The DOI matches its Crossref record; 444 of the 445 references it cites were found in a registry or an index.
The Oxygen Paradox, the French Paradox, and age-related diseases
Open accessAbstract
A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately correct or true. How is it possible, for example, that oxygen "a toxic environmental poison" could be also indispensable for life (Beckman and Ames Physiol Rev 78(2):547-81, 1998; Stadtman and Berlett Chem Res Toxicol 10(5):485-94, 1997)?: the so-called Oxygen Paradox (Davies and Ursini 1995; Davies Biochem Soc Symp 61:1-31, 1995). How can French people apparently disregard the rule that high dietary intakes of cholesterol and saturated fats (e.g., cheese and paté) will result in an early death from cardiovascular diseases (Renaud and de Lorgeril Lancet 339(8808):1523-6, 1992; Catalgol et al. Front Pharmacol 3:141, 2012; Eisenberg et al. Nat Med 22(12):1428-1438, 2016)?: the so-called, French Paradox. Doubtless, the truth is not a duality and epistemological bias probably generates apparently self-contradictory conclusions. Perhaps nowhere in biology are there so many apparently contradictory views, and even experimental results, affecting human physiology and pathology as in the fields of free radicals and oxidative stress, antioxidants, foods and drinks, and dietary recommendations; this is particularly true when issues such as disease-susceptibility or avoidance, "healthspan," "lifespan," and ageing are involved. Consider, for example, the apparently paradoxical observation that treatment with low doses of a substance that is toxic at high concentrations may actually induce transient adaptations that protect against a subsequent exposure to the same (or similar) toxin. This particular paradox is now mechanistically explained as "Adaptive Homeostasis" (Davies Mol Asp Med 49:1-7, 2016; Pomatto et al. 2017a; Lomeli et al. Clin Sci (Lond) 131(21):2573-2599, 2017; Pomatto and Davies 2017); the non-damaging process by which an apparent toxicant can activate biological signal transduction pathways to increase expression of protective genes, by mechanisms that are completely different from those by which the same agent induces toxicity at high concentrations. In this review, we explore the influences and effects of paradoxes such as the Oxygen Paradox and the French Paradox on the etiology, progression, and outcomes of many of the major human age-related diseases, as well as the basic biological phenomenon of ageing itself.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Under conditions of an imbalanced redox state, increased mitochondrial ROS production might lead to modifications of the arterial walls180, followed by an inflammatory environment181.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [181]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Items 201–400 of 444
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
Yamamoto, M., Yang, G., Hong, C., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317700 · Cited by 239
The role of declining adaptive homeostasis in ageing
Pomatto, L. C. D., & Davies, K. J. A. (2017) · The Journal of Physiology · doi:10.1113/jp275072 · Cited by 231 · cited 3×
“…explained as BAdaptive Homeostasis^ (Davies Mol Asp Med 49:1–7, 2016; Pomatto et al. 2017a; Lomeli et al. Clin Sci (Lond) 131(21):2573–2599, 2017; Pomatto and Davies 2017); the non-damaging process by which an apparent toxicant can activate biological signal transduction pathways to increase…”
BackgroundSelf-citationRoy, K., Wu, Y., Meitzler, J. L., Juhasz, A. N., Liu, H., Jiang, G., Lu, J., Antony, S., & Doroshow, J. H. (2015) · Clinical Science · doi:10.1042/cs20140542 · Cited by 230
Tissue Distribution and Putative Physiological Function of NOX Family NADPH Oxidases
Krause, K. (2004) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.jjid.2004.s28 · Cited by 230 · cited 2×
“One member of the Nox family, Nox4, is well expressed in kidneys, but is also abundant in the vascular system and in many other tissues and cells (Krause 2004), including osteoclasts (Yang et al. 2004), where its activity appears to be related to bone resorption.”
BackgroundOxidative stress and its biomarkers in systemic lupus erythematosus
Shah, D., Mahajan, N., Sah, S., Nath, S. K., & Paudyal, B. (2014) · Journal of Biomedical Science · doi:10.1186/1423-0127-21-23 · Cited by 230
The association between Mediterranean diet adherence and Parkinson's disease
Alcalay, R. N., Gu, Y., Mejia‐Santana, H., Cote, L., Marder, K. S., & Scarmeas, N. (2012) · Movement Disorders · doi:10.1002/mds.24918 · Cited by 228
A New Superoxide-generating Oxidase in Murine Osteoclasts
Yang, S., Madyastha, P. R., Bingel, S. A., Ries, W. L., & Key, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001004200 · Cited by 226
UV-Induced Oxidative Stress and Photoaging
Wenk, J., Brenneisen, P., Meewes, C., Wlaschek, M., Peters, T., Blaudschun, R., Ma, W., Kuhr, L., Schneider, L. A., & Scharffetter‐Kochanek, K. (2000) · KARGER eBooks · doi:10.1159/000060656 · Cited by 225
Apolipoprotein E receptors: linking brain development and alzheimer's disease
Herz, J., & Beffert, U. (2000) · Nature reviews. Neuroscience · doi:10.1038/35036221 · Cited by 224 · cited 2×
“…most important genetic risk factor for Alzheimer’s disease and a risk factor of atherosclerosis, while APOE2 is protective for Alzheimer disease and atherosclerosis (except if associated with type III familial hyperlipiproteinemia) (Mahley et al. 2009; Herz and Beffert 2000; Davignon et al. 1988).”
BackgroundMeasurement and Meaning of Oxidatively Modified DNA Lesions in Urine
Cooke, M. S., Oliński, R., & Loft, S. H. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0751 · Cited by 223 · cited 1×
“The measurement of 8-oxodG and 8-oxoGua, the related nucleobase, in human fluids including urine, plasma, and saliva offers a non-invasive method to indirectly assess oxidatively generated damage in nuclear DNA (Cooke et al. 2008).”
MethodCalcium Metabolism and Oxidative Stress in Bone Fractures: Role of Antioxidants
Sheweita, S. A., & Khoshhal, K. I. (2007) · Current Drug Metabolism · doi:10.2174/138920007780866852 · Cited by 220 · cited 4×
“It has been suggested that an enhanced osteoclastic activity may increase the superoxide anion generation and/ or inhibit superoxide dismutase (SOD) and glutathione peroxidase activities with concomitant bone destruction (Sheweita and Khoshhal 2007).”
BackgroundInfluentialLow fat dietary intervention with ω-3 fatty acid supplementation in multiple sclerosis patients
Weinstock‐Guttman, B., Baier, M. L., Park, Y., Feichter, J., Kwen, P. L., Gallagher, E., Venkatraman, J. T., Meksawan, K., Deinehert, S., Pendergast, D., et al. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.05.024 · Cited by 219 · cited 1×
“Similarly, a low fat diet supplemented with the omega-3 fatty acids from fish oil has also been shown to decrease the severity of MS symptoms (Weinstock-Guttman et al. 2005).”
BackgroundMadamanchi, N. R., Hakim, Z. S., & Runge, M. S. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.01085.x · Cited by 216 · cited 1×
“Atherosclerosis that begins early in life and progresses gradually is a major cause of cardiovascular disease (Madamanchi et al. 2005).”
BackgroundErmak, G., Morgan, T. E., & Davies, K. J. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102829200 · Cited by 216 · cited 1×
“In patients with Alzheimer disease, RCAN1-1L is expressed twice as much relative to non-Alzheimer disease controls suggesting that RCAN1-1L may have a role in Alzheimer disease (Ermak et al. 2001; Harris et al. 2007).”
BackgroundSelf-citationMeat‐Adaptive Genes and the Evolution of Slower Aging in Humans
Finch, C. E., & Stanford, C. B. (2004) · The Quarterly Review of Biology · doi:10.1086/381662 · Cited by 216 · cited 2×
“2000), its persistence in human populations may represent its adaptive value under conditions of high pathogen exposure (Finch and Stanford 2004; Martin and Finch 2016).”
