Sleep abnormalities in type 2 diabetes may be associated with glycemic control
Abstract
Sleep disturbances may be associated with impaired glucose metabolism. The aim of this study was to evaluate sleep duration and quality in relation to glycemic control in patients with type 2 diabetes. In a cross-sectional study, sleep duration and quality were assessed in 47 middle-aged patients with type 2 diabetes treated with oral agents and without sleep disturbing complications and 23 healthy control subjects similar by age, sex, body mass index, occupation and schooling. Sleep was recorded by wrist-actigraphy for three consecutive days under free-living conditions. Univariate analysis showed lower sleep maintenance (P = 0.002) and sleep efficiency (P = 0.005), and higher fragmentation index (P < 0.0001), total activity score (P = 0.05) and moving time (P < 0.0001) in patients with type 2 diabetes. After adjusting for age, gender and schooling, fragmentation index and moving time remained significantly higher in the patients with diabetes (P < 0.05, both). HbA1c correlated inversely with sleep efficiency (r = -0.29; P = 0.047) and positively with moving time (r = 0.31; P = 0.031). These findings suggest that type 2 diabetes is associated with sleep disruptions even in the absence of complications or obesity. The relevance of sleep abnormalities to metabolic control and possible strategies to improve sleep quality in type 2 diabetes deserve further investigation.
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Frequency of nocturnal awakenings, as measured by actigraphy, correlated positively with HbA1c levels in patients with type 2 diabetes.
“Frequency of nocturnal awakenings, as measured by actigraphy, correlated positively with HbA1c levels in patients with type 2 diabetes.37”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [37]
In people with type 2 diabetes, sleep quality is generally worse based on both subjective and objective estimates.
“Sleep quality is generally worse based on both subjective and objective estimates in people with type 2 diabetes (T2DM) [178].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [178]
A small Italian study did use wrist actigraphy to compare the sleep of patients with type 2 diabetes with healthy control subjects and found higher sleep fragmentation in the patients with diabetes.
“A small Italian study did use wrist actigraphy to compare the sleep of patients with type 2 diabetes with healthy control subjects and found higher sleep fragmentation in the patients with diabetes (14).”
From Cross-Sectional Associations Between Measures of Sleep and Markers of Glucose Metabolism Among Subjects With and Without Diabetes (2011) · cites this paper as [14]
A study in Italy found significantly higher sleep fragmentation using wrist actigraphy in patients with type 2 diabetes compared with healthy controls.
“A study in Italy found significantly higher sleep fragmentation using wrist actigraphy in patients with type 2 diabetes compared with healthy controls (14).”
From Cross-Sectional Associations Between Measures of Sleep and Markers of Glucose Metabolism Among Subjects With and Without Diabetes (2011) · cites this paper as [14]
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- Authors
- Trento, M., Broglio, F., Riganti, F., Basile, M., Borgo, E., Kucich, C., Passera, P., Tibaldi, P., Tomelini, M., Cavallo, F., Ghigo, E., & Porta, M.
- Affiliations
- University of Turin (IT)
- Corresponding author
- Trento, M.
- Venue
- Acta Diabetologica
- Published
- 2008-08-07
- Volume
- 45
- Issue
- 4
- Pages
- 225-229
- ISSN
- 0940-5429 (ISSN-L)
- 1432-5233
- OpenAlex
- W2009061043
- Cited by
- 104
- References
- 24
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 6 · 2012: 7
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Diabetologica (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- Ministero della Salute
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- type 2 diabetes, sleep disorders, sleep quality, sleep duration, glycemic control, HbA1c, sleep fragmentation, sleep efficiency, actigraphy, middle-aged adults
- MeSH terms
- Analysis of Variance, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Male, Middle Aged, Motor Activity, Reference Values, Sleep, Sleep Wake Disorders, Smoking, Body Mass Index, Age of Onset
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