Structure, biological activity, and enzymatic transformation of fucoidans from the brown seaweeds

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Fucoidan Induces ROS‐Dependent Apoptosis in 5637 Human Bladder Cancer Cells by Downregulating Telomerase Activity via Inactivation of the PI3K/Akt Signaling Pathway

Han, M. H., Lee, D., Jeong, J., Hong, S. H., Choi, I., Cha, H., Kim, S., Kim, H., Park, C., Kim, G., et al. (2016) · Drug Development Research · doi:10.1002/ddr.21367 · Cited by 61 · see citing works

Fucoidan-based nanomaterial and its multifunctional role for pharmaceutical and biomedical applications

Iqbal, M. W., Riaz, T., Mahmood, S., Bilal, M., Manzoor, M. F., Qamar, S. A., & Qi, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2106182 · Cited by 61 · see citing works

Fucoidanases

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Design Polysaccharides of Marine Origin: Chemical Modifications to Reach Advanced Versatile Compounds

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Anti-inflammatory effect of a sulphated polysaccharide fraction extracted from the red algaeHypnea musciformisvia the suppression of neutrophil migration by the nitric oxide signalling pathway

de Brito, T. V., Prudêncio, R. D. S., Sales, A. B., Júnior, F. D. C. V., Candeira, S. J. N., Franco, Á. X., Aragão, K. S., Ribeiro, R. D. A., de Souza, M. H. L. P., Chaves, L. D. S., et al. (2013) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12024 · Cited by 55 · see citing works

Sulfated Polysaccharides from Seaweeds: A Promising Strategy for Combatting Viral Diseases—A Review

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Endo-1,4-fucoidanase from Vietnamese marine mollusk Lambis sp. which producing sulphated fucooligosaccharides

Silchenko, A. S., Игоревич, К. М., Zakharenko, A. M., Usoltseva, R. V., Khánh, H. H. N., Dmitrenok, P. S., Isakov, V. V., & Николаевна, З. Т. (2014) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2014.02.007 · Cited by 53 · see citing works

Enzymatic transformation and anti-tumor activity of Sargassum horneri fucoidan

Rasin, A. B., Silchenko, A. S., Игоревич, К. М., Malyarenko, O. S., Zueva, A. O., Kalinovsky, A. I., Airong, J., Surits, V. V., & Ermakova, S. P. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116635 · Cited by 49 · see citing works

Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression

Chen, L., Liu, P., Chen, Y., Tseng, H., Shen, P.-C., Hwang, P., & Hsu, H.-L. (2017) · Scientific Reports · doi:10.1038/s41598-017-12111-1 · Cited by 49 · see citing works

Potential Use of Polysaccharides from the Brown Alga Undaria pinnatifida as Anticoagulants

Faggio, C., Morabito, M., Minicante, S. A., Piano, G. L., Pagano, M., & Genovese, G. (2015) · Brazilian Archives of Biology and Technology · doi:10.1590/s1516-8913201500400 · Cited by 48 · see citing works

A combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex

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Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum

Cao, H., Walton, J. D., Brumm, P. J., & Phillips, G. N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.583286 · Cited by 48 · see citing works

Polysaccharide isolated from Agardhiella ramosissima: Chemical structure and anti-inflammation activity

Batista, J. A., Dias, E. G. D. N., de Brito, T. V., Prudêncio, R. S., Silva, R. O., Ribeiro, R. A., de Souza, M. H. L. P., de Paula, R. C. M., Feitosa, J. P. A., Chaves, L. S., et al. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.08.071 · Cited by 47 · see citing works

Polysaccharide extracted from Taraxacum platycarpum root exerts immunomodulatory activity via MAPK and NF-κB pathways in RAW264.7 cells

Talapphet, N., Palanisamy, S., Li, C., Ma, N., Prabhu, N. M., & You, S. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114519 · Cited by 45 · see citing works

Seaweed sulfated polysaccharides and their medicinal properties

Zaitseva, O. O., Sergushkina, M. I., Khudyakov, A. N., Polezhaeva, T. V., & Solomina, O. N. (2022) · Algal Research · doi:10.1016/j.algal.2022.102885 · Cited by 44 · see citing works

Flavobacterium ahnfeltiae sp. nov., a new marine polysaccharide-degrading bacterium isolated from a Pacific red alga

Nedashkovskaya, O. I., Balabanova, L., Zhukova, N. V., Kim, S., Bakunina, I. Y., & Rhee, S. (2014) · Archives of Microbiology · doi:10.1007/s00203-014-1010-2 · Cited by 45 · see citing works

Immunostimulatory Activity of Fucoidan from the Brown AlgaFucus evanescens: Role of Sulfates and Acetates

Khil’chenko, S., Zaporozhets, T. S., Шевченко, Н. М., Николаевна, З. Т., Vogel, U., Seeberger, P. H., & Lepenies, B. (2011) · Journal of Carbohydrate Chemistry · doi:10.1080/07328303.2011.604456 · Cited by 45 · see citing works

Structure Analysis and Anti-Tumor and Anti-Angiogenic Activities of Sulfated Galactofucan Extracted from Sargassum thunbergii