BackgroundSelf-citationGilchrest, B. A. (2013) · Journal of Investigative Dermatology · doi:10.1038/skinbio.2013.176 · Cited by 215
Pomatto, L. C. D., Carney, C., Shen, B., Wong, S., Halaszynski, K., Salomon, M. P., Davies, K. J. A., & Tower, J. (2016) · Current Biology · doi:10.1016/j.cub.2016.10.044 · Cited by 214
Self-citationUsing 21st Century Science to Improve Risk-Related Evaluations
Board on Environmental Studies and Toxicology, Studies, D. O. E. A. L., & National Academies of Sciences, E. (2017) · National Academies Press eBooks · doi:10.17226/24635 · Cited by 212
Gerczuk, P. Z., & Kloner, R. A. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.07.054 · Cited by 210 · cited 1×
“In general, clinical trials reducing infarct size by giving agents at reperfusion have been disappointing (Gerczuk and Kloner 2012).”
BackgroundSelf-citationPrzyklenk, K., & Kloner, R. A. (1989) · Circulation Research · doi:10.1161/01.res.64.1.86 · Cited by 210 · cited 2×
“In addition, superoxide dismutase and catalase improved the ultrastructural appearance of the microvessels (Przyklenk and Kloner 1989).”
BackgroundSelf-citationThe association of cardiovascular disease with the long-term incidence of age-related maculopathy
Klein, R., Klein, B. E. K., Tomany, S. C., & Cruickshanks, K. J. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00599-2 · Cited by 209
The emerging role of the mitochondrial-derived peptide humanin in stress resistance
Yen, K., Lee, C. D., Mehta, H. H., & Cohen, P. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0203 · Cited by 208
Self-citationLIPID PEROXIDATION AS CAUSE OF NIGRAL CELL DEATH IN PARKINSON'S DISEASE
Dexter, D. T., Carter, C. J., Javoy-Agid, F., Agid, Y., Lees, A. J., Jenner, P. G., & MARSDEN, C. D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92471-2 · Cited by 207
Sánchez-Rodrı́guez, M. A., Ruíz-Ramos, M., Correa‐Muñoz, E., & Mendoza-Núñez, V. M. (2007) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-8-124 · Cited by 206
Acquired disorders of elastic tissue: part I. increased elastic tissue and solar elastotic syndromes
Lewis, K. G., Bercovitch, L. G., Dill, S. W., & Robinson‐Bostom, L. (2004) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.03.013 · Cited by 205
Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis
Özgöçmen, S., Kaya, H., Fadıllıoğlu, E., Baykara, R. A., & Yılmaz, Z. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9270-z · Cited by 204
Antioxidants and Radiation Therapy
Borek, C. G. (2004) · Journal of Nutrition · doi:10.1093/jn/134.11.3207s · Cited by 204 · cited 1×
“3) (Borek 2004).”
Stimulation of osteoclastic bone resorption by hydrogen peroxide
Bax, B. E., Alam, A. S. M. T., Banerji, B., Bax, C. M. R., Bevis, P. J. R., Stevens, C. R., Moonga, B. S., Blake, D. R., & Zaidi, M. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80311-0 · Cited by 201
Elastin structure and its involvement in skin photoageing
Weihermann, A. C., Lorencini, M., Brohem, C. A., & de Carvalho, C. M. (2017) · International Journal of Cosmetic Science · doi:10.1111/ics.12372 · Cited by 195
Reversible 26S Proteasome Disassembly upon Mitochondrial Stress
Livnat‐Levanon, N., Kevei, É., Kleifeld, O., Krutauz, D., Segref, A., Rinaldi, T., Erpapazoglou, Z., Cohen, M. M., Reis, N., Hoppe, T., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.030 · Cited by 194
Effect of low saturated fat diet in early and late cases of multiple sclerosis
Swank, R. L., & Dugan, B. (1990) · The Lancet · doi:10.1016/0140-6736(90)91533-g · Cited by 194 · cited 1×
“A low fat diet has been shown to result in lower deterioration and death rates (Swank and Dugan 1990).”
BackgroundCoenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients
Portakal, O., Özkaya, Ö., İnal, M., Bozan, B., Koşan, M., & Sayek, İ. (2000) · Clinical Biochemistry · doi:10.1016/s0009-9120(00)00067-9 · Cited by 194
Recognizing the impact of ambient air pollution on skin health
Mancebo, S. E., & Wang, S. Q. (2015) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13250 · Cited by 190 · cited 1×
“At the interface between the body and the environment, the skin is directly exposed to numerous chemical oxidants and other air pollutants, all of which are potent inducers of reactive oxygen/nitrogen species (Mancebo and Wang 2015; Valacchi et al. 2012).”
BackgroundSuperoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer.
Janssen, A. M., Bosman, C., van Duijn, W., de Ruit, M. M. O.-V., Kubben, F. J. G. M., Griffioen, G. G., Lamers, C. B. H. W., van Krieken, J. H. J. M., van de Velde, C. J., & Verspaget, H. W. (2000) · PubMed · Cited by 186
Oxygen radicals, nitric oxide and human inflammatory joint disease.
Halliwell, B. B. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.6.505 · Cited by 181 · cited 2×
“aggregates that can activate neutrophils and set up a Bvicious cycle^ (Halliwell 1995) of free radical production.”
BackgroundKohno, H., Chen, Y., Kevany, B. M., Pearlman, E. M., Miyagi, M., Maeda, T., Palczewski, K., & Maeda, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.448712 · Cited by 180
Gruosso, T., Mieulet, V., Cardon, M., Bourachot, B., Kieffer, Y., Devun, F., Dubois, T., Dutreix, M., Vincent‐Salomon, A., Miller, K. M., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505891 · Cited by 179
Self-citationToy, W. A., Petzinger, G. M., Leyshon, B. J., Akopian, G. K., Walsh, J. P., Hoffman, M., Vuckovic, M. G., & Jakowec, M. W. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.017 · Cited by 178
Self-citationMOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism
Lee, C., Kim, K. H., & Cohen, P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.05.015 · Cited by 178 · cited 3×
“…encoded within the mtDNA, has been shown to normalize mitochondrial function and to prevent metabolic deterioration, vascular disease, diabetes, and neurodegeneration, namely the mitochondrial-derived peptides, humanin (Yen et al. 2013), MOTS-c (Lee et al. 2016a), and SHLPs (Cobb et al. 2016).”
BackgroundSelf-citationLefort, S., Joffre, C., Kieffer, Y., Givel, A.-M., Bourachot, B., Zago, G., Bieche, I., Dubois, T., Meseure, D., Vincent-Salomon, A., et al. (2014) · Autophagy · doi:10.4161/15548627.2014.981788 · Cited by 173
Self-citationSwaroop, A., Branham, K. E., Chen, W., & Abecasis, G. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm212 · Cited by 173
Steinbeck, M. J., Appel, W. H., Verhoeven, A. J., & Karnovsky, M. J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.3.765 · Cited by 171
Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation.
Lunec, J., Blake, D. R., McCleary, S. J., Brailsford, S., & BACON, P. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112212 · Cited by 171
Involvement of free radicals in ageing: a consequence or cause of senescence
Nohl, H. (1993) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072638 · Cited by 169 · cited 1×
“If these two actions are not in balance, pathology ensues (Boyle et al. 2003; Nohl 1993; Wauquier et al. 2009; Vaananen et al. 2000).”
BackgroundKlein, R., Klein, R., & Jensen, S. C. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30023-2 · Cited by 167 · cited 1×
“Curiously, the reverse is the case: high levels of HDL, protective against atherosclerosis, are associated with AMD (Klein et al. 1993; Klein et al. 1997; Klein et al. 2003; Delcourt et al. 2001; van Leeuwen et al. 2004; Paun et al. 2015).”
BackgroundMolecular composition of drusen as related to substructural phenotype.
