Route of nicotine administration influences in vivo dopamine neuron activity: habituation, needle injection, and cannula infusion
Open accessAbstract
Mesolimbic dopamine (DA) systems play a critical role in tobacco addiction driven by nicotine. Nicotine activates midbrain DA neurons and, consequently, elevates DA concentrations in targets, especially in the nucleus accumbens (NAc) of the ventral striatum. The route of drug administration influences the impact of addictive drugs. Here, we examine whether the nature of the administration alters DA neuron activity and DA concentrations in the NAc. Using unhabituated naïve freely moving rats, microdialysis measurements showed that nicotine administered via needle injection caused greater DA release in the NAc than the same dose administered via an implanted chronic cannula. After habituation to the needle injections, however, there was no significant difference in DA signaling between the needle and cannula routes of administration. Consistent with these microdialysis results after habituation, our in vivo tetrode unit recordings showed no significant difference in midbrain DA neuron activity in response to nicotine delivered by needle or cannula as long as predictive cues were avoided
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Aversive stimuli result in increased DA in target areas.
“resulting in increased DA in target areas (Dong et al., 2010; Horvitz, 2000; Kienast et al., 2008).”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Dong et al., 2010
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- Authors
- Dong, Y., Zhang, T., Li, W., Doyon, W., & Dani, J. A.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Dani, John A.
- Venue
- Journal of Molecular Neuroscience
- Published
- 2009-08-28
- Volume
- 40
- Issue
- 1-2
- Pages
- 164-171
- ISSN
- 0895-8696 (ISSN-L)
- 1559-1166
- PMC
- PMC2891747
- OpenAlex
- W2163055705
- Cited by
- 23
- References
- 71
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Centers for Disease Control and Prevention
- National Institute on Drug Abuse (R01DA009411, DA009411)
- National Institute of Neurological Disorders and Stroke (NS021229, R37NS021229, R01NS021229)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, dopaminergic neurons, route of administration, needle injection, nucleus accumbens, mesolimbic dopamine system, tobacco dependence, habituation, dopamine release, midbrain dopaminergic neurons, predictive cues
- MeSH terms
- Action Potentials, Animals, Brain, Catheterization, Cues, Dopamine, Drug Administration Routes, Infusion Pumps, Injections, Male, Needles, Neurons, Nicotine, Nucleus Accumbens, Reward, Tobacco Use Disorder, Microdialysis, Ventral Tegmental Area, Nicotinic Agonists, Substance-Related Disorders, Rats, Long-Evans, Extracellular Fluid, Rats
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