Cited by 1,910Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems

The DOI matches its Crossref record; 226 of the 227 references it cites were found in a registry or an index.

Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P.·2006·Pharmaceutical Research

Open this paper in CoChat — free account

Abstract

Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and hydrophilic shell are currently successfully used as pharmaceutical carriers for water-insoluble drugs and demonstrate a series of attractive properties as drug carriers. Among the micelle-forming compounds, amphiphilic copolymers, i.e., polymers consisting of hydrophobic block and hydrophilic block, are gaining an increasing attention. Polymeric micelles possess high stability both in vitro and in vivo and good biocompatibility, and can solubilize a broad variety of poorly soluble pharmaceuticals many of these drug-loaded micelles are currently at different stages of preclinical and clinical trials. Among polymeric micelles, a special group is formed by lipid-core micelles, i.e., micelles formed by conjugates of soluble copolymers with lipids (such as polyethylene glycol-phosphatidyl ethanolamine conjugate, PEG-PE). Polymeric micelles, including lipid-core micelles, carrying various reporter (contrast) groups may become the imaging agents of choice in different imaging modalities. All these micelles can also be used as targeted drug delivery systems. The targeting can be achieved via the enhanced permeability and retention (EPR) effect (into the areas with the compromised vasculature), by making micelles of stimuli-responsive amphiphilic block-copolymers, or by attaching specific targeting ligand molecules to the micelle surface. Immunomicelles prepared by coupling monoclonal antibody molecules to p-nitrophenylcarbonyl groups on the water-exposed termini of the micelle corona-forming blocks demonstrate high binding specificity and targetability. This review will discuss some recent trends in using micelles as pharmaceutical carriers.

Integrity signals

Registry

Crossref · 10.1007/s11095-006-9132-0

Cites

226 of 226 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565
Surfactants and interfacial phenomena
Rosen, M. J., & Kunjappu, J. T. (2005) · Choice Reviews Online · doi:10.5860/choice.42-2832 · Cited by 5,402
Drug-like properties and the causes of poor solubility and poor permeability
Lipinski, C. A. (2000) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(00)00107-6 · Cited by 3,776
Foundations of Colloid Science
Hunter, R. J. (1987) · Cited by 3,721
Handbook of Pharmaceutical Excipients
Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (1994) · Cited by 3,493
Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene- b -poly(acrylic acid) Block Copolymers
Zhang, L., & Eisenberg, A. (1995) · Science · doi:10.1126/science.268.5218.1728 · Cited by 2,474
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., & Jain, R. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4607 · Cited by 2,438
Self-citation
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030
Self-citation
Structure and design of polymeric surfactant-based drug delivery systems
Torchilin, V. P. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00299-1 · Cited by 1,844
Self-citation

Show all 227 references

Research works printed but not linked: 10

D. D. Lasic and F. J. Martin. Stealth Liposomes, CRC, Boca Raton, Florida, 1995.
B. A. Shabner and G. M. Collings (eds.), Cancer Chemotherapy: Principles and Practice, J.B. Lippincott, Philadelphia, 1990.
D. Thompson and M. V. Chaubal. Cyclodextrins (CDS)—excipients by definition, drug delivery systems by function (part I: injectable applications). Drug Deliv. Technol. 2:34–38 (2000).
A. Martin (ed.), Physical Pharmacy. Lippinkott, Williams and Wilkins, Philadelphia, 1993.
P. H. Elworthy, A. T. Florence, and C. B. Macfarlane (eds.), Solubilization by Surface Active Agents, Chapman & Hall, London, UK, 1968.
M. Jones and J. Leroux. Polymeric micelles—a new generation of colloidal drug carriers. Eur. J. Pharm. Biopharm. 48:101–111 (1999). · DOI · Paper page
G. S. Kwon and K. Kataoka. Block copolymer micelles as long-circulating drug vehicles. Adv. Drug Deliv. Rev. 16:295–309 (1995). · DOI
D. D. Lasic, M. C. Woodle, F. J. Martin, and T. Valentincic. Phase behavior of “stealth-lipid” decithin mixtures. Period. Biol. 93:287–290 (1991).
V. Weissig, K. R. Whiteman, and V. P. Torchilin. Accumulation of protein-loaded long-circulating micelles and liposomes in subcutaneous Lewis lung carcinoma in mice. Pharm. Res. 15:1552–1556 (1998). · DOI
C. F. Van Norstrum, D. Naradovic, J. Barends, M. J. Van Steenbergen, and W. E. Hennink. Nanoparticles and hydrogels with transient stability from thermosensitive block copolymers. Proceedings of 30th CRS Meeting, UK (2003) #163.

