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Gut microbiome signatures predict cognitive impairment in older cancer survivors
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · cited 2×
“The composition and function of the gut microbiota significantly differ in many human diseases, including aging, and also significantly impact gut-brain functions [13, 14].”
Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
Vich Vila, A., Collij, V., Sanna, S., Sinha, T., Imhann, F., Bourgonje, A. R., Mujagic, Z., Jonkers, D. M. A. E., Masclee, A. A. M., Fu, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14177-z · Cited by 791
Absorption of Short-Chain Fatty Acids by the Colon
Ruppin, H., Bar-Meir, S., Soergel, K. H., Wood, C. M., & Schmitt, M. G. (1980) · Gastroenterology · doi:10.1016/s0016-5085(19)30508-6 · Cited by 736
Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease
Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170020 · Cited by 449
Dysbiosis of human gut microbiome in young-onset colorectal cancer
Yang, Y., Du, L., Shi, D., Kong, C., Liu, J., Liu, G., Li, X., & Ma, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-27112-y · Cited by 303
Manderino, L., Carroll, I., Azcarate-Peril, M. A., Rochette, A., Heinberg, L., Peat, C., Steffen, K., Mitchell, J., & Gunstad, J. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000492 · Cited by 125
Altered gut microbiota in older adults with mild cognitive impairment: a case-control study
Fan, K.-C., Lin, C.-C., Liu, Y.-C., Chao, Y.-P., Lai, Y.-J., Chiu, Y.-L., & Chuang, Y.-F. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1162057 · Cited by 47
Research works printed but not linked: 68
- Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12–49.
- Song BC, Bai J. Microbiome-gut-brain axis in cancer treatment-related psychoneurological toxicities and symptoms: a systematic review. Support Care Cancer. 2021;29:605–17. · DOI
- Whittaker AL, George RP, O’Malley L. Prevalence of cognitive impairment following chemotherapy treatment for breast cancer: a systematic review and meta-analysis. Sci Rep. 2022;12:2135. · DOI · Paper page
- Luo J, Schousboe JT, Ensrud KE, Hendryx M. Long-term changes of cognitive impairment among older breast cancer survivors. J Cancer Surviv. 2023;17:1760–8. · DOI
- Zer A, Pond GR, Razak ARA, Tirona K, Gan HK, Chen EX, et al. Association of neurocognitive deficits with radiotherapy or chemoradiotherapy for patients with head and neck cancer. JAMA Otolaryngol Head Neck Surg. 2018;144:71–9.
- Amidi A, Wu LM, Pedersen AD, Mehlsen M, Pedersen CG, Rossen P, et al. Cognitive impairment in testicular cancer survivors 2 to 7 years after treatment. Support Care Cancer. 2015;23:2973–9. · DOI
- Vardy JL, Dhillon HM, Pond GR, Rourke SB, Bekele T, Renton C, et al. Cognitive function in patients with colorectal cancer who do and do not receive chemotherapy: a prospective, longitudinal, controlled study. J Clin Oncol. 2015;33:4085–92. · DOI · Paper page
- Holtfrerich SKC, Knipper S, Purwins J, Castens J, Beyer B, Schlomm T, et al. The impact of long-term androgen deprivation therapy on cognitive function and socioeconomic decision making in prostate cancer patients. Psychooncology. 2020;29:1338–46. · DOI
- Mishra SP, Jain S, Wang B, Wang S, Miller BC, Lee JY, et al. Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function. JCI Insight. 2024;9:e168443. · DOI
- Chaudhari DS, Jain S, Yata VK, Mishra SP, Kumar A, Fraser A, et al. Unique trans-kingdom microbiome structural and functional signatures predict cognitive decline in older adults. Geroscience. 2023;45:2819–34. · DOI
- Mishra SP, Wang B, Jain S, Ding J, Rejeski J, Furdui CM, et al. A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut. Gut. 2023;72:1848–65. · DOI · Paper page
- Wilkins LJ, Monga M, Miller AW. Defining dysbiosis for a cluster of chronic diseases. Sci Rep. 2019;9:12918. · DOI · Paper page
- Nagpal R, Neth BJ, Wang S, Craft S, Yadav H. Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer’s disease markers in subjects with mild cognitive impairment. EBioMedicine. 2019;47:529–42. · DOI · Paper page
