Hedonic Hot Spots in the Brain
Abstract
Hedonic “liking” for sensory pleasures is an important aspect of reward, and excessive ‘liking’ of particular rewards might contribute to excessive consumption and to disorders such as obesity. The present review aims to summarize recent advances in the identification of brain substrates for food ‘liking’ with a focus on opioid hot spots in the nucleus accumbens and ventral pallidum. Drug microinjection studies have shown that opioids in both areas amplify the ‘liking’ of sweet taste rewards. Modern neuroscience tools such as Fos plume mapping have further identified hedonic hot spots within the accumbens and pallidum, where opioids are especially tuned to magnify ‘liking’ of food rewards. Hedonic hot spots in different brain structures may interact with each other within the larger functional circuitry that interconnects them. Better understanding of how brain hedonic hot spots increase the positive affective impact of natural sensory pleasures will help characterize the neural mechanisms potentially involved in ‘liking’ for many rewards.
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Multiple brain regions not addressed in the review contribute to reward processing, including the subthalamic nucleus, ventral pallidum, subiculum, lateral habenula, and extended amygdala.
“Additionally, there are multiple brain regions not addressed in this review that contribute to reward processing, including the subthalamic nucleus and ventral pallidum, the subiculum, the lateral habenula, and the extended amygdala [736,737].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [737]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
(1994) · DigitalGeorgetown (Georgetown University Library) · Cited by 10,542 · see citing works
DESCARTES' ERROR: Emotion, Reason, and the Human Brain
Marg, E. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03988.x · Cited by 8,177 · see citing works
Well-being : the foundations of hedonic psychology
Kahneman, D. J., Diener, E. F., & Schwarz, N. (1999) · Cited by 7,472 · see citing works
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
Self-citationEmotion, Decision Making and the Orbitofrontal Cortex
Bechara, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.295 · Cited by 3,589 · see citing works
Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176 · see citing works
The human orbitofrontal cortex: linking reward to hedonic experience
Kringelbach, M. L. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1747 · Cited by 2,180 · see citing works
Food reward: brain substrates of wanting and liking
Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901 · see citing works
Self-citationProgress in Psychobiology and Physiological Psychology
Fluharty, S. J., & Grill, H. J. (2003) · Progress in psychobiology and physiological psychology · doi:10.1108/s0363-0951200318 · Cited by 1,701 · see citing works
Neurons in the orbitofrontal cortex encode economic value
Padoa-Schioppa, C., & Assad, J. A. (2006) · Nature · doi:10.1038/nature04676 · Cited by 1,598 · see citing works
Cabanac, M. (1971) · Science · doi:10.1126/science.173.4002.1103 · Cited by 1,521 · see citing works
Robinson, T. E., & Berridge, K. C. (2003) · Annual Review of Psychology · doi:10.1146/annurev.psych.54.101601.145237 · Cited by 1,509 · see citing works
Self-citationThe functions of the orbitofrontal cortex
Rolls, E. T. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00277-x · Cited by 1,327 · see citing works
Relative reward preference in primate orbitofrontal cortex
Tremblay, L., & Schultz, W. (1999) · Nature · doi:10.1038/19525 · Cited by 1,314 · see citing works
Efferent connections of the parabrachial nucleus in the rat
Saper, C. B., & Loewy, A. D. (1980) · Brain Research · doi:10.1016/0006-8993(80)91117-8 · Cited by 1,217 · see citing works
The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats
Grill, H. J., & Norgren, R. (1978) · Brain Research · doi:10.1016/0006-8993(78)90568-1 · Cited by 1,203 · see citing works
Hypothalamic control of food intake in rats and cats.
