Social peers rescue autism‐relevant sociability deficits in adolescent mice
Open accessAbstract
Behavioral therapies are currently the most effective interventions for treating the diagnostic symptoms of autism. We employed a mouse model of autism to evaluate components of behavioral interventions that improve sociability in mice. BTBR T+tf/J (BTBR) is an inbred mouse strain that exhibits prominent behavioral phenotypes with face validity to all three diagnostic symptom categories of autism, including robust and well‐replicated deficits in social approach and reciprocal social interactions. To investigate the role of peer interactions in the development of sociability, BTBR juvenile mice were reared in the same home cage with juvenile mice of a highly social inbred strain, C57BL/6J (B6). Subject mice were tested as young adults for sociability and repetitive behaviors. B6 controls reared with B6 showed their strain‐typical high sociability. BTBR controls reared with BTBR showed their strain‐typical lack of sociability. In contrast, BTBR reared with B6 as juveniles showed significant sociability as young adults. A 20‐day intervention was as effective as a 40‐day intervention for improving social approach behavior. High levels of repetitive self‐grooming in BTBR were not rescued by peer‐rearing with B6, indicating specificity of the intervention to the social domain. These results from a robust mouse model of autism support the interpretation that social enrichment with juvenile peers is a beneficial intervention for improving adult outcome in the social domain. This novel paradigm may prove useful for discovering factors that are essential for effective behavioral treatments, and biological mechanisms underlying effective behavioral interventions.
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Housing BTBR mice with highly social C57BL/6 mice has been reported to enhance social interactions in the BTBR strain.
“Housing BTBR mice with highly social C57BL/6 mice has been reported to enhance the social interactions in the BTBR strain 82 .”
From Progress toward treatments for synaptic defects in autism (2013) · cites this paper as [82]
Inbred strains are genetically homogeneous and commercially available, maximizing their feasibility as translational tools in medications development.
“These inbred strains are genetically homogeneous and commercially available, maximizing their feasibility as translational tools in medications development (71–73).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [73]
Cohousing with C57BL/6J mice restores social deficits in BTBR mice.
“While previous studies have shown that BTBR mice harbor a different microbial community in the gut (Coretti et al., 2017; Golubeva et al., 2017) and cohousing with C57BL/6J mice has been shown to restore their social deficits (Yang et al., 2011), the nature of the bacterial species which may be causally related to the social behavioral deficits in this ASD model remains unknown.”
From Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder (2019) · cites this paper as Yang et al., 2011
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- Authors
- Yang, M., Perry, K., Weber, M. D., Katz, A. M., & Crawley, J. N.
- Affiliations
- National Institutes of Health (US)
- National Institute of Mental Health (US)
- Corresponding author
- Yang, Mu
- Venue
- Autism Research
- Publisher
- Wiley
- Published
- 2010-10-06
- Volume
- 4
- Issue
- 1
- Pages
- 17-27
- ISSN
- 1939-3792 (ISSN-L)
- 1939-3806
- PMC
- PMC3065860
- OpenAlex
- W1984005834
- Cited by
- 106
- References
- 79
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 15
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autism Research (publishedVersion, public-domain)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- University of California, Davis
- National Institute of Mental Health (ZIAMH002179)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, social dysfunction, social enrichment, peer rearing, BTBR T+tf/J mice, C57BL/6J mice, social approach behavior, behavior therapy, mouse models of autism
- MeSH terms
- Age Factors, Animals, Child, Child Development Disorders, Pervasive, Communication, Disease Models, Animal, DNA Mutational Analysis, Genotype, Genetic Carrier Screening, Humans, Mice, Neurologic Mutants, Peer Group, Phenotype, Social Behavior, Social Environment, Stereotyped Behavior, Synapses, Mice
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