Hageman, G. S., & Mullins, R. F. (1999) · PubMed · Cited by 167
Hof, R. V., & Ralston, S. H. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.11.1797 · Cited by 166 · cited 1×
“Osteoblasts stimulated with proinflammatory cytokines and/or endotoxin in vitro express iNOS (van't Hof and Ralston 1997), but it is still not clear whether osteoclasts express this enzyme.”
BackgroundImpaired Parathyroid Hormone Metabolism in Patients with Chronic Renal Failure
FREITAG, J., Martin, K. J., Hruska, K. A., Anderson, C. B., Conrades, M. B., Ladenson, J. H., Klahr, S., & Slatopolsky, E. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801052980107 · Cited by 165
Petzinger, G. M., Holschneider, D. P., Fisher, B. E., McEwen, S. C., Kintz, N. M., Halliday, M. R., Toy, W., Walsh, J. W., Beeler, J. A., & Jakowec, M. W. (2015) · Brain Plasticity · doi:10.3233/bpl-150021 · Cited by 160
Self-citationZhang, H., Liu, H., Davies, K. J. A., Sioutas, C., Finch, C. E., Morgan, T. E., & Forman, H. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.042 · Cited by 155
Self-citationExpression of Nitric Oxide Synthase Isoforms in Bone and Bone Cell Cultures
Helfrich, M., Evans, D. M., Grabowski, P., Pollock, J. S., Ohshima, H., & Ralston, S. H. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.7.1108 · Cited by 155
Kloner, R. A., Hale, S. L., Dai, W., Gorman, R. C., Shuto, T., Koomalsingh, K. J., Gorman, J. H., Sloan, R. C., Frasier, C. R., Watson, C. A., et al. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.001644 · Cited by 155 · cited 1×
“In general, clinical trials reducing infarct size by giving agents at reperfusion have been disappointing (Gerczuk and Kloner 2012).”
BackgroundSelf-citationLycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women
RAO, L. G. S., Mackinnon, E. S., Josse, R. G., Murray, T. M., Strauss, A., & Rao, A. V. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0205-z · Cited by 155
The Biphasic Effects of Nitric Oxide in Primary Rat Osteoblasts Are cGMP Dependent
Mancini, L., Moradi‐Bidhendi, N., Becherini, L., Martineti, V., & Macintyre, I. J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3164 · Cited by 153
Jonas, J. B. (2010) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2010.227 · Cited by 152
Öhman, H., Savikko, N. M., Strandberg, T. E., Kautiainen, H., Raivio, M., Laakkonen, M., Tilvis, R. S., & Pitkälä, K. H. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14059 · Cited by 152
Photoaging. Manifestations, prevention, and treatment.
Kligman, L. H. (1986) · PubMed · Cited by 152
Xie, W., & Chung, K. K. K. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07769.x · Cited by 151 · cited 1×
“Alpha-synuclein impairs normal mitochondrial fission (biogenesis) (Xie and Chung 2012).”
McKay, G. J., Patterson, C. C., Chakravarthy, U., Dasari, S., Klaver, C. C., Vingerling, J. R., Ho, L., de Jong, P. T. V. M., Fletcher, A. E., Young, I. S., et al. (2011) · Human Mutation · doi:10.1002/humu.21577 · Cited by 151
Rezkalla, S. H., Dharmashankar, K., Abdalrahman, I. B., & Kloner, R. A. (2010) · Journal of Interventional Cardiology · doi:10.1111/j.1540-8183.2010.00561.x · Cited by 150
Self-citationBellingan, G. J., Maksimow, M., Howell, D. C. J., Stotz, M., Beale, R. J., Beatty, M., Walsh, T. S., Binning, A. R., Davidson, A., Kuper, M., et al. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70259-5 · Cited by 148
Photoaging: Manifestations, Prevention, and Treatment
Kligman, L. H. (1989) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30708-0 · Cited by 147 · cited 2×
“Photoaging is an accelerated form of ageing, specifically of the skin, resulting from exposure to ultraviolet (UV) light (Kligman 1989; Gilchrest 2013), causing the formation of deep wrinkles, loss of skin tone, dryness, elastic tissue clumping, pigmentary alteration, and exaggerated bruising (Yaar…”
BackgroundTuróczi, T. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00117-2 · Cited by 146
Levy, O., Calippe, B., Lavalette, S., Hu, S. J., Raoul, W., Dominguez, E., Housset, M., Pâques, M., Sahel, J., Bemelmans, A., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404524 · Cited by 143
Self-citationVitamin E supplementation and cataract
McNeil, J. J., Robman, L. D., Tikellis, G., Sinclair, M. I., McCarty, C. A., & Taylor, H. R. (2004) · Ophthalmology · doi:10.1016/j.ophtha.2003.04.009 · Cited by 143
“Smooth Muscle Cell Stiffness Syndrome”—Revisiting the Structural Basis of Arterial Stiffness
Sehgel, N. L., Vatner, S. F., & Meininger, G. A. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00335 · Cited by 143 · cited 2×
“It is becoming increasingly clear that VSMC plasticity significantly contributes to arterial stiffening in ageing (Lacolley et al. 2012; Sehgel et al. 2015).”
BackgroundResveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation
Yang, S. J., & Lim, Y. (2014) · Metabolism · doi:10.1016/j.metabol.2014.02.003 · Cited by 141 · cited 2×
“One of the most well-characterized components of red wine is resveratrol and has been linked to numerous beneficial health improvements (Yang and Lim 2014).”
BackgroundInfarct size reduction by propranolol before and after coronary ligation in dogs.
Rasmussen, M. M., Reimer, K. A., Kloner, R. A., & Jennings, R. B. (1977) · Circulation · doi:10.1161/01.cir.56.5.794 · Cited by 140
Self-citationImpaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation
Heeren, J., Grewal, T., Laatsch, A., Becker, N., Rinninger, F., Rye, K.-A., & Beisiegel, U. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409324200 · Cited by 139
Ngo, J. K., Pomatto, L. C. D., & Davies, K. J. A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.015 · Cited by 138 · cited 2×
“…to such oxidized protein aggregates (sometimes called lipofuscin) become inactive, thus further decreasing clearance of damaged proteins and enabling ever-increasing protein aggregation as heat shock and oxidative stress lead to its up-regulation (Ngo et al. 2013; Pinti et al. 2010, 2011, 2016).”
BackgroundSelf-citationOxidative Stress Involvement in α -Synuclein Oligomerization in Parkinson's Disease Cybrids
Esteves, A. R., Arduíno, D. M., Swerdlow, R. H., Oliveira, C. R., & Cardoso, S. M. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2247 · Cited by 137
Measurement of oxidatively generated base damage in cellular DNA
Cadet, J., Douki, T., & Ravanat, J.-L. (2011) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.02.004 · Cited by 136 · cited 4×
“High performance liquid chromatography coupled with electrospray ionization tandemmass spectrometry (HPLC-ESI-MS/MS) in the multiple reaction monitoring mode has become a relevant alternative thus providing unambiguous damage characterization and quantitative information (Lee et al. 2010a; Cadet et al. 2011).”
BackgroundMethodInfluentialSelf-citationReffelmann, T., & Kloner, R. A. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00270.2002 · Cited by 135 · cited 2×
“It was observed that size of the no-reflow zone expands over the first few hours after reperfusion of an epicardial coronary artery, suggesting worsening microvascular damage during the phase of reperfusion (Reffelmann and Kloner 2002).”
BackgroundSelf-citationThe genetics of human longevity: an intricacy of genes, environment, culture and microbiome
Dato, S., Rose, G., Crocco, P., Monti, D., Garagnani, P., Franceschi, C., & Passarino, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.03.011 · Cited by 135
Cullen, J. J., Mitros, F. A., & Oberley, L. W. (2003) · Pancreas · doi:10.1097/00006676-200301000-00005 · Cited by 134 · cited 3×
“Clinically, histological studies found a decrease in the expression/activity of antioxidant enzymes in precancerous tissues (Bostwick et al. 2000; Cullen et al. 2003; Sander et al. 2003).”
