Z., Cheng, Y.-H., Huang, C.-C., Marsh, E., Yin, P., Milad, M. P., Confino, E., Reierstad, S., Innes, J., et al. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.061804 · Cited by 346 · see citing works
Role of Estrogen Receptor-β in Endometriosis
Bulun, S., Monsavais, D., Pavone, M., Dyson, M., Xue, Q., Attar, E., Tokunaga, H., & Su, E. (2012) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1299596 · Cited by 307 · see citing works
Estrogenic control of mitochondrial function
Klinge, C. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101435 · Cited by 302 · see citing works
Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ
Achanta, G., Sasaki, R., Li, F., Carew, J. S., Lu, W., Pelicano, H., Keating, M. J., & Huang, P. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600819 · Cited by 285 · see citing works
Borrás, C., Gambini, J., Gómez-Cabrera, M. C., Sastre, J., Pallardó, F., Mann, G., & Viña, J. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00151.x · Cited by 257 · see citing works
Chen, Y., Li, H., Huang, C., Twu, N.-F., Yen, M., Wang, P., Chou, T., Liu, Y., Chao, K.-C., & Yang, M. (2010) · The Journal of Pathology · doi:10.1002/path.2761 · Cited by 245 · see citing works
Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis
Bulun, S., Cheng, Y.-H., Pavone, M., Xue, Q., Attar, E., Trukhacheva, E., Tokunaga, H., Utsunomiya, H., Yin, P., Luo, X., et al. (2010) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1242991 · Cited by 243 · see citing works
Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells
Desai, S. P., Bhatia, S. N., Toner, M., & Irimia, D. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.03.025 · Cited by 223 · see citing works
Matsuzaki, S., & Darcha, C. (2012) · Human Reproduction · doi:10.1093/humrep/der442 · Cited by 216 · see citing works
Shaaban, A. M., Green, A. R., Karthik, S., Alizadeh, Y., Hughes, T. A., Harkins, L., Ellis, I. O., Robertson, J. F. R., Paish, E. C., Saunders, P. T. K., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4528 · Cited by 212 · see citing works
Sex differences in inflammation, redox biology, mitochondria and autoimmunity
Di Florio, D. N., Sin, J., Coronado, M. J., Atwal, P. S., & Fairweather, D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101482 · Cited by 185 · see citing works
Stabile, L. P., Đačić, S., Land, S. R., Lenzner, D. E., Dhir, R., Acquafondata, M. B., Landreneau, R. J., Grandis, J. R., & Siegfried, J. M. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0992 · Cited by 158 · see citing works
The management of menopause in women with a history of endometriosis: A systematic review
Gemmell, L. C., Webster, K. E., Kirtley, S., Vincent, K., Zondervan, K. T., & Becker, C. M. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx011 · Cited by 154 · see citing works
Trukhacheva, E., Lin, Z., Reierstad, S., Cheng, Y.-H., Milad, M., & Bulun, S. E. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1466 · Cited by 143 · see citing works
New insights into the role of mitochondrial calcium homeostasis in cell migration
Paupe, V., & Prudent, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.039 · Cited by 142 · see citing works
Oxidative stress biomarkers in patients with endometriosis: systematic review
Carvalho, L. F. P., Samadder, A. N., Agarwal, A., Fernandes, L. F. C., & Abrão, M. S. (2012) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2439-7 · Cited by 140 · see citing works
Cystic and Adenofibromatous Clear Cell Carcinomas of the Ovary
Veras, E. F. T., Mao, T., Ayhan, A., Ueda, S. M., Lai, H. C., Hayran, M., Shih, I., & Kurman, R. J. (2009) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31819c4271 · Cited by 133 · see citing works
Risk of Gynecologic Cancer According to the Type of Endometriosis
