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Gut microbiome signatures predict cognitive impairment in older cancer survivors

Miller, Brandi C., Haggler, Jayden A., Chaudhari, Diptaraj S., Shukla, Rohit, Kumar, Vivek, Mishra, Sidharth P., Masternak, Michal M., Holland, Peter, Labyak, Corinne, Golden, Adam, Dangiolo, Mariana, Arikawa, Andrea Y., Kociolek, Judyta, Fraser, Amoy, Williams, Cynthia, Agronin, Marc, Aymat, Mariolga, Pledger, Warren, Yadav, Hariom, Jain, Shalini·2025·GeroScience

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  1. Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12–49.
  2. Song BC, Bai J. Microbiome-gut-brain axis in cancer treatment-related psychoneurological toxicities and symptoms: a systematic review. Support Care Cancer. 2021;29:605–17. · DOI
  3. Whittaker AL, George RP, O’Malley L. Prevalence of cognitive impairment following chemotherapy treatment for breast cancer: a systematic review and meta-analysis. Sci Rep. 2022;12:2135. · DOI · Paper page
  4. Luo J, Schousboe JT, Ensrud KE, Hendryx M. Long-term changes of cognitive impairment among older breast cancer survivors. J Cancer Surviv. 2023;17:1760–8. · DOI
  5. Zer A, Pond GR, Razak ARA, Tirona K, Gan HK, Chen EX, et al. Association of neurocognitive deficits with radiotherapy or chemoradiotherapy for patients with head and neck cancer. JAMA Otolaryngol Head Neck Surg. 2018;144:71–9.
  6. Amidi A, Wu LM, Pedersen AD, Mehlsen M, Pedersen CG, Rossen P, et al. Cognitive impairment in testicular cancer survivors 2 to 7 years after treatment. Support Care Cancer. 2015;23:2973–9. · DOI
  7. Vardy JL, Dhillon HM, Pond GR, Rourke SB, Bekele T, Renton C, et al. Cognitive function in patients with colorectal cancer who do and do not receive chemotherapy: a prospective, longitudinal, controlled study. J Clin Oncol. 2015;33:4085–92. · DOI · Paper page
  8. Holtfrerich SKC, Knipper S, Purwins J, Castens J, Beyer B, Schlomm T, et al. The impact of long-term androgen deprivation therapy on cognitive function and socioeconomic decision making in prostate cancer patients. Psychooncology. 2020;29:1338–46. · DOI
  9. Mishra SP, Jain S, Wang B, Wang S, Miller BC, Lee JY, et al. Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function. JCI Insight. 2024;9:e168443. · DOI
  10. Chaudhari DS, Jain S, Yata VK, Mishra SP, Kumar A, Fraser A, et al. Unique trans-kingdom microbiome structural and functional signatures predict cognitive decline in older adults. Geroscience. 2023;45:2819–34. · DOI
  11. Mishra SP, Wang B, Jain S, Ding J, Rejeski J, Furdui CM, et al. A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut. Gut. 2023;72:1848–65. · DOI · Paper page
  12. Wilkins LJ, Monga M, Miller AW. Defining dysbiosis for a cluster of chronic diseases. Sci Rep. 2019;9:12918. · DOI · Paper page
  13. Nagpal R, Neth BJ, Wang S, Craft S, Yadav H. Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer’s disease markers in subjects with mild cognitive impairment. EBioMedicine. 2019;47:529–42. · DOI · Paper page
  14. Wu L, Han Y, Zheng Z, Peng G, Liu P, Yue S, et al. Altered gut microbial metabolites in amnestic mild cognitive impairment and Alzheimer’s disease: signals in host–microbe interplay. Nutrients. 2021;13:228. · DOI · Paper page
  15. Montassier E, Gastinne T, Vangay P, Al‐Ghalith G, Bruley des Varannes S, Massart S, Moreau P, Potel G, de La Cochetière M, Batard E. Chemotherapy‐driven dysbiosis in the intestinal microbiome. Aliment Pharmacol Ther. 2015;42:515–28. · DOI · Paper page
  16. Chua LL, Rajasuriar R, Azanan MS, Abdullah NK, Tang MS, Lee SC, et al. Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation. Microbiome. 2017;5:35. · DOI
  17. Deleemans JM, Chleilat F, Reimer RA, Baydoun M, Piedalue K-A, Lowry DE, et al. The chemo-gut pilot study: associations between gut microbiota, gastrointestinal symptoms, and psychosocial health outcomes in a cross-sectional sample of young adult cancer survivors. Curr Oncol. 2022;29:2973–94. · DOI