BackgroundInfluentialExercise, APOE genotype, and the evolution of the human lifespan
Raichlen, D. A., & Alexander, G. E. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.001 · Cited by 132 · cited 2×
“APOE4, believed to be the ancestral form (Raichlen and Alexander 2014), evolved to APOE3, and APOE3 to APOE2 due to two polymorphisms (rs429358 and rs7412, respectively) that are imbedded in a well-defined CpG island, and lead to two cysteine-arginine interchanges at residues 112 and 158 (Yu et al.…”
BackgroundFree radical scavenger, edaravone, in stroke with internal carotid artery occlusion
Toyoda, Ḱ., Fujii, K., Kamouchi, M., Nakane, H., Arihiro, S., Okada, Y., Ibayashi, S., & Iida, M. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.03.002 · Cited by 132
Superoxide and bone resorption
Key, L. L., Wolf, W. C. D., Gundberg, C. M., & Ries, W. L. (1994) · Bone · doi:10.1016/8756-3282(94)90821-4 · Cited by 130
Postischemic Myocardial "Stunning": A Clinically Relevant Phenomenon
PATEL, B., KLONER, R. A., PRZYKLENK, K., & D, E. B. M. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-4-626 · Cited by 129
Self-citationThe genetic contribution to the pathogenesis of rheumatoid arthritis
Reveille, J. D. (1998) · Current Opinion in Rheumatology · doi:10.1097/00002281-199805000-00007 · Cited by 128 · cited 2×
“A genetic component clearly plays a role as there is a clear association between a group of major histocompatibility complex cell surface receptors and disease predilection (Reveille 1998).”
BackgroundThiagarajan, R., & Manikandan, R. (2013) · Free Radical Research · doi:10.3109/10715762.2013.777155 · Cited by 128 · cited 1×
“In the eye lens, free radicals target the polyunsaturated fatty acids and lens crystallin proteins leading to the initiation of cataracts (Thiagarajan and Manikandan 2013).”
BackgroundSmit, M., de Knijff, P., Rosseneu, M., Bury, J., Klasen, E., Frants, R., & Havekes, L. (1988) · Human Genetics · doi:10.1007/bf01790099 · Cited by 127
No-Reflow Phenomenon: Maintaining Vascular Integrity
Kloner, R. A. (2011) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248411405990 · Cited by 127 · cited 6×
“Perfusion defects within the myocardium have been observed by contrast enhanced magnetic resonance imaging, echocardiographic contrast injections, and nuclear studies (Kloner 2011).”
BackgroundMethodResultInfluentialSelf-citationHydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae
Fraser, J., Helfrich, M., WALLACE, H. M., & Ralston, S. H. (1996) · Bone · doi:10.1016/8756-3282(96)00177-9 · Cited by 126
Reffelmann, T., Hale, S. L., Dow, J., & Kloner, R. A. (2003) · Circulation · doi:10.1161/01.cir.0000101917.80668.e1 · Cited by 125
Self-citationArnold, J. M. O., D, E. B. M., Sándor, T., & Kloner, R. A. (1985) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(85)80305-3 · Cited by 125
Self-citationRutar, M., Natoli, R., & Provis, J. M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-221 · Cited by 125 · cited 2×
“…neovascularisation (CNV) (Tsutsumi et al. 2003; Sakurai et al. 2003) and photoreceptor degeneration (Combadiere et al. 2007; Sennlaub et al. 2013; Rutar et al. 2012; Suzuki et al. 2012; Kohno et al. 2013; CruzGuilloty et al. 2013; Hu et al. 2015; Eandi et al. 2016) in advanced AMD (Moore and…”
BackgroundCruz‐Guilloty, F., Saeed, A. M., Echegaray, J. J., Duffort, S., Ballmick, A., Tan, Y., Betancourt, M., Viteri, E. J., Ramkhellawan, G. C., Ewald, E. J., et al. (2013) · International Journal of Inflammation · doi:10.1155/2013/503725 · Cited by 120
Self-citationMitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer
Pinti, M., Gibellini, L., Liu, Y., Xu, S., Lü, B., & Cossarizza, A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2039-3 · Cited by 119
Hadri, K. E., Mahmood, D. F. D., Couchie, D., Jguirim-Souissi, I., Genze, F., Diderot, V., Syrovets, T., Lunov, O., Simmet, T., & Rouis, M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.249334 · Cited by 118
Self-citationHale, S. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00456-5 · Cited by 118 · cited 3×
“Other experimental therapies that have reduced the no-reflow phenomenon in our myocardial infarct models include therapeutic hypothermia, when administered either early, during the phase of ischemia, in which it also reduces myocardial infarct size (Hale et al. 2003); or when administered late, after reperfusion has a…”
BackgroundFarkas, T., Sylvester, V., & ARCHER, D. B. (1971) · American Journal of Ophthalmology · doi:10.1016/0002-9394(71)90963-9 · Cited by 117 · cited 2×
“The presence of large drusen, sizeable extracellular deposits of lipids and glycoproteins (Farkas et al. 1971) in Bruch’s membrane (BM), are a major risk factor for debilitating late AMD (Klein et al.”
BackgroundCholesterol and age-related macular degeneration: is there a link?
van Leeuwen, R., Klaver, C. C. W., Vingerling, J. R., Albert Hofman, D., van Duijn, C. M., Stricker, B. H. C., & de Jong, P. T. V. M. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.09.015 · Cited by 117
The Immunoproteasome in oxidative stress, aging, and disease
Johnston-Carey, H. K., Pomatto, L. C. D., & Davies, K. J. A. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2016.1172554 · Cited by 117 · cited 1×
“Proteasome, a protease involved in the degradation of both normal ubiquitinylated proteins and mutated or damaged proteins, regulates a vast number of cellular functions (Bonet-Costa et al. 2016; Johnston-Carey et al. 2015).”
BackgroundSelf-citationCD14 signalling in lipid rafts: new ligands and co-receptors
Schmitz, G., & Orsó, E. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200210000-00007 · Cited by 115 · cited 2×
“IIRC ligands, such as bacterial lipopolysaccharides, overcome this separation, as they bind to the extracellular domains of both co-receptors (CD14 and TLRs), bringing the receptors and their intracellular domains closely together, which activates Myd88, NFκB and induces the transcription of inflammatory cytokines (Sc…”
BackgroundNewington, J. T., Rappon, T., Albers, S. S., Wong, D. Y. L., Rylett, R. J., & Cumming, R. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.366195 · Cited by 115
Suzuki, M., Tsujikawa, M., Itabe, H., Du, Z.-J., Xie, P., Matsumura, N., Fu, X., Zhang, R., Sonoda, K., Egashira, K., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.097683 · Cited by 115
Takimoto, M., & Hamada, T. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01288.2013 · Cited by 115 · cited 3×
“…lactate levels following bouts of aerobic exercise, specific regional up-regulation of lactate transporters have been found in the cortex, hippocampus, and hypothalamus, indicating a preferential utilization of peripheral lactate during supra-physiological conditions (Takimoto and Hamada 2014).”