Sorted by citations

Items 301–400 of 1,000

Recent developments in lipid-based pharmaceutical nanocarriers
Musacchio, T. (2010) · Frontiers in bioscience · doi:10.2741/3795 · Cited by 114
Nanoparticle encapsulated silvercarbene complexes and their antimicrobial and anticancer properties: A perspective
Youngs, W. J., Knapp, A. R., Wagers, P. O., & Tessier, C. A. (2011) · Dalton Transactions · doi:10.1039/c1dt11100k · Cited by 110
PEG–lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication
Gill, K. K., Kaddoumi, A., & Nazzal, S. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2014.997735 · Cited by 111
Multifunctional nanoparticles for use in theranostic applications
Cole, J. T., & Holland, N. B. (2015) · Drug Delivery and Translational Research · doi:10.1007/s13346-015-0218-2 · Cited by 109
Bioreducible core-crosslinked hyaluronic acid micelle for targeted cancer therapy
Han, H. S., Choi, K. Y., Ko, H., Jeon, J., Saravanakumar, G., Suh, Y. D., Lee, D. S., & Park, J. H. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.032 · Cited by 108
PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers
Lu, J., Huang, Y., Zhao, W., Marquez, R. T., Meng, X., Li, J., Gao, X., Venkataramanan, R., Wang, Z., & Song, L. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.073 · Cited by 108
Nanomedicine based curcumin and doxorubicin combination treatment of glioblastoma with scFv-targeted micelles: In vitro evaluation on 2D and 3D tumor models
Sarısözen, C., Dhokai, S., Tsikudo, E. G., Luther, E., Rachman, I. M., & Torchilin, V. P. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.08.013 · Cited by 109
Self-citation
Nanotechnology-based drug delivery for the treatment of CNS disorders
Mittal, K. R., Pharasi, N., Sarna, B., Singh, M., Rachana, R., Haider, S., Singh, S. K., Dua, K., Jha, S. K., Dey, A., et al. (2022) · Translational Neuroscience · doi:10.1515/tnsci-2022-0258 · Cited by 118
Multifunctionality of lipid-core micelles for drug delivery and tumour targeting
Sawant, R. R., & Torchilin, V. P. (2010) · Molecular Membrane Biology · doi:10.3109/09687688.2010.516276 · Cited by 116
Self-citation
Poly(lactic-co-glycolic acid) nanoparticles as candidate DNA vaccine carrier for oral immunization of Japanese flounder (Paralichthys olivaceus) against lymphocystis disease virus
Tian, J., & Yu, J. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2010.09.016 · Cited by 107
Challenges facing colloidal delivery systems: From synthesis to the clinic
Johnston, A. P. R., Such, G. K., Ng, S. L., & Caruso, F. (2010) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2010.11.003 · Cited by 107
Supramolecular Self‐Assembly of Nonlinear Amphiphilic and Double Hydrophilic Block Copolymers in Aqueous Solutions
Ge, Z., & Liu, S. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200900182 · Cited by 110
Nanocarriers for Diagnosis and Targeting of Breast Cancer
Sharma, A. K., Jain, N. K., & Sareen, R. (2013) · BioMed Research International · doi:10.1155/2013/960821 · Cited by 107
Singlet oxygen-responsive micelles for enhanced photodynamic therapy
Li, X., Gao, M., Xin, K., Zhang, L., Ding, D., Kong, D., Wang, Z., Shi, Y., Kiessling, F. M., Lammers, T., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.05.025 · Cited by 106
Lactoferrin, a unique molecule with diverse therapeutical and nanotechnological applications
Sabra, S. A., & Agwa, M. M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.167 · Cited by 110
Design, Synthesis, and Biological Evaluation of β‐Lactam Antibiotic‐Based Imidazolium‐ and Pyridinium‐Type Ionic Liquids
Cole, M. R., Li, M., El‐Zahab, B., Janes, M. E., Hayes, D. J., & Warner, I. M. (2011) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2011.01114.x · Cited by 106
Treatment of Experimental Arthritis with Stealth-Type Polymeric Nanoparticles Encapsulating Betamethasone Phosphate
Ishihara, T., Kubota, T., Choi, T., & Higaki, M. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.150276 · Cited by 106
Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging
Chen, G., Wang, L., Cordie, T. M., Vokoun, C. R., Eliceiri, K. W., & Gong, S. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.01.006 · Cited by 105
Advanced drug delivery nanosystems (aDDnSs): a mini-review
Demetzos, C., & Pippa, Ν. (2013) · Drug Delivery · doi:10.3109/10717544.2013.844745 · Cited by 105
Nanoparticles and cells: good companions and doomed partnerships
Maysinger, D. (2007) · Organic & Biomolecular Chemistry · doi:10.1039/b704275b · Cited by 107
How do polymeric micelles cross epithelial barriers?
Pepić, I., Lovrić, J., & Filipović-Grčić, J. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.04.012 · Cited by 102
A nanogel of on-site tunable pH-response for efficient anticancer drug delivery
Zhou, T., Xiao, C., Fan, J. R., Chen, S., Shen, J., Wu, W., & Zhou, S. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.08.017 · Cited by 103
Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer
Brinkman, A. M., Chen, G., Wang, Y., Hedman, C. J., Sherer, N. M., Havighurst, T. C., Gong, S., & Xu, W. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.05.041 · Cited by 104
Peptide hormones and lipopeptides: from self‐assembly to therapeutic applications
Hutchinson, J. A., Burholt, S., & Hamley, I. W. (2017) · Journal of Peptide Science · doi:10.1002/psc.2954 · Cited by 110
Peptide-Based Polymer Therapeutics
Duro‐Castaño, A., Conejos‐Sánchez, I., & Vicent, M. J. (2014) · Polymers · doi:10.3390/polym6020515 · Cited by 106
In Vitro Evaluation of Theranostic Polymeric Micelles for Imaging and Drug Delivery in Cancer
Kumar, R., Kulkarni, A., Nagesha, D. K., & Sridhar, S. (2012) · Theranostics · doi:10.7150/thno.3927 · Cited by 103
Reduction‐Sensitive Reversibly Crosslinked Biodegradable Micelles for Triggered Release of Doxorubicin
Xu, Y., Meng, F., Cheng, R., & Zhong, Z. (2009) · Macromolecular Bioscience · doi:10.1002/mabi.200900233 · Cited by 102
Driving forces for drug loading in drug carriers
Li, Y., & Li, Y. (2015) · Journal of Microencapsulation · doi:10.3109/02652048.2015.1010459 · Cited by 103
Polymer‐based stimuli‐responsive nanosystems for biomedical applications
Joglekar, M., & Trewyn, B. G. (2013) · Biotechnology Journal · doi:10.1002/biot.201300073 · Cited by 102
Near infrared fluorescent imaging of brain tumor with IR780 dye incorporated phospholipid nanoparticles
Li, S., Johnson, J. S., Peck, A. S., & Xie, Q. R. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-016-1115-2 · Cited by 100
Nanomicelles: an Emerging Platform for Drug Delivery to the Eye
Vadlapudi, A. D., & Mitra, A. K. (2012) · Therapeutic Delivery · doi:10.4155/tde.12.122 · Cited by 101
Radioactive Labeling of Defined HPMA-Based Polymeric Structures Using [18F]FETos for In Vivo Imaging by Positron Emission Tomography
Herth, M. M., Barz, M., Moderegger, D., Allmeroth, M., Jahn, M., Thews, O., Zentel, R., & Rösch, F. (2009) · Biomacromolecules · doi:10.1021/bm8014736 · Cited by 103
Looped Structure of Flowerlike Micelles Revealed by 1H NMR Relaxometry and Light Scattering
de Graaf, A. J., Boere, K. W. M., Kemmink, J., Fokkink, R. G., van Nostrum, C. F., Rijkers, D. T. S., van der Gucht, J., Wienk, H., Baldus, M., Mastrobattista, E., et al. (2011) · Langmuir · doi:10.1021/la2019605 · Cited by 104
Smart pH responsive drug delivery system based on poly(HEMA-co-DMAEMA) nanohydrogel
Roointan, A., Farzanfar, J., Mohammadi‐Samani, S., Behzad‐Behbahani, A., & Farjadian, F. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.10.001 · Cited by 100
Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
Benameur, T., Soleti, R., Panaro, M. A., Torre, M. E. L., Monda, V., Messina, G., & Porro, C. (2021) · Molecules · doi:10.3390/molecules26164794 · Cited by 105
Paclitaxel-Loaded Polymeric Micelles Modified with MCF-7 Cell-Specific Phage Protein: Enhanced Binding to Target Cancer Cells and Increased Cytotoxicity
