Gut microbiome and kidney disease: a bidirectional relationship
Open accessAbstract
Recent technological advances and efforts, including powerful metagenomic and metatranscriptomic analyses, have led to a tremendous growth in our understanding of microbial communities. Changes in microbial abundance or composition of human microbial communities impact human health or disease state. However, explorations into the mechanisms underlying host-microbe interactions in health and disease are still in their infancy. Although changes in the gut microbiota have been described in patients with kidney disease, the relationships between pathogenesis, mechanisms of disease progression, and the gut microbiome are still evolving. Here, we review changes in the host-microbiome symbiotic relationship in an attempt to explore the bidirectional relationship in which alterations in the microbiome affect kidney disease progression and how kidney disease may disrupt a balanced microbiome. We also discuss potential targeted interventions that may help re-establish this symbiosis and propose more effective ways to deploy traditional treatments in patients with kidney disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Emerging evidence has led to expansion of this concept to that of the brain-gut-kidney axis.
“Emerging evidence has led to expansion of this concept to that of the brain-gut-kidney axis9,118,160,161 (TABLE 2).”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [118]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works
Levey, A., Eckardt, K., Tsukamoto, Y., Levin, A., Coresh, J., Rossert, J., de Zeeuw, D., Hostetter, T., Lameire, N., & Eknoyan, G. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00365.x · Cited by 3,963 · see citing works
The human microbiome: at the interface of health and disease
Cho, I., & Blaser, M. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3182 · Cited by 3,449 · see citing works
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358 · see citing works
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677 · see citing works
The NIH Human Microbiome ProjectPreprint
The NIH HMP Working Group, Peterson, J. L., Garges, S., Giovanni, M. Y., McInnes, P., Wang, L., Schloss, J. A., Bonazzi, V. R., McEwen, J. E., Wetterstrand, K. A., et al. (2009) · Genome Research · doi:10.1101/gr.096651.109 · Cited by 2,104 · see citing works
The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead
Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789 · see citing works
Dysbiosis of the gut microbiota in disease
Carding, S., Verbeke, K., Vipond, D. T., Corfe, B. M., & Owen, L. J. (2015) · Microbial Ecology in Health & Disease · doi:10.3402/mehd.v26.26191 · Cited by 1,710 · see citing works
H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE
Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623 · see citing works
Interactions between commensal intestinal bacteria and the immune system
Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,607 · see citing works
Gut Dysbiosis Is Linked to Hypertension
Yang, T., Santisteban, M. M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J. M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05315 · Cited by 1,478 · see citing works
Tang, W. H. W., Wang, Z., Kennedy, D. J., Wu, Y., Buffa, J. A., Agatisa-Boyle, B., Li, X. S., Levison, B. S., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.305360 · Cited by 1,223 · see citing works
Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191 · see citing works
Chronic kidney disease alters intestinal microbial flora
Vaziri, N. D., Wong, J., Pahl, M., Piceno, Y. M., Yuan, J., DeSantis, T. Z., Ni, Z., Nguyen, T.-H., & Andersen, G. L. (2013) · Kidney International · doi:10.1038/ki.2012.345 · Cited by 1,164 · see citing works
Jakobsson, H. E., Jernberg, C., Andersson, A. F., Sjölund-Karlsson, M., Jansson, J. K., & Engstrand, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009836 · Cited by 1,160 · see citing works
Overweight, Ethnicity, and the Prevalence of Hypertension in School-Aged Children
Sorof, J. M., Lai, D., Turner, J., Poffenbarger, T., & Portman, R. J. (2004) · Pediatrics · doi:10.1542/peds.113.3.475 · Cited by 1,075 · see citing works
Microbial community profiling for human microbiome projects: Tools, techniques, and challengesPreprint
Hamady, M., & Knight, R. D. (2009) · Genome Research · doi:10.1101/gr.085464.108 · Cited by 1,002 · see citing works
The Gut Microbiome, Kidney Disease, and Targeted Interventions
Ramezani, A., & Raj, D. S. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013080905 · Cited by 752 · see citing works
Experimental and analytical tools for studying the human microbiome
Kuczynski, J., Lauber, C. L., Walters, W. A., Parfrey, L. W., Clemente, J. C., Gevers, D., & Knight, R. D. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3129 · Cited by 710 · see citing works
Human Microbiome in Health and Disease
Pflughoeft, K. J., & Versalovic, J. A. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132421 · Cited by 528 · see citing works
Gu, Q., Burt, V. L., Dillon, C. F., & Yoon, S. (2012) · Circulation · doi:10.1161/circulationaha.112.096156 · Cited by 521 · see citing works