Saavalainen, L., Lassus, H. J., But, A., Tiitinen, A. E., Härkki, P., Gissler, M., Pukkala, ., & Heikinheimo, O. (2018) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002624 · Cited by 132 · see citing works
Respiratory chain complex I deficiency caused by mitochondrial DNA mutations
Swalwell, H., Kirby, D. M., Blakely, E. L., Mitchell, A., Salemi, R., Sugiana, C., Compton, A. G., Tucker, E. J., Ke, B., Lamont, P. J., et al. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.18 · Cited by 128 · see citing works
Expression of oestrogen receptor-alpha and -beta in ovarian endometriomata
Fujimoto, J. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.8.742 · Cited by 123 · see citing works
Molecular biology of endometriosis: from aromatase to genomic abnormalities
Monsivais, D., Kakinuma, T., Furukawa, Y., Bernardi, L., Pavone, M., Dyson, M., & Bulun, S. (2015) · Seminars in Reproductive Medicine · doi:10.1055/s-0035-1554053 · Cited by 112 · see citing works
Estrogen Receptor β Functions through Nongenomic Mechanisms in Lung Cancer Cells
Zhang, G., Liu, X., Farkas, A. M., Parwani, A. V., Lathrop, K. L., Lenzner, D. E., Land, S. R., & Srinivas, H. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0431 · Cited by 110 · see citing works
Hsieh, Y.-C., Yu, H.-P., Suzuki, T., Choudhry, M. A., Schwacha, M. G., Bland, K. I., & Chaudry, I. H. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.06.001 · Cited by 108 · see citing works
Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms
Chuffa, L. G. D. A., Lupi, L. A., Cucielo, M. S., Silveira, H. S., Reiter, R. J., & Seiva, F. R. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010300 · Cited by 105 · see citing works
Zhang, H., Niu, Y., Feng, J., Guo, H., Ye, X., & Cui, H. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.01.028 · Cited by 101 · see citing works
Solakidi, S., Psarra, A. G., & Sekeris, C. E. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.05.010 · Cited by 80 · see citing works
Gynecological conditions and the risk of endometrial cancer
Rowlands, I. J., Nagle, C. M., Spurdle, A. B., & Webb, P. M. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.08.022 · Cited by 77 · see citing works
Stefano, I. D., Zannoni, G. F., Prisco, M. G., Fagotti, A., Tortorella, L., Vizzielli, G., Mencaglia, L., Scambia, G., & Gallo, D. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.05.025 · Cited by 76 · see citing works
Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall
Liu, Z., Gou, Y., Zhang, H., Zuo, H., Zhang, H., Liu, Z., & Yao, D. (2014) · Redox Biology · doi:10.1016/j.redox.2014.11.001 · Cited by 76 · see citing works
Ligand-Independent Antiapoptotic Function of Estrogen Receptor-β in Lung Cancer Cells
Zhang, G., Yanamala, N. V. K., Lathrop, K. L., Zhang, L., Klein‐Seetharaman, J., & Srinivas, H. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0125 · Cited by 68 · see citing works
Placing mitochondrial DNA mutations within the progression model of type I endometrial carcinoma
Guerra, F., Kurelac, I., Cormio, A., Zuntini, R., Amato, L. B., Ceccarelli, C., Santini, D., Cormio, G., Fracasso, F., Selvaggi, L. E., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr146 · Cited by 62 · see citing works
Monsivais, D., Dyson, M. T., Yin, P., Navarro, A., Coon, J. S., Pavone, M. E., & Bulun, S. E. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.01.012 · Cited by 62 · see citing works
Hudelist, G., Keckstein, J., Czerwenka, K. F., Lass, H., Walter, I., Auer, M., Wieser, F., Wenzl, R. J., Kubista, E., & Singer, C. F. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.06.014 · Cited by 57 · see citing works
Chen, J., Russo, P. A., Cooke, C., Russo, I. H., & Russo, J. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.05.008 · Cited by 55 · see citing works
