Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning

Rosenkranz, J. Amiel; Grace, Anthony A.

doi:10.1038/417282a

Cited by 348Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning

Rosenkranz, J. Amiel, Grace, Anthony A.·2002·Nature

DOI 10.1038/417282a

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Abstract

Pavlovian conditioning results when an innocuous stimulus, such as an odour, is paired with a behaviourally relevant stimulus, such as a foot-shock, so that eventually the former stimulus alone will elicit the behavioural response of the latter. The lateral nucleus of the amygdala (LAT) is necessary for the emotional memory formation in this paradigm. Enhanced neuronal firing in LAT to conditioned stimuli emerge in parallel with the behavioural changes and are dependent on local dopamine. To study the changes in neuronal excitability and synaptic drive that contribute to the pavlovian conditioning process, here we used in vivo intracellular recordings to examine LAT neurons during pavlovian conditioning in rats. We found that repeated pairings of an odour with a foot-shock resulted in enhanced post-synaptic potential (PSP) responses to the odour and increased neuronal excitability. However, a non-paired odour displayed PSP decrement. The dopamine antagonist haloperidol blocked the PSP enhancement and associated increased neuronal excitability, without reversing previous conditioning. These results demonstrate that conditioning and habituation processes produce opposite effects on LAT neurons and that dopamine is important in these events, consistent with its role in emotional memory formation.

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Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning.
“Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning (8–18).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [9]
It is widely believed that LA plasticity underlying fear learning occurs as a result of a Hebbian mechanism whereby the shock US directly depolarizes LA pyramidal cells that are concurrently activated by weaker CS inputs, resulting in potentiation of the CS input synapses.
“It is widely believed that LA plasticity underlying fear learning occurs as a result of a Hebbian mechanism whereby the shock US directly depolarizes LA pyramidal cells that are concurrently activated by weaker CS inputs, resulting in potentiation of the CS input synapses (5, 6, 9, 31).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [9]
Dopamine is required for association between stimuli and aversive events in the amygdala.
“dopamine is required for association between stimuli and aversive events in the amygdala [69].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [69]

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Authors: Rosenkranz, J. A., & Grace, A. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: Rosenkranz, J. Amiel
ORCID: Rosenkranz, J. Amiel
Grace, Anthony A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-05
Volume: 417
Issue: 6886
Pages: 282-287
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/417282a
OpenAlex: W1979166255
Cited by: 348
References: 31
Citations by year: 2026: 10 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 19 · 2016: 6 · 2015: 19 · 2014: 25 · 2013: 13 · 2012: 15
FWCI: 11.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: dopamine, classical conditioning, lateral amygdala, emotional memory, neuronal excitability, synaptic drive, haloperidol, habituation, conditioned stimulus, footshock, synaptic potentiation
MeSH terms: Amygdala, Analysis of Variance, Anesthesia, Animals, Conditioning, Classical, Dopamine, Electroshock, Evoked Potentials, Somatosensory, Haloperidol, Male, Memory, Neurons, Odorants, Receptors, Dopamine, Smell, Rats, Sprague-Dawley, Dopamine Antagonists, Excitatory Postsynaptic Potentials, Rats

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Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning

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