Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex
Abstract
When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the food eaten to satiety decreased, whereas there was no similar decrease for the odour of a food not eaten in the meal. This effect was shown both by a voxel-wise SPM contrast (p < 0.05 corrected) and an ANOVA performed on the mean percentage change in BOLD signal in the identified clusters of voxels (p < 0.006). These results show that activation of a region of the human orbitofrontal cortex is related to olfactory sensory-specific satiety.
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Subjective pleasantness in humans is coded by neural activity in the medial orbitofrontal cortex as measured by fMRI and is subject to sensory-specific satiety.
“Similarly, subjective pleasantness in humans was coded by neural activity in the medial orbitofrontal cortex as measured by functional MRI (fMRI) and was subject to sensory-specific satiety, a form of reinforcer devaluation”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [117]
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- Authors
- OʼDoherty, J., Rolls, E. T., Francis, S., Bowtell, R., McGlone, F., Kobal, G., Renner, B., & Ahne, G.
- Affiliations
- University of Oxford (GB)
- University of Nottingham (GB)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Venue
- NeuroReport
- Published
- 2000-03
- Volume
- 11
- Issue
- 4
- Pages
- 893-897
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W4243190995
- Cited by
- 361
- References
- 8
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 8 · 2018: 10 · 2017: 19 · 2016: 20 · 2015: 17 · 2014: 13 · 2013: 18 · 2012: 26
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- sensory-specific satiety, orbitofrontal cortex, food aroma, satiety, reward value, BOLD signal
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