Neuropathological observations in a case of autism presenting with self-injury behavior
Abstract
We report the neuropathological evaluation of a 24-year-old autistic woman suffering from a residual state of infantile autism and presenting with self-injury behavior since childhood. Her behavior included head-banging, eye-gouging and self-biting. All intended therapeutic measures remained without effect, including high doses of psychotropic drugs. At autopsy, numerous neurofibrillary tangles were found in the perirhinal and entorhinal cortex where they were frequently grouped in nests or clusters. A few neurofibrillary tangles were also observed in the amygdala and in the prepiriform and orbito-frontal cortex. In the cortex, tangles were located in both layers II and III. There were no neuritic plaques or amyloid deposits. Interestingly, neurofibrillary tangles have been described in brains of individuals who had experienced repeated head injuries such as boxers (dementia pugilistica) and soccer players, suggesting that in our case a similar mechanism induced tangle formation and resulted in the loss of selective neuronal populations.
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The clinical symptoms associated with CTE were examined in case summaries throughout the twentieth century; however, the disease presentation described in these reports was inconsistent.
“The clinical symptoms associated with this disease were examined in case summaries throughout the twentieth century; however, the disease presentation described in these reports was inconsistent [38, 65, 92, 100, 126].”
From The neuropathology of sport (2014) · cites this paper as [92]
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Self-citationChronic Effects of Mild Neurotrauma: Putting the Cart Before the Horse?
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Clinical Presentation of Chronic Traumatic Encephalopathy
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Gamma entrainment frequency affects mood, memory and cognition: an exploratory pilot study
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Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation?Preprint
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Cortical Neuropathology in Aging and Dementing Disorders
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Alzheimer?s disease?a sum greater than its parts?
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Evidence of traumatic brain injury in headbutting bovids
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Imaging in Chronic Traumatic Encephalopathy and Traumatic Brain Injury
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Neuropathological analysis of an adult case of the Cornelia de Lange syndrome
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Screening of dementia indicating signs in adults with intellectual disabilities
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Chronic Traumatic Encephalopathy
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Early Orbitofrontal-Limbic Dysfunction and Autism
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Recent Advances in Chronic Traumatic Encephalopathy
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Effect of the Gamma Entrainment Frequency in Pertinence to Mood, Memory and Cognition
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- Authors
- Hof, P. R., Knabe, R., Bovier, P., & Bouras, C.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of Geneva (CH)
- ORCID
- Hof, P. R.
- Venue
- Acta Neuropathologica
- Published
- 1991-09
- Volume
- 82
- Issue
- 4
- Pages
- 321-326
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2012670826
- Cited by
- 151
- References
- 31
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 14 · 2018: 8 · 2017: 11 · 2016: 6 · 2015: 13 · 2014: 6 · 2013: 8 · 2012: 5
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, self-harm, neurofibrillary tangles, perirhinal cortex, entorhinal cortex, amygdala, chronic traumatic encephalopathy, repeated head injury, neuropathology
- MeSH terms
- Adult, Amygdala, Atrophy, Autistic Disorder, Brain Diseases, Brain Injuries, Cerebral Cortex, Female, Humans, Temporal Lobe, Self-Injurious Behavior, Neurofibrillary Tangles
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