Dopamine in amygdala gates limbic processing of aversive stimuli in humans
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Dopamine is released under stress and modulates processing of aversive stimuli. We found that dopamine storage capacity in human amygdala, measured with 6-[(18)F]fluoro-L-DOPA positron emission tomography, was positively correlated with functional magnetic resonance imaging blood oxygen level-dependent signal changes in amygdala and dorsal anterior cingulate cortex that were evoked by aversive stimuli. Furthermore, functional connectivity between these two regions was inversely related to trait anxiety. Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament.
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Aversive stimuli result in increased DA in target areas.
“resulting in increased DA in target areas (Dong et al., 2010; Horvitz, 2000; Kienast et al., 2008).”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Kienast et al., 2008
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- Authors
- Kienast, T., Hariri, A. R., Schlagenhauf, F., Wrase, J., Sterzer, P., Buchholz, H. G., Smolka, M. N., Gründer, G., Cumming, P., Kumakura, Y., Bartenstein, P., Dolan, R. J., & Heinz, A.
- Affiliations
- Stiftung Charité (DE)
- University of Pittsburgh (US)
- Johannes Gutenberg University Mainz (DE)
- Technische Universität Dresden (DE)
- RWTH Aachen University (DE)
- Ludwig-Maximilians-Universität München (DE)
- Research Center for Advanced Science and Technology, The University of Tokyo (JP)
- Wellcome Centre for Human Neuroimaging (GB)
- Corresponding author
- Heinz, Andreas
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2008-11-02
- Volume
- 11
- Issue
- 12
- Pages
- 1381-1382
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2060669801
- Cited by
- 177
- References
- 15
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 16 · 2013: 20 · 2012: 15
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Deutsche Forschungsgemeinschaft (HE 2597/4, HE 2597/4-3)
- National Institutes of Health (MH072837)
- National Institute of Mental Health (MH072837, K01MH072837)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dopamine, amygdala, aversive stimuli, trait anxiety, dorsal anterior cingulate cortex, functional connectivity, emotional processing, individual differences, BOLD signal
- MeSH terms
- Adult, Affect, Amygdala, Brain Mapping, Dihydroxyphenylalanine, Dopamine, Fluorine Radioisotopes, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Psychophysics, Positron-Emission Tomography
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