Wang, T., Petrenko, V. A., & Torchilin, V. P. (2010) · Molecular Pharmaceutics · doi:10.1021/mp1001125 · Cited by 100
Self-citation
Effect of the non-ionic surfactant Poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers
Fischer, S. M., Brandl, M., & Fricker, G. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.04.010 · Cited by 100
Polymeric Materials for Theranostic Applications
Wang, Z., Niu, G., & Chen, X. S. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1103-7 · Cited by 101
Role of nanoparticles in enhancing chemotherapy efficacy for cancer treatment
Ghazal, H., Waqar, A., Yaseen, F., Shahid, M., Sultana, M., Tariq, M., Bashir, M. K., Tahseen, H., Raza, T., & Ahmad, F. (2024) · Next Materials · doi:10.1016/j.nxmate.2024.100128 · Cited by 102
The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes
Ahmed, S. E., Martins, A. M., & Husseini, G. A. (2014) · Journal of drug targeting · doi:10.3109/1061186x.2014.954119 · Cited by 103
Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease
Lameijer, M., Tang, J., Nahrendorf, M., Beelen, R. H. J., & Mulder, W. J. M. (2013) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2013.819216 · Cited by 98
Polyoxazoline Thermoresponsive Micelles as Radionuclide Delivery Systems
Hrubý, M., Filippov, S. K., Pánek, J., Nováková, M. (., Macková, H., Kučka, J., Větvička, D., & Ulbrich, K. (2010) · Macromolecular Bioscience · doi:10.1002/mabi.201000034 · Cited by 98
Validation of a Novel Molecular Dynamics Simulation Approach for Lipophilic Drug Incorporation into Polymer Micelles
Kasimova, A., Pavan, G. M., Danani, A., Mondon, K., Cristiani, A., Scapozza, L., Gurny, R., & Möller, M. (2012) · The Journal of Physical Chemistry B · doi:10.1021/jp2104819 · Cited by 98
RETRACTED ARTICLE: Self-organized nanotube materials and their application in bioengineering
Shimizu, T., Minamikawa, H., Kogiso, M., Aoyagi, M., Kameta, N., Ding, W., & Masuda, M. (2014) · Polymer Journal · doi:10.1038/pj.2014.72 · Cited by 97
Retracted
Micellar Nanocarriers: Potential Nose-to-Brain Delivery of Zolmitriptan as Novel Migraine Therapy
Jain, R. D., Nabar, S., Dandekar, P. P., & Patravale, V. B. (2010) · Pharmaceutical Research · doi:10.1007/s11095-009-0041-x · Cited by 97
Self-assembled micellar nanoparticles of a novel star copolymer for thermo and pH dual-responsive drug release
Liu, Y., Cao, X., Luo, M., Le, Z., & Xu, W. (2009) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2008.10.007 · Cited by 96
Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine
Wang, T., Wang, N., Song, H., Xi, X., Wang, J., Hao, A., & Li, T. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.06.015 · Cited by 96
Core cross-linked block ionomer micelles as pH-responsive carriers for cis-diamminedichloroplatinum(II)
Oberoi, H. S., Laquer, F. C., Marky, L. A., Kabanov, A. V., & Bronich, T. K. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.03.028 · Cited by 94
Target Delivery of a Novel Antitumor Organoplatinum(IV)‐Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo
Sun, T., Cui, W., Yan, M., Qin, G., Guo, W., Gu, H., Liu, S., & Wu, Q. (2016) · Advanced Materials · doi:10.1002/adma.201601778 · Cited by 94
Polyhydroxybutyrate production from marine source and its application
Kavitha, G., Rengasamy, R., & Inbakandan, D. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.12.155 · Cited by 94
Drug Delivery and Imaging with Polydiacetylene Micelles
Gravel, E., Ogier, J. R., Arnauld, T., Mackiewicz, N., Ducongè, F., & Doris, E. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201102769 · Cited by 104
Micro/Nanostructured Polymeric Systems for Biomedical and Pharmaceutical Applications
Chiellini, E., Piras, A. M., Errico, C., & Chiellini, E. (2008) · Nanomedicine · doi:10.2217/17435889.3.3.367 · Cited by 94
Nanoparticulate Systems for Drug Delivery and Targeting to the Central Nervous System
Craparo, E. F., Bondı̀, M. L., Pitarresi, G. L., & Cavallaro, G. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00199.x · Cited by 94