Anand, B. K., & Brobeck, J. R. (1951) · PubMed · Cited by 1,197 · see citing works
Changes in brain activity related to eating chocolate: From pleasure to aversion
Small, D. M. (2001) · Brain · doi:10.1093/brain/124.9.1720 · Cited by 1,179 · see citing works
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076 · see citing works
Teitelbaum, P., & Epstein, A. N. (1962) · Psychological Review · doi:10.1037/h0039285 · Cited by 884 · see citing works
Groenewegen, H. J., Vermeulen‐Vanderzee, E., Kortschot, A. T., & Witter, M. P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90275-2 · Cited by 867 · see citing works
Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning
Schoenbaum, G. M., Chiba, A. A., & Gallagher, M. (1998) · Nature Neuroscience · doi:10.1038/407 · Cited by 849 · see citing works
Berendse, H. W., Graaf, Y. G.-D., & Groenewegen, H. J. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903160305 · Cited by 847 · see citing works
Kringelbach, M. L. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1064 · Cited by 824 · see citing works
Dissociation of Neural Representation of Intensity and Affective Valuation in Human Gustation
Small, D. M., Gregory, M. D., Mak, Y. E., Gitelman, D. R., Mesulam, M. M., & Parrish, T. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00467-7 · Cited by 789 · see citing works
Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
Zubieta, J.-K., Bueller, J. A., Jackson, L. R., Scott, D. J., Xu, Y., Koeppe, R. A., Nichols, T. E., & Stohler, C. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0439-05.2005 · Cited by 779 · see citing works
Wyvell, C. L., & Berridge, K. C. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08122.2000 · Cited by 764 · see citing works
Self-citationTaste pathways to hypothalamus and amygdala
Norgren, R. (1976) · The Journal of Comparative Neurology · doi:10.1002/cne.901660103 · Cited by 761 · see citing works
Steiner, J. E., Glaser, D., Hawilo, M. E., & Berridge, K. C. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00051-8 · Cited by 752 · see citing works
Self-citationBerridge, K. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00072-x · Cited by 721 · see citing works
Self-citationPredictability modulates human brain response to reward
Berns, G. S., McClure, S. M., Pagnoni, G., & Montague, P. R. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02793.2001 · Cited by 711 · see citing works
Berridge, K. C. (2003) · Brain and Cognition · doi:10.1016/s0278-2626(03)00014-9 · Cited by 694 · see citing works
Self-citationDrug-activation of brain reward pathways
Wise, R. A. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00063-5 · Cited by 684 · see citing works
Peciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671 · see citing works
Self-citationOrbitofrontal Cortex and Representation of Incentive Value in Associative Learning
Gallagher, M., McMahan, R. W., & Schoenbaum, G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06610.1999 · Cited by 593 · see citing works
Different representations of pleasant and unpleasant odours in the human brain
Rolls, E. T., Kringelbach, M. L., & de Araújo, I. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02779.x · Cited by 566 · see citing works
Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
Peciña, S., Cagniard, B., Berridge, K. C., Aldridge, J. W., & Zhuang, X. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09395.2003 · Cited by 551 · see citing works
Self-citationOpioid modulation of taste hedonics within the ventral striatum
Kelley, A. E., Bakshi, V. P., Haber, S. N., Steininger, T. L., Will, M. J., & Zhang, M. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00751-5 · Cited by 526 · see citing works
Zahm, D. S. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00065-2 · Cited by 487 · see citing works
Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex
OʼDoherty, J., Rolls, E. T., Francis, S., Bowtell, R., McGlone, F., Kobal, G., Renner, B., & Ahne, G. (2000) · NeuroReport · doi:10.1097/00001756-200002070-00035 · Cited by 482 · see citing works
Aragona, B. J., Liu, Y., Yu, Y. J., Curtis, J. T., Detwiler, J. M., Insel, T. R., & Wang, Z. (2006) · Nature Neuroscience · doi:10.1038/nn1613 · Cited by 473 · see citing works
Rolls, E. T., Sienkiewicz, Z. J., & Yaxley, S. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00774.x · Cited by 466 · see citing works
Groenewegen, H. J., Berendse, H. W., & Haber, S. N. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90115-v · Cited by 456 · see citing works
Roitman, M. F., Wheeler, R. A., & Carelli, R. M. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.055 · Cited by 453 · see citing works
Francis, S., Rolls, E. T., Bowtell, R. W., McGlone, F. P., O’Doherty, J. P., Browning, A., Clare, S., & Smith, E. (1999) · Neuroreport · doi:10.1097/00001756-199902250-00003 · Cited by 421 · see citing works
The topographic order of inputs to nucleus accumbens in the rat
Phillipson, O. T., & Griffiths, A. C. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90002-8 · Cited by 415 · see citing works
Mogenson, G. J., Swanson, L. W., & Wu, M. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-01-00189.1983 · Cited by 410 · see citing works
Peciña, S., & Berridge, K. C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02102-8 · Cited by 405 · see citing works
Self-citationThe Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake
Smith, K. S., & Berridge, K. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-05.2005 · Cited by 391 · see citing works
Self-citationTempel, A., & Zukin, R. S. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.12.4308 · Cited by 383 · see citing works
Different Roles for Orbitofrontal Cortex and Basolateral Amygdala in a Reinforcer Devaluation Task
Pickens, C. L., Saddoris, M. P., Setlow, B., Gallagher, M., Holland, P. C., & Schoenbaum, G. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11078.2003 · Cited by 379 · see citing works
Berridge, K. C., Venier, I. L., & Robinson, T. E. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.1.36 · Cited by 356 · see citing works
Self-citationHuman Cortical Responses to Water in the Mouth, and the Effects of Thirst
de Araújo, I. E., Kringelbach, M. L., Rolls, E. T., & McGlone, F. P. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00297.2003 · Cited by 334 · see citing works
Greenwald, M. K., Johanson, C.-E., Moody, D. E., Woods, J. H., Kilbourn, M. R., Koeppe, R. A., Schuster, C. R., & Zubieta, J.-K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300251 · Cited by 320 · see citing works
Voorn, P., Jorritsma‐Byham, B., Dijk, C. V., & Buijs, R. M. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902510106 · Cited by 318 · see citing works
Opioid peptides and the control of human ingestive behaviour
Yeomans, M. R., & Gray, R. W. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00041-6 · Cited by 317 · see citing works
Berridge, K. C., & Valenstein, E. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.3 · Cited by 302 · cited 2× · see citing works
“Instead, mesolimbic electrodes may have generally produced a false pleasure, that is, by generating motivational ‘wanting’ without hedonic ‘liking’ (Berridge and Valenstein 1991; Berridge 2003).”
BackgroundSelf-citationCagniard, B., Balsam, P. D., Brunner, D., & Zhuang, X. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300966 · Cited by 282 · see citing works
Neural associations of the substantia innominata in the rat: Afferent connections
Grove, E. A. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902770302 · Cited by 281 · see citing works
Tindell, A. J., Berridge, K. C., Zhang, J., Peciña, S., & Aldridge, J. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04411.x · Cited by 268 · see citing works
Self-citationZhang, M., & Kelley, A. E. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00198-6 · Cited by 260 · see citing works
PLEASURE AND BRAIN ACTIVITY IN MAN
Heath, R. G. (1972) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-197201000-00002 · Cited by 254 · see citing works
Usuda, I., Tanaka, K., & Chiba, T. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00359-x · Cited by 248 · see citing works
Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards
Robinson, S., Sandstrom, S. M., Denenberg, V. H., & Palmiter, R. D. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.1.5 · Cited by 247 · see citing works
Pickel, V. M., Chan, J., Kash, T. L., Rodrı́guez, J.-J., & Mackie, K. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.015 · Cited by 243 · see citing works
Ventral pallidum firing codes hedonic reward: when a bad taste turns good
Tindell, A. J., Smith, K. S., Peciña, S., Berridge, K. C., & Aldridge, J. W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00576.2006 · Cited by 241 · see citing works
Self-citationFood for thought: hedonic experience beyond homeostasis in the human brain
Kringelbach, M. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.035 · Cited by 236 · see citing works
Dynamic changes in nucleus accumbens dopamine efflux during the Coolidge effect in male rats
Fiorino, D. F., Coury, A., & Phillips, A. G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04849.1997 · Cited by 226 · see citing works
Amygdaloid projections to ventromedial striatal subterritories in the primate
Fudge, J. L., Kunishio, K., Walsh, P., Richard, C., & Haber, S. N. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00546-2 · Cited by 226 · see citing works
Efferent connections of the substantia innominata in the rat
Grove, E. A. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902770303 · Cited by 222 · see citing works
Cromwell, H. C., & Berridge, K. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90053-p · Cited by 220 · see citing works
Self-citationTaha, S. A., & Fields, H. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3975-04.2005 · Cited by 217 · see citing works
Recovery from the Failure to Eat Produced by Hypothalamic Lesions
Teitelbaum, P., & Stellar, E. (1954) · Science · doi:10.1126/science.120.3126.894 · Cited by 216 · see citing works
The role of dopamine in the nucleus accumbens and striatum during sexual behavior in the female rat
Becker, J. B., Rudick, C. N., & Jenkins, W. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03236.2001 · Cited by 206 · see citing works
Brain mechanisms of drug reward and euphoria.
Wise, R. A., & Bozarth, M. A. (1985) · PubMed · Cited by 206 · see citing works
Zahm, D. S., Záborszky, L., Alones, V., & Heimer, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90331-2 · Cited by 196 · see citing works
Peciña, S., Schulkin, J., & Berridge, K. C. (2006) · BMC Biology · doi:10.1186/1741-7007-4-8 · Cited by 194 · see citing works
Self-citationFeeding induced by opioid stimulation of the ventral striatum: role of opiate receptor subtypes.
Bakshi, V. P., & Kelley, A. E. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38247-9 · Cited by 193 · see citing works
Chang, J., Sawyer, S. F., Lee, R., & Woodward, D. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01224.1994 · Cited by 177 · see citing works
Solinas, M., & Goldberg, S. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300720 · Cited by 174 · see citing works
Involvement of dynorphin and the kappa opioid receptor in feeding
Morley, J. E., & Levine, A. S. (1983) · Peptides · doi:10.1016/0196-9781(83)90069-4 · Cited by 172 · see citing works
The anhedonia hypothesis: mark III.
Wise, R. A. (1985) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00020306 · Cited by 169 · see citing works
Baylis, L. L., & Gaffan, D. (1991) · Experimental Brain Research · doi:10.1007/bf00230535 · Cited by 166 · see citing works
Ahn, S., & Phillips, A. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-j0003.1999 · Cited by 160 · see citing works
Mucha, R. F., & Iversen, S. D. (1986) · Brain Research · doi:10.1016/0006-8993(86)90622-0 · Cited by 159 · see citing works
Endogenous cannabinoids and appetite
Kirkham, T. C., & Williams, C. M. (2001) · Nutrition Research Reviews · doi:10.1079/095442201108729141 · Cited by 152 · see citing works
Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo
Maidment, N. T., Brumbaugh, D. R., Rudolph, V. D., Erdelyi, E., & Evans, C. J. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90407-7 · Cited by 151 · see citing works
Peoples, L. L., & West, M. O. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03459.1996 · Cited by 149 · see citing works
Peciña, S. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00044-0 · Cited by 148 · see citing works
Self-citationParker, L. A., Maier, S., Rennie, M., & Crebolder, J. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.6.999 · Cited by 142 · see citing works
Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat
Cooper, S. J. (1983) · Neuropharmacology · doi:10.1016/0028-3908(83)90247-2 · Cited by 133 · see citing works
Endogenous cannabinoids and appetite.
