Multi-Target Drug Candidates for Multifactorial Alzheimer’s Disease: AChE and NMDAR as Molecular Targets

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Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

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Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease

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Emerging Therapeutic Promise of Ketogenic Diet to Attenuate Neuropathological Alterations in Alzheimer’s Disease

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Exploring the Multifunctional Neuroprotective Promise of Rasagiline Derivatives for Multi-Dysfunctional Alzheimer’s Disease

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Neuroinflammation Signaling Modulated by ASS234, a Multitarget Small Molecule for Alzheimer’s Disease Therapy

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Novel conjugates of tacrine with 1,2,4,-thiadiazole as highly effective cholinesterase inhibitors, blockers of NMDA receptors, and antioxidants

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Autophagic Dysfunction in Type 2 Diabetes Mellitus: Pathophysiology and Therapeutic Implications

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Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

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Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010–2020)

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The recent development of donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's agents: highlights from 2010 to 2020

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Anti-Alzheimer’s Molecules Derived from Marine Life: Understanding Molecular Mechanisms and Therapeutic Potential

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Chalcone Derivatives with a High Potential as Multifunctional Antioxidant Neuroprotectors

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Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis

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The role of high mobility group box 1 in neuroinflammatory related diseases

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Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer’s Disease, a Potential Therapeutic Target

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Exploring the Role of Monoamine Oxidase Activity in Aging and Alzheimer’s Disease

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Proteomic alterations in the cerebellum and hippocampus in an Alzheimer’s disease mouse model: Alleviating effect of palmatine

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Mitochondrial Complex I and β-Amyloid Peptide Interplay in Alzheimer’s Disease: A Critical Review of New and Old Little Regarded Findings

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Exploration of Neuroprotective Properties of a Naturally Inspired Multifunctional Molecule (F24) against Oxidative Stress and Amyloid β Induced Neurotoxicity in Alzheimer’s Disease Models

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High-throughput optical assays for sensing serine hydrolases in living systems and their applications

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The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment

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The amplification of CNS damage in Alzheimer's disease due to SARS-CoV2 infection

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Quercetin-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer’s Agents

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CADMA-Chem: A Computational Protocol Based on Chemical Properties Aimed to Design Multifunctional Antioxidants

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Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties

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Linagliptin and Empagliflozin Inhibit Microtubule Affinity Regulatory Kinase 4: Repurposing Anti-Diabetic Drugs in Neurodegenerative Disorders Using In Silico and In Vitro Approaches

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Rational Design of Multifunctional Ferulic Acid Derivatives Aimed for Alzheimer’s and Parkinson’s Diseases

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Multi-combined QSAR, molecular docking, molecular dynamics simulation, and ADMET of Flavonoid derivatives as potent cholinesterase inhibitors

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Direct Evidence for Using Coriandrum sativum var. microcarpum Essential Oil to Ameliorate Scopolamine-Induced Memory Impairment and Brain Oxidative Stress in the Zebrafish Model

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Structural insights into gating mechanism and allosteric regulation of NMDA receptors

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Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways

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Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer’s disease

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Design, synthesis, and biological evaluation of novel donepezil-tacrine hybrids as multi-functional agents with low neurotoxicity against Alzheimer’s disease

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Amelioration of Amyloid‐β Induced Alzheimer's Disease by <i>Bacopa monnieri</i> through Modulation of Mitochondrial Dysfunction and GSK‐3β/Wnt/β‐Catenin Signaling

Sushma, Sahu, M. R., Murugan, N. A., & Mondal, A. C. (2024) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.202300245 · Cited by 17 · see citing works

In Silico and In Vitro Studies of Benzothiazole-Isothioureas Derivatives as a Multitarget Compound for Alzheimer’s Disease

Rosales‐Hernández, M. C