Stromal cells in tumor microenvironment and breast cancer

Molecular portraits of human breast tumours

Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551 · see citing works

Cancer statistics, 2012

Siegel, R., Naishadham, D., & Jemal, A. (2012) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20138 · Cited by 10,679 · see citing works

The distribution of secondary growths in cancer of the breast.

Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277 · see citing works

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works

Tumors: Wounds That Do Not Heal

Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1× · see citing works

MicroRNA Gene Expression Deregulation in Human Breast Cancer

Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053 · see citing works

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759 · see citing works

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.

Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650 · see citing works

Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials

Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2011) · The Lancet · doi:10.1016/s0140-6736(11)60993-8 · Cited by 3,075 · see citing works

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874 · see citing works

Mechanisms of Bone Metastasis

Roodman, G. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra030831 · Cited by 2,752 · see citing works

The Biology of Chemokines and their Receptors

Rossi, D., & Zlotnik, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.217 · Cited by 2,410 · see citing works

International Journal of Oncology

(2026) · International Journal of Oncology · doi:10.3892/ijo · Cited by 2,332 · see citing works

Distinct role of macrophages in different tumor microenvironments

Lewis, C. E., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4005 · Cited by 2,225 · see citing works

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Jonjić, S., Mutter, W., Weiland, F., Reddehase, M. J., & Koszinowski, U. H. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.4.1199 · Cited by 2,106 · see citing works

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

DeNardo, D. G., Brennan, D. J., Rexhepaj, E., Ruffell, B., Shiao, S. L., Madden, S. F., Gallagher, W. M., Wadhwani, N., Keil, S. D., Junaid, S. A., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0028 · Cited by 1,715 · see citing works

Stromal gene expression predicts clinical outcome in breast cancer

Finak, G., Bertos, N., Pepin, F., Sadekova, S., Souleimanova, M., Zhao, H., Chen, H., Ömeroğlu, G., Meterissian, S. H., Ömeroğlu, A., et al. (2008) · Nature Medicine · doi:10.1038/nm1764 · Cited by 1,687 · see citing works

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

Lin, E. Y., Nguyen, A. V., Russell, R. G., & Pollard, J. W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.727 · Cited by 1,594 · see citing works

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

Erez, N., Truitt, M., Olson, P., & Hanahan, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.041 · Cited by 1,515 · see citing works

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

Gabbiani, G., Ryan, G. B., & Majno, G. (1971) · Experientia · doi:10.1007/bf02147594 · Cited by 1,485 · see citing works

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

Pavlides, S., Whitaker-Menezes, D., Castello-Cros, R., Flomenberg, N., Witkiewicz, A. K., Frank, P. G., Casimiro, M. C., Wang, C., Fortina, P., Addya, S., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.23.10238 · Cited by 1,391 · see citing works

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374 · see citing works

Tumor-Infiltrating CD8+Lymphocytes Predict Clinical Outcome in Breast Cancer

Mahmoud, S., Paish, E. C., Powe, D. G., Macmillan, R. D., Grainge, M. J., Lee, A. H. S., Ellis, I. O., & Green, A. R. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.5037 · Cited by 1,367 · see citing works

Molecular and Cellular Endocrinology

Rainey, W. E., & Rodgers, R. J. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.10.007 · Cited by 1,309 · see citing works

Molecular characterization of the tumor microenvironment in breast cancer

Allinen, M., Beroukhim, R., Cai, L., Brennan, C., Lahti-Domenici, J., Huang, H., Porter, D., Hu, M., Chin, L., Richardson, A., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.010 · Cited by 1,299 · see citing works

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

Leek, R., Lewis, C. E., Whitehouse, R. M., Greenall, M. J., Clarke, J., & Harris, A. L. (1996) · PubMed · Cited by 1,187 · see citing works

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

Acharyya, S., Oskarsson, T., Vanharanta, S., Malladi, S., Kim, J., Morris, P. G., Manova-Todorova, K., Leversha, M., Hogg, N., Seshan, V. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.042 · Cited by 1,085 · see citing works

Breast Cancer Subtypes Based on ER/PR and Her2 Expression: Comparison of Clinicopathologic Features and Survival

Onitilo, A. A., Engel, J. M., Greenlee, R. T., & Mukesh, B. N. (2009) · Clinical Medicine & Research · doi:10.3121/cmr.2009.825 · Cited by 1,023 · see citing works

Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts

Zeisberg, E. M., Potenta, S., Xie, L., Zeisberg, M., & Kalluri, R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-3127 · Cited by 1,011 · see citing works

Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

Kojima, Y., Acar, A., Eaton, E. N., Mellody, K. T., Scheel, C., Ben‐Porath, I., Önder, T. T., Wang, Z. C., Richardson, A. L., Weinberg, R. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013805107 · Cited by 851 · see citing works