BackgroundTsakiri, E. N., Sykiotis, G. P., Papassideri, I. S., Terpos, E., Dimopoulos, M. A., Gorgoulis, V. G., Bohmann, D., & Trougakos, I. P. (2013) · Aging Cell · doi:10.1111/acel.12111 · Cited by 113
Reduced levels of human apoE4 protein in an animal model of cognitive impairment
Sullivan, P. M., Han, B., Liu, F., Mace, B. E., Ervin, J. F., Wu, S., Koger, D., Paul, S., & Bales, K. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.011 · Cited by 113
Truncated Thioredoxin: Physiological Functions and Mechanism
Pekkari, K., & Holmgren, A. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604771978345 · Cited by 111
Bosset, S., Bonnet, M., Barre, P., Chalon, A., Kurfürst, R., Bonté, F., Schnebert, S., Varlet, B. L., & Nicolas, J. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05456.x · Cited by 111
Regulated expression of apolipoprotein E by human retinal pigment epithelial cells
Ishida, B. Y., Bailey, K. R., Duncan, K. G., Chalkley, R. J., Burlingame, A. L., Kane, J. P., & Schwartz, D. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300306-jlr200 · Cited by 111
Emerging role of Lon protease as a master regulator of mitochondrial functions
Pinti, M., Gibellini, L., Nasi, M., Biasi, S. D., Bortolotti, C. A., Iannone, A., & Cossarizza, A. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.03.025 · Cited by 110
Determination of new types of DNA lesions in human sperm
Badouard, C., Menezo, Y., Panteix, G., Ravanat, J., Douki, T., Cadet, J., & Favier, A. (2008) · Zygote (Cambridge. Print) · doi:10.1017/s0967199407004340 · Cited by 108
Self-citationMusumeci, G., Szychlinska, M. A., & Mobasheri, A. (2015) · PubMed · doi:10.14670/hh-30.1 · Cited by 106 · cited 2×
“Ageing results in cell senescence (Musumeci et al. 2015), loss of chondrocyte phenotype and thus abnormal remodeling of the extracellular matrix (Quintero et al.”
BackgroundOxidative damage DNA: 8-oxoGua and 8-oxodG as molecular markers of cancer
Roszkowski, K., Jóźwicki, W., Błaszczyk, P., Mucha-Małecka, A., & Siomek, A. (2011) · Medical Science Monitor · doi:10.12659/msm.881805 · Cited by 106
The effects of chronic sunscreen use on the histologic changes of dermatoheliosis
Boyd, A. S., Naylor, M., Cameron, G. S., Pearse, A. D., Gaskell, S. A., & Neldner, K. H. (1995) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(95)90284-8 · Cited by 106
Trumble, B. C., Stieglitz, J., Blackwell, A. D., Allayee, H., Beheim, B., Finch, C. E., Gurven, M., & Kaplan, H. (2017) · The FASEB Journal · doi:10.1096/fj.201601084r · Cited by 106
Self-citationRaisz, L. G. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-6-199703150-00007 · Cited by 102 · cited 1×
“Therefore, primary estrogen deficiency in postmenopausal women can, through a loss of antioxidant potency, depress osteoblastic activity and indirectly enhance osteoclastic activity, leading to a reduction in skeletal mass and osteoporosis (Heaney et al. 1978; Raisz 1997).”
BackgroundLad, E. M., Cousins, S. W., Arnam, J. S. V., & Proia, A. D. (2015) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-015-3094-z · Cited by 102
The role of oxidative stress in Huntington’s disease: Are antioxidants good therapeutic candidates?
Gil-Mohapel, J., Brocardo, P., & Christie, B. (2014) · Current Drug Targets · doi:10.2174/1389450115666140115113734 · Cited by 101
APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration
Levy, O., Lavalette, S., Hu, S. J., Housset, M., Raoul, W., Eandi, C. M., Sahel, J., Sullivan, P. M., Guillonneau, X., & Sennlaub, F. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2468-15.2015 · Cited by 101
Self-citationRadical Decisions in Cancer: Redox Control of Cell Growth and Death
Sainz, R. M., Lombó, F., & Mayo, J. C. (2012) · Cancers · doi:10.3390/cancers4020442 · Cited by 100 · cited 2×
“The sustained presence of reactive oxygen species is associated with the development of metabolic perturbations that provide cancer cells with amino acids, lipids, and nucleotides to further boost their uncontrolled proliferation (Sainz et al. 2012).”
BackgroundNeurogenesis in the adult rat brain after intermittent hypoxia
Zhu, L., Zhao, T., Li, H.-S., Zhao, H., Wu, L., Ding, A.-S., Fan, W.-H., & Fan, M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.04.075 · Cited by 100
Tan, A. G., Mitchell, P., Flood, V. M., Burlutsky, G., Rochtchina, E., Cumming, R. G., & Wang, J. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1899 · Cited by 99
Bellamy, V., Vanneaux, V., Bel, A., Nemetalla, H., Boitard, S. E., Farouz, Y., Joanne, P., Perier, M., Robidel, E., Mandet, C., et al. (2014) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2014.10.008 · Cited by 99
Self-citationThe Proteasome and Oxidative Stress in Alzheimer's Disease
Bonet-Costa, V., Pomatto, L. C.-D., & Davies, K. J. A. (2016) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6802 · Cited by 99 · cited 2×
“Proteasome, a protease involved in the degradation of both normal ubiquitinylated proteins and mutated or damaged proteins, regulates a vast number of cellular functions (Bonet-Costa et al. 2016; Johnston-Carey et al. 2015).”
Self-citationRCAN1‐1L is overexpressed in neurons of Alzheimer's disease patients
Harris, C. D., Ermak, G., & Davies, K. J. A. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05717.x · Cited by 97 · cited 1×
“In patients with Alzheimer disease, RCAN1-1L is expressed twice as much relative to non-Alzheimer disease controls suggesting that RCAN1-1L may have a role in Alzheimer disease (Ermak et al. 2001; Harris et al. 2007).”
BackgroundSelf-citationBrozović, A., Durán, G. E., Wang, Y. C., Francisco, E. B., & Sikic, B. I. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.04.015 · Cited by 97
Crosstalk between reverse cholesterol transport and innate immunity
Azzam, K. M., & Fessler, M. B. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.02.001 · Cited by 96 · cited 1×
“APOE and APOA-I can also bind and neutralize lipophilic TLR ligands (such as βamyloid and LPS) and inhibit the induction of inflammatory cytokines (Azzam and Fessler 2012).”
BackgroundShen, J., Deininger, P. L., Hunt, J. D., & Zhao, H. (2006) · Cancer · doi:10.1002/cncr.22417 · Cited by 96
Przyklenk, K., Ghafari, G., Eitzman, D. T., & Kloner, R. A. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90281-7 · Cited by 96
Self-citationKhatri, N., & Man, H. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00199 · Cited by 96 · cited 2×
“(Khatri and Man 2013), thus inducing shifts in astrocytic metabolism to meet the neuroenergetics demands of glutamate-glutamine cycling.”
BackgroundVan Eck, M., Herijgers, N., Yates, J., Pearce, N. J., Hoogerbrugge, P. M., Groot, P. H. E., & Van Berkel, T. J. C. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.11.3117 · Cited by 96
Subretinal mononuclear phagocytes induce cone segment loss via IL-1β
Eandi, C. M., Charles‐Messance, H., Augustin, S., Dominguez, E., Lavalette, S., Forster, V., Hu, S. J., Siqueiros‐Márquez, L., Craft, C. M., Sahel, J., et al. (2016) · eLife · doi:10.7554/elife.16490 · Cited by 96
Self-citationHu, S. J., Calippe, B., Lavalette, S., Roubeix, C., Montassar, F., Housset, M., Levy, O., Delarasse, C., Pâques, M., Sahel, J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3955-14.2015 · Cited by 95
Self-citationProteomics of Vitreous Humor of Patients with Exudative Age-Related Macular Degeneration
Koss, M., Hoffmann, J., Nguyen, N., Pfister, M., Mischak, H., Mullen, W., Husi, H., Ręjdak, R., Koch, F., Jankowski, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096895 · Cited by 95
VanLeeuwen, J., Petzinger, G. M., Walsh, J. P., Akopian, G. K., Vuckovic, M., & Jakowec, M. W. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22216 · Cited by 94
Self-citationTsakiri, E. N., Sykiotis, G. P., Papassideri, I. S., Gorgoulis, V. G., Bohmann, D., & Trougakos, I. P. (2013) · The FASEB Journal · doi:10.1096/fj.12-221408 · Cited by 94
The Clinical Presentation of Systemic Lupus Erythematosus
Lahita, R. G. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374994-9.10030-0 · Cited by 93 · cited 1×
“In early stages of systemic lupus erythematosus, joint pain is typically mild, but then increases significantly as the disease progresses (Lahita 2011).”
