Cited by 182Autism Spectrum Disorder ResearchNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism

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Fatemi, S. Hossein, Reutiman, Teri J., Folsom, Timothy D., Rooney, Robert J., Patel, Diven H., Thuras, Paul D.·2010·Journal of Autism and Developmental Disorders

Abstract

We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA(A) subunits previously associated with autism (GABRalpha4; GABRalpha5; GABRbeta1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRalpha4, GABRalpha5, GABRbeta1) and one demonstrated concordance in cerebellum (GABBetaR1). These results provide further evidence of impairment of GABAergic signaling in autism.

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  • Reduced GABAA and GABAB receptor density and system activity have been reported in the brains of autistic patients.

    “Additionally, other studies have reported reduced GABAA [129, 130] and GABAB [124, 130] receptor density and system activity in the brains of autistic patients.”
  • In the cerebellum, concordant reductions have been observed in mRNA and protein levels for GABAB R1 receptor in subjects with autism.

    “In cerebellum, concordant reductions have been observed in mRNA and protein levels for GABAB R1 receptor in subjects with autism [130].”

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Authors
Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Rooney, R. J., Patel, D. H., & Thuras, P. D.
Affiliations
University of Minnesota (US)
Corresponding author
Fatemi, S. Hossein
Venue
Journal of Autism and Developmental Disorders
Published
2010-01-12
Volume
40
Issue
6
Pages
743-750
ISSN
  • 0162-3257 (ISSN-L)
  • 1573-3432
OpenAlex
W2005822031
Cited by
182
References
44
Citations by year
2026: 5 · 2025: 2 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 13 · 2016: 14 · 2015: 16 · 2014: 16 · 2013: 20 · 2012: 14
FWCI
10.86
Type
journal article
Language
en
Open access
Locations
  • Journal of Autism and Developmental Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Parkinson Foundation
  • Parkinson's Foundation
  • National Institutes of Health
  • National Institute of Mental Health (R24MH068855)
  • National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD052074)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, GABAA receptor, GABAB receptors, GABBR1, gene expression, mRNA levels, protein abundance, GABAergic neurotransmission, superior frontal cortex, cerebellum
MeSH terms
Adult, Autistic Disorder, Brain Chemistry, Cerebellum, Electrophoresis, Polyacrylamide Gel, Female, Humans, Male, Middle Aged, Receptors, GABA-A, RNA, Messenger, Blotting, Western, Receptors, GABA-B, Reverse Transcriptase Polymerase Chain Reaction, Young Adult

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