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

Iliopoulos, D., Jaeger, S. A., Hirsch, H. A., Bulyk, M. L., & Struhl, K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.023 · Cited by 830 · see citing works

Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression

Spaeth, E. L., Dembinski, J. L., Sasser, A. K., Watson, K., Klopp, A., Hall, B., Andreeff, M., & Marini, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004992 · Cited by 807 · see citing works

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

Sun, Y., Campisi, J., Higano, C., Beer, T. M., Porter, P., Coleman, I., True, L., & Nelson, P. S. (2012) · Nature Medicine · doi:10.1038/nm.2890 · Cited by 793 · see citing works

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

Garin‐Chesa, P., Old, L. J., & Rettig, W. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.18.7235 · Cited by 749 · see citing works

MicroRNAs: key regulators of stem cells

Gangaraju, V. K., & Lin, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2621 · Cited by 731 · see citing works

Identification of fibroblast heterogeneity in the tumor microenvironment

Sugimoto, H., Mundel, T. M., Kieran, M. W., & Kalluri, R. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.12.3354 · Cited by 700 · see citing works

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

Yang, M., Chen, J., Su, F., Yu, B., Su, F., Lin, L., Liu, Y., Huang, J.-D., & Song, E. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-117 · Cited by 693 · see citing works

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

Tan, W., Zhang, W., Strasner, A., Grivennikov, S. I., Cheng, J. Q., Hoffman, R. M., & Karin, M. (2011) · Nature · doi:10.1038/nature09707 · Cited by 647 · see citing works

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

Chen, J., Yao, Y., Gong, C., Yu, F., Su, S., Chen, J., Liu, B., Deng, H., Wang, F., Lin, L., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.006 · Cited by 645 · see citing works

Targeting tumor‐associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

Loeffler, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26532 · Cited by 633 · see citing works

Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach

Zeisberger, S. M., Odermatt, B., Marty, C., Zehnder-Fjällman, A. H. M., Ballmer‐Hofer, K., & Schwendener, R. A. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603240 · Cited by 622 · see citing works

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

Farmer, P. J., Bonnefoi, H. R., Anderle, P., Cameron, D., Wirapati, P., Becette, V., André, S., Piccart, M. J., Campone, M., Brain, E. G. C., et al. (2009) · Nature Medicine · doi:10.1038/nm.1908 · Cited by 618 · see citing works

Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness

Giannoni, E., Bianchini, F., Masieri, L., Serni, S., Torre, E., Calorini, L., & Chiarugi, P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0785 · Cited by 596 · see citing works

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

Östman, A., & Augsten, M. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.01.003 · Cited by 542 · see citing works

Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer

Martinet, L., Garrido, I., Filleron, T., Guellec, S. L., Bellard, E., Fournié, J., Rochaix, P., & Girard, J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0431 · Cited by 523 · see citing works

Distinct epigenetic changes in the stromal cells of breast cancers

Hu, M., Yao, J., Cai, L., Bachman, K., van den Brûle, F., Velculescu, V. E., & Polyák, K. (2005) · Nature Genetics · doi:10.1038/ng1596 · Cited by 520 · see citing works

Pten in stromal fibroblasts suppresses mammary epithelial tumours

Trimboli, A. J., Cantemir-Stone, C. Z., Li, F., Wallace, J. A., Merchant, A. S., Creasap, N., Thompson, J. C., Caserta, E., Wang, H., Chong, J.-L., et al. (2009) · Nature · doi:10.1038/nature08486 · Cited by 501 · see citing works

Reduction of caveolin and caveolae in oncogenically transformed cells.

Koleske, A. J., Baltimore, D., & Lisanti, M. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1381 · Cited by 500 · see citing works

Regulation of In Situ to Invasive Breast Carcinoma Transition

Hu, M., Yao, J., Carroll, D. K., Weremowicz, S., Chen, H., Carrasco, D. R., Richardson, A. L., Violette, S. M., Nikolskaya, T., Nikolsky, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.03.007 · Cited by 497 · see citing works

Leukocyte composition of human breast cancer

Ruffell, B., Au, A., Rugo, H. S., Esserman, L. J., Hwang, E. S., & Coussens, L. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104303108 · Cited by 481 · see citing works

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

Martinez‐Outschoorn, U., Balliet, R. M., Rivadeneira, D. B., Chiavarina, B., Pavlides, S., Wang, C., Whitaker‐Menezes, D., Daumer, K. M., Lin, Z., Witkiewicz, A. K., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.16.12553 · Cited by 460 · see citing works

Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment

Iyengar, P., Espina, V. A., Williams, T. W., Lin, Y., Berry, D. C., Jelicks, L. A., Lee, H., Temple, K. A., Graves, R., Pollard, J. W., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23424 · Cited by 429 · see citing works

CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells

Tsuyada, A., Chow, A., Wu, J., Somlo, G., Chu, P. G., Loera, S., Luu, T. H., Li, A. X., Wu, X., Ye, W., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3567 · Cited by 408 · see citing works

Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome

Bergamaschi, A., Tagliabue, E., Sørlie, T., Naume, B., Triulzi, T., Orlandi, R., Russnes, H., Nesland, J. M., Tammi, R., Auvinen, P., et al. (2007) · The Journal of Pathology · doi:10.1002/path.2278 · Cited by 387 · see citing works

Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects

Zhang, W., Zhu, X., Sun, H., Xiong, Y., Zhuang, P., Xu, H., Kong, L., Wang, L., Wu, W., & Tang, Z. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2904 · Cited by 373 · see citing works

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

Iyengar, P., Combs, T. P., Shah, S. J., Gouon–Evans, V., Pollard, J. W., Albanese, C., Flanagan, L., Tenniswood, M., Guha, C., Lisanti, M. P., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206737 · Cited by 364 · see citing works

MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

Farazi, T. A., Horlings, H. M., ten Hoeve, J. J., Mihailović, A., Halfwerk, H., Morozov, P. S., Brown, M., Hafner, M., Reyal, F., van Kouwenhove, M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0608 · Cited by 344 · see citing works

Tissue-resident stem cells promote breast cancer growth and metastasis

Muehlberg, F. L., Song, Y.-H., Krohn, A., Pinilla, S. P., Droll, L. H., Leng, X., Seidensticker, M., Ricke, J., Altman, A. M., Devarajan, E., et al. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp036 · Cited by 330 · see citing works

Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung

Harris, R. E. (2009) · Inflammopharmacology · doi:10.1007/s10787-009-8049-8 · Cited by 329 · see citing works

Amino-Biphosphonate–Mediated MMP-9 Inhibition Breaks the Tumor-Bone Marrow Axis Responsible for Myeloid-Derived Suppressor Cell Expansion and Macrophage Infiltration in Tumor Stroma

Melani, C. C., Sangaletti, S., Barazzetta, F. M., Werb, Z., & Colombo, M. P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1882 · Cited by 329 · see citing works

Monocyte/macrophage infiltration in tumors: modulators of angiogenesis

Dirkx, A. E. M., Egbrink, M. G. A. O., Wagstaff, J., & Griffioen, A. W. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0905495 · Cited by 326 · see citing works

Selective Evolution of Stromal Mesenchyme with p53 Loss in Response to Epithelial Tumorigenesis

Hill, R., Song, Y., Cardiff, R. D., & Van Dyke, T. (2005) · Cell · doi:10.1016/j.cell.2005.09.030 · Cited by 324 · see citing works

Transforming growth factor-beta1 induces desmoplasia in an experimental model of human pancreatic carcinoma.

Löhr, M. J., Schmidt, C., Ringel, J., Kluth, M., Müller, P., Nizze, H., & Jesnowski, R. (2001) · PubMed · Cited by 323 · see citing works

Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells

Walter, M., Liang, S., Ghosh, S., Hornsby, P. J., & Li, R. (2009) · Oncogene · doi:10.1038/onc.2009.130 · Cited by 312 · see citing works

Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions

Laoui, D., Movahedi, K., Overmeire, E. V., den Bossche, J. V., Schouppe, E., Mommer, C., Nikolaou, A., Morias, Y., BAETSELIER, P. D., & Ginderachter, J. A. V. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113371dl · Cited by 304 · see citing works

Targeting Tumor-Associated Macrophages and Inhibition of MCP-1 Reduce Angiogenesis and Tumor Growth in a Human Melanoma Xenograft

Gazzaniga, S., Bravo, A., Guglielmotti, A., van Rooijen, N., Maschi, F., Vecchi, A., Mantovani, A., Mordoh, J., & Wainstok, R. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700827 · Cited by 302 · see citing works

Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression.

Shekhar, M. P. V., Werdell, J., Santner, S. J., Pauley, R. J., & Tait, L. R. (2001) · PubMed · Cited by 286 · see citing works

The p16<SUP>INK4a</SUP>-RB pathway : molecular link between cellular senescence and tumor suppression

Ohtani, N., Yamakoshi, K., Takahashi, A., & Hara, E. (2004) · The Journal of Medical Investigation · doi:10.2152/jmi.51.146 · Cited by 276 · see citing works

Zoledronic acid repolarizes tumour‐associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway

Coscia, M., Quaglino, E., Iezzi, M., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00926.x · Cited by 275 · see citing works

Heterocycle-Containing Bisphosphonates Cause Apoptosis and Inhibit Bone Resorption by Preventing Protein Prenylation: Evidence from Structure-Activity Relationships in J774 Macrophages

Luckman, S. P., Coxon, F. P., Ebetino, F. H., et al. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.11.1668 · Cited by 274 · see citing works

Mesenchymal Stem Cells Derived from Human Adipose Tissues Favor Tumor Cell Growth in vivo

Yu, J. M., Jun, E. S., Bae, Y. C., & Jung, J. S. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0181 · Cited by 270 · see citing works

Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome

Campbell, M. J., Tonlaar, N., Garwood, E. R., Huo, D., Moore, D. H., Khramtsov, A., der Au, A., Baehner, F. L., Chen, Y., Malaka, D. O., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1154-y · Cited by 270 · see citing works

Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.

