Cited by 361Olfactory and Sensory Function StudiesRegulation of Appetite and ObesityNeural and Behavioral Psychology Studies

Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex

OʼDoherty, J, Rolls, E T., Francis, S, Bowtell, R, McGlone, F, Kobal, G, Renner, B, Ahne, G·2000·NeuroReport

Abstract

When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the food eaten to satiety decreased, whereas there was no similar decrease for the odour of a food not eaten in the meal. This effect was shown both by a voxel-wise SPM contrast (p < 0.05 corrected) and an ANOVA performed on the mean percentage change in BOLD signal in the identified clusters of voxels (p < 0.006). These results show that activation of a region of the human orbitofrontal cortex is related to olfactory sensory-specific satiety.

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Crossref · 10.1097/00001756-200003200-00046

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8 of 8 references verified0 citation errors · 0 not checkable

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  • Subjective pleasantness in humans is coded by neural activity in the medial orbitofrontal cortex as measured by fMRI and is subject to sensory-specific satiety.

    “Similarly, subjective pleasantness in humans was coded by neural activity in the medial orbitofrontal cortex as measured by functional MRI (fMRI) and was subject to sensory-specific satiety, a form of reinforcer devaluation”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [117]

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Authors
OʼDoherty, J., Rolls, E. T., Francis, S., Bowtell, R., McGlone, F., Kobal, G., Renner, B., & Ahne, G.
Affiliations
  • University of Oxford (GB)
  • University of Nottingham (GB)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Venue
NeuroReport
Published
2000-03
Volume
11
Issue
4
Pages
893-897
ISSN
0959-4965 (ISSN-L)
OpenAlex
W4243190995
Cited by
361
References
8
Citations by year
2026: 4 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 8 · 2018: 10 · 2017: 19 · 2016: 20 · 2015: 17 · 2014: 13 · 2013: 18 · 2012: 26
FWCI
4.69
Type
journal article
Language
en
Open access
closed
Locations
Neuroreport (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
sensory-specific satiety, orbitofrontal cortex, food aroma, satiety, reward value, BOLD signal

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