- Wu L, Han Y, Zheng Z, Peng G, Liu P, Yue S, et al. Altered gut microbial metabolites in amnestic mild cognitive impairment and Alzheimer’s disease: signals in host–microbe interplay. Nutrients. 2021;13:228. · DOI · Paper page
- Montassier E, Gastinne T, Vangay P, Al‐Ghalith G, Bruley des Varannes S, Massart S, Moreau P, Potel G, de La Cochetière M, Batard E. Chemotherapy‐driven dysbiosis in the intestinal microbiome. Aliment Pharmacol Ther. 2015;42:515–28. · DOI · Paper page
- Chua LL, Rajasuriar R, Azanan MS, Abdullah NK, Tang MS, Lee SC, et al. Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation. Microbiome. 2017;5:35. · DOI
- Deleemans JM, Chleilat F, Reimer RA, Baydoun M, Piedalue K-A, Lowry DE, et al. The chemo-gut pilot study: associations between gut microbiota, gastrointestinal symptoms, and psychosocial health outcomes in a cross-sectional sample of young adult cancer survivors. Curr Oncol. 2022;29:2973–94. · DOI
- Smith KS, Tissier A, Bail JR, Novak JR, Morrow CD, Demark-Wahnefried W, et al. Health-related quality of life is associated with fecal microbial composition in breast cancer survivors. Support Care Cancer. 2023;31:10. · DOI
- Okubo R, Kinoshita T, Katsumata N, Uezono Y, Xiao J, Matsuoka YJ. Impact of chemotherapy on the association between fear of cancer recurrence and the gut microbiota in breast cancer survivors. Brain Behav Immun. 2020;85:186–91. · DOI
- Paulsen JA, Ptacek TS, Carter SJ, Liu N, Kumar R, Hyndman L, et al. Gut microbiota composition associated with alterations in cardiorespiratory fitness and psychosocial outcomes among breast cancer survivors. Support Care Cancer. 2017;25:1563–70. · DOI
- Masternak MM, Yadav H. Microbiome in aging of gut and brain (MiaGB): paving the ways to understand gut-brain axis in aging. Aging Pathobiol Ther. 2022;4:1–3. · DOI
- Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9. · DOI · Paper page
- James AS, Adil NA, Goltz D, Tangudu D, Chaudhari DS, Shukla R, et al. Abnormalities in gut virome signatures linked with cognitive impairment in older adults. Gut Microbes. 2024;16:2431648. · DOI
- Beghini F, McIver LJ, Blanco-Míguez A, Dubois L, Asnicar F, Maharjan S, et al. Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3. Elife. 2021;10:e65088. · DOI · Paper page
- Buchfink B, Xie C, Huson DH. Fast and sensitive protein alignment using DIAMOND. Nat Methods. 2015;12:59–60. · DOI · Paper page
- Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12:R60. · DOI · Paper page
- Jemimah S, Chabib CMM, Hadjileontiadis L, AlShehhi A. Gut microbiome dysbiosis in Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis. PLoS ONE. 2023;18:e0285346. · DOI
- Chen W, Liu F, Ling Z, Tong X, Xiang C. Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer. PLoS ONE. 2012;7:e39743. · DOI · Paper page
- El Alam MB, Sims TT, Kouzy R, Biegert GW, Jaoude JA, Karpinets TV, et al. A prospective study of the adaptive changes in the gut microbiome during standard-of-care chemoradiotherapy for gynecologic cancers. PLoS ONE. 2021;16:e0247905. · DOI
- Wu J, Gan Y, Li M, Chen L, Liang J, Zhuo J, et al. Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota. Biomed Pharmacother. 2020;124:109883. · DOI
- Huang X, Fang Q, Rao T, Zhou L, Zeng X, Tan Z, et al. Leucovorin ameliorated methotrexate induced intestinal toxicity via modulation of the gut microbiota. Toxicol Appl Pharmacol. 2020;391:114900. · DOI
- Xia T, Zhang J, Han L, Jin Z, Wang J, Li X, et al. Protective effect of magnolol on oxaliplatin-induced intestinal injury in mice. Phytother Res. 2019;33:1161–72. · DOI
- Zhou B, Xia X, Wang P, Chen S, Yu C, Huang R, et al. Induction and amelioration of methotrexate-induced gastrointestinal toxicity are related to immune response and gut microbiota. EBioMedicine. 2018;33:122–33. · DOI
- Forsgård RA, Marrachelli VG, Korpela K, Frias R, Collado MC, Korpela R, et al. Chemotherapy-induced gastrointestinal toxicity is associated with changes in serum and urine metabolome and fecal microbiota in male Sprague-Dawley rats. Cancer Chemother Pharmacol. 2017;80:317–32. · DOI
