Cited by 498Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersChild and Animal Learning Development

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The ‘Fractionable Autism Triad’: A Review of Evidence from Behavioural, Genetic, Cognitive and Neural Research

Happé, Francesca, Ronald, Angelica·2008·Neuropsychology Review

DOI 10.1007/s11065-008-9076-8

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Abstract

Autism is diagnosed on the basis of a triad of impairments in social interaction, communication, and flexible imaginative functions (with restricted and repetitive behaviors and interests; RRBIs). There has been a strong presumption that these different features of the syndrome are strongly intertwined and proceed from a common cause at the genetic, cognitive and neural levels. In this review we examine evidence for an alternative approach, considering the triad as largely 'fractionable'. We present evidence from our own twin studies, and review relevant literature on autism and autistic-like traits in other groups. We suggest that largely independent genes may operate on social skills/impairments, communication abilities, and RRBIs, requiring a change in molecular-genetic research approaches. At the cognitive level, we suggest that satisfactory accounts exist for each of the triad domains, but no single unitary account can explain both social and nonsocial features of autism. We discuss the implications of the fractionable-triad approach for both diagnosis and future research directions.

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Meeting of minds: the medial frontal cortex and social cognition
Amodio, D. M., & Frith, C. D. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1884 · Cited by 3,782 · cited 1×
“…a large and growing body of research, using a wide array of tasks requiring attribution of mental states, suggests that theory of mind is associated with activation of medial prefrontal cortex, temporo-parietal junction, and amygdala complex (see Amodio and Frith 2006 for a comprehensive review).”
Background
Genome-wide association studies for common diseases and complex traits
Hirschhorn, J. N., & Daly, M. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1521 · Cited by 2,923
The weak coherence account: detail-focused cognitive style in autism spectrum disorders
Happé, F., & Frith, U. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0039-0 · Cited by 2,884
Untitled work
(1989) · UCL Discovery (University College London) · Cited by 2,724
Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification
Wing, L., & Gould, J. (1979) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01531288 · Cited by 2,587 · cited 4×
“…collected from a psychiatric and ‘mental retardation’ register, investigated the prevalence of the triad of impairments and whether they tended to occur together, and was carried out on a clinical sample of children selected from an epidemiological study in Camberwell, London (Wing and Gould 1979).”
BackgroundInfluential
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461
Handbook of Autism and Pervasive Developmental Disorders
(2005) · Wiley eBooks · doi:10.1002/9780470939352 · Cited by 2,262
Enhanced Perceptual Functioning in Autism: An Update, and Eight Principles of Autistic Perception
Mottron, L., Dawson, M., Soulières, I., Hubert, B., & Burack, J. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0040-7 · Cited by 1,957
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Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839

Show all 161 references

Research works printed but not linked: 1

Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2008). Behavioral Genetics (4th ed.). New York: Worth.

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Authors: Happé, F., & Ronald, A.
Affiliations: Birkbeck, University of London (GB)
ORCID: Ronald, Angelica
Venue: Neuropsychology Review
Publisher: Springer Science and Business Media LLC
Published: 2008-10-28
Volume: 18
Issue: 4
Pages: 287-304
ISSN: 1040-7308 (ISSN-L)
1573-6660
DOI: 10.1007/s11065-008-9076-8
OpenAlex: W2078162851
Cited by: 498
References: 161
Citations by year: 2026: 7 · 2025: 17 · 2024: 17 · 2023: 25 · 2022: 23 · 2021: 31 · 2020: 14 · 2019: 24 · 2018: 31 · 2017: 26 · 2016: 30 · 2015: 33 · 2014: 46 · 2013: 51 · 2012: 34
FWCI: 2.20
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychology Review (publishedVersion)
PubMed (publishedVersion)
BIROn (Birkbeck, University of London) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Autism Speaks (AS1650)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
Keywords: autism spectrum disorder, social interaction deficits, communication disorders, restricted and repetitive behaviors, autistic traits, twin studies, genetic architecture, autism diagnosis
MeSH terms: Autistic Disorder, Behavior, Communication, Compulsive Behavior, Family Health, Humans, Interpersonal Relations, Nervous System, Biomedical Research

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The ‘Fractionable Autism Triad’: A Review of Evidence from Behavioural, Genetic, Cognitive and Neural Research

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