BackgroundHiginbotham, K. G., RICE, J., Diwan, B. A., Kasprzak, K. S., Reed, C. D., & Perantoni, A. O. (1992) · PubMed · Cited by 93
Bidault, G., Garcia, M., Vantyghem, M., Ducluzeau, P., Morichon, R., Thiyagarajah, K., Moritz, S., Capeau, J., Vigouroux, C., & Béréziat, V. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301933 · Cited by 93
Self-citationEffects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice.
Ong, J. M., Zorapapel, N. C., Rich, K. A., Wagstaff, R. E., Lambert, R. W., Rosenberg, S., Moghaddas, F., Pirouzmanesh, A., Aoki, A. M., & Kenney, M. C. (2001) · PubMed · Cited by 92
High IL-13 production by human neonatal T cells: neonate immune system regulator?
Ribeiro-do-Couto, L. M., Boeije, L. C. M., Kroon, J., Hooibrink, B., Breur-Vriesendorp, B. S., Aarden, L. A., & Boog, C. J. P. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200111)31:11 · Cited by 91
Cerebral metabolism after forced or voluntary physical exercise
Kinni, H. A., Guo, M., Ding, J. Y., Konakondla, S., Dornbos, D., Tran, R., Guthikonda, M., & Ding, Y. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.076 · Cited by 91
Langemann, H., Kabiersch, A., & Newcombe, J. (2008) · European Neurology · doi:10.1159/000116835 · Cited by 91 · cited 1×
“Analysis of MS plaques revealed elevated reactive oxygen species generation and decreased antioxidant levels (Langemann et al. 1992).”
BackgroundPathogenesis of solar elastosis: synthesis or degradation?
Sellheyer, K. (2003) · Journal of Cutaneous Pathology · doi:10.1034/j.1600-0560.2003.00018.x · Cited by 91 · cited 1×
“Actinic elastosis is characterized by an accumulation of elastotic material composed of abnormal elastin in addition to loss of fibrillar collagens and proteoglycans (Gilchrest 2013; El-Domyati et al. 2002; Sellheyer 2003; Weihermann et al. 2016).”
BackgroundJoanne, P., Κιτσαρά, Μ., Boitard, S. E., Naemetalla, H., Vanneaux, V., Pernot, M., Larghero, J., Forest, P., Chen, Y., Menasché, P., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.035 · Cited by 87
Self-citationRalston, S. H., & Grabowski, P. (1996) · Bone · doi:10.1016/8756-3282(96)00101-9 · Cited by 86 · cited 2×
“iNOS-mediated NO· that may augment bone gain by inhibiting prostaglandin-induced bone resorption (Ralston and Grabowski 1996).”
BackgroundDarden, A., Ries, W. L., Wolf, W. C. D., Rodriguiz, R. M., & Key, L. L. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110515 · Cited by 86
Mitochondrial Dysfunction in Parkinson's Disease: Pathogenesis and Neuroprotection
Mounsey, R. B., & Teismann, P. (2010) · Parkinson s Disease · doi:10.4061/2011/617472 · Cited by 86 · cited 1×
“Since then, the involvement of mitochondria has been shown to be much more complex, with defect in: trafficking, biogenesis, mitophagy, activation of apoptosis, oxidative stress, and calcium buffering capacity (Mounsey and Teismann 2011).”
BackgroundKarihtala, P., Kauppila, S., Puistola, U., & Jukkola‐Vuorinen, A. (2011) · Histopathology · doi:10.1111/j.1365-2559.2011.03835.x · Cited by 85
Durak, İ., Perk, H., Kavutçu, M., Canbolat, O., Akyol, Ö., & Bedük, Y. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90199-6 · Cited by 84
Berger, C. E. M., Rathod, H., Gillespie, J., Horrocks, B. R., & Datta, H. K. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.11.2092 · Cited by 82
The Liver: Morphology, Biochemistry, Physiology
(1964) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(64)80409-0 · Cited by 81 · cited 1×
“The liver plays a crucial role in overall human health and is necessary for proper immune function and lipid and carbohydrate metabolism (Rouiller 2013).”
BackgroundSmoak, K. A., Aloor, J. J., Madenspacher, J. H., Merrick, B. A., Collins, J. B., Zhu, X., Cavigiolio, G., Oda, M. N., Parks, J. S., & Fessler, M. B. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.006 · Cited by 81
Expression of Nox4 in osteoclasts
Yang, S., Zhang, Y., Ries, W. L., & Key, L. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20048 · Cited by 80
Age-Related Cataract in a Randomized Trial of Vitamins E and C in Men
Christen, W. G. (2010) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2010.266 · Cited by 79
Effect of APOE ε4 allele on survival and fertility in an adverse environment
van Exel, E. R., Koopman, J. J. E., van Bodegom, D., Meij, H. J., de Knijff, P., Ziem, J. B., Finch, C. E., & Westendorp, R. G. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179497 · Cited by 79
Self-citationAhmed, U., Anwar, A., Savage, R. S., Thornalley, P. J., & Rabbani, N. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1154-3 · Cited by 78
Lefèvre, C., Auclair, M., Boccara, F., Bastard, J.-P., Capeau, J., Vigouroux, C., & Caron-Debarle, M. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.110.213603 · Cited by 77
Self-citationLevels of oxidative damage and lipid peroxidation in thyroid neoplasia
Young, O., Crotty, T., O'Connell, R., O'Sullivan, J. N., & Curran, A. J. (2009) · Head & Neck · doi:10.1002/hed.21247 · Cited by 75
Kageyama, Y., Takahashi, M., Ichikawa, T., Torikai, E., & Nagano, A. (2008) · PubMed · Cited by 75
Durak, İ., Işik, C. Ü., Canbolat, O., Akyol, Ö., & Kavutçu, M. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90174-s · Cited by 75
Lo, H., Kloner, R. A., & D, E. B. M. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)91033-1 · Cited by 73 · cited 2×
“1993), calcium channel blockers (Lo et al. 1985), and beta blockers (Rasmussen et al.”
BackgroundSelf-citationMaintenance of proteins and aging: The role of oxidized protein repair
Petropoulos, I., & Friguet, B. (2006) · Free Radical Research · doi:10.1080/10715760600917144 · Cited by 73 · cited 2×
“altered proteins during ageing is due to both an increased production of modified proteins and a decreased efficacy of the mechanisms responsible for their removal (Petropoulos and Friguet 2006).”
BackgroundSelf-citationMechanical properties and structure of carotid arteries in mice lacking desmin
Lacolley, P. J., Challande, P., Boumaza, S., Cohuet, G., Laurent, S., Boutouyrie, P., Grimaud, J.-A., Paulin, D., Lamazière, J. D., & Li, Z. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00278-4 · Cited by 73
Self-citationRies, W. L., Key, L. L., & Rodriguiz, R. M. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650070810 · Cited by 71 · cited 1×
“An increase or decrease in superoxide anion production by osteoclasts is associated with, respectively, stimulated or inhibited osteoclastic bone resorption (Garrett et al. 1990; Berger et al. 2001; Ries et al. 1992).”
BackgroundEpigenetic signature and enhancer activity of the human APOE gene
Yu, C., Cudaback, E., Foraker, J. E., Thomson, Z., Leong, L., Lutz, F., Gill, J. A., Saxton, A. D., Kraemer, B. C., Navas, P. A., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt354 · Cited by 71
Gruosso, T., Garnier, C., Abélanet, S., Kieffer, Y., Lemesre, V., Bellanger, D., Bièche, I., Marangoni, E., Sastre‐Garau, X., Mieulet, V., et al. (2015) · Nature Communications · doi:10.1038/ncomms9583 · Cited by 70
Self-citationMericskay, M. (2015) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2015.10.004 · Cited by 69 · cited 1×
“Myocardial NAD+ level decreases in the failing heart of many different mouse models of heart failure (Mericskay 2016).”