Jin, W., Wu, W., Tang, H. T., Wei, B., Wang, H., Sun, J., Zhang, W., & Zhong, W. (2019) · Marine Drugs · doi:10.3390/md17010052 · Cited by 45 · see citing works

Systematic Characteristics of Fucoidan: Intriguing Features for New Pharmacological Interventions

Jeong, S., Lee, S., Lee, G.-T., Hyun, J., & Ryu, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111771 · Cited by 44 · see citing works

Oligo-Fucoidan Prevents M2 Macrophage Differentiation and HCT116 Tumor Progression

Chen, L., Tseng, H., Chen, Y., Haq, A. T. A., Hwang, P., & Hsu, H.-L. (2020) · Cancers · doi:10.3390/cancers12020421 · Cited by 42 · see citing works

Fucoidan: A Versatile Biopolymer for Biomedical Applications

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Basic fibroblast growth factor released from fucoidan-modified chitosan/alginate scaffolds for promoting fibroblasts migration

Zeng, H.-Y., & Huang, Y. (2018) · Journal of Polymer Research · doi:10.1007/s10965-018-1476-8 · Cited by 41 · see citing works

Fucoidan–Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice

Chang, P.-M., Li, K.-L., & Lin, Y. (2019) · Marine Drugs · doi:10.3390/md17010069 · Cited by 41 · see citing works

miRNAs as Regulators of Antidiabetic Effects of Fucoidans

Zhao, C., Lai, S., Wu, D., Liu, D., Zou, X., Ismail, A., El-Seedi, H. R., Arroo, R., & Xiao, J. (2019) · eFood · doi:10.2991/efood.k.190822.001 · Cited by 40 · see citing works

Effects of a polysaccharide-rich extract derived from Irish-sourced Laminaria digitata on the composition and metabolic activity of the human gut microbiota using an in vitro colonic model

Strain, C., Collins, K. C., Naughton, V. R., McSorley, E. M., Stanton, C., Smyth, T. J., Soler‐Vila, A., Rea, M. C., Ross, R. P., Cherry, P., et al. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01909-6 · Cited by 39 · see citing works

Purification and Characterization of Fucoidan from the Brown Seaweed Sargassum binderi Sonder

Sinurat, E., Peranginangin, R., & Saepudin, E. (2016) · SQUALEN Bulletin of Marine and Fisheries Postharvest and Biotechnology · doi:10.15578/squalen.v10i2.133 · Cited by 39 · see citing works

Structure of Fucoidan from Brown Seaweed Turbinaria ornata as Studied by Electrospray Ionization Mass Spectrometry (ESIMS) and Small Angle X-ray Scattering (SAXS) Techniques

Thanh, T., Tran, V., Yuguchi, Y., Bui, L., & Nguyen, T. T. (2013) · Marine Drugs · doi:10.3390/md11072431 · Cited by 38 · see citing works

Drug delivery for bioactive polysaccharides to improve their drug-like properties and curative efficacy

Li, Z., Wang, L., Lin, X., Shen, L., & Feng, Y. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1396383 · Cited by 36 · see citing works

Are multifunctional marine polysaccharides a myth or reality?

Ermakova, S. P., Игоревич, К. М., Trincone, A., & Tatyana, Z. (2015) · Frontiers in Chemistry · doi:10.3389/fchem.2015.00039 · Cited by 35 · see citing works

Seasonal variations of the composition, structural features, and antitumor properties of polysaccharides from Padina pavonica (Lebanon) as a function of composition

Men’shova, R. V., Ermakova, S. P., Rachidi, S. M., Al-Hajje, A. H., Zvyagintseva, T. N., & Kanaan, H. M. (2012) · Chemistry of Natural Compounds · doi:10.1007/s10600-012-0091-x · Cited by 34 · see citing works

Fucoidan: Structure and bioactivity

Li, B., Lu, F., Wei, X., & Zhao, R. (2008) · Molecules · doi:10.3390/molecules13081671 · Cited by 1,383 · see citing works

Fucoidans: a new frontier in brown seaweed research and biotechnology

Tonon, T., Aachmann, F. L., Ferrières, V., & Hervé, C. (2026) · The Cell Surface · doi:10.1016/j.tcsw.2026.100179

Fucoidans from Brown Alga Fucus evanescens: Structure and Biological Activity

Menshova, R. V., Shevchenko, N. M., Imbs, T. I., Zvyagintseva, T. N., Malyarenko, O. S., Zaporoshets, T. S., Besednova, N. N., & Ermakova, S. P. (2016) · Frontiers in Marine Science · doi:10.3389/fmars.2016.00129 · Cited by 85 · see citing works

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

Ale, M. T., Mikkelsen, J. D., & Meyer, A. S. (2011) · Marine Drugs · doi:10.3390/md9102106 · Cited by 779 · see citing works

Fucoidans and fucoidanases—focus on techniques for molecular structure elucidation and modification of marine polysaccharides

Holtkamp, A. D., Kelly, S., Ulber, R., & Lang, S. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1790-x · Cited by 175 · see citing works