Nanomedicine-Mediated Therapies to Target Breast Cancer Stem Cells
He, L., Gu, J. H., Lim, L. Y., Yuan, Z., & Mo, J. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00313 · Cited by 94
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs
Tesauro, D., Accardo, A., Aloj, L., Morelli, G., & Aurilio, M. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s53593 · Cited by 93
Pegylated Phospholipid Micelles Induce Endoplasmic Reticulum-Dependent Apoptosis of Cancer Cells but not Normal Cells
Wang, J., Fang, X., & Liang, W. P. (2012) · ACS Nano · doi:10.1021/nn300571c · Cited by 93
Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons
Kim, M., Shin, M., Zhao, Y., Ghosh, M., & Son, Y. (2024) · Small Science · doi:10.1002/smsc.202400280 · Cited by 97
pH-triggered block copolymer micelles based on a pH-responsive PDPA (poly[2-(diisopropylamino)ethyl methacrylate]) inner core and a PEO (poly(ethylene oxide)) outer shell as a potential tool for the cancer therapy
Giacomelli, F. C., Štěpánek, P., Giacomelli, C., Schmidt, V., Jäger, E., Jäger, A., & Ulbrich, K. (2011) · Soft Matter · doi:10.1039/c1sm05992k · Cited by 93
Lactose mediated liver-targeting effect observed by ex vivo imaging technology
Ma, P., Liu, S., Huang, Y., Chen, X., Zhang, L., & Jing, X. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.019 · Cited by 94
Nanosystem trends in drug delivery using quality-by-design concept
Li, J., Qiao, Y., & Wu, Z. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.019 · Cited by 93
A robust method for critical micelle concentration determination using coumarin-6 as a fluorescent probe
Fluksman, A., & Benny, O. (2019) · Analytical Methods · doi:10.1039/c9ay00577c · Cited by 92
Micellar carriers for the delivery of multiple therapeutic agents
Thipparaboina, R., Chavan, R. B., Kumar, D. K., Modugula, S., & Shastri, N. R. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.07.046 · Cited by 93
Evaluation of Multivalent, Functional Polymeric Nanoparticles for Imaging Applications
Shokeen, M., Pressly, E. D., Hagooly, A., Zheleznyak, A., Ramos, N. N., Fiamengo, A. L., Welch, M. J., Hawker, C. J., & Anderson, C. J. (2011) · ACS Nano · doi:10.1021/nn102278w · Cited by 93
Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review
Tanbour, R., Martins, A. M., Pitt, W. G., & Husseini, G. A. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160217125215 · Cited by 92
Dual pH-Responsive Shell-Cleavable Polycarbonate Micellar Nanoparticles for in Vivo Anticancer Drug Delivery
Liu, S., Ono, R. J., Yang, C. H., Gao, S., Tan, J. Y. M., Hedrick, J. L., & Yang, Y. Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b01954 · Cited by 96
Rationally engineered nanoparticles target multiple myeloma cells, overcome cell-adhesion-mediated drug resistance, and show enhanced efficacy in vivo
Kiziltepe, T., Ashley, J. D., Stefanick, J. F., Qi, Y. M., Alves, N. J., Handlogten, M. W., Suckow, M. A., Navari, R. M., & Bilgiçer, B. (2012) · Blood Cancer Journal · doi:10.1038/bcj.2012.10 · Cited by 91
Preparation and characterization of guar gum nanoparticles
Soumya, R. S., Ghosh, S., & Abraham, E. T. (2009) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2009.11.003 · Cited by 92
Near-Infrared Phosphorescent Polymeric Nanomicelles: Efficient Optical Probes for Tumor Imaging and Detection
Kumar, R., Ohulchanskyy, T. Y., Roy, I., Gupta, S., Borek, C., Thompson, M. E., & Prasad, P. N. (2009) · ACS Applied Materials & Interfaces · doi:10.1021/am9001293 · Cited by 92
Responsive fluorescent Bi2O3@PVA hybrid nanogels for temperature-sensing, dual-modal imaging, and drug delivery
Zhu, H., Li, Y., Qiu, R., Shi, L., Wu, W., & Zhou, S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.003 · Cited by 92
Novel technologies to enhance solubility of food-derived bioactive compounds: A review
Recharla, N., Riaz, M., Ko, S., & Park, S. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.10.001 · Cited by 92