p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease
Wu, I., Hsu, K., Lee, C., Sun, C., Hsu, H.-J., Tsai, C.-J., Tzen, C., Wang, Y.-C., Lin, C.-Y., & Wu, M.-S. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq580 · Cited by 510 · see citing works
Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion
Andrade‐Oliveira, V., Amano, M. T., Corrêa-Costa, M., Castoldi, Â., Felizardo, R. J. F., de Almeida, D. C., Bassi, Ê. J., Moraes‐Vieira, P. M., Hiyane, M. I., Rodas, A. C. D., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014030288 · Cited by 504 · see citing works
Chapter 12: Human Microbiome Analysis
Morgan, X. C., & Huttenhower, C. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002808 · Cited by 496 · see citing works
The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease
Anders, H., Andersen, K., & Stecher, B. (2013) · Kidney International · doi:10.1038/ki.2012.440 · Cited by 495 · see citing works
Meyer, T. W., & Hostetter, T. H. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071313 · Cited by 458 · see citing works
Uremic toxins originating from colonic microbial metabolism
Evenepoel, P., Meijers, B. K. I., Bammens, B., & Verbeke, K. (2009) · Kidney International · doi:10.1038/ki.2009.402 · Cited by 448 · see citing works
Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome
Fujimura, K. E., & Lynch, S. V. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.007 · Cited by 414 · see citing works
Development of the human gastrointestinal microbiota and insights from high-throughput sequencing
Dominguez-Bello, M. G., Blaser, M. J., Ley, R. E., & Knight, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.011 · Cited by 405 · see citing works
Bammens, B., Evenepoel, P., Keuleers, H., Verbeke, K., & Vanrenterghem, Y. F. C. (2006) · Kidney International · doi:10.1038/sj.ki.5000115 · Cited by 388 · see citing works
Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY)
Rossi, M., Johnson, D. W., Morrison, M., Pascoe, E. M., Coombes, J. S., Forbes, J. M., Szeto, C., McWhinney, B. C., Ungerer, J. P. J., & Campbell, K. L. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05240515 · Cited by 379 · see citing works
Logares, R., Sunagawa, S., Salazar, G., Cornejo‐Castillo, F. M., Ferrera, I., Sarmento, H., Hingamp, P., Ogata, H., de Vargas, C., Lima‐Mendez, G., et al. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12250 · Cited by 343 · see citing works
Missailidis, C., Hällqvist, J., Qureshi, A. R., Barany, P., Heimbürger, O., Lindholm, B., Stenvinkel, P., & Bergman, P. (2016) · PLOS ONE · doi:10.1371/journal.pone.0141738 · Cited by 338 · see citing works
Hypertension in children and adolescents: epidemiology and natural history
Falkner, B. E. (2009) · Pediatric Nephrology · doi:10.1007/s00467-009-1200-3 · Cited by 325 · see citing works
p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease
Meijers, B. K. I., Claes, K. J., Bammens, B., de Loor, H., Viaene, L., Verbeke, K., Kuypers, D. R. J., Vanrenterghem, Y. F. C., & Evenepoel, P. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07971109 · Cited by 316 · see citing works
The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites
Ursell, L. K., Clemente, J. C., Rideout, J. R., Gevers, D., Caporaso, J. G., & Knight, R. D. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.03.010 · Cited by 310 · see citing works
The Human Microbiome and Its Potential Importance to Pediatrics
Johnson, C. L., & Versalovic, J. A. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2736 · Cited by 310 · see citing works
Sirich, T. L., Plummer, N. S., Gardner, C. D., Hostetter, T. H., & Meyer, T. W. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00490114 · Cited by 297 · see citing works
Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD
Schulman, G., Berl, T., Beck, G. J., Remuzzi, G., Ritz, E., Arita, K., Kato, A., & Shimizu, M. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014010042 · Cited by 288 · see citing works
Microbiome, Inflammation, and Cancer
Francescone, R., Hou, V., & Grivennikov, S. I. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000048 · Cited by 269 · see citing works
Probiotics and chronic kidney disease
Koppe, L., Mafra, D., & Fouque, D. P. (2015) · Kidney International · doi:10.1038/ki.2015.255 · Cited by 264 · see citing works
Biodiversity and functional genomics in the human microbiome
Morgan, X. C., Segata, N., & Huttenhower, C. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.09.005 · Cited by 262 · see citing works
Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN)
Angelis, M. D., Montemurno, E., Píccolo, M. C., Vannini, L., Lauriero, G., Maranzano, V., Gozzi, G., Serrazanetti, D. I., Dalfino, G., Gobbetti, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099006 · Cited by 236 · see citing works
Wang, I. ‐., Wu, Y. Y., Yang, Y., Ting, I., Lin, C. C., Yen, T., Chen, J.-H., Wang, C., Huang, C.-F., & Lin, H. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0088 · Cited by 223 · see citing works
Fecal microbiota transplantation in relapsing Clostridium difficile infection