BackgroundSelf-citationDow, J., & Kloner, R. A. (2007) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248407300897 · Cited by 68
Self-citationFiamingo, A., Montembault, A., Boitard, S. E., Naemetalla, H., Agbulut, O., Delair, T., Filho, S. P. C., Menasché, P., & David, L. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00075 · Cited by 68
Self-citationThe Liver: Morphology, Biochemistry, Physiology
(1964) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(64)80408-9 · Cited by 68
8‐Oxo‐7,8‐dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients
Dziaman, T., Banaszkiewicz, Z., Roszkowski, K., Gackowski, D., Wisniewska, E., Różalski, R., Foksiński, M., Siomek, A., Speina, E., Winczura, A., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28374 · Cited by 66
Baraibar, M. A., & Friguet, B. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.10.007 · Cited by 66 · cited 6×
“Protein carbonylation is irreversible and often leads to loss of function or gain of toxic function of the targeted proteins (Baraibar and Friguet 2013).”
BackgroundInfluentialSelf-citationCouchie, D., Vaisman, B. L., Abderrazak, A., Mahmood, D. F. D., Hamza, M. M., Canesi, F., Diderot, V., Hadri, K. E., Nègre‐Salvayre, A., Page, A. Y. L., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.027612 · Cited by 66
Self-citationEx vivo evaluation of radical sun protection factor in popular sunscreens with antioxidants
Wang, S. Q., Osterwalder, U., & Jung, K. (2011) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2010.07.009 · Cited by 65 · cited 7×
“It is calculated from the ratio of free radicals in unprotected skin to those in protected skin with the radicals quantified using electron spin resonance (ESR) spectroscopy (Wang et al. 2011).”
BackgroundMethodInfluentialTurer, A. T., Mahaffey, K. W., Gallup, D. S., Weaver, W. D., Christenson, R. H., Every, N. R., & Ohman, E. M. (2005) · Current Controlled Trials in Cardiovascular Medicine · doi:10.1186/1468-6708-6-12 · Cited by 65
Roles of vitamin C in radiation-induced DNA damage in presence and absence of copper
Cai, L., Koropatnick, J. D., & Cherian, M. G. (2001) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(01)00210-1 · Cited by 63 · cited 1×
“Yet, in the presence of transition metals, vitamin C, paradoxically, contributes to DNA damage (Cai et al. 2001).”
BackgroundYoshida, M., Takashima, Y., Inoue, M., Iwasaki, M., Otani, T., Sasaki, S., Tsugane, S., & for the JPHC Study Group (2007) · European Journal of Nutrition · doi:10.1007/s00394-006-0641-8 · Cited by 61
Pomatto, L. C. D., Wong, S., Carney, C., Shen, B., Tower, J., & Davies, K. J. A. (2017) · Aging · doi:10.18632/aging.101218 · Cited by 59
Self-citationDevelopmental Regulation of Nitric Oxide Synthase Expression in Rat Skeletal Bone
Hukkanen, M., Platts, L. A. M., de Marticorena, I. F., O'Shaughnessy, M. C., MacIntyre, I. M., & Polak, J. M. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.6.868 · Cited by 58
Radicals generated by bone cutting and fracture
Symons, M. C. R. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02174-4 · Cited by 57 · cited 1×
“When bone fracture occurs, the damaged tissues generate a remarkable amount of active radicals that are formed from the molecular interactions between embedded collagen strands and the mineral phase, and this phenomenon may facilitate bone healing (Symons 1996).”
BackgroundSexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis
Pomatto, L. C. D., Tower, J., & Davies, K. J. A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx083 · Cited by 56
Self-citationLannuzel, A., Ruberg, M., & Michel, P. P. (2008) · Movement Disorders · doi:10.1002/mds.22300 · Cited by 54 · cited 1×
“In line with this hypothesis, complex-1 inhibitors such as MPTP, rotenone, and the recently discovered annonacin can killed dopaminergic neurons in vitro and reproduce parkinsonism in animals (Lannuzel et al. 2008; Champy et al. 2004; Höglinger et al. 2003).”
Background[Coronary risk factors. The French paradox].
Richard, J. L. (1987) · PubMed · Cited by 53
Allen, A., & Messier, C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.11.025 · Cited by 53 · cited 1×
“Consistent with this, several groups have reported increased expression of the glucose transporters GLUT1 (endothelial- and astrocytespecific) and GLUT3 (neuron-specific) in motor control regions following treadmill exercise (Allen and Messier 2013; Takimoto and Hamada 2014; Kinni et al. 2011).”
BackgroundAssi, M., Derbré, F., Lefeuvre‐Orfila, L., & Rébillard, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.019 · Cited by 53
Self-citationFunctional characterization of the promoter of the human Lon protease gene
Pinti, M., Gibellini, L., Biasi, S. D., Nasi, M., Roat, E., O’Connor, J., & Cossarizza, A. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.09.010 · Cited by 52
Nuclear oxidative damage correlates with poor survival in colorectal cancer
Sheridan, J., Wang, L., Tosetto, M., Sheahan, K. D., Hyland, J. C., Fennelly, D. W., O’Donoghue, D., Mulcahy, H. E., & O'Sullivan, J. N. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604821 · Cited by 52
Prostate cancer and physical activity: Adaptive response to oxidative stress
Rébillard, A., Lefeuvre‐Orfila, L., Guéritat, J., & Cillard, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.009 · Cited by 52
Self-citationHale, S. L., Herring, M. J., & Kloner, R. A. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.112.004234 · Cited by 52 · cited 3×
“the no-reflow zone but has no effect on myocardial infarct size (Hale et al. 2013).”
BackgroundSelf-citationGalmiche, G., Labat, C., Mericskay, M., Ait‐Aissa, K., Blanc, J., Retailleau, K., Bourhim, M., Coletti, D., Loufrani, L., Gao-Li, J., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301076 · Cited by 52
Self-citationCellular and molecular mechanisms of aging and age related diseases
Robert, L. (2000) · Pathology & Oncology Research · doi:10.1007/bf03032651 · Cited by 51 · cited 1×
“Chronic age-related conditions such as osteoarthritis demonstrate de-regulation of common molecular and cellular mechanisms (Ladislas 2000).”
BackgroundLee, K., Shu, X., Gao, Y.-T., Ji, B., Yang, G., Blair, A. E., Rothman, N., Zheng, W., Chow, W., & Kang, D. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-1098 · Cited by 51
Chalam, K. V., Grover, S., Sambhav, K., Balaiya, S., & Murthy, R. K. (2014) · Journal of Ophthalmology · doi:10.1155/2014/502174 · Cited by 51
Paun, C. C., Ersoy, L., Schick, T., Groenewoud, J. M. M., Lechanteur, Y. T. E., Fauser, S., Hoyng, C. B., de Jong, E. K., & den Hollander, A. I. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17035 · Cited by 51
Langlois, B., Belozertseva, E., Parlakian, A., Bourhim, M., Gao-Li, J., Blanc, J., Tian, L., Coletti, D., Labat, C., Ramdame-Cherif, Z., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12024-z · Cited by 51
Self-citationBoden, H., Ahmed, T. A.-H. N., Velders, M. A., van der Hoeven, B. L., Hoogslag, G. E., Bootsma, M., le Cessie, S., Cobbaert, C. M., Delgado, V., van der Laarse, A., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.01.284 · Cited by 49
Ermak, G., Hench, K. J., Chang, K. T., Sachdev, S., & Davies, K. J. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900639200 · Cited by 47
Self-citationROLE OF STATINS IN THE DEVELOPMENT AND PROGRESSION OF AGE-RELATED MACULAR DEGENERATION
VanderBeek, B. L., Zacks, D. N., Talwar, N., Nan, B., & Stein, J. D. (2013) · Retina · doi:10.1097/iae.0b013e318276e0cf · Cited by 45
Larroque-Cardoso, P., Camaré, C., Nadal-Wollbold, F., Grazide, M.-H., Pucelle, M., Garoby-Salom, S., Bogdanowicz, P., Josse, G., Schmitt, A.-M., Uchida, K., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.84 · Cited by 45
Hormesis in Health and Disease
Rattan, S. I. S., & Bourg, É. L. (2014) · CRC Press eBooks · doi:10.1201/b17042 · Cited by 45
Clément, N., Glorian, M., Raymondjean, M., Andréani, M., & Limon, I. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20673 · Cited by 44
Self-citationGuéritat, J., Lefeuvre‐Orfila, L., Vincent, S., Crétual, A., Ravanat, J., Gratas‐Delamarche, A., Rannou‐Bekono, F., & Rébillard, A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.09.009 · Cited by 42
Self-citationWang, Z., Guo, Y., Myers, K. G., Heintz, R., & Holschneider, D. P. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.020 · Cited by 42 · cited 1×
“At the interface between the body and the environment, the skin is directly exposed to numerous chemical oxidants and other air pollutants, all of which are potent inducers of reactive oxygen/nitrogen species (Mancebo and Wang 2015; Valacchi et al. 2012).”