Bronzert, D. A., Pantazis, P. A., Antoniades, H. N., Kasid, A., Davidson, N. E., Dickson, R. B., & Lippman, M. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5763 · Cited by 266 · see citing works

High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-β1

Qian, B., Katsaros, D., Lu, L., Preti, M., Durando, A., Arisio, R., Mu, L., & Yu, H. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0219-7 · Cited by 261 · see citing works

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

Martinez‐Outschoorn, U., Pavlides, S., Whitaker‐Menezes, D., Daumer, K. M., Milliman, J. N., Chiavarina, B., Migneco, G., Witkiewicz, A. K., Cantarin, M. P. M., Flomenberg, N., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.12.12048 · Cited by 247 · see citing works

Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer

Musumeci, M., Coppola, V., Addario, A., Patrizii, M., Maugeri‐Saccà, M., Memeo, L., Colarossi, C., Francescangeli, F., Biffoni, M., Collura, D., et al. (2011) · Oncogene · doi:10.1038/onc.2011.140 · Cited by 235 · see citing works

MicroRNA-21: From Cancer to Cardiovascular Disease

Jazbutyte, V., & Thum, T. (2010) · Current Drug Targets · doi:10.2174/138945010791591403 · Cited by 226 · see citing works

Human breast carcinoma desmoplasia is PDGF initiated

Shao, Z., Nguyen, M. T. N., & Barsky, S. H. (2000) · Oncogene · doi:10.1038/sj.onc.1203785 · Cited by 222 · see citing works

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

Capparelli, C., Chiavarina, B., Whitaker-Menezes, D., Pestell, T. G., Pestell, R. G., Hulit, J., Andò, S., Howell, A., Martinez-Outschoorn, U. E., Sotgia, F., et al. (2012) · Cell Cycle · doi:10.4161/cc.21884 · Cited by 221 · see citing works

Role of COX-2 in epithelial–stromal cell interactions and progression of ductal carcinoma in situ of the breast

Hu, M. S., Peluffo, G., Chen, H., Gelman, R. S., Schnitt, S. J., & Polyák, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813306106 · Cited by 205 · see citing works

Molecular Pathways: Osteoclast-Dependent and Osteoclast-Independent Roles of the RANKL/RANK/OPG Pathway in Tumorigenesis and Metastasis

Dougall, W. C. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2507 · Cited by 200 · see citing works

MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways

Davis‐Dusenbery, B. N., & Hata, A. (2010) · Genes & Cancer · doi:10.1177/1947601910396213 · Cited by 195 · see citing works

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

Sloan, E. K., Ciocca, D. R., Pouliot, N., Natoli, A. L., Restall, C. M., Henderson, M. A., Fanelli, M. A., Cuello-Carrión, F. D., Gago, F. E., & Anderson, R. L. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080924 · Cited by 191 · see citing works

Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts

Roland, C. L., Dineen, S. P., Lynn, K. D., Sullivan, L. A., Dellinger, M. T., Sadegh, L., Sullivan, J. P., Shames, D. S., & Brekken, R. A. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0280 · Cited by 189 · see citing works

Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors

Jotzu, C., Alt, E., Welte, G., Li, J., Hennessy, B. T., Devarajan, E., Krishnappa, S., Pinilla, S. P., Droll, L. H., & Song, Y. (2011) · Cellular Oncology · doi:10.1007/s13402-011-0012-1 · Cited by 189 · see citing works

Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation

Strutz, F. M., Zeisberg, M., Hemmerlein, B., Sattler, B., Hummel, K. M., Becker, V., & Muller, G. A. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00997.x · Cited by 183 · see citing works

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

Martinez‐Outschoorn, U., Goldberg, A. F., Zhao, L., Ko, Y., Flomenberg, N., Wang, C., Pavlides, S., Pestell, R. G., Howell, A., Sotgia, F., et al. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.12.10.17780 · Cited by 175 · see citing works

Breast Cancer DNA Methylation Profiles in Cancer Cells and Tumor Stroma: Association with HER-2/neu Status in Primary Breast Cancer

Fiegl, H., Millinger, S., Goebel, G., Müller‐Holzner, E., Marth, C., Laird, P. W., & Widschwendter, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2508 · Cited by 172 · see citing works