An Enzyme-Responsive Nanogel Carrier Based on PAMAM Dendrimers for Drug Delivery
Wang, Y., Luo, Y., Zhao, Q., Wang, Z., Xu, Z., & Jia, X. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b05567 · Cited by 91
Interplay between Molecular Packing, Drug Loading, and Core Cross-Linking in Bottlebrush Copolymer Micelles
Unsal, H., Onbulak, S., Calik, F., Er-Rafik, M., Schmutz, M., Sanyal, A., & Rzayev, J. (2017) · Macromolecules · doi:10.1021/acs.macromol.6b02182 · Cited by 91
Nanoparticles Targeting Receptors on Breast Cancer for Efficient Delivery of Chemotherapeutics
Jahan, S., Karim, M. E., & Chowdhury, E. H. (2021) · Biomedicines · doi:10.3390/biomedicines9020114 · Cited by 92
Endolysosomal environment-responsive photodynamic nanocarrier to enhance cytosolic drug delivery via photosensitizer-mediated membrane disruption
Lee, C., Park, W., Park, S., & Na, K. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.037 · Cited by 90
Photoresponsive Coumarin-Tethered Multifunctional Magnetic Nanoparticles for Release of Anticancer Drug
Sambath, K., Puvvada, N., Kumar, B. N. P., Rajput, S., Pathak, A., Mandal, M., & Singh, N. D. P. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am401059k · Cited by 90
Preparation of polysaccharide derivates chitosan-graft-poly(ɛ-caprolactone) amphiphilic copolymer micelles for 5-fluorouracil drug delivery
Gu, C., Le, V., Lang, M., & Liu, J. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.01.026 · Cited by 91
Polymeric biomaterials with engineered degradation
Deshayes, S., & Kasko, A. M. (2013) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.26765 · Cited by 90
Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo
Zhao, J., Liu, J., Wei, T., Ma, X., Cheng, Q., Huo, S., Zhang, C., Zhang, Y., Duan, X., & Liang, X. (2016) · Nanoscale · doi:10.1039/c5nr08966b · Cited by 90
Pluronic-SAILs (surface active ionic liquids) mixed micelles as efficient hydrophobic quercetin drug carriers
Singla, P., Singh, O., Chabba, S., & Mahajan, R. K. (2017) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2017.11.044 · Cited by 89
Recent Advances in Nanoencapsulation of Phytochemicals to Combat Obesity and Its Comorbidities
Göktaş, Z., Zu, Y., Abbasi, M., Galyean, S., Wu, D., Fan, Z., & Wang, S. F. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00131 · Cited by 95
Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems
Fu, Y., Ding, Y., Zhang, L., Zhang, Y., Liu, J., & Yu, P. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113372 · Cited by 91
Folate-conjugated crosslinked biodegradable micelles for receptor-mediated delivery of paclitaxel
Xiong, J., Meng, F., Wang, C., Cheng, R., Liu, Z., & Zhong, Z. (2011) · Journal of Materials Chemistry · doi:10.1039/c0jm04410e · Cited by 88
Nanomaterials for cancer therapies
Zhou, Q., Zhang, L., & Wu, H. Y. (2017) · Nanotechnology Reviews · doi:10.1515/ntrev-2016-0102 · Cited by 89
α-Tocopherol succinate-modified chitosan as a micellar delivery system for paclitaxel: Preparation, characterization and in vitro/in vivo evaluations
Liang, N., Sun, S., Li, X., Piao, H., Piao, H., Cui, F., & Fang, L. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.12.004 · Cited by 88
Past and future evolution in colloidal drug delivery systems
Boyd, B. J. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.1.69 · Cited by 89
Ultrasonically triggered drug delivery: Breaking the barrier
Husseini, G. A., Pitt, W. G., & Martins, A. M. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2014.07.051 · Cited by 87
FRET-enabled biological characterization of polymeric micelles
Morton, S. W., Zhao, X., Quadir, M. A., & Hammond, P. T. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.027 · Cited by 88
A DFT study on electronic and optical properties of aspirin-functionalized B12N12 fullerene-like nanocluster
Vessally, E., Esrafili, M. D., Nurazar, R., Nematollahi, P., & Bekhradnia, A. (2016) · Structural Chemistry · doi:10.1007/s11224-016-0858-y · Cited by 87