Rohlke, F., & Stollman, N. (2012) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12453637 · Cited by 214 · see citing works
Gut Microbiota and Tacrolimus Dosing in Kidney Transplantation
Lee, J. R., Muthukumar, T., Dadhania, D., Taur, Y., Jenq, R. R., Toussaint, N. C., Ling, L., Pamer, E., & Suthanthiran, M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0122399 · Cited by 211 · see citing works
Dinakaran, V., Rathinavel, A., Muthuirulan, P., Sivakumar, R., Gunasekaran, P., & Rajendhran, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105221 · Cited by 200 · see citing works
Schulman, G., Agarwal, R., Acharya, M., Berl, T., Blumenthal, S. S., & Kopyt, N. P. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.12.036 · Cited by 200 · see citing works
Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire
Kalantar‐Zadeh, K., Kopple, J. D., Deepak, S., Block, D., & Block, G. (2002) · Journal of Renal Nutrition · doi:10.1053/jren.2002.29598 · Cited by 191 · see citing works
Human Microbiota Characterization in the Course of Renal Transplantation
Fricke, W. F., Maddox, C., Song, Y., & Bromberg, J. S. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12588 · Cited by 178 · see citing works
Species-Level Analysis of DNA Sequence Data from the NIH Human Microbiome Project
Conlan, S., Kong, H. H., & Segre, J. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047075 · Cited by 175 · see citing works
Bliss, D., Stein, T., Schleifer, C., & Settle, R. G. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.3.392 · Cited by 164 · see citing works
Guida, B., Germanò, R., Trio, R., Russo, D., Memoli, B., Grumetto, L., Barbato, F., & Cataldi, M. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.04.007 · Cited by 161 · see citing works
Akizawa, T., Asano, Y., Morita, S., Wakita, T., Ônishi, Y., Fukuhara, S., Gejyo, F., Matsuo, S., Yorioka, N., & Kurokawa, K. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.05.011 · Cited by 158 · see citing works
The human gut microbiome, a taxonomic conundrum
Sankar, S. A., Lagier, J., Pontarotti, P., Raoult, D., & Fournier, P. (2015) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2015.03.004 · Cited by 144 · see citing works
Increased plasma phenylacetic acid in patients with end-stage renal failure inhibits iNOS expression
Jankowski, J., van der Giet, M., Jankowski, V., Schmidt, S. C., Hemeier, M., Mahn, B., Giebing, G., Tölle, M., Luftmann, H., Schlüter, H., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15524 · Cited by 131 · see citing works
The intestinal microbiome in type 1 diabetes
Dunne, J. L., Triplett, E. W., Gevers, D., Xavier, R. J., Insel, R. A., Danska, J. S., & Atkinson, M. A. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12321 · Cited by 127 · see citing works
Effects of orally administered antibiotics on the bioavailability of amlodipine
Yoo, H. H., Kim, I. S., Yoo, D.-H., & Kim, D. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000773 · Cited by 120 · see citing works
Jang, H. R., Gandolfo, M. T., Ko, G. J., Satpute, S. R., Racusen, L. C., & Rabb, H. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90769.2008 · Cited by 112 · see citing works
Singh, R., van Nood, E., Nieuwdorp, M., Dam, B., ten Berge, I. J. M., Geerlings, S. E., & Bemelman, F. J. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12683 · Cited by 111 · see citing works
Increased plasma phenylacetic acid in patients with end-stage renal failure inhibits iNOS expression
Jankowski, J., van der Giet, M., Jankowski, V., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200315524 · Cited by 103 · see citing works
Niwa, T., Emoto, Y., Maeda, K., et al. (1991) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/6.2.105 · Cited by 94 · see citing works
Gut microbiome in chronic kidney disease
Wing, M. R., Patel, S. S., Ramezani, A., & Raj, D. S. (2015) · Experimental Physiology · doi:10.1113/ep085283 · Cited by 89 · see citing works
Ueda, H., Shibahara, N., Takagi, S., et al. (2007) · Therapeutic Apheresis and Dialysis · doi:10.1111/j.1744-9987.2007.00430.x · Cited by 83 · see citing works
The Colon: An Overlooked Site for Therapeutics in Dialysis Patients
Poesen, R., Meijers, B. K. I., & Evenepoel, P. (2013) · Seminars in Dialysis · doi:10.1111/sdi.12082 · Cited by 79 · see citing works
Harnessing the power of the human microbiome
Blaser, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002112107 · Cited by 67 · see citing works
The Microbiome and Obesity—An Established Risk for Certain Types of Cancer
Rogers, C. J., Prabhu, K. S., & Vijay–Kumar, M. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000049 · Cited by 67 · see citing works
Irritable bowel syndrome, inflammatory bowel disease and the microbiome
Major, G., & Spiller, R. E. (2013) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000032 · Cited by 67 · see citing works
Autoantibodies to hLAMP-2 in ANCA-Negative Pauci-Immune Focal Necrotizing GN
Peschel, A., Basu, N., Benharkou, A., Brandes, R., Brown, M. K., Dieckmann, R., Rees, A. J., & Kain, R. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013030320 · Cited by 66 · see citing works
Influence of prebiotic and probiotic supplementation on the progression of chronic kidney disease.
