Cited by 37Epigenetics and DNA MethylationTreatment of Major DepressionStress Responses and Cortisol

The importance of epigenetics in diagnostics and treatment of major depressive disorder

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Czarny, Piotr, Białek, Katarzyna, Ziółkowska, Sylwia, Strycharz, Justyna, Barszczewska, Gabriela, Sliwinski, Tomasz·2021·Journal of Personalized Medicine

Abstract

Recent studies imply that there is a tight association between epigenetics and a molecular mechanism of major depressive disorder (MDD). Epigenetic modifications, i.e., DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA), are able to influence the severity of the disease and the outcome of the therapy. This article summarizes the most recent literature data on this topic, i.e., usage of histone deacetylases as therapeutic agents with an antidepressant effect and miRNAs or lncRNAs as markers of depression. Due to the noteworthy potential of the role of epigenetics in MDD diagnostics and therapy, we have gathered the most relevant data in this area.

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  1. [47]Booij L. Szyf M. Carballedo A. Frey E.-M. Morris D. Ly V. Fahey C. Meaney J. Gill M. Frodl T. The role of SLC6A4 DNA methylation in stress-related changes in hippocampal volume: A study in depressed patients and healthy controls Proceedings of the 29th CINP World Congress of Neuropsychopharmacology Vancouver, BC, Canada 22–26 June 2014

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Authors
Czarny, P., Białek, K., Ziółkowska, S., Strycharz, J., Barszczewska, G., & Sliwinski, T.
Affiliations
  • Medical University of Lodz (PL)
  • University of Łódź (PL)
  • Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland
Venue
Journal of Personalized Medicine
Publisher
MDPI AG
Published
2021-03-01
Volume
11
Issue
3
Pages
167
ISSN
2075-4426 (ISSN-L)
OpenAlex
W3135306269
Cited by
37
References
210
Citations by year
2026: 2 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 3
FWCI
0.71
Type
journal article
Language
en
Open access
Locations
  • Journal of Personalized Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
major depressive disorder, epigenetics, DNA methylation, histone modifications, microRNA, long non-coding RNA, histone deacetylase inhibitors, antidepressant treatment, depression biomarkers, depression diagnosis

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