Fundamentals, challenges, and nanomedicine‐based solutions for ocular diseases
Srinivasarao, D. A., Lohiya, G., & Katti, D. S. (2018) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1548 · Cited by 87
Engineering the Architecture of Elastin‐Like Polypeptides: From Unimers to Hierarchical Self‐Assembly
Saha, S., Banskota, S., Roberts, S., Kirmani, N., & Chilkoti, A. (2020) · Advanced Therapeutics · doi:10.1002/adtp.201900164 · Cited by 88
Review of Contemporary Self-Assembled Systems for the Controlled Delivery of Therapeutics in Medicine
Osorno, L. L., Brandley, A., Maldonado, D., Yiantsos, A., Mosley, R. J., & Byrne, M. E. (2021) · Nanomaterials · doi:10.3390/nano11020278 · Cited by 91
Facile construction of dual-bioresponsive biodegradable micelles with superior extracellular stability and activated intracellular drug release
Chen, W., Meng, F., Cheng, R., Deng, C., Feijén, J., & Zhong, Z. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.05.273 · Cited by 87
Curcumin-polymeric nanoparticles against colon-26 tumor-bearing mice: cytotoxicity, pharmacokinetic and anticancer efficacy studies
Chaurasia, S., Chaubey, P., Patel, R. R., Kumar, N., & Mishra, B. (2015) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2015.1064941 · Cited by 86
Premature drug release of polymeric micelles and its effects on tumor targeting
Miller, T., Breyer, S., van Colen, G., Mier, W., Haberkorn, U., Geißler, S., Voss, S., Weigandt, M., & Göpferich, A. M. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.01.059 · Cited by 89
Crystal engineering approach to improve the solubility of mebendazole
Chen, J., Wang, Z., Wu, C., Song, L., & Lu, T. (2012) · CrystEngComm · doi:10.1039/c2ce25724f · Cited by 86
Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges
Haque, S., Whittaker, M. R., McIntosh, M. P., Pouton, C. W., & Kaminskas, L. M. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.03.002 · Cited by 86
Factors affecting toxicity and efficacy of polymeric nanomedicines
Igarashi, E. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.02.007 · Cited by 90
Folate Receptor–Targeted Polymeric Micellar Nanocarriers for Delivery of Orlistat as a Repurposed Drug against Triple-Negative Breast Cancer
Paulmurugan, R., Bhethanabotla, R. M., Mishra, K., Devulapally, R., Foygel, K., Sekar, T. V., Ananta, J. S., Massoud, T. F., & Joy, A. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0579 · Cited by 85
Drug delivery targets and systems for targeted treatment of rheumatoid arthritis
Feng, X., & Chen, Y. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1433680 · Cited by 84
Strategies to improve the physicochemical properties of peptide-based drugs
Lee, M. F., & Poh, C. L. (2023) · Pharmaceutical Research · doi:10.1007/s11095-023-03486-0 · Cited by 90

Authors: Torchilin, V. P.
Affiliations: Northeastern University (US)
Corresponding author: Torchilin, V. P.
ORCID: Torchilin, V. P.
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 2006-11-16
Volume: 24
Issue: 1
Pages: 1-16
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1007/s11095-006-9132-0
OpenAlex: W2016156919
Cited by: 1,910
References: 227
Citations by year: 2026: 52 · 2025: 80 · 2024: 70 · 2023: 68 · 2022: 88 · 2021: 99 · 2020: 94 · 2019: 68 · 2018: 98 · 2017: 115 · 2016: 144 · 2015: 140 · 2014: 126 · 2013: 142 · 2012: 133
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Keywords: polymeric micelles, amphiphilic block copolymers, poorly water-soluble drugs, drug solubilization, targeted drug delivery, enhanced permeability and retention effect, stimuli-responsive polymers, targeting ligands, monoclonal antibody conjugation, nanocarriers
MeSH terms: Animals, Chemistry, Pharmaceutical, Contrast Media, Drug Carriers, Drug Compounding, Humans, Micelles, Polymers, Drug Delivery Systems, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Micellar Nanocarriers: Pharmaceutical Perspectives

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks