Cited by 112Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesAdipose Tissue and Metabolism

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Effects of exercise on adipokines and the metabolic syndrome

You, Tongjian, Nicklas, Barbara J.·2008·Current Diabetes Reports

DOI 10.1007/s11892-008-0003-4

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Abstract

Adipokines, or adipose tissue-derived cytokines/proteins, may be important factors linking excess adipose tissue to individual metabolic risk factors, and the overall metabolic syndrome. Current evidence supports that aerobic exercise, alone or combined with hypocaloric diet, improves symptoms of the metabolic syndrome, possibly by altering systemic levels of inflammatory adipokines. A number of studies show that increased physical activity leads to lower circulating levels of proinflammatory cytokines and higher levels of adiponectin. However, limited data show that exercise training does not influence adipose tissue adipokine expression or release. Conversely, exercise training may influence cytokine production by circulating mononuclear cells, another important source of elevated inflammation. Future studies are needed to investigate the cellular mechanisms by which exercise training affects inflammation and whether alterations in inflammation are one mechanism by which exercise improves components of the metabolic syndrome in at-risk individuals.

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Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100 · cited 1×
“The mechanism through which exercise modifies mononuclear cell production of adipokines is unknown, but could be that acute exercise results in release of “myokines” (muscle-derived cytokines; eg, IL-6) [ 47 ], and when performed regularly, adaptations in the immune system cause lower cytokine release from mononuclear…”
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C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular Events: An 8-Year Follow-Up of 14 719 Initially Healthy American Women
Ridker, P. M., Buring, J. E., Cook, N. R., & Rifai, N. (2003) · Circulation · doi:10.1161/01.cir.0000055014.62083.05 · Cited by 2,292
The Metabolic Syndrome: Prevalence and Associated Risk Factor Findings in the US Population From the Third National Health and Nutrition Examination Survey, 1988-1994
Park, Y.-W., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M. R., & Heymsfield, S. B. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.4.427 · Cited by 2,074
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women: A Randomized Trial
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511
Prospective Analysis of The Insulin-Resistance Syndrome (Syndrome X)
Haffner, S. M., Valdez, R. A., Hazuda, H. P., Mitchell, B. D., Morales, P. A., & D, M. P. S. M. (1992) · Diabetes · doi:10.2337/diab.41.6.715 · Cited by 1,234
Adiponectin as an anti-inflammatory factor
Ouchi, N., & Walsh, K. X. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 910
The Framingham Offspring Study
Allhoff, P., Laaser, U., & Heinrich, J. (1991) · Springer eBooks · doi:10.1007/978-3-642-95642-3_25 · Cited by 832
Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes
Wolf, A. M., Wolf, D. G. F., Rumpold, H. F., Enrich, B., & Tilg, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.145 · Cited by 821
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TRUJILLO, M. E., & Scherer, P. E. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01426.x · Cited by 782
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Ghanim, H., Aljada, A., Hofmeyer, D., Syed, T., Mohanty, P., & Dandona, P. (2004) · Circulation · doi:10.1161/01.cir.0000142055.53122.fa · Cited by 611
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Colbert, L. H., Visser, M., Simonsick, E. M., Tracy, R. P., Newman, A. B., Kritchevsky, S. B., Pahor, M., Taaffe, D. R., Brach, J. S., Rubin, S., et al. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52307.x · Cited by 479
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Nassis, G. P., Papantakou, K., Skenderi, K., Triandafillopoulou, M., Kavouras, S. A., Yannakoulia, M., Chrousos, G. P., & Sidossis, L. S. (2005) · Metabolism · doi:10.1016/j.metabol.2005.05.013 · Cited by 470
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Reilly, M. P., & Rader, D. J. (2003) · Circulation · doi:10.1161/01.cir.0000088846.10655.e0 · Cited by 466
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Bruun, J. M., Helge, J. W., Richelsen, B., & Stallknecht, B. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00506.2005 · Cited by 437
Long-term Exercise and Atherogenic Activity of Blood Mononuclear Cells in Persons at Risk of Developing Ischemic Heart Disease
Smith, J. K. (1999) · JAMA · doi:10.1001/jama.281.18.1722 · Cited by 420
Clinical Importance of Obesity Versus the Metabolic Syndrome in Cardiovascular Risk in Women
Kip, K. E., Marroquin, O. C., Kelley, D. E., Johnson, B. D., Kelsey, S. F., Shaw, L. J., Rogers, W. J., & Reís, S. E. (2004) · Circulation · doi:10.1161/01.cir.0000115514.44135.a8 · Cited by 411
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Monzillo, L. U., Hamdy, O., Horton, E. S., Ledbury, S., Mullooly, C., Jarema, C., Porter, S., Ovalle, K., Moussa, A., & Mantzoros, C. S. (2003) · Obesity Research · doi:10.1038/oby.2003.144 · Cited by 395
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Authors: You, T., & Nicklas, B. J.
Affiliations: University at Buffalo, State University of New York (US)
Corresponding author: You, Tongjian
ORCID: You, Tongjian
Nicklas, Barbara J.
Venue: Current Diabetes Reports
Publisher: Springer Science and Business Media LLC
Published: 2008-02
Volume: 8
Issue: 1
Pages: 7-11
ISSN: 1534-4827 (ISSN-L)
1539-0829
DOI: 10.1007/s11892-008-0003-4
OpenAlex: W2158995409
Cited by: 112
References: 50
Citations by year: 2026: 1 · 2025: 2 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 12 · 2013: 11 · 2012: 8
FWCI: 1.14
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Diabetes Reports (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01-AG/DK20583, P30AG-21332, P30AG021332)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adipokines, metabolic syndrome, aerobic exercise, hypocaloric diet, adiponectin, inflammatory cytokines, adipose tissue inflammation, exercise training, mononuclear cells, obesity
MeSH terms: Diet, Humans, Exercise, Metabolic Syndrome, Caloric Restriction, Adipokines

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Effects of exercise on adipokines and the metabolic syndrome

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