- Chen H, Zhang F, Li R, Liu Y, Wang X, Zhang X, et al. Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota. Biomed Pharmacother. 2020;124:109829. · DOI
- Wang Y, Sun L, Chen S, Guo S, Yue T, Hou Q, et al. The administration of Escherichia coli Nissle 1917 ameliorates irinotecan–induced intestinal barrier dysfunction and gut microbial dysbiosis in mice. Life Sci. 2019;231:116529. · DOI
- Stringer AM, Al-Dasooqi N, Bowen JM, Tan TH, Radzuan M, Logan RM, et al. Biomarkers of chemotherapy-induced diarrhoea: a clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases. Support Care Cancer. 2013;21:1843–52. · DOI
- Aarnoutse R, Ziemons J, Hillege LE, de Vos-Geelen J, de Boer M, Bisschop SM, et al. Changes in intestinal microbiota in postmenopausal oestrogen receptor-positive breast cancer patients treated with (neo) adjuvant chemotherapy. NPJ Breast Cancer. 2022;8:89. · DOI
- Sevcikova A, Izoldova N, Stevurkova V, Kasperova B, Chovanec M, Ciernikova S, et al. The impact of the microbiome on resistance to cancer treatment with chemotherapeutic agents and immunotherapy. Int J Mol Sci. 2022;23:488. · DOI
- Kossowska M, Olejniczak S, Karbowiak M, Mosiej W, Zielińska D, Brzezicka A. The interplay between gut microbiota and cognitive functioning in the healthy aging population: a systematic review. Nutrients. 2024;16:852. · DOI
- Jena PK, Setayesh T, Sheng L, Di Lucente J, Jin LW, Wan Y-JY. Intestinal microbiota remodeling protects mice from western diet-induced brain inflammation and cognitive decline. Cells. 2022;11:504. · DOI
- Yang LL, Millischer V, Rodin S, MacFabe DF, Villaescusa JC, Lavebratt C. Enteric short-chain fatty acids promote proliferation of human neural progenitor cells. J Neurochem. 2020;154:635–46. · DOI · Paper page
- Perales-Puchalt A, Perez-Sanz J, Payne KK, Svoronos N, Allegrezza MJ, Chaurio RA, et al. Frontline science: microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol. 2018;103:799–805. · DOI
- Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y, et al. Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther. 2021;6:263. · DOI · Paper page
- Ahmadi S, Wang S, Nagpal R, Wang B, Jain S, Razazan A, et al. A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis. JCI Insight. 2020;5:e132055. · DOI · Paper page
- Zhang Y, Chen L, Hu M, Kim JJ, Lin R, Xu J, et al. Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet. Aging (Albany NY). 2020;12:9173–87. · DOI
- Olaisen M, Flatberg A, Granlund AvB, Røyset ES, Martinsen TC, Sandvik AK, et al. Bacterial mucosa-associated microbiome in inflamed and proximal noninflamed ileum of patients with Crohn’s disease. Inflamm Bowel Dis. 2021;27:12–24. · DOI
- Kelly TN, Bazzano LA, Ajami NJ, He H, Zhao J, Petrosino JF, et al. Gut microbiome associates with lifetime cardiovascular disease risk profile among Bogalusa Heart Study participants. Circ Res. 2016;119:956–64. · DOI · Paper page
- Lozano CP, Wilkens LR, Shvetsov YB, Maskarinec G, Park S-Y, Shepherd JA, et al. Associations of the dietary inflammatory index with total adiposity and ectopic fat through the gut microbiota, LPS, and C-reactive protein in the Multiethnic Cohort-Adiposity Phenotype Study. Am J Clin Nutr. 2022;115:1344–56. · DOI
- Balakrishnan B, Luckey D, Wright K, Davis JM, Chen J, Taneja V. Eggerthella lenta augments preclinical autoantibody production and metabolic shift mimicking senescence in arthritis. Sci Adv. 2023;9:eadg1129. · DOI
- Thota VR, Dacha S, Natarajan A, Nerad J. Eggerthella lenta bacteremia in a Crohn’s disease patient after ileocecal resection. Future Microbiol. 2011;6:595–7. · DOI
- Ugarte-Torres A, Gillrie MR, Griener TP, Church DL. Eggerthella lenta bloodstream infections are associated with increased mortality following empiric piperacillin-tazobactam (TZP) monotherapy: a population-based cohort study. Clin Infect Dis. 2018;67:221–8. · doi:10.1093/cid/ciy057
- Alexander M, Ang QY, Nayak RR, Bustion AE, Sandy M, Zhang B, et al. Human gut bacterial metabolism drives Th17 activation and colitis. Cell Host Microbe. 2022;30:17–30.e9. · DOI · Paper page
- Louis P, Flint HJ. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol Lett. 2009;294:1–8. · DOI · Paper page
