CoChat
Sign Up
Cited by 251Endometriosis Research and TreatmentAntioxidant Activity and Oxidative StressNitric Oxide and Endothelin Effects

Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis

Open access
Donnez, Jacques, Binda, Maria Mercedes, Donnez, Olivier, Dolmans, Marie-Madeleine·2016·Fertility and Sterility
DOI 10.1016/j.fertnstert.2016.07.1075
Open this paper in CoChat — free account

Abstract

Endometriosis is a disorder associated with a general inflammatory response in the peritoneal cavity. Oxidative stress is a potential factor involved in the pathophysiology of this disease, and reactive oxygen species (ROS) are implicated in this process. Indeed, in healthy individuals, ROS and antioxidants are in balance, but when balance is tipped toward an overabundance of ROS, oxidative stress occurs and can impact the entire reproductive lifespan of a woman. Reactive oxygen species are intermediaries produced by normal oxygen metabolism but are known to have deleterious effects. Excessive release of ROS induces cellular damage and alters cellular function by regulating protein activity and gene expression, leading to harmful effects. To protect themselves, cells have developed antioxidant systems to limit production of ROS, inactivate them, and repair cell damage. Understanding of the control of hemoglobin, heme, and iron-induced redox balance in endometriosis led us to propose a number of hypotheses to explain why oxidative stress is induced in case of pelvic endometriosis. Erythrocytes, apoptotic endometrial tissue, and cell debris transplanted into the peritoneal cavity by menstrual reflux and macrophages have all been cited as potential inducers of oxidative stress. Erythrocytes are likely to release pro-oxidant and proinflammatory factors, such as hemoglobin and its highly toxic by-products heme and iron, into the peritoneal environment. Iron and heme are essential to living cells, but unless appropriately chelated, free iron, and to a lesser extent heme, play a key role in the formation of deleterious ROS.

Integrity signals

Registry

Crossref · 10.1016/j.fertnstert.2016.07.1075

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Oxidative stress in the uterus during menstruation and in the peritoneal cavity following retrograde menstruation are recognized as potential causative factors to induce genetic or epigenetic changes.

    “First, the oxidative stress in the uterus during menstruation and in the peritoneal cavity following retrograde menstruation (248) are recognized as potential causative factors to induce genetic or epigenetic changes.”

    From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [248]

  • Retrograde menstruation and bleeding of endometriotic lesions are responsible for erythrocytes in the pelvic cavity, which release pro-oxidant and proinflammatory factors like hemoglobin and its byproducts heme and iron.

    “Retrograde menstruation and bleeding of endometriotic lesions are responsible for the presence of erythrocytes in the pelvic cavity, which are likely to release pro-oxidant and proinflammatory factors like hemoglobin and its highly toxic byproducts heme and iron [27,28,29,30].”

    From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [30]

  • Suppressing ovulation and reducing menstrual bleeding greatly reduces the number of erythrocytes regurgitated into the pelvis, resulting in a decrease in oxidative stress and the inflammatory environment.

    “Of course, suppressing ovulation and reducing the amount of menstrual bleeding greatly reduces the number of erythrocytes regurgitated into the pelvis, resulting in a decrease in oxidative stress and the inflammatory environment [30].”

    From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [30]

  • By inducing amenorrhea and halting menstrual bleeding and reflux, or even simply lessening its severity, pelvic oxidative stress, the main source of inflammation, can be significantly reduced.

    “By inducing amenorrhea and halting menstrual bleeding and reflux, or even simply lessening its severity, pelvic oxidative stress, the main source of inflammation, can be significantly reduced [30].”

    From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [30]

  • Retrograde menstruation and bleeding in endometriosis lesions generate an iron overload and oxidative stress in the peritoneal cavity and/or in the endometriosis tissue.

    “Retrograde menstruation and bleeding in endometriosis lesions generate an iron overload and oxidative stress in the peritoneal cavity (109) and/or in the endometriosis tissue (110).”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [109]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Donnez, J., Binda, M. M., Donnez, O., & Dolmans, M.-M.
Affiliations
  • UCLouvain (BE)
  • Cliniques Universitaires Saint-Luc (BE)
Corresponding author
Dolmans, Marie-Madeleine
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2016-10
Volume
106
Issue
5
Pages
1011-1017
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2016.07.1075
OpenAlex
W2515189190
Semantic Scholar
167a6e84e12265cafa8a82a56c2deaae1e4d2fc9
Cited by
251
References
71
Citations by year
2026: 14 · 2025: 36 · 2024: 32 · 2023: 28 · 2022: 30 · 2021: 26 · 2020: 23 · 2019: 17 · 2018: 22 · 2017: 20 · 2016: 3
FWCI
2.92
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Libraries (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
endometriosis, oxidative stress, reactive oxygen species, antioxidants, heme, iron, hemoglobin, erythrocytes, macrophages, peritonitis, redox homeostasis, pathogenesis
MeSH terms
Animals, Antioxidants, Endometriosis, Erythrocytes, Female, Hemoglobins, Humans, Iron, Macrophages, Peritoneal Cavity, Risk Factors, Biomarkers, Reactive Oxygen Species, Oxidative Stress, Inflammation Mediators

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review