The importance of epigenetics in diagnostics and treatment of major depressive disorder
Open accessAbstract
Recent studies imply that there is a tight association between epigenetics and a molecular mechanism of major depressive disorder (MDD). Epigenetic modifications, i.e., DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA), are able to influence the severity of the disease and the outcome of the therapy. This article summarizes the most recent literature data on this topic, i.e., usage of histone deacetylases as therapeutic agents with an antidepressant effect and miRNAs or lncRNAs as markers of depression. Due to the noteworthy potential of the role of epigenetics in MDD diagnostics and therapy, we have gathered the most relevant data in this area.
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Histone modifications play a central role in the epigenetic regulation of depression by influencing chromatin structure and transcriptional control.
“Histone modifications play a central role in the epigenetic regulation of depression by influencing chromatin structure and transcriptional control (Czarny et al., 2021; Nestler et al., 2016).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Czarny et al., 2021
Epigenetic pathways serve as molecular bridges between environmental exposures and long-term changes in brain function.
“These pathways serve as molecular bridges between environmental exposures—such as early-life stress or chronic adversity—and long-term changes in brain function (Czarny et al., 2021).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Czarny et al., 2021
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- Authors
- Czarny, P., Białek, K., Ziółkowska, S., Strycharz, J., Barszczewska, G., & Sliwinski, T.
- Affiliations
- Medical University of Lodz (PL)
- University of Łódź (PL)
- Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland
- Venue
- Journal of Personalized Medicine
- Publisher
- MDPI AG
- Published
- 2021-03-01
- Volume
- 11
- Issue
- 3
- Pages
- 167
- ISSN
- 2075-4426 (ISSN-L)
- PMC
- PMC7999864
- OpenAlex
- W3135306269
- Cited by
- 37
- References
- 210
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 3
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Personalized Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, epigenetics, DNA methylation, histone modifications, microRNA, long non-coding RNA, histone deacetylase inhibitors, antidepressant treatment, depression biomarkers, depression diagnosis
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