Kirkham, F. J., & Williams, C. M. (2001) · PubMed · doi:10.1079/nrr200118 · Cited by 133 · see citing works
Morphine enhances hedonic taste palatability in rats
Doyle, T. G., Berridge, K. C., & Gosnell, B. A. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90572-b · Cited by 131 · see citing works
Self-citationCooper, S. J., & Estall, L. B. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90028-4 · Cited by 130 · see citing works
Relative reward processing in primate striatum
Cromwell, H. C., Hassani, O. K., & Schultz, W. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-2223-z · Cited by 129 · see citing works
Gordh, A. S., & Berridge, K. C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02691-3 · Cited by 128 · see citing works
Self-citationVentral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes
Tindell, A. J., Berridge, K. C., & Aldridge, J. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1437-03.2004 · Cited by 128 · see citing works
Self-citationParker, L. A., Maier, S., Rennie, M., et al. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.6.999 · Cited by 126 · see citing works
Anhedonia After a Selective Bilateral Lesion of the Globus Pallidus
Miller, J. M., Vorel, S. R., Tranguch, A. J., Kenny, E. T., Mazzoni, P., van Gorp, W. G., & Kleber, H. D. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.5.786 · Cited by 120 · see citing works
Cannabinoid Modulation of Opiate Reinforcement through the Ventral Striatopallidal Pathway
Caillé, S., & Parsons, L. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300848 · Cited by 118 · see citing works
Schallert, T. J., & Whishaw, I. Q. (1978) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077504 · Cited by 116 · see citing works
Lundy, R. F., & Norgren, R. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00840.2003 · Cited by 115 · see citing works
Chlordiazepoxide directly enhances positive ingestive reactions in rats
Berridge, K. C., & Treit, D. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90341-2 · Cited by 111 · see citing works
Self-citationChurchill, L., & Kalivas, P. W. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450408 · Cited by 110 · see citing works
Opioid Modulation of Ventral Pallidal Inputs
Napier, T. C., & Mitrovic, I. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09268.x · Cited by 106 · see citing works
Stimulation of food intake following opioid microinjection into the nucleus accumbens septi in rats
Majeed, N. H., Przewklocka, B., Wędzony, K., & Przewklocki, R. (1986) · Peptides · doi:10.1016/0196-9781(86)90083-5 · Cited by 105 · see citing works
Blockade of GABAA receptors in the medial ventral pallidum elicits feeding in satiated rats
Stratford, T. R., Kelley, A. E., & Simansky, K. J. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01239-1 · Cited by 105 · see citing works
Neurochemical modulation of ingestive behavior in the ventral pallidum
Shimura, T., Imaoka, H., & Yamamoto, T. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04689.x · Cited by 102 · see citing works
Orbitofrontal Ensemble Activity Monitors Licking and Distinguishes Among Natural Rewards
Gutiérrez, R., Carmena, J. M., Nicolelis, M. A. L., & Simon, S. A. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00467.2005 · Cited by 101 · see citing works
Olive, M. F., Antón, B., Micevych, P. E., Evans, C. J., & Maidment, N. T. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07471.1997 · Cited by 89 · see citing works
On the neural computation of utility: implications from studies of brain stimulation reward
Shizgal, P. (1999) · CogPrints (University of Southampton) · Cited by 87 · see citing works
Hoebel, B. G., Rada, P. V., Mark, G. P., & Pothos, E. N. (1999) · Cited by 86 · see citing works
Hyperphagia induced by direct administration of midazolam into the parabrachial nucleus of the rat
Higgs, S., & Cooper, S. J. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00446-3 · Cited by 75 · see citing works
Carelli, R. M., & Deadwyler, S. A. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00442-x · Cited by 68 · see citing works
Bengtson, C. P., & Osborne, P. B. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.2649 · Cited by 63 · see citing works
Central enhancement of taste pleasure by intraventricular morphine.
Peciña, S., & Berridge, K. C. (1995) · PubMed · Cited by 63 · see citing works
Self-citationWard, H. G., Nicklous, D. M., Aloyo, V. J., & Simansky, K. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04674.x · Cited by 61 · see citing works
Kim, E., Quinn, J. G., Levine, A. S., & O‘Hare, E. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.001 · Cited by 60 · see citing works
Morphine enhancement of sucrose palatability: Analysis by the taste reactivity test
Rideout, H. J., & Parker, L. A. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02077-2 · Cited by 58 · see citing works
Approach and withdrawal analysis of the effects of hypothalamic stimulation and lesions in rats.