The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin

Pontiggia, O., Sampayo, R. G., Raffo, D., Motter, A. N., Xu, R., Bissell, M. J., Joffé, E. B. D. K., & Simian, M. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1766-x · Cited by 166 · see citing works

BRCA1 promoter methylation in sporadic breast tumors: relationship to gene expression profiles

Matros, E., Wang, Z. C., Lodeiro, G., Miron, A., Iglehart, J. D., & Richardson, A. L. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-7603-8 · Cited by 165 · see citing works

Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture

Sadlonova, A., Novák, Z., Johnson, M. R., Bowe, D. B., Gault, S. R., Page, G. P., Thottassery, J. V., Welch, D. R., & Frost, A. R. (2004) · Breast Cancer Research · doi:10.1186/bcr949 · Cited by 158 · see citing works

Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion

Pinilla, S., Alt, E., Abdul Khalek, F. J., Jotzu, C., Muehlberg, F., Beckmann, C., & Song, Y.-H. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.013 · Cited by 156 · see citing works

p53 Attenuates Cancer Cell Migration and Invasion through Repression of SDF-1/CXCL12 Expression in Stromal Fibroblasts

Moskovits, N. B.-C., Kalinkovich, A., Bar, J., Lapidot, T., & Oren, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2323 · Cited by 152 · see citing works

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 down-regulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy

Mercier, I., Casimiro, M. C., Wang, C., Rosenberg, A., Quong, J. N., Minkeu, A., Allen, K. G., Danilo, C., Sotgia, F., Bonuccelli, G., et al. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.8.6220 · Cited by 151 · see citing works

The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts

Aprelikova, O. N., Xiang, Y., Palla, J. B., Wei, B., John, S., Yi, M., Stephens, R. M., Simpson, R. J., Risinger, J. I., Jazaeri, A. A., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.21.13674 · Cited by 151 · see citing works

Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics

Mukhtar, R. A., Nseyo, O., Campbell, M., & Esserman, L. (2011) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.97 · Cited by 150 · see citing works

Periprostatic Adipose Tissue as a Modulator of Prostate Cancer Aggressiveness

Finley, D. S., Calvert, V. S., Inokuchi, J., Lau, A., Narula, N., Petricoin, E. F., Zaldivar, F. P., Santos, R. T., Tyson, D. R., & Ornstein, D. K. (2009) · The Journal of Urology · doi:10.1016/j.juro.2009.06.015 · Cited by 150 · see citing works

Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages

Cecchini, M. G., Felix, R., Fleisch, H. A., & Cooper, P. H. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020209 · Cited by 144 · see citing works

Global Hypomethylation of Genomic DNA in Cancer-Associated Myofibroblasts

Jiang, L., Gonda, T. A., Gamble, M. V., Salas, M. C., Seshan, V., Tu, S., Twaddell, W. S., Hegyi, P. J., Lázár, G., Steele, I. A., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1319 · Cited by 142 · see citing works

MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination

Fazi, F., & Nervi, C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn151 · Cited by 137 · see citing works

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

Hiraoka, K., Zenmyo, M., Watari, K., Iguchi, H., Fotovati, A., Kimura, Y. N., Hosoi, F., Shoda, T., Nagata, K., Osada, H., et al. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00880.x · Cited by 132 · see citing works

Evidence for Nonautonomous Effect of <i>p53</i> Tumor Suppressor in Carcinogenesis

Kiaris, H., Chatzistamou, I., Trimis, G., Frangou-Plemmenou, M., Pafiti-Kondi, A., & Kalofoutis, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3791 · Cited by 128 · see citing works

Cancer-associated adipocytes promotes breast tumor radioresistance.

Bochet, L., Meulle, A., Imbert, S., Salles, B., Valet, P., & Muller, C. (2011) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2011.06.101 · Cited by 127 · see citing works

IL-2 Immunotoxin Therapy Modulates Tumor-Associated Regulatory T Cells and Leads to Lasting Immune-Mediated Rejection of Breast Cancers in neu -Transgenic Mice

Knutson, K. L., Dang, Y., Lu, H., Lukas, J. L., Almand, B., Gad, E. A., Azeke, E., & Disis, M. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.84 · Cited by 127 · see citing works

Macrophages direct tumour histology and clinical outcome in a colon cancer model

Oosterling, S. J., van der Bij, G. J., Meijer, G. A., et al. (2005) · The Journal of Pathology · doi:10.1002/path.1830 · Cited by 125 · see citing works

Cancer-Associated Fibroblasts Induce Matrix Metalloproteinase–Mediated Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cells

Johansson, A., Ansell, A., Jerhammar, F., Lindh, M. B., Grenman, R. A., Munck‐Wikland, E., Östman, A., & Roberg, K. B. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0030 · Cited by 124 · see citing works

Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype

Robinson, C. M., Neary, R., Levendale, A. L., Watson, C. J., & Baugh, J. A. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-74 · Cited by 123 · see citing works

Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility

Aprelikova, O. N., Palla, J. B., Hibler, B. P., Yu, X., Greer, Y. E., Yi, M., Stephens, R., Maxwell, G. L., Jazaeri, A. A., Risinger, J. I., et al. (2012) · Oncogene · doi:10.1038/onc.2012.351 · Cited by 122 · see citing works

Role of cancer-associated fibroblasts in breast cancer development and prognosis

Aboussekhra, A. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113362aa · Cited by 119 · see citing works

Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors

Jotzu, C., Alt, E., Welte, G., Li, J., Hennessy, B. T., Devarajan, E., Krishnappa, S., Pinilla, S., Droll, L., & Song, Y.-H. (2010) · Analytical Cellular Pathology · doi:10.1155/2010/695162 · Cited by 114 · see citing works

Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met

Mueller, K. L., Madden, J. M., Zoratti, G. L., Kuperwasser, C., List, K., & Boerner, J. L. (2012) · Breast Cancer Research · doi:10.1186/bcr3224 · Cited by 112 · see citing works

Fibroblast Growth Factor Receptor 2–Positive Fibroblasts Provide a Suitable Microenvironment for Tumor Development and Progression in Esophageal Carcinoma

Zhang, C., Fu, L., Fu, J., Hu, L., Yang, H., Rong, T.-H., Li, Y., Liu, H., Fu, S.-B., Zeng, Y.-X., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2824 · Cited by 111 · see citing works

MicroRNAs in embryonic stem cell function and fate.Preprint

Tiscornia, G., & Belmonte, J. C. I. (2010) · Genes & Development · doi:10.1101/gad.1982910 · Cited by 109 · see citing works

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment

Trimmer, C., Sotgia, F., Whitaker‐Menezes, D., Balliet, R. M., Eaton, G. J., Martinez‐Outschoorn, U., Pavlides, S., Howell, A., Iozzo, R. V., Pestell, R. G., et al. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.4.14101 · Cited by 107 · see citing works

Unraveling the Obesity and Breast Cancer Links: A Role for Cancer-Associated Adipocytes?

Dirat, B., Bochet, L., Escourrou, G., Valet, P., & Muller, C. (2010) · Endocrine development · doi:10.1159/000316896 · Cited by 105 · see citing works

Direct Involvement of Breast Tumor Fibroblasts in the Modulation of Tamoxifen Sensitivity

Shekhar, M. P. V., Santner, S. J., Carolin, K. A., & Tait, L. R. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061004 · Cited by 105 · see citing works

Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma

Veltman, J. D., Lambers, M. E. H., van Nimwegen, M., Hendriks, R. W., Hoogsteden, H. C., Hegmans, J. P., & Aerts, J. G. J. V. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605814 · Cited by 104 · see citing works

The prognostic significance of tumor-associated stroma in invasive breast carcinoma

Ahn, S., Cho, J., Sung, J., Lee, J. E., Nam, S. J., Kim, K.-M., & Cho, E. Y. (2012) · Tumor Biology · doi:10.1007/s13277-012-0411-6 · Cited by 101 · see citing works

Epithelial–mesenchymal transition in breast cancer lines is mediated through PDGF‐D released by tissue‐resident stem cells

Devarajan, E., Song, Y., Krishnappa, S., & Alt, E. (2011) · International Journal of Cancer · doi:10.1002/ijc.26493 · Cited by 100 · see citing works

Function and Localization of MicroRNAs in Mammalian CellsPreprint

Leung, A. K. L., & Sharp, P. A. (2006) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2006.71.049 · Cited by 96 · see citing works

Angiogenesis and inflammation in invasive carcinoma of the breast.

Lee, A. H., Happerfield, L. C., Bobrow, L. G., & Millis, R. R. (1997) · Journal of Clinical Pathology · doi:10.1136/jcp.50.8.669 · Cited by 95 · see citing works

The significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the “protease-centered” hypothesis

Man, Y., & Sang, Q. A. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.08.037 · Cited by 94 · see citing works

Forkhead Box F1 Regulates Tumor-Promoting Properties of Cancer-Associated Fibroblasts in Lung Cancer

Saito, R.-A., Micke, P., Paulsson, J., Augsten, M., Peña, C., Jönsson, P., Botling, J., Edlund, K., Johansson, L., Carlsson, P., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3644 · Cited by 93 · see citing works

Contribution of Fibroblast and Mast Cell (Afferent) and Tumor (Efferent) IL-6 Effects within the Tumor Microenvironment

Hugo, H. J., Lebret, S. C., Tomaskovic‐Crook, E., et al. (2012) · Cancer Microenvironment · doi:10.1007/s12307-012-0098-7 · Cited by 91 · see citing works

Transient Tumor-Fibroblast Interactions Increase Tumor Cell Malignancy by a TGF-β Mediated Mechanism in a Mouse Xenograft Model of Breast Cancer

