Structures of Oligosaccharides Derived from Cladosiphon okamuranus Fucoidan by Digestion with Marine Bacterial Enzymes
Abstract
A fucoidan-utilizing marine bacterium, Fucophilus fucoidanolyticus, was cultivated in medium containing fucoidan from Cladosiphon okamuranus. The C. okamuranus fucoidan was digested into oligosaccharides with the intracellular enzymes of F. fucoidanolyticus, and their structures were determined by nuclear magnetic resonance analyses. Some of their structures are represented by one general structural formula, (-3 L-Fuc palpha1-3 L-Fuc p(4- O-sulfate)alpha1-3 L-Fuc p(4- O-sulfate)alpha1-3( D-Glc pUAalpha1-2) L-Fuc palpha1)(m)-3 L-Fuc palpha1-3 L-Fuc p(4- O-sulfate)alpha1-3 L-Fuc p(4- O-sulfate) alpha1-3 L-Fuc p ( m = 0, 1, 2, or 3). We concluded that all oligosaccharides obtained were derived from a sulfated-fucose-containing polysaccharide of C. okamuranus, which has a repeating unit of (-3 L-Fuc palpha1-3 L-Fuc p(4- O-sulfate)alpha1-3 L-Fuc p(4- O-sulfate)alpha1-3( D-Glc pUAalpha1-2) L-Fuc palpha1-).
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Another type of fucoidanase catalyses glycosidic bonds (both α(1→3)- and α(1→4)-bonds) in the fucose-backbone via random endo-type hydrolysis.
“the other type of fucoidanase catalyses the glycosidic bonds (both a(1A3)-, a(1A4)-bonds) in the fucose-back bone via random endo-type hydrolysis”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [33]
One type of fucoidanase catalyses cleavage of small, low molecular weight oligosaccharides from the end of fucoidan backbone chains.
“one type of fucoidanase catalyses the cleavage of small, low molecular weight oligosaccharides from the end of the fucoidan backbone chains”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [33]
α-L-fucosidase only catalyses cleavage of α-L-fucosyl linkages at the nonreducing termini, releasing fucose from the fucose-backbone structure in fucoidans.
“a-L-fucosidase only catalyses the cleavage the a-L-fucosyl linkages at the nonreducing termini, releasing fucose from the fucose-backbone structure in fucoidans (Enzyme type 3, Fig. 1).”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [33]
At least one intracellular fucoidanase from Fucophilus fucoidanolyticus seems able to catalyse splitting of 1,3α-glycosidic bonds and has been demonstrated to express deacetylase activity effective on acetylated fucoidans from Cladosiphon okamuranus.
“At least one of them (intracellular fucoidanase) seems to have the ability to catalyse the splitting of 1,3a-glycosidic bonds and has also been demonstrated to express deacetylase activity being effective on acetylated fucoidans from Cladosiphon okamuranus.33”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [33]
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- Authors
- Shimanaka, K., Ikai, K., Kato, I., Sakai, T., & Ishizuka, K.
- Affiliations
- Takara BIO Inc. (Japan) (JP)
- Corresponding author
- Sakai, Takeshi
- ORCID
- Sakai, Takeshi
- Venue
- Marine Biotechnology
- Published
- 2003-12-01
- Volume
- 5
- Issue
- 6
- Pages
- 536-544
- ISSN
- 1436-2228 (ISSN-L)
- 1436-2236
- OpenAlex
- W2040829022
- Cited by
- 83
- References
- 14
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 5
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Marine Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, Cladosiphon okamuranus, oligosaccharide structure, polysaccharide degradation, repeating unit, sulfated polysaccharides
- MeSH terms
- Phaeophyceae, Bacteria, Magnetic Resonance Spectroscopy, Oligosaccharides, Polysaccharides
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