- Bai S, Bai H, Li D, Zhong Q, Xie J, Chen J-J. Gut microbiota-related inflammation factors as a potential biomarker for diagnosing major depressive disorder. Front Cell Infect Microbiol. 2022;12:831186. · DOI
- Anhê FF, Barra NG, Cavallari JF, Henriksbo BD, Schertzer JD. Metabolic endotoxemia is dictated by the type of lipopolysaccharide. Cell Rep. 2021;36:109691. · DOI · Paper page
- Skvarc DR, Dean OM, Byrne LK, Gray L, Lane S, Lewis M, et al. The effect of N-acetylcysteine (NAC) on human cognition–a systematic review. Neurosci Biobehav Rev. 2017;78:44–56. · DOI
- Sepehrmanesh Z, Heidary M, Akasheh N, Akbari H, Heidary M. Therapeutic effect of adjunctive N-acetyl cysteine (NAC) on symptoms of chronic schizophrenia: a double-blind, randomized clinical trial. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:289–96. · DOI
- Huang Q, Aluise CD, Joshi G, Sultana R, St. Clair DK, Markesbery WR, et al. Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairment. J Neurosci Res. 2010;88:2618–29. · DOI
- Bloemendaal M, Froböse MI, Wegman J, Zandbelt BB, van de Rest O, Cools R, et al. Neuro-cognitive effects of acute tyrosine administration on reactive and proactive response inhibition in healthy older adults. eNeuro. 2018;5:ENEURO.0035-17.2018. · DOI
- Goyal MS, Blazey T, Metcalf NV, McAvoy MP, Strain JF, Rahmani M, Durbin TJ, Xiong C, Benzinger TL-S, Morris JC, Raichle ME, Vlassenko AG. Brain aerobic glycolysis and resilience in Alzheimer disease. Proc Natl Acad Sci U S A. 2023;120:e2212256120. · DOI
- Brumfield KD, Huq A, Colwell RR, Olds JL, Leddy MB. Microbial resolution of whole genome shotgun and 16S amplicon metagenomic sequencing using publicly available NEON data. PLoS ONE. 2020;15:e0228899. · DOI · Paper page
- Coker OO, Wu WKK, Wong SH, Sung JJ, Yu J. Altered gut archaea composition and interaction with bacteria are associated with colorectal cancer. Gastroenterology. 2020;159:1459–70.e5. · DOI · Paper page
- Han X, Robinson LA, Jensen RE, Smith TG, Yabroff KR. Factors associated with health-related quality of life among cancer survivors in the United States. JNCI Cancer Spectr. 2021;5:pkaa123. · DOI
- Lavdaniti M, Owens DA, Liamopoulou P, Marmara K, Zioga E, Mantzanas MS, et al. Factors influencing quality of life in breast cancer patients six months after the completion of chemotherapy. Dis Sci. 2019;7:26.
- Huang Y, Yang W, Liu H, Duan J, Zhang Y, Liu M, et al. Effect of high-dose methotrexate chemotherapy on intestinal Bifidobacteria, Lactobacillus and Escherichia coli in children with acute lymphoblastic leukemia. Exp Biol Med (Maywood). 2012;237:305–11. · DOI
- Han F, Luo C, Lv D, Tian L, Qu C. Risk factors affecting cognitive impairment of the elderly aged 65 and over: a cross-sectional study. Front Aging Neurosci. 2022;14:903794. · DOI
- Singh RK, Chang H-W, Yan D, Lee KM, Ucmak D, Wong K, et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15:73. · DOI · Paper page
Metadata
- Authors
- Miller, B. C., Haggler, J. A., Chaudhari, D. S., Shukla, R., Kumar, V., Mishra, S. P., Masternak, M. M., Holland, P., Labyak, C., Golden, A., Dangiolo, M., Arikawa, A. Y., Kociolek, J., Fraser, A., Williams, C., Agronin, M., Aymat, M., Pledger, W., Yadav, H., & Jain, S.
- Venue
- GeroScience
- Published
- 2025-11-01
- Volume
- 48
- Issue
- 4
- Pages
- 5575-5596
- ISSN
- 2509-2723
- Cited by
- 7
- References
- 7
- Language
- en
- Licence
- creativecommons.org/licenses/by/4.0 (tdm)
- creativecommons.org/licenses/by/4.0 (vor)
- Funders
- Florida Department of Health (22A17)
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- Miller, B. C., Haggler, J. A., Chaudhari, D. S., Shukla, R., Kumar, V., Mishra, S. P., Masternak, M. M., Holland, P., Labyak, C., Golden, A., Dangiolo, M., Arikawa, A. Y., Kociolek, J., Fraser, A., Williams, C., Agronin, M., Aymat, M., Pledger, W., Yadav, H., & Jain, S. (2025). Gut microbiome signatures predict cognitive impairment in older cancer survivors. GeroScience. https://doi.org/10.1007/s11357-025-01917-x
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