Oxidative Damage and Mitochondrial DNA Mutations with Endometriosis
Kao, S., HUANG, H., Hsieh, R., Chen, S., Tsai, M.-C., & Tzeng, C.-R. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.021 · Cited by 54 · see citing works
Self-citationReversal of fortune: estrogen receptor-β in endometriosis
Simmen, R. C. M., & Kelley, A. S. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0080 · Cited by 46 · see citing works
Álvarez‐Delgado, C., Mendoza-Rodríguez, C. A., Picazo, O., & Cerbón, M. A. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.015 · Cited by 41 · see citing works
Cutting SRC-1 down to size in endometriosis
Dyson, M. T., & Bulun, S. E. (2012) · Nature Medicine · doi:10.1038/nm.2855 · Cited by 34 · see citing works
Zang, H., Sahlin, L., Masironi, B., & Hirschberg, A. L. (2008) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318148bb99 · Cited by 30 · see citing works
Chakravarty, D., Srinivasan, R., Ghosh, S., Gopalan, S., Rajwanshi, A., & MAJUMDAR, S. (2007) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2006.00851.x · Cited by 29 · see citing works
Giddabasappa, A., Bauler, M., Barrett, C. M., Coss, C., Wu, Z., Miller, D. D., Dalton, J., & Eswaraka, J. (2010) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.10-5630 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Estrogenic control of mitochondrial function
Klinge, C. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101435 · Cited by 302 · see citing works
Oxidative stress: A common pathological state in a high-risk population for osteoporosis
Zhang, C., Li, H., Li, J., Hu, J., Yang, K., & Tao, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114834 · Cited by 219 · see citing works
Sex differences in inflammation, redox biology, mitochondria and autoimmunity
Di Florio, D. N., Sin, J., Coronado, M. J., Atwal, P. S., & Fairweather, D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101482 · Cited by 185 · see citing works
Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms
Chuffa, L. G. D. A., Lupi, L. A., Cucielo, M. S., Silveira, H. S., Reiter, R. J., & Seiva, F. R. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010300 · Cited by 105 · see citing works
Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis
Shen, H., Zhang, T., Yang, H., Lai, Z., Zhou, W., Mei, J., Shi, J., Zhu, R., Xu, F., Li, D., et al. (2021) · Theranostics · doi:10.7150/thno.55241 · Cited by 107 · see citing works
Anderson, G. (2019) · BioMolecular Concepts · doi:10.1515/bmc-2019-0017 · Cited by 67 · see citing works
From mitochondria to sarcopenia: role of 17β-estradiol and testosterone
Tian, X., Lou, S., & Shi, R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1156583 · Cited by 54 · see citing works
Endometriosis and Cancer: Exploring the Role of Macrophages
Artemova, D. A., Vishnyakova, P., Khashchenko, K. E. P., Elchaninov, A. V., Sukhikh, G. T., & Fatkhudinov, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105196 · Cited by 53 · see citing works
Kobayashi, A., Azuma, K., Ikeda, K., & Inoue, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186683 · Cited by 50 · see citing works
Park, S., Ham, J., Yang, C., Park, W., Park, H., An, G., Song, J., Hong, T., Park, S. J., Kim, H. S., et al. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12842 · Cited by 43 · see citing works
Kobayashi, H., Kimura, M., Maruyama, S., Nagayasu, M., & Imanaka, S. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.12.044 · Cited by 44 · see citing works
Male Macrophages and Fibroblasts from C57/BL6J Mice Are More Susceptible to Inflammatory Stimuli
Barcena, M. L., Niehues, M. H., Christiansen, C., Estepa, M., Haritonow, N., Sadighi, A. H., Müller‐Werdan, U., Ladilov, Y. V., & Regitz‐Zagrosek, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.758767 · Cited by 36 · see citing works