Stellar, J. R., Brooks, F. H., & Mills, L. E. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077590 · Cited by 57 · see citing works
̃a, S. P., & Berridge, K. C. (1996) · Brain Research · doi:10.1016/0006-8993(96)00325-3 · Cited by 57 · see citing works
Self-citationBrainstem systems mediate the enhancement of palatability by chlordiazepoxide
Berridge, K. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)91128-6 · Cited by 52 · see citing works
Self-citationPleasure, Unfelt Affect, and Irrational Desire
Berridge, K. C. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511806582.015 · Cited by 50 · see citing works
Self-citationRolls, E. T. (1998) · doi:10.1093/oso/9780198524649.003.0005 · Cited by 46 · see citing works
Hakan, R. L., Berg, G. I., & Henriksen, S. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)90730-w · Cited by 43 · see citing works
RICHARDSON, D., REYNOLDS, S., COOPER, S., & Berridge, K. C. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.05.006 · Cited by 37 · see citing works
Self-citationPeciña, S. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00325-3 · Cited by 35 · see citing works
Self-citationNeuropharmacology of appetite and taste preferences
Cooper, S. J., & Higgs, S. (1994) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198547877.003.0009 · Cited by 29 · see citing works
Hakan, R. L., & Eyl, C. (1995) · Synapse · doi:10.1002/syn.890200212 · Cited by 12 · see citing works
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Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347 · see citing works
Self-citationA framework for studying the neurobiology of value-based decision making
Rangel, A., Camerer, C., & Montague, P. R. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2357 · Cited by 2,184 · see citing works
Dissecting components of reward: ‘liking’, ‘wanting’, and learning
Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942 · see citing works
Self-citationReconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254 · see citing works
Self-citation“Liking” and “wanting” food rewards: Brain substrates and roles in eating disorders
Berridge, K. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.044 · Cited by 1,147 · see citing works
Self-citationDiscriminative and affective touch: Sensing and feeling.
McGlone, F., Wessberg, J., & Olausson, H. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.001 · Cited by 1,112 · see citing works
Reward Processing by the Opioid System in the Brain
Le Merrer, J., Becker, J. A. J., Befort, K., & Kieffer, B. L. (2009) · Physiological Reviews · doi:10.1152/physrev.00005.2009 · Cited by 1,013 · see citing works
The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.003 · Cited by 873 · see citing works
Self-citationTranslational principles of deep brain stimulation
Kringelbach, M. L., Jenkinson, N., Owen, S. L. F., & Aziz, T. Z. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2196 · Cited by 853 · see citing works
Mendl, M., Burman, O. H. P., Parker, R. M. A., & Paul, E. S. (2009) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2009.02.023 · Cited by 763 · see citing works
Reward mechanisms in obesity: new insights and future directions
Kenny, P. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.016 · Cited by 748 · see citing works
From prediction error to incentive salience: mesolimbic computation of reward motivation.
Berridge, K. C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.07990.x · Cited by 700 · see citing works
Self-citationEarly Influences on the Development of Food Preferences
Ventura, A. K., & Worobey, J. (2013) · Current Biology · doi:10.1016/j.cub.2013.02.037 · Cited by 641 · see citing works
Intense Sweetness Surpasses Cocaine Reward
Lenoir, M., Serre, F., Cantin, L., & Ahmed, S. H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000698 · Cited by 608 · see citing works
The basic emotional circuits of mammalian brains: Do animals have affective lives?
Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.08.003 · Cited by 562 · see citing works
Ventral pallidum roles in reward and motivation
Smith, K. S., Tindell, A. J., Aldridge, J. W., & Berridge, K. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.038 · Cited by 548 · see citing works
Self-citation“Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior
Hebebrand, J., Albayrak, Ö., Adan, R. A. H., Antel, J., Diéguez, C., de Jong, J. W., Leng, G., Menzies, J. R. W., Mercer, J. G., Murphy, M., et al. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.016 · Cited by 526 · see citing works
Towards a functional neuroanatomy of pleasure and happiness
Kringelbach, M. L., & Berridge, K. C. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.08.006 · Cited by 528 · see citing works
Self-citationBarch, D. M., & Dowd, E. C. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq068 · Cited by 478 · see citing works
Kühn, S., & Gallinat, J. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07590.x · Cited by 474 · see citing works
Smith, K. S., & Berridge, K. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4205-06.2007 · Cited by 450 · see citing works
Self-citationDopamine modulates the reward experiences elicited by music
Ferreri, L., Herrero, E. M., Zatorre, R. J., Ripollés, P., Gómez-Andrés, A., Alicart, H., Olivé, G., Marco‐Pallarés, J., Antonijoan, R. M., Valle, M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811878116 · Cited by 440 · see citing works
Yin, H. H., Ostlund, S. B., & Balleine, B. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06422.x · Cited by 416 · see citing works
Food Reward in the Absence of Taste Receptor Signaling
de Araujo, I. E., Oliveira-Maia, A. J., Sotnikova, T. D., Gainetdinov, R. R., Caron, M. G., Nicolelis, M. A. L., & Simon, S. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.032 · Cited by 431 · see citing works
Relatively strong automatic appetitive action‐tendencies in male carriers of the OPRM1 G‐allele
Wiers, R. W., Rinck, M., Dictus, M., & Van Den Wildenberg, E. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00454.x · Cited by 377 · see citing works
Discriminative touch and emotional touch.
