Cited by 87Sleep and related disordersObstructive Sleep Apnea ResearchCircadian rhythm and melatonin

The Interlinked Rising Epidemic of Insufficient Sleep and Diabetes Mellitus

Open access
Chattu, Vijay Kumar, Chattu, Soosanna Kumary, Burman, Deepa, Spence, David Warren, Pandi-Perumal, Seithikurippu R.·2019·Healthcare

Abstract

For healthy existence, humans need to spend one-third of their time sleeping. Any qualitative or quantitative disturbances in sleep would result in an increased prevalence of obesity, metabolic disorders, diabetes, cardiovascular diseases, and hypertension. The paper aims to highlight the growing global problem of insufficient sleep and its significant impact on the rising incidence of diabetes mellitus. An extensive literature search was done in all major databases for "insufficient sleep" and "Diabetes Mellitus" for this review. Shorter (<6 h) and longer (>9 h) durations of sleep have been adversely related to insulin resistance. Though the relation between insufficient sleep and diabetes mellitus is more or less understood, little is known about how oversleeping or hypersomnia (10⁻12 h) increases the risk of diabetes. The relationship between sleep disturbances and diabetes is dual-sided, as chronic sleep disturbances would elevate the risk of developing insulin resistance, while diabetes would worsen the quality of sleep. Both the qualitative and quantitative disturbances in sleep significantly increase the risk of developing diabetes, which is supported by numerous community-based and hospital-based epidemiological studies discussed in this review. Obstructive sleep apnea is one of the most common sleep disorders and is characterized by chronic intermittent hypoxia and increased sympathetic activity, thus leading to a higher prevalence of diabetes. Sleep therapy may serve as a low-cost method for fighting against the rising epidemic of diabetes.

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Authors
Chattu, V. K., Chattu, S. K., Burman, D., Spence, D. W., & Pandi-Perumal, S. R.
Affiliations
  • University of the West Indies (TT)
  • University of Pittsburgh (US)
  • Independent Researcher, 652 Dufferin Street, Toronto, ON M6K 2B4, Canada
  • Somnogen Canada Inc., College Street, Toronto, ON M1H 1C5, Canada
Corresponding author
Chattu, Vijay Kumar
Venue
Healthcare
Publisher
MDPI AG
Published
2019-03-05
Volume
7
Issue
1
Pages
37
ISSN
2227-9032 (ISSN-L)
OpenAlex
W2920706025
Cited by
87
References
102
Citations by year
2026: 9 · 2025: 17 · 2024: 11 · 2023: 13 · 2022: 15 · 2021: 6 · 2020: 12 · 2019: 4
FWCI
1.37
Type
journal article
Language
en
Open access
Locations
  • Healthcare (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Centers for Disease Control and Prevention
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
insufficient sleep, diabetes mellitus, insulin resistance, hypersomnia, sleep duration, sleep disorders, obstructive sleep apnea, intermittent hypoxia, sleep quality, obesity, metabolic disorders, sleep therapy

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