Anderson, G. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.07.014 · Cited by 28 · see citing works
Queathem, E. D., Welly, R. J., Clart, L., Rowles, C. C., Timmons, H., Fitzgerald, M., Eichen, P. A., Lubahn, D. B., & Vieira‐Potter, V. J. (2021) · Cells · doi:10.3390/cells10123453 · Cited by 30 · see citing works
Álvarez‐Delgado, C. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111661 · Cited by 24 · see citing works
Mitochondria as the target for disease related hormonal dysregulation
Shaw, G. A. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100350 · Cited by 24 · see citing works
Khashchenko, K. E. P., Vysokikh, M. Y., Marey, M. V., Sidorova, K. O., Manukhova, L. A., Shkavro, N. N., Uvarova, E. V., Chuprynin, V. D., Fatkhudinov, T., Adamyan, L. V., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084238 · Cited by 23 · see citing works
Li, Y., Lin, Y., Li, Y., Liu, X., Li, D., Wang, X., Wang, L., Zhu, Y. Z., Yu, M., & Du, M. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.68224 · Cited by 22 · see citing works
Self-citationNonhormonal Treatment for Endometriosis Focusing on Redox Imbalance
Nagayasu, M., Imanaka, S., Kimura, M., Maruyama, S., & Kobayashi, H. (2021) · Gynecologic and Obstetric Investigation · doi:10.1159/000512628 · Cited by 19 · see citing works
Zhao, W., Hou, Y., Zhang, Q., Yu, H., Meng, M., Zhang, H., & Zhou, Y. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105636 · Cited by 18 · see citing works
Song, J., Ham, J., Park, S., Park, S. J., Kim, H. S., Song, G., & Lim, W. (2023) · Antioxidants · doi:10.3390/antiox12071324 · Cited by 16 · see citing works
Impact of Gut and Reproductive Tract Microbiota on Estrogen Metabolism in Endometriosis
Li, Z., Yin, Z., Chen, W. X., & Wang, Z. (2025) · American Journal of Reproductive Immunology · doi:10.1111/aji.70109 · Cited by 15 · see citing works
Ren, Y., Wang, X., Guo, J., Wang, D., Li, X., Cheng, X., & Wang, X. (2022) · Reproductive Sciences · doi:10.1007/s43032-021-00831-9 · Cited by 14 · see citing works
Malik, S., Chakraborty, D., Agnihotri, P., Sharma, A., & Biswas, S. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101854 · Cited by 12 · see citing works
Mitochondrial dynamics: Molecular mechanism and implications in endometriosis
Marino, Y., Inferrera, F., Genovese, T., Cuzzocrea, S., Fusco, R., & Paola, R. D. (2025) · Biochimie · doi:10.1016/j.biochi.2025.01.012 · Cited by 14 · see citing works
Nie, J., Yi, Y., Liu, X., & Guo, S.-W. (2025) · Human Reproduction Open · doi:10.1093/hropen/hoaf028 · Cited by 11 · see citing works
Hinton, A. O., Jr., Neikirk, K., Le, H., Harris, C., Oliver, A. F., Martin, P., & Gaye, A. (2024) · Aging advances. · doi:10.4103/agingadv.agingadv-d-24-00012 · Cited by 11 · see citing works
Mitophagy involved the biological processes of hormones
Ma, Y., Zheng, Y., Zhou, Y., Weng, N., & Zhu, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115468 · Cited by 9 · see citing works
Yu, Y., Zhu, Y., Gao, M., Wang, Y., Li, S., & Gou, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1624569 · Cited by 8 · see citing works
Self-citationHigh dissolved oxygen exacerbates ammonia toxicity with sex-dependent manner in zebrafish
Sun, S.-X., Hu, C.-T., Qiao, F., Chen, L., Zhang, M., & Du, Z. (2023) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2023.109549 · Cited by 8 · see citing works
Sharifi, M., Nikoo, N. R., Badehnoosh, B., Shafabakhsh, R., Asemi, R., Reiter, R. J., & Asemi, Z. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154368 · Cited by 8 · see citing works
Queathem, E. D., Fitzgerald, M., Welly, R. J., Rowles, C. C., Schaller, K., Bukhary, S., Baines, C. P., Rector, R. S., Padilla, J., Manrique‐Acevedo, C., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.920675 · Cited by 5 · see citing works
