Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population
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Abstract. Mallon L, Broman J‐E, Hetta J (University Hospital, Uppsala, and Falun Hospital, Falun; and Institute of Clinical Neuroscience, Göteborg; Sweden). Sleep complaints predict coronary artery disease mortality in males: a 12‐year follow‐up study of a middle‐aged Swedish population. J Intern Med 2002; 251: 207–216. Objectives. Only a few prospective surveys have been performed to investigate the relationship between sleep complaints and coronary artery disease (CAD) mortality. This study was conducted to determine whether sleep complaints in a middle‐aged population predicted total mortality and CAD mortality. Design. A population‐based prospective study. Setting. The County of Dalarna, Sweden. Subjects and methods. In 1983, a random sample of 1870 subjects aged 45–65 years responded to a postal questionnaire (response rate 70.2%) including questions about sleep complaints and various diseases. Mortality data for the period 1983–95 were collected, and Cox proportional hazard analyses were used to examine the mortality risks. Results. At 12‐year follow‐up 165 males (18.2%) and 101 females (10.5%) had died. After adjustment for a wide range of important putative risk factors, difficulties initiating sleep (DIS) were related to CAD death in males [relative risk (RR), 3.1; 95% confidence interval (CI), 1.5–6.3; P < 0.01], but not in females. Short or long sleep duration did not influence risk of CAD mortality or total mortality for either gender. Depression in males increased the risk of death attributed to CAD (RR, 3.0; 95% CI, 1.1–8.4; P < 0.05) and total mortality (RR, 2.2; 95% CI, 1.1–4.5; P < 0.05). Conclusion. These results provide evidence that there is an association between difficulties falling asleep and CAD mortality in males.
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Poor subjective sleep quality was associated with increased coronary artery disease mortality in men (RR 3.1, 95% CI 1.5-6.3).
“Poor subjective sleep quality was also associated with increased coronary artery disease mortality in men (RR: 3.1, 95%CI 1.5–6.3) [212].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [212]
A few studies examined cardiovascular disease mortality in relation to self-reported sleep duration, but none found a significant association in fully adjusted models.
“A few studies have examined cardiovascular disease mortality in relation to self-reported sleep duration, but none found a significant association in fully adjusted models [212–214].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [212]
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- Authors
- Mallon, L., Broman, J. ‐., & Hetta, J.
- Affiliations
- Uppsala University Hospital (SE)
- Corresponding author
- Mallon, L.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2002-03-03
- Volume
- 251
- Issue
- 3
- Pages
- 207-216
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2021456009
- Cited by
- 495
- References
- 53
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 5 · 2023: 14 · 2022: 17 · 2021: 16 · 2020: 14 · 2019: 16 · 2018: 22 · 2017: 28 · 2016: 30 · 2015: 38 · 2014: 23 · 2013: 36 · 2012: 25
- FWCI
- 18.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lundbeckfonden
- Vetenskapsrådet
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep complaints, coronary artery disease mortality, sleep duration, depression, all-cause mortality, middle-aged men, sex differences, cardiovascular risk factors
- MeSH terms
- Aged, Coronary Disease, Female, Follow-Up Studies, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Sweden, Comorbidity
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