Stuelten, C. H., Busch, J. I., Tang, B., Flanders, K. C., Oshima, A., Sutton, E. C., Karpova, T., Roberts, A. B., Wakefield, L. M., & Niederhuber, J. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009832 · Cited by 90 · see citing works

Downregulation of miR-92a Is Associated with Aggressive Breast Cancer Features and Increased Tumour Macrophage Infiltration

Nilsson, S., Möller, C., Jirström, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036051 · Cited by 89 · see citing works

p16INK4A Represses the paracrine tumor-promoting effects of breast stromal fibroblasts

Al‐Ansari, M. M., Hendrayani, S., Shehata, A. I., & Aboussekhra, A. (2012) · Oncogene · doi:10.1038/onc.2012.270 · Cited by 88 · see citing works

Effects of human breast fibroblasts on growth and 17β-estradiol dehydrogenase activity of MCF-7 cells in culture

Adams, E. F., NEWTON, C. J., Braunsberg, H., et al. (1988) · Breast Cancer Research and Treatment · doi:10.1007/bf01805840 · Cited by 82 · see citing works

Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change

Tyan, S., Hsu, C.-H., Peng, K.-L., Chen, C.-C., Kuo, W., Lee, E. Y.-H. P., Shew, J., Chang, K., Juan, L., & Lee, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035128 · Cited by 80 · see citing works

Highly Proliferative Fibroblasts Forming Fibrotic Focus Govern Metastasis of Invasive Ductal Carcinoma of the Breast

Hasebe, T., Sasaki, S., Imoto, S., & Ochiai, A. (2001) · Modern Pathology · doi:10.1038/modpathol.3880310 · Cited by 73 · see citing works

Clonal Mutations in the Cancer-Associated Fibroblasts: The Case against Genetic Coevolution

Campbell, I., Polyák, K., & Haviv, I. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4253 · Cited by 70 · see citing works

The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue

(2000) · doi:10.1002/1096-9896(2000)9999:9999 · Cited by 70 · see citing works

Up‐regulation of pro‐inflammatory genes as adaptation to hypoxia in MCF‐7 cells and in human mammary invasive carcinoma microenvironment

Tafani, M., Russo, A., Vito, M. D., Sale, P., Pellegrini, L., Schito, L., Gentileschi, S., Bracaglia, R., Marandino, F., Garaci, E., et al. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01493.x · Cited by 67 · see citing works

Obesity and breast cancer

Bakar, D., & Mehrzad, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90965-5.00006-4 · Cited by 65 · see citing works

Targeting the Tumor Stroma as a Novel Treatment Strategy for Breast Cancer

Tchou, J. C., & Conejo-Garcia, J. R. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-397927-8.00003-8 · Cited by 62 · see citing works

Obesity and breast cancer.

Ligibel, J. A. (2011) · PubMed · Cited by 54 · see citing works

Specific protein and miRNA patterns characterise tumour-associated fibroblasts in bladder cancer

Enkelmann, A., Heinzelmann, J., von Eggeling, F., Walter, M., Berndt, A., Wunderlich, H., & Junker, K. (2010) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-010-0932-6 · Cited by 48 · see citing works

Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors

Trimis, G. G., Chatzistamou, I., Politi, K. A., Kiaris, H., & Papavassiliou, A. G. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn252 · Cited by 44 · see citing works

Interleukin‐8 derived from local tissue‐resident stromal cells promotes tumor cell invasion

Welte, G., Alt, E., Devarajan, E., Krishnappa, S., Jotzu, C., & Song, Y. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20854 · Cited by 41 · see citing works

Bone metastasis in breast cancer: The story of RANK-Ligand

Azim, H. A., Kamal, N. S., & Azim, H. A. (2012) · Journal of the Egyptian National Cancer Institute · doi:10.1016/j.jnci.2012.06.002 · Cited by 38 · see citing works

Mesenchymal stem cells and carcinoma-associated fibroblasts sensitize breast cancer cells in 3D cultures to kinase inhibitors

Dittmer, J. (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.1073 · Cited by 35 · see citing works

Epigenetic mechanisms regulating CYP19 transcription in human breast adipose fibroblasts

Knower, K. C., To, S. Q., Simpson, E. R., & Clyne, C. D. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.035 · Cited by 34 · see citing works

Unlike Pancreatic Cancer Cells Pancreatic Cancer Associated Fibroblasts Display Minimal Gene Induction after 5-Aza-2′-Deoxycytidine

Yu, J. Q., Walter, K., Omura, N., Hong, S., Young, A., Li, A., Vincent, A., & Goggins, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043456 · Cited by 31 · see citing works

PS1-05: Disparities in Breast Cancer Survival by Molecular Subtype and Race/Ethnicity