  18. Smith KS, Tissier A, Bail JR, Novak JR, Morrow CD, Demark-Wahnefried W, et al. Health-related quality of life is associated with fecal microbial composition in breast cancer survivors. Support Care Cancer. 2023;31:10. · DOI
  19. Okubo R, Kinoshita T, Katsumata N, Uezono Y, Xiao J, Matsuoka YJ. Impact of chemotherapy on the association between fear of cancer recurrence and the gut microbiota in breast cancer survivors. Brain Behav Immun. 2020;85:186–91. · DOI
  20. Paulsen JA, Ptacek TS, Carter SJ, Liu N, Kumar R, Hyndman L, et al. Gut microbiota composition associated with alterations in cardiorespiratory fitness and psychosocial outcomes among breast cancer survivors. Support Care Cancer. 2017;25:1563–70. · DOI
  21. Masternak MM, Yadav H. Microbiome in aging of gut and brain (MiaGB): paving the ways to understand gut-brain axis in aging. Aging Pathobiol Ther. 2022;4:1–3. · DOI
  22. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9. · DOI · Paper page
  23. James AS, Adil NA, Goltz D, Tangudu D, Chaudhari DS, Shukla R, et al. Abnormalities in gut virome signatures linked with cognitive impairment in older adults. Gut Microbes. 2024;16:2431648. · DOI
  24. Beghini F, McIver LJ, Blanco-Míguez A, Dubois L, Asnicar F, Maharjan S, et al. Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3. Elife. 2021;10:e65088. · DOI · Paper page
  25. Buchfink B, Xie C, Huson DH. Fast and sensitive protein alignment using DIAMOND. Nat Methods. 2015;12:59–60. · DOI · Paper page
  26. Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12:R60. · DOI · Paper page
  27. Jemimah S, Chabib CMM, Hadjileontiadis L, AlShehhi A. Gut microbiome dysbiosis in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis. PLoS ONE. 2023;18:e0285346. · DOI
  28. Chen W, Liu F, Ling Z, Tong X, Xiang C. Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer. PLoS ONE. 2012;7:e39743. · DOI · Paper page
  29. El Alam MB, Sims TT, Kouzy R, Biegert GW, Jaoude JA, Karpinets TV, et al. A prospective study of the adaptive changes in the gut microbiome during standard-of-care chemoradiotherapy for gynecologic cancers. PLoS ONE. 2021;16:e0247905. · DOI
  30. Wu J, Gan Y, Li M, Chen L, Liang J, Zhuo J, et al. Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota. Biomed Pharmacother. 2020;124:109883. · DOI
  31. Huang X, Fang Q, Rao T, Zhou L, Zeng X, Tan Z, et al. Leucovorin ameliorated methotrexate induced intestinal toxicity via modulation of the gut microbiota. Toxicol Appl Pharmacol. 2020;391:114900. · DOI
  32. Xia T, Zhang J, Han L, Jin Z, Wang J, Li X, et al. Protective effect of magnolol on oxaliplatin-induced intestinal injury in mice. Phytother Res. 2019;33:1161–72. · DOI
  33. Zhou B, Xia X, Wang P, Chen S, Yu C, Huang R, et al. Induction and amelioration of methotrexate-induced gastrointestinal toxicity are related to immune response and gut microbiota. EBioMedicine. 2018;33:122–33. · DOI
  34. Forsgård RA, Marrachelli VG, Korpela K, Frias R, Collado MC, Korpela R, et al. Chemotherapy-induced gastrointestinal toxicity is associated with changes in serum and urine metabolome and fecal microbiota in male Sprague-Dawley rats. Cancer Chemother Pharmacol. 2017;80:317–32. · DOI
  35. Chen H, Zhang F, Li R, Liu Y, Wang X, Zhang X, et al. Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota. Biomed Pharmacother. 2020;124:109829. · DOI
  36. Wang Y, Sun L, Chen S, Guo S, Yue T, Hou Q, et al. The administration of Escherichia coli Nissle 1917 ameliorates irinotecan–induced intestinal barrier dysfunction and gut microbial dysbiosis in mice. Life Sci. 2019;231:116529. · DOI
  37. Stringer AM, Al-Dasooqi N, Bowen JM, Tan TH, Radzuan M, Logan RM, et al. Biomarkers of chemotherapy-induced diarrhoea: a clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases. Support Care Cancer. 2013;21:1843–52. · DOI