McGlone, F. P., Vallbo, Å. B., Olausson, H., Löken, L. S., & Wessberg, J. (2007) · Canadian Journal of Experimental Psychology/Revue canadienne de psychologie expérimentale · doi:10.1037/cjep2007019 · Cited by 324 · see citing works
Subliminal Instrumental Conditioning Demonstrated in the Human Brain
Pessiglione, M., Petrovic, P., Daunizeau, J., Palminteri, S., Dolan, R. J., & Frith, C. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.005 · Cited by 308 · see citing works
Panksepp, J. (2007) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2007.00045.x · Cited by 314 · see citing works
Enhanced Striatal Dopamine Release During Food Stimulation in Binge Eating Disorder
Wang, G., Geliebter, A., Volkow, N. D., Telang, F. W., Logan, J., Jayne, M. C., Galanti, K., Selig, P. A., Han, H., Zhu, W., et al. (2011) · Obesity · doi:10.1038/oby.2011.27 · Cited by 313 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
O'Hara, C., Campbell, I. C., & Schmidt, U. H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.012 · Cited by 271 · see citing works
The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance
Nieuwenhuizen, A. G., & Rutters, F. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.12.011 · Cited by 263 · see citing works
Evaluating the rewarding nature of social interactions in laboratory animals
Trezza, V., Campolongo, P., & Vanderschuren, L. J. M. J. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.05.007 · Cited by 258 · see citing works
Anhedonia and Substance Dependence: Clinical Correlates and Treatment Options
Hatzigiakoumis, D. S., Martinotti, G., Giannantonio, M. D., & Janiri, L. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00010 · Cited by 238 · see citing works
The neural correlates of subjective pleasantness
Kühn, S., & Gallinat, J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.065 · Cited by 232 · see citing works
Building a neuroscience of pleasure and well-being
Berridge, K. C., & Kringelbach, M. L. (2011) · Psychology of Well-Being: Theory, Research and Practice · doi:10.1186/2211-1522-1-3 · Cited by 229 · see citing works
Self-citationBarch, D. M., Pagliaccio, D., & Luking, K. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_376 · Cited by 218 · see citing works
Faget, L. C., Zell, V., Souter, E. A., McPherson, A. D., Ressler, R. L., Gutierrez-Reed, N. A., Yoo, J. H., Dulcis, D., & Hnasko, T. S. (2018) · Nature Communications · doi:10.1038/s41467-018-03125-y · Cited by 213 · see citing works
A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks
Karin, O., Raz, M., Tendler, A., Bar, A., Korem Kohanim, Y., Milo, T., & Alon, U. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209510 · Cited by 200 · see citing works
Wanting and liking: observations from the Neuroscience and Psychology Laboratory.
Berridge, K. C. (2009) · Inquiry · doi:10.1080/00201740903087359 · Cited by 204 · see citing works
Self-citationCoordinated Accumbal Dopamine Release and Neural Activity Drive Goal-Directed Behavior
Cheer, J. F., Aragona, B. J., Heien, M. L., Seipel, A. T., Carelli, R. M., & Wightman, R. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.021 · Cited by 202 · see citing works
Reward, motivation, and emotion of pain and its relief
Porreca, F., & Navratilova, E. (2017) · Pain · doi:10.1097/j.pain.0000000000000798 · Cited by 198 · see citing works
Good Vibrations: Cross-frequency Coupling in the Human Nucleus Accumbens during Reward Processing
Cohen, M. X., Axmacher, N., Lenartz, D., Elger, C. E., Sturm, V., & Schlaepfer, T. E. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21062 · Cited by 197 · see citing works
Twenty-Five Lessons from Computational Neuromodulation
Dayan, P. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.027 · Cited by 190 · see citing works
Coenen, V. A., Honey, C. R., Hurwitz, T. A., Rahman, A. A., McMaster, J., Bürgel, U., & Mädler, B. (2009) · Neurosurgery · doi:10.1227/01.neu.0000345631.54446.06 · Cited by 187 · see citing works
Panksepp, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.015 · Cited by 184 · see citing works
Unipolar depression does not moderate responses to the Sweet Taste Test
Dichter, G. S., Smoski, M. J., Kampov-Polevoy, A. B., Gallop, R., & Garbutt, J. C. (2010) · Depression and Anxiety · doi:10.1002/da.20690 · Cited by 175 · see citing works
Fox, C. R., & Poldrack, R. A. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374176-9.00011-7 · Cited by 169 · see citing works
Volman, S. F., Lammel, S., Margolis, E. B., Kim, Y., Richard, J. M., Roitman, M. F., & Lobo, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3250-13.2013 · Cited by 168 · see citing works
Mannella, F., Gurney, K., & Baldassarre, G. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00135 · Cited by 166 · see citing works
Panksepp, J., Lane, R. D., Solms, M., & Smith, R. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.010 · Cited by 167 · see citing works