Liu, X., Yu, X., Lyu, J., Li, F., Shang, Y., Lyu, Y., & Liu, J. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.103724 · Cited by 4 · see citing works
Regulated cell death in endometrial diseases: from molecular mechanisms to targeted therapies
Zi, D., Sun, J. Y., Zuo, N., Li, T., Liang, J., Hu, J., Na, Z., Zhang, H., He, L., & Li, D. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04192-z · Cited by 4 · see citing works
The role of estrogens in mitochondrial metabolism
Kit, O. I., Frantsiyants, E. M., Shikhlyarova, A. I., Neskubina, I. V., & Ilchenko, S. A. (2024) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2024-2-123-132 · Cited by 2 · see citing works
Crawford, D. R., Sinha, S., Nair, N. U., Ryan, B. M., Barnholtz‐Sloan, J. S., Mount, S. M., Erez, A., Aldape, K., Castle, P. E., Rajagopal, P. S., et al. (2022) · Cancers · doi:10.3390/cancers14235885 · Cited by 2 · see citing works
Baig, S. I., Umar, A., Ejaz, H., Ali, Y., & Wattoo, J. I. (2025) · In Silico Pharmacology · doi:10.1007/s40203-025-00479-2 · Cited by 1 · see citing works
Yang, J., Wang, N., Tong, S., & Zhao, P. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112334 · Cited by 1 · see citing works
Aberrant mitochondria in endometriosis: From pathogenic mechanisms to therapeutic opportunities
Rong, Y., Zhu, J., Wang, C. C., Zhang, J., & Chen, Y. (2026) · iScience · doi:10.1016/j.isci.2026.115916 · Cited by 1 · see citing works
Endometriosis – hormones and treatment
Obrycka, P., Soczyńska, J., Gawełczyk, W., Tomecka, P., & Mozdziak, P. E. (2024) · Medical Journal of Cell Biology · doi:10.2478/acb-2024-0008 · Cited by 1 · see citing works
Pyroptosis-Related Gene Markers Can Effectively Diagnose Endometriosis and Predict PrognosisPreprint
S., J. M., Thilsath Parveen, S., Liu, Y., J.S., C., X.L., Y., D.Y., L., B., J., Yadavalli Srujana, S., & Y.S., M. (2022) · Research Square · doi:10.21203/rs.3.rs-1935526/v1
Frantsiyants, E. M., Bandovkina, V. А., Moiseenko, T. I., Menshenina, A. P., Petrova, Y. A., Neskubina, I. V., Trepitaki, L. K., Surikova, E. I., Rogozin, M. A., Cheryarina, N. D., et al. (2025) · South Russian Journal of Cancer · doi:10.37748/2686-9039-2025-6-4-1
Shaw, G. A., Wegener, A. J., Stadtler, H., & Neigh, G. N. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05961-2
Lee, J., Yeo, S. G., Kim, H. O., Lee, J. M., Singh, M. K., Kim, S. S., Oh, T. I., & Park, D. C. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1878450
- Authors
- Liao, T.-L., Lee, Y.-C., Tzeng, C.-R., Wang, Y.-P., Chang, H.-Y., Lin, Y.-F., & Kao, S.-H.
- Affiliations
- Taipei Medical University (TW)
- Taipei Medical University Hospital (TW)
- Corresponding author
- Kao, Shu-Huei
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 134
- Pages
- 359-373
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2914087220
- Cited by
- 44
- References
- 47
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 3
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Taipei Medical University Repository (submittedVersion)
- Funders
- Basic Research (NSC 96-2320-B-038-009, NSC 99-2632-B-038-001-MY3)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- endometriosis, estrogen receptor beta, mitochondrial translocation, oxidative stress, apoptosis resistance, reactive oxygen species, mitochondrial bioenergetics, mitochondrial DNA, D-loop, DNA polymerase gamma, superoxide dismutase, Bcl-2, cell migration, estradiol
- MeSH terms
- Organelle Biogenesis, Endometriosis, Energy Metabolism, Female, Humans, Mitochondria, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Protein Transport, Estrogen Receptor beta, Mitochondrial Dynamics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
