Cited by 495Sleep and related disordersObstructive Sleep Apnea ResearchSleep and Work-Related Fatigue

Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population

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Mallon, L., Broman, J.‐E., Hetta, J.·2002·Journal of Internal Medicine

Abstract

Abstract. Mallon L, Broman J‐E, Hetta J (University Hospital, Uppsala, and Falun Hospital, Falun; and Institute of Clinical Neuroscience, Göteborg; Sweden). Sleep complaints predict coronary artery disease mortality in males: a 12‐year follow‐up study of a middle‐aged Swedish population. J Intern Med 2002; 251: 207–216. Objectives. Only a few prospective surveys have been performed to investigate the relationship between sleep complaints and coronary artery disease (CAD) mortality. This study was conducted to determine whether sleep complaints in a middle‐aged population predicted total mortality and CAD mortality. Design. A population‐based prospective study. Setting. The County of Dalarna, Sweden. Subjects and methods. In 1983, a random sample of 1870 subjects aged 45–65 years responded to a postal questionnaire (response rate 70.2%) including questions about sleep complaints and various diseases. Mortality data for the period 1983–95 were collected, and Cox proportional hazard analyses were used to examine the mortality risks. Results. At 12‐year follow‐up 165 males (18.2%) and 101 females (10.5%) had died. After adjustment for a wide range of important putative risk factors, difficulties initiating sleep (DIS) were related to CAD death in males [relative risk (RR), 3.1; 95% confidence interval (CI), 1.5–6.3; P < 0.01], but not in females. Short or long sleep duration did not influence risk of CAD mortality or total mortality for either gender. Depression in males increased the risk of death attributed to CAD (RR, 3.0; 95% CI, 1.1–8.4; P < 0.05) and total mortality (RR, 2.2; 95% CI, 1.1–4.5; P < 0.05). Conclusion. These results provide evidence that there is an association between difficulties falling asleep and CAD mortality in males.

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Crossref · 10.1046/j.1365-2796.2002.00941.x

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Authors
Mallon, L., Broman, J. ‐., & Hetta, J.
Affiliations
Uppsala University Hospital (SE)
Corresponding author
Mallon, L.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2002-03-03
Volume
251
Issue
3
Pages
207-216
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
OpenAlex
W2021456009
Cited by
495
References
53
Citations by year
2026: 2 · 2025: 12 · 2024: 5 · 2023: 14 · 2022: 17 · 2021: 16 · 2020: 14 · 2019: 16 · 2018: 22 · 2017: 28 · 2016: 30 · 2015: 38 · 2014: 23 · 2013: 36 · 2012: 25
FWCI
18.61
Type
journal article
Language
en
Open access
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Lundbeckfonden
  • Vetenskapsrådet
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
sleep complaints, coronary artery disease mortality, sleep duration, depression, all-cause mortality, middle-aged men, sex differences, cardiovascular risk factors
MeSH terms
Aged, Coronary Disease, Female, Follow-Up Studies, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Sweden, Comorbidity

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