Cited by 177Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

Dopamine in amygdala gates limbic processing of aversive stimuli in humans

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Kienast, Thorsten, Hariri, Ahmad R, Schlagenhauf, Florian, Wrase, Jana, Sterzer, Philipp, Buchholz, Hans Georg, Smolka, Michael N, Gründer, Gerhard +5 more·2008·Nature Neuroscience

Abstract

Dopamine is released under stress and modulates processing of aversive stimuli. We found that dopamine storage capacity in human amygdala, measured with 6-[(18)F]fluoro-L-DOPA positron emission tomography, was positively correlated with functional magnetic resonance imaging blood oxygen level-dependent signal changes in amygdala and dorsal anterior cingulate cortex that were evoked by aversive stimuli. Furthermore, functional connectivity between these two regions was inversely related to trait anxiety. Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament.

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Authors
Kienast, T., Hariri, A. R., Schlagenhauf, F., Wrase, J., Sterzer, P., Buchholz, H. G., Smolka, M. N., Gründer, G., Cumming, P., Kumakura, Y., Bartenstein, P., Dolan, R. J., & Heinz, A.
Affiliations
  • Stiftung Charité (DE)
  • University of Pittsburgh (US)
  • Johannes Gutenberg University Mainz (DE)
  • Technische Universität Dresden (DE)
  • RWTH Aachen University (DE)
  • Ludwig-Maximilians-Universität München (DE)
  • Research Center for Advanced Science and Technology, The University of Tokyo (JP)
  • Wellcome Centre for Human Neuroimaging (GB)
Corresponding author
Heinz, Andreas
Venue
Nature Neuroscience
Published
2008-11-02
Volume
11
Issue
12
Pages
1381-1382
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2060669801
Cited by
177
References
15
Citations by year
2026: 3 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 16 · 2013: 20 · 2012: 15
FWCI
6.63
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Max Planck Digital Library (submittedVersion, other-oa)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • Deutsche Forschungsgemeinschaft (HE 2597/4, HE 2597/4-3)
  • National Institutes of Health (MH072837)
  • National Institute of Mental Health (MH072837, K01MH072837)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dopamine, amygdala, aversive stimuli, trait anxiety, dorsal anterior cingulate cortex, functional connectivity, emotional processing, individual differences, BOLD signal
MeSH terms
Adult, Affect, Amygdala, Brain Mapping, Dihydroxyphenylalanine, Dopamine, Fluorine Radioisotopes, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Psychophysics, Positron-Emission Tomography

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