The relationship between stress, dietary restraint, and food preferences in women
Habhab, S., Sheldon, J. P., & Loeb, R. C. (2008) · Appetite · doi:10.1016/j.appet.2008.12.006 · Cited by 159 · see citing works
Pelchat, M. L. (2009) · Journal of Nutrition · doi:10.3945/jn.108.097816 · Cited by 154 · see citing works
Anchors, scales and the relative coding of value in the brain
Seymour, B., & McClure, S. M. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.07.010 · Cited by 152 · see citing works
Dong, X., Li, S., & Kirouac, G. J. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1445-8 · Cited by 143 · see citing works
Animal pleasure and its moral significance
Balcombe, J. P. (2009) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2009.02.012 · Cited by 145 · see citing works
Predicting personality from network-based resting-state functional connectivity
Nostro, A. D., Müller, V. I., Varikuti, D. P., Pläschke, R. N., Hoffstaedter, F., Langner, R., Patil, K. R., & Eickhoff, S. B. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1651-z · Cited by 138 · see citing works
Special Review: Decision Utility, The Brain, and Pursuit of Hedonic Goals
Berridge, K. C., & Aldridge, J. W. (2008) · Social Cognition · doi:10.1521/soco.2008.26.5.621 · Cited by 139 · see citing works
Self-citationOpioid reward ‘liking’ and ‘wanting’ in the nucleus accumbens
Peciña, S. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.006 · Cited by 132 · see citing works
Self-citationOrbitofrontal reward sensitivity and impulsivity in adult attention deficit hyperactivity disorder
Wilbertz, G., Tebartz van Elst, L., Delgado, M. R., Maier, S., Feige, B., Philipsen, A., & Blechert, J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.011 · Cited by 125 · see citing works
“You Say it's Liking, I Say it's Wanting …”. On the difficulty of disentangling food reward in man
Havermans, R. C. (2011) · Appetite · doi:10.1016/j.appet.2011.05.310 · Cited by 125 · see citing works
Petrovic, P., Pleger, B., Seymour, B., Klöppel, S., de Martino, B., Critchley, H., & Dolan, R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2807-08.2008 · Cited by 130 · see citing works
Get Aroused and Be Stronger: Emotional Facilitation of Physical Effort in the Human Brain
Schmidt, L., Cléry-Melin, M.-L., Lafargue, G., Valabrègue, R., Fossati, P., Dubois, B., & Pessiglione, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1951-09.2009 · Cited by 123 · see citing works
Dopamine regulation of social choice in a monogamous rodent species
Aragona, B. J. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.015.2009 · Cited by 119 · see citing works
“This sub-region is critical for processing positive affect and unconditioned aspects of associative learning (Di Chiara and Bassareo, 2007; Ikemoto, 2007; Pecina et al., 2006).”
BackgroundSelective breeding for differential saccharin intake as an animal model of drug abuse
Carroll, M. E., Morgan, A. D., Anker, J. J., Perry, J. L., & Dess, N. K. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830c3632 · Cited by 118 · see citing works
Hedonic Hotspots: Generating Sensory Pleasure in the Brain
Smith, K. S., Mahler, S. V., Peciña, S., & Berridge, K. C. (2009) · Oxford University Press eBooks · doi:10.1093/oso/9780195331028.003.0003 · Cited by 117 · see citing works
Self-citationExtended Heroin Access Increases Heroin Choices Over a Potent Nondrug Alternative
Lenoir, M., Cantin, L., Vanhille, N., Serre, F., & Ahmed, S. H. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.17 · Cited by 114 · see citing works
Emerging trends in in vivo neurochemical monitoring by microdialysis
Kennedy, R. T. (2013) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2013.06.012 · Cited by 114 · see citing works
The Structure of Temperament and Personality Traits: A Developmental PerspectivePreprint
Shiner, R. L., & DeYoung, C. G. (2011) · RePEc: Research Papers in Economics · Cited by 114 · see citing works
Colavito, V., Tesoriero, C., Wirtu, A. T., Grassi-Zucconi, G., & Bentivoglio, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.021 · Cited by 117 · see citing works
Zellner, M. R., Watt, D. F., Solms, M., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.01.003 · Cited by 112 · see citing works
Finlayson, G., & Dalton, M. (2012) · Current Obesity Reports · doi:10.1007/s13679-011-0007-2 · Cited by 111 · see citing works
Metabolic Regulation of Brain Response to Food Cues
de Araújo, I. E., Lin, T., Veldhuizen, M. G., & Small, D. M. (2013) · Current Biology · doi:10.1016/j.cub.2013.04.001 · Cited by 111 · see citing works
Strong, M. N., Yoneyama, N., Fretwell, A. M., Snelling, C., Tanchuck, M. A., & Finn, D. A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.10.008 · Cited by 110 · see citing works
Does the kappa opioid receptor system contribute to pain aversion?
Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., Morón, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105 · see citing works
Hedonic and motivational roles of opioids in food reward: Implications for overeating disorders
Peciña, S., & Smith, K. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.016 · Cited by 104 · see citing works
Self-citationHPA Axis Interactions with Behavioral Systems
Packard, A. E. B., Egan, A. E., & Ulrich‐Lai, Y. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150042 · Cited by 130 · see citing works
Cerebral interactions of pain and reward and their relevance for chronic pain
Becker, S., Gandhi, W., & Schweinhardt, P. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.013 · Cited by 103 · see citing works
What are intrinsic motivations? A biological perspective
Baldassarre, G. (2011) · IEEE International Conference on Development and Learning (ICDL) · doi:10.1109/devlrn.2011.6037367 · Cited by 102 · see citing works
The role of motivation and reward neural systems in vocal communication in songbirds
Riters, L. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.04.002 · Cited by 100 · see citing works
Case Study of Ecstatic Meditation: fMRI and EEG Evidence of Self‐Stimulating a Reward System
Hagerty, M. R., Isaacs, J., Brasington, L., Shupe, L., Fetz, E. E., & Cramer, S. C. (2013) · Neural Plasticity · doi:10.1155/2013/653572 · Cited by 100 · see citing works
Hedonic sensitivity in adolescent and adult rats: Taste reactivity and voluntary sucrose consumption
Wilmouth, C. E., & Spear, L. P. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.02.009 · Cited by 96 · see citing works
Sweet taste pleasantness is modulated by morphine and naltrexone
Eikemo, M., Løseth, G. E., Johnstone, T., Gjerstad, J., Willoch, F., & Leknes, S. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4403-x · Cited by 92 · see citing works
Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary, M. M., Polosecki, P. I., Cecchi, G., DeAraujo, I. E., Barron, D. S., Constable, R. T., Whang, P. G., Thomas, D.-A. M., Mowafi, H. O., Small, D. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918682117 · Cited by 90 · see citing works
A Neural Signature of Affiliative Emotion in the Human Septohypothalamic Area
Moll, J., Bado, P., de Oliveira‐Souza, R., Bramati, I. E., Lima, D. O., Paiva, F. F., Sato, J. R., Tovar-Moll, F. F., & Zahn, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6508-11.2012 · Cited by 87 · see citing works
A novel mouse model of glucagon‐like peptide‐1 receptor expression: A look at the brain
Graham, D. L., Durai, H. H., Trammell, T. S., Noble, B. L., Mortlock, D. P., Galli, A., & Stanwood, G. D. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24905 · Cited by 89 · see citing works
Reduced hedonic capacity in euthymic bipolar subjects: a trait-like feature
Di Nicola, M., De Risio, L., Battaglia, C., Camardese, G., Tedeschi, D., Mazza, M., Martinotti, G., Pozzi, G., Niolu, C., Di Giannantonio, M., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.004 · Cited by 87 · see citing works
Neural and psychological underpinnings of gambling disorder: A review
Grant, J. E., Odlaug, B. L., & Chamberlain, S. R. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.10.007 · Cited by 88 · see citing works
Suardi, A., Sotgiu, I., Costa, T., Cauda, F., & Rusconi, M. (2016) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-016-0414-7 · Cited by 80 · see citing works
Falowski, S. M., Sharan, A. D., Reyes, B. A. S., Sikkema, C. L., Szot, P., & Bockstaele, E. J. V. (2011) · Neurosurgery · doi:10.1227/neu.0b013e3182237346 · Cited by 87 · see citing works
The adolescent brain: Insights from functional neuroimaging research
Ernst, M., & Mueller, S. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20615 · Cited by 85 · see citing works
The Rise and Fall of Political Orders
Lebow, R. N. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108578820 · Cited by 84 · see citing works
Dalton, M., Blundell, J. E., & Finlayson, G. (2013) · Obesity Facts · doi:10.1159/000354599 · Cited by 86 · see citing works
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Reybrouck, M., Vuust, P., & Brattico, E. (2021) · Brain Sciences · doi:10.3390/brainsci11121553 · Cited by 84 · see citing works
Boswell, R. G., Potenza, M. N., & Grilo, C. M. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.10.014 · Cited by 82 · see citing works
Ayres, C., Agranonik, M., Portella, A. K., Filion, F., Johnston, C. C., & Silveira, P. P. (2012) · International Journal of Pediatrics · doi:10.1155/2012/657379 · Cited by 81 · see citing works
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Plasse, G., Schrama, R., van Seters, S., Vanderschuren, L. J. M. J., & Westenberg, H. G. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033455 · Cited by 78 · see citing works
- Authors
- Peciña, S., Smith, K. S., & Berridge, K. C.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Peciña, Susana
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2006-12
- Volume
- 12
- Issue
- 6
- Pages
- 500-511
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2016426141
- Cited by
- 441
- References
- 131
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 9 · 2023: 32 · 2022: 17 · 2021: 13 · 2020: 28 · 2019: 16 · 2018: 30 · 2017: 18 · 2016: 24 · 2015: 17 · 2014: 29 · 2013: 27 · 2012: 32
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-63649, R01MH063649)
- National Institute on Drug Abuse (DA015188, R01DA015188)
- National Institute on Deafness and Other Communication Disorders (DC-00011)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- food liking, opioid signaling, nucleus accumbens, ventral pallidum, reward, sweet taste, neural circuits, obesity, overeating
- MeSH terms
- Animals, Behavior, Animal, Brain, Brain Mapping, Emotions, Globus Pallidus, Humans, Neural Pathways, Nucleus Accumbens, Reward
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