Malleshappa, P. (2016) · PubMed · Cited by 64 · see citing works
Staphylococcal superantigens and T cell expansions in Wegener's granulomatosis
Popa, E. R., Stegeman, C. A., Bos, N. A., et al. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02157.x · Cited by 63 · see citing works
Contrasting circulating microbiome in cardiovascular disease patients and healthy individuals
Rajendhran, J., Shankar, M., Dinakaran, V., Rathinavel, A., & Gunasekaran, P. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.07.232 · Cited by 63 · see citing works
Obesity and the gut microbiome: pathophysiological aspects
Bradlow, H. L. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0063 · Cited by 52 · see citing works
Association between probiotic and yogurt consumption and kidney disease: insights from NHANES
Yacoub, R., Kaji, D. A., Patel, S., Simoes, P. K., Busayavalasa, D., Nadkarni, G. N., He, C., Coca, S. G., & Uribarri, J. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0127-3 · Cited by 48 · see citing works
Acacia gum supplementation of a low-protein diet in children with end-stage renal disease
Al-Mosawi, A. J. (2004) · Pediatric Nephrology · doi:10.1007/s00467-004-1562-5 · Cited by 43 · see citing works
New insight into the gut microbiome through metagenomics
Nielsen, J., & Ji, B. (2015) · Advances in Genomics and Genetics · doi:10.2147/agg.s57215 · Cited by 36 · see citing works
Ram, J. L., Karim, A. S., Sendler, E. D., & Kato, I. (2011) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2011.555598 · Cited by 34 · see citing works
Fouque, D. P., Casal, M. C., Lindley, E. J., Rogers, S. D., Pancířová, J., Kernc, J., & Copley, J. B. (2014) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2013.11.003 · Cited by 18 · see citing works
Does the gut microbiome hold clues to obesity and diabetes?
Gross, M. (2013) · Current Biology · doi:10.1016/j.cub.2013.04.047 · Cited by 14 · see citing works
High prevalence of Helicobacter pylori infection in Japanese patients with membranous nephropathy
Moriyama, T., KANEKO, T., FUJII, M., et al. (2006) · Alimentary Pharmacology & Therapeutics Symposium Series · doi:10.1111/j.1746-6342.2006.00044.x · Cited by 13 · see citing works
Solt, I., Kim, M. J., & Cohavy, O. (2011) · PubMed · Cited by 6 · see citing works
Role of Uremic Toxins and Oxidative Stress in Chronic Kidney Disease
Fukagawa, M., & Watanabe, Y. (2011) · Therapeutic Apheresis and Dialysis · doi:10.1111/j.1744-9987.2010.00881.x · Cited by 6 · see citing works
The gastrointestinal tract in uremia.
Sud, K., & Sakhuja (1997) · PubMed · Cited by 5 · see citing works
1. Dietary Treatment and Life-style Management in CKD Patients
Nakao, T. (2012) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.101.1340 · Cited by 3 · see citing works
Title Page / Table of Contents
(2005) · American Journal of Nephrology · doi:10.1159/000084130 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753 · see citing works
Milosevic, I., Vujovic, A., Barac, A., Djelic, M., Korac, M., Radovanovic Spurnic, A., Gmizic, I., Stevanovic, O., Djordjevic, V., Lekic, N., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020395 · Cited by 551 · see citing works
Food as medicine: targeting the uraemic phenotype in chronic kidney disease
Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G., Evenepoel, P., & Stenvinkel, P. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00345-8 · Cited by 238 · see citing works
- Authors
- Al Khodor, S., & Shatat, I. F.
- Affiliations
- Medical University of South Carolina (US)
- ORCID
- Shatat, Ibrahim F.
- Venue
- Pediatric Nephrology
- Published
- 2016-04-29
- Volume
- 32
- Issue
- 6
- Pages
- 921-931
- ISSN
- 0931-041X (ISSN-L)
- 1432-198X
- PMC
- PMC5399049
- OpenAlex
- W2342635156
- Cited by
- 191
- References
- 91
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 23 · 2023: 20 · 2022: 24 · 2021: 19 · 2020: 23 · 2019: 22 · 2018: 18 · 2017: 8
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Pediatric Nephrology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- gut microbiota, kidney disease, host-microbe interactions, bidirectional relationship, dysbiosis, disease progression, pediatric kidney disease
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Carbon, Child, Renal Dialysis, Humans, Hypertension, Indican, Indoles, Oxides, Disease Progression, Dietary Supplements, Renal Insufficiency, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
