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Mechanisms Underlying Visceral Hypersensitivity in Irritable Bowel Syndrome
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“Increasing research on the human microbiome has highlighted the role of gut microbial dysbiosis in IBS [4].”
From A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS) (2018) · cites this paper as [4]
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Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
Self-citationAGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384
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Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
The impact of irritable bowel syndrome on health-related quality of life
Gralnek, I. M., Hays, R. D., Kilbourne, A., Naliboff, B., & Mayer, E. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.16484 · Cited by 781 · cited 1×
“Quality of life is on average decreased in patients with IBS as compared with the general population [15] and has been reported to be worse than that found in patients with gastroesophageal reflux disease on all domains except physical functioning [16].”
BackgroundRole for protease activity in visceral pain in irritable bowel syndrome
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · cited 1×
“These proteases were involved in the activation of sensory neurons, as well as generation of colonic hypersensitivity when infused in the colon of recipient mice, through a mechanism involving the activation of protease activated receptor-2 [61].”
BackgroundSelf-citationPiche, T., Barbara, G., Aubert, P., Bruley des Varannes, S., Dainese, R., Nano, J. L., Cremon, C., Stanghellini, V, De Giorgio, R., Galmiche, J. P., et al. (2009) · Gut · doi:10.1136/gut.2007.140806 · Cited by 540
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Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact
Hungin, A. P. S., Chang, L., Locke, G. R., Dennis, E. H., & Barghout, V. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02463.x · Cited by 494
Irritable bowel syndrome in general practice: prevalence, characteristics, and referral
Thompson, W. G., Heaton, K. W., Smyth, G. T., & Smyth, C. (2000) · Gut · doi:10.1136/gut.46.1.78 · Cited by 477 · cited 1×
“IBS is an extremely common condition with a worldwide prevalence of 10%–20% in the general population [6, 7]. IBS accounts for about 3% of all general practice consultation and up to 40% of all gastrointestinal referrals [ 8 ], leading to an impressive societal expenditure.”
BackgroundWhitehead, W. E., Crowell, M. D., Robinson, J. C., Heller, B. R., & Schuster, M. M. (1992) · Gut · doi:10.1136/gut.33.6.825 · Cited by 432 · cited 1×
“Patients with IBS often relate the onset or aggravation of symptoms following physiologic or pathologic events/ factors, including certain foods (eg, spicy food, fatty meals, coffee) [32] or stress [33].”
BackgroundGwee, K.-A. (2003) · Gut · doi:10.1136/gut.52.4.523 · Cited by 415
Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis
Wang, L.-H., Fang, X.-C., & Pan, G.-Z. (2004) · Gut · doi:10.1136/gut.2003.021154 · Cited by 387 · cited 1×
“In the latter, nerve fibers appeared in clusters surrounding an increased number of mast cells [77].”
BackgroundCremon, C., Gargano, L., Morselli-Labate, A. M., Santini, D., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.94 · Cited by 342
Self-citationWHITEHEAD, W., & PALSSON, O. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70099-x · Cited by 314 · cited 1×
“Anxiety, which is more commonly found in patients with IBS as compared to healthy controls, may increase visceral hypersensitivity [ 24 ].”
BackgroundVillani, A., Lemire, M., Thabane, M., Belisle, A., Geneau, G., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., Franchimont, D., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.049 · Cited by 244 · cited 1×
“[65], has identified three variants as independent risk factors for postinfectious IBS, encoding epithelial barrier function and innate immune response to enteric bacteria.”
BackgroundCremon, C., Carini, G., Wang, B., Vasina, V., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Grundy, D., Tonini, M., De Ponti, F., et al. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.86 · Cited by 223
Self-citationPARK, J. H., RHEE, P., KIM, H. S., LEE, J. H., KIM, Y., KIM, J. J., & RHEE, J. C. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.04143.x · Cited by 196 · cited 1×
“Interestingly, one of these studies demonstrated that the increased number of mast cells was correlated with visceral hypersensitivity [57].”
ResultMucosal cytokine imbalance in irritable bowel syndrome
Macsharry, J., O'Mahony, L., Fanning, A., Bairead, E., Sherlock, G., Tiesman, J., Fulmer, A., Kiely, B., Dinan, T. G., Shanahan, F., et al. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802276127 · Cited by 174
CORINALDESI, R., STANGHELLINI, V., CREMON, C., GARGANO, L., COGLIANDRO, R. F., DE GIORGIO, R., BARTESAGHI, G., CANOVI, B., & BARBARA, G. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04041.x · Cited by 131
Self-citationAlterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome
Aerssens, J., Camilleri, M., Talloen, W., Thielemans, L., Göhlmann, H. W. H., Van den Wyngaert, I., Thielemans, T., De Hoogt, R., Andrews, C. N., Bharucha, A. E., et al. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.11.012 · Cited by 124 · cited 1×
“[64], showed differential expression of several genes, many of which directed toward the host defense mechanisms against microbiological pathogens, in the colonic mucosa of patients with IBS in comparison with controls.”
Result
Research works printed but not linked: 77
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Metadata
- Authors
- Barbara, G., Cremon, C., De Giorgio, R., Dothel, G., Zecchi, L., Bellacosa, L., Carini, G., Stanghellini, V., & Corinaldesi, R.
- Venue
- Current Gastroenterology Reports
- Published
- 2011-05-03
- Volume
- 13
- Issue
- 4
- Pages
- 308-315
- ISSN
- 1522-8037
- 1534-312X
- Cited by
- 123
- References
- 22
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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