  38. Aarnoutse R, Ziemons J, Hillege LE, de Vos-Geelen J, de Boer M, Bisschop SM, et al. Changes in intestinal microbiota in postmenopausal oestrogen receptor-positive breast cancer patients treated with (neo) adjuvant chemotherapy. NPJ Breast Cancer. 2022;8:89. · DOI
  39. Sevcikova A, Izoldova N, Stevurkova V, Kasperova B, Chovanec M, Ciernikova S, et al. The impact of the microbiome on resistance to cancer treatment with chemotherapeutic agents and immunotherapy. Int J Mol Sci. 2022;23:488. · DOI
  40. Kossowska M, Olejniczak S, Karbowiak M, Mosiej W, Zielińska D, Brzezicka A. The interplay between gut microbiota and cognitive functioning in the healthy aging population: a systematic review. Nutrients. 2024;16:852. · DOI
  41. Jena PK, Setayesh T, Sheng L, Di Lucente J, Jin LW, Wan Y-JY. Intestinal microbiota remodeling protects mice from western diet-induced brain inflammation and cognitive decline. Cells. 2022;11:504. · DOI
  42. Yang LL, Millischer V, Rodin S, MacFabe DF, Villaescusa JC, Lavebratt C. Enteric short-chain fatty acids promote proliferation of human neural progenitor cells. J Neurochem. 2020;154:635–46. · DOI · Paper page
  43. Perales-Puchalt A, Perez-Sanz J, Payne KK, Svoronos N, Allegrezza MJ, Chaurio RA, et al. Frontline science: microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol. 2018;103:799–805. · DOI
  44. Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y, et al. Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther. 2021;6:263. · DOI · Paper page
  45. Ahmadi S, Wang S, Nagpal R, Wang B, Jain S, Razazan A, et al. A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis. JCI Insight. 2020;5:e132055. · DOI · Paper page
  46. Zhang Y, Chen L, Hu M, Kim JJ, Lin R, Xu J, et al. Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet. Aging (Albany NY). 2020;12:9173–87. · DOI
  47. Olaisen M, Flatberg A, Granlund AvB, Røyset ES, Martinsen TC, Sandvik AK, et al. Bacterial mucosa-associated microbiome in inflamed and proximal noninflamed ileum of patients with Crohn’s disease. Inflamm Bowel Dis. 2021;27:12–24. · DOI
  48. Kelly TN, Bazzano LA, Ajami NJ, He H, Zhao J, Petrosino JF, et al. Gut microbiome associates with lifetime cardiovascular disease risk profile among Bogalusa Heart Study participants. Circ Res. 2016;119:956–64. · DOI · Paper page
  49. Lozano CP, Wilkens LR, Shvetsov YB, Maskarinec G, Park S-Y, Shepherd JA, et al. Associations of the dietary inflammatory index with total adiposity and ectopic fat through the gut microbiota, LPS, and C-reactive protein in the Multiethnic Cohort-Adiposity Phenotype Study. Am J Clin Nutr. 2022;115:1344–56. · DOI
  50. Balakrishnan B, Luckey D, Wright K, Davis JM, Chen J, Taneja V. Eggerthella lenta augments preclinical autoantibody production and metabolic shift mimicking senescence in arthritis. Sci Adv. 2023;9:eadg1129. · DOI
  51. Thota VR, Dacha S, Natarajan A, Nerad J. Eggerthella lenta bacteremia in a Crohn’s disease patient after ileocecal resection. Future Microbiol. 2011;6:595–7. · DOI
  52. Ugarte-Torres A, Gillrie MR, Griener TP, Church DL. Eggerthella lenta bloodstream infections are associated with increased mortality following empiric piperacillin-tazobactam (TZP) monotherapy: a population-based cohort study. Clin Infect Dis. 2018;67:221–8. · doi:10.1093/cid/ciy057
  53. Alexander M, Ang QY, Nayak RR, Bustion AE, Sandy M, Zhang B, et al. Human gut bacterial metabolism drives Th17 activation and colitis. Cell Host Microbe. 2022;30:17–30.e9. · DOI · Paper page
  54. Louis P, Flint HJ. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol Lett. 2009;294:1–8. · DOI · Paper page
  55. Bai S, Bai H, Li D, Zhong Q, Xie J, Chen J-J. Gut microbiota-related inflammation factors as a potential biomarker for diagnosing major depressive disorder. Front Cell Infect Microbiol. 2022;12:831186. · DOI