BackgroundSauvaigo, S., Petec, C., Caillat, S., Odin, F., & Cadet, J. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5559 · Cited by 42
Self-citationChronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease
Ermak, G., & Davies, K. J. A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.016 · Cited by 41 · cited 2×
“RCAN1-1L is transiently elevated to defend against acute stress including oxidative stress; however, long-term elevation of RCAN1-1L is linked to DS and Alzheimer disease (Ermak and Davies 2013).”
BackgroundSelf-citation
Flagged first, then by citations
1 of the 445 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Garrod AB (1859) Treatise on nature of gout and rheumatic gout. Walton and Maberly, London
- Kurien BT, Mohan C, Scofield H (2012) Mechanisms of tissue damage-free radicals and fibrosis. In: Wallace DJ (ed) Dubois’ Lupus Erythematosus and Related Syndromes E-Book: Expert Consult-Online, 8th edn. Elsevier Health Sciences, London, p 175–189
- Rui Yin QC, Hamblin MR (2015) Skin aging and photoaging, in Skin photoaging. Morgan & Claypool, San Rafael, pp 1–4
- Yaar M, Gilchrest BA (2012) Aging of the skin, in Fitspatrick’s dermatology in general medicine. McGraw Hill, New York, pp 1213–1211
Cited by
Sorted by citations
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990
Charlton, N. C., Mastyugin, M., Török, B., & Török, M. (2023) · Molecules · doi:10.3390/molecules28031057 · Cited by 292
“The so-called “French Paradox” especially increased interest in dietary small molecule antioxidants after it was noted that despite high saturated fat and alcohol intake, Mediterranean populations are less likely to develop coronary heart disease [42].”
BackgroundOxInflammation: From Subclinical Condition to Pathological Biomarker
Valacchi, G., Virgili, F., Cervellati, C., & Pecorelli, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00858 · Cited by 212
“Possible leaks from this outpost can be then countered by further repair systems such as proteinases, lipases, DNA repair enzymes (Davies et al., 2017).”
BackgroundMelatonin: Clinical Perspectives in Neurodegeneration
Cardinali, D. P. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00480 · Cited by 210
“Although the regular intake of antioxidants has been proposed for prevention of neurodegeneration, its effectiveness, however, has been questioned (3).”
BackgroundMarcucci, G., Domazetovic, V., Nediani, C., Ruzzolini, J., Favre, C., & Brandi, M. L. (2023) · Antioxidants · doi:10.3390/antiox12020373 · Cited by 200
“It has also been demonstrated that ROS stimulates osteoclastogenesis through RANKL as reported in human stromal cells [26,81].”
Background
Metadata
- Authors
- Davies, J. M. S., Cillard, J., Friguet, B., Cadenas, E., Cadet, J., Cayce, R., Fishmann, A., Liao, D., Bulteau, A.-L., Derbré, F., Rébillard, A., Burstein, S., Hirsch, E., Kloner, R. A., Jakowec, M., Petzinger, G., Sauce, D., Sennlaub, F., Limon, I., Ursini, F., Maiorino, M., Economides, C., Pike, C. J., Cohen, P., Salvayre, A. N., Halliday, M. R., Lundquist, A. J., Jakowec, N. A., Mechta-Grigoriou, F., Mericskay, M., Mariani, J., Li, Z., Huang, D., Grant, E., Forman, H. J., Finch, C. E., Sun, P. Y., Pomatto, L. C. D., Agbulut, O., Warburton, D., Neri, C., Rouis, M., Cillard, P., Capeau, J., Rosenbaum, J., & Davies, K. J. A.
- Affiliations
- University of Southern California (US)
- Université de Rennes (FR)
- Centre National de la Recherche Scientifique (FR)
- Université de Sherbrooke (CA)
- Good Samaritan Hospital (US)
- École Normale Supérieure de Lyon (FR)
- Université Rennes 2 (FR)
- Huntington Medical Research Institutes (US)
- Inserm (FR)
- Institut de la Vision (FR)
- University of Padua (IT)
- Université Paris-Sud (FR)
- Corresponding author
- Davies, Kelvin J. A.
- ORCID
- Friguet, Bertrand
- Cadenas, Enrique
- Cadet, Jean
- Bulteau, Anne-Laure
- Rébillard, Amélie
- Kloner, Robert A.
- Jakowec, Michael
- Petzinger, Giselle
- Sauce, Delphine
- Sennlaub, Florian
- Limon, Isabelle
- Ursini, Fulvio
- Maiorino, Matilde
- Pike, Christian J.
- Cohen, Pinchas
- Halliday, Matthew R.
- Lundquist, Adam J.
- Jakowec, Nicolaus A.
- Mericskay, Mathias
- Mariani, Jean
- Li, Zhenlin
- Grant, Ellsworth
- Forman, Henry J.
- Finch, Caleb E.
- Sun, Patrick Y.
- Pomatto, Laura C. D.
- Agbulut, Onnik
- Warburton, David
- Rouis, Mustapha
- Capeau, Jacqueline
- Rosenbaum, Jean
- Davies, Kelvin J. A.
- Venue
- GeroScience
- Published
- 2017-12
- Volume
- 39
- Issue
- 5-6
- Pages
- 499-550
- ISSN
- 2152-4041 (ISSN-L)
- 2509-2715
- 2509-2723
- PMC
- PMC5745211
- OpenAlex
- W2779963304
- Cited by
- 82
- References
- 445
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 19 · 2018: 7
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- GeroScience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Funders
- National Science Foundation (#DGE-1418060)
- National Institute of Environmental Health Sciences (#ES023864, #R01ES020812, #D43ES022862, #ES003598)
- Institut National de la Santé et de la Recherche Médicale
- National Institute on Aging (# AG-040753, # AG058068, # P01AG034906, # R01AG034430, # AG052374)
- Agence Nationale de la Recherche
- Université Pierre et Marie Curie
- Université Toulouse III - Paul Sabatier
- Conseil Régional de Bretagne
- Ligue Contre le Cancer
- Fondation de France
- Centre National de la Recherche Scientifique
- Assistance Publique - Hôpitaux de Paris
- U.S. Department of Defense (DOD-PC160353U)
- American Foundation for Aging Research
- Don Roberto Gonzalez and Family Foundation
- National Parkinson Foundation
- National Heart, Lung, and Blood Institute (#U01HL122681)
- Pasadena Guild
- Children's Hospital Los Angeles
- the webb foundation
- The Garland Foundation
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- oxygen paradox, French paradox, free radicals, oxidative stress, antioxidants, cardiovascular disease, age-related diseases, healthspan, lifespan, aging, adaptive homeostasis, hormesis, epigenetics, epigenetic reprogramming, epigenetic drift, epigenetic plasticity, epigenetic memory, epigenetic inheritance, epigenetic noise
- MeSH terms
- Diet, High-Protein, Adaptation, Physiological, Aged, Aged, 80 and over, Aging, Female, France, Free Radicals, Humans, Hypercholesterolemia, Male, Middle Aged, Oxygen, Geriatric Assessment, Oxidative Stress, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