Haque, R., Ahmed, S., Schottinger, J. E., et al. (2012) · Clinical Medicine & Research · doi:10.3121/cmr.2012.1100.ps1-05 · Cited by 4 · see citing works

Hypoxia and the extracellular matrix: drivers of tumour metastasis

Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3726 · Cited by 1,520 · see citing works

Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

Vizoso, F., Eiro, N., Cid, S., Schneider, J., & Perez-Fernandez, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091852 · Cited by 1,363 · see citing works

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

Shiga, K., Hara, M., Nagasaki, T., Sato, T., Takahashi, H., & Takeyama, H. (2015) · Cancers · doi:10.3390/cancers7040902 · Cited by 774 · see citing works

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Nunes, A. S., Barros, A. S., Costa, E. C., Moreira, A. F., & Correia, I. J. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26845 · Cited by 721 · see citing works

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

Zhang, R., Qi, F., Zhao, F., Li, G., Shao, S., Zhang, X., Yuan, L., & Feng, Y. (2019) · Cell Death &amp; Disease · doi:10.1038/s41419-019-1435-2 · Cited by 343 · see citing works

Microfluidic modelling of the tumor microenvironment for anti-cancer drug development

Shang, M., Soon, R. H., Lim, C. T., Khoo, B. L., & Han, J. (2019) · Lab on a Chip · doi:10.1039/c8lc00970h · Cited by 227 · see citing works

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

Kharaishvili, G., Simkova, D., Bouchalova, K., Gachechiladze, M., Narsia, N., & Bouchal, J. (2014) · Cancer Cell International · doi:10.1186/1475-2867-14-41 · Cited by 197 · see citing works

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

Ahmed, S., Bradshaw, A.-D., Gera, S., Dewan, M., & Xu, R. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6010005 · Cited by 174 · see citing works

Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment

Truong, D., Puleo, J., Llave, A., Mouneimne, G., Kamm, R. D., & Nikkhah, M. (2016) · Scientific Reports · doi:10.1038/srep34094 · Cited by 135 · see citing works

Hypoxia and the phenomenon of immune exclusion

Pietrobon, V., & Marincola, F. M. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-020-02667-4 · Cited by 119 · see citing works

Breast Fibroblasts and ECM Components Modulate Breast Cancer Cell Migration through the Secretion of MMPs in a 3D Microfluidic Co-Culture Model

Lugo-Cintrón, K. M., Gong, M. M., Ayuso, J. M., Tomko, L. A., Beebe, D. J., Virumbrales-Muñoz, M., & Ponik, S. M. (2020) · Cancers · doi:10.3390/cancers12051173 · Cited by 103 · see citing works

Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device

Yu, T., Guo, Z., Fan, H., Song, J., Liu, Y., Gao, Z., & Wang, Q. (2016) · Oncotarget · doi:10.18632/oncotarget.8232 · Cited by 70 · see citing works

Fibroblast-associated tumour microenvironment induces vascular structure-networked tumouroid

Lee, S. W., Kwak, H. S., Kang, M.-H., Park, Y.-Y., & Jeong, G. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-20886-0 · Cited by 68 · see citing works

Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis

Qureshi, R., Picon-Ruiz, M., Sho, M., Van Booven, D., Nunes de Paiva, V., Diaz-Ruano, A. B., Ince, T. A., & Slingerland, J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111672 · Cited by 37 · see citing works

Multifaceted Interplay between Hormones, Growth Factors and Hypoxia in the Tumor Microenvironment

Lappano, R., Todd, L. A., Stanic, M., Cai, Q., Maggiolini, M., Marincola, F., & Pietrobon, V. (2022) · Cancers · doi:10.3390/cancers14030539 · Cited by 32 · see citing works

Histomorphological stratification of stromal types associated with canine mammary tumours

Devi, S. S., George, A. J., Dhanushkrishna, B., et al. (2022) · Journal of Veterinary and Animal Sciences · doi:10.51966/jvas.2022.53.4.688-693 · Cited by 1 · see citing works

Experimental approaches to the study of cancer–stroma interactions: recent findings suggest a pivotal role for stroma in carcinogenesis

West, R. B., & van de Rijn, M. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700666 · Cited by 29 · see citing works

Molecular Aspects of Stromal-Parenchymal Interactions in Malignant Neoplasms

Zalatnai, A. (2006) · Current Molecular Medicine · doi:10.2174/156652406778195053 · Cited by 52 · see citing works

Tumour-Stromal Interactions in Breast Cancer: The Role of Stroma in Tumourigenesis

Kim, J. B., Stein, R. C., & O'Hare, M. J. (2005) · Tumor Biology · doi:10.1159/000086950 · Cited by 114 · see citing works

Tumour-Promoting Stromal Myofibroblasts in Human Carcinomas

Polanska, U. M., Mellody, K. T., & Orimo, A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6615-5_16 · Cited by 6 · see citing works