  56. Anhê FF, Barra NG, Cavallari JF, Henriksbo BD, Schertzer JD. Metabolic endotoxemia is dictated by the type of lipopolysaccharide. Cell Rep. 2021;36:109691. · DOI · Paper page
  57. Skvarc DR, Dean OM, Byrne LK, Gray L, Lane S, Lewis M, et al. The effect of N-acetylcysteine (NAC) on human cognition–a systematic review. Neurosci Biobehav Rev. 2017;78:44–56. · DOI
  58. Sepehrmanesh Z, Heidary M, Akasheh N, Akbari H, Heidary M. Therapeutic effect of adjunctive N-acetyl cysteine (NAC) on symptoms of chronic schizophrenia: a double-blind, randomized clinical trial. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:289–96. · DOI
  59. Huang Q, Aluise CD, Joshi G, Sultana R, St. Clair DK, Markesbery WR, et al. Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairment. J Neurosci Res. 2010;88:2618–29. · DOI
  60. Bloemendaal M, Froböse MI, Wegman J, Zandbelt BB, van de Rest O, Cools R, et al. Neuro-cognitive effects of acute tyrosine administration on reactive and proactive response inhibition in healthy older adults. eNeuro. 2018;5:ENEURO.0035-17.2018. · DOI
  61. Goyal MS, Blazey T, Metcalf NV, McAvoy MP, Strain JF, Rahmani M, Durbin TJ, Xiong C, Benzinger TL-S, Morris JC, Raichle ME, Vlassenko AG. Brain aerobic glycolysis and resilience in Alzheimer disease. Proc Natl Acad Sci U S A. 2023;120:e2212256120. · DOI
  62. Brumfield KD, Huq A, Colwell RR, Olds JL, Leddy MB. Microbial resolution of whole genome shotgun and 16S amplicon metagenomic sequencing using publicly available NEON data. PLoS ONE. 2020;15:e0228899. · DOI · Paper page
  63. Coker OO, Wu WKK, Wong SH, Sung JJ, Yu J. Altered gut archaea composition and interaction with bacteria are associated with colorectal cancer. Gastroenterology. 2020;159:1459–70.e5. · DOI · Paper page
  64. Han X, Robinson LA, Jensen RE, Smith TG, Yabroff KR. Factors associated with health-related quality of life among cancer survivors in the United States. JNCI Cancer Spectr. 2021;5:pkaa123. · DOI
  65. Lavdaniti M, Owens DA, Liamopoulou P, Marmara K, Zioga E, Mantzanas MS, et al. Factors influencing quality of life in breast cancer patients six months after the completion of chemotherapy. Dis Sci. 2019;7:26.
  66. Huang Y, Yang W, Liu H, Duan J, Zhang Y, Liu M, et al. Effect of high-dose methotrexate chemotherapy on intestinal Bifidobacteria, Lactobacillus and Escherichia coli in children with acute lymphoblastic leukemia. Exp Biol Med (Maywood). 2012;237:305–11. · DOI
  67. Han F, Luo C, Lv D, Tian L, Qu C. Risk factors affecting cognitive impairment of the elderly aged 65 and over: a cross-sectional study. Front Aging Neurosci. 2022;14:903794. · DOI
  68. Singh RK, Chang H-W, Yan D, Lee KM, Ucmak D, Wong K, et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15:73. · DOI · Paper page

Metadata

Authors
Miller, B. C., Haggler, J. A., Chaudhari, D. S., Shukla, R., Kumar, V., Mishra, S. P., Masternak, M. M., Holland, P., Labyak, C., Golden, A., Dangiolo, M., Arikawa, A. Y., Kociolek, J., Fraser, A., Williams, C., Agronin, M., Aymat, M., Pledger, W., Yadav, H., & Jain, S.
Venue
GeroScience
Published
2025-11-01
Volume
48
Issue
4
Pages
5575-5596
ISSN
2509-2723
Cited by
7
References
7
Language
en
Licence
Funders
Florida Department of Health (22A17)

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Miller, B. C., Haggler, J. A., Chaudhari, D. S., Shukla, R., Kumar, V., Mishra, S. P., Masternak, M. M., Holland, P., Labyak, C., Golden, A., Dangiolo, M., Arikawa, A. Y., Kociolek, J., Fraser, A., Williams, C., Agronin, M., Aymat, M., Pledger, W., Yadav, H., & Jain, S. (2025). Gut microbiome signatures predict cognitive impairment in older cancer survivors. GeroScience. https://doi.org/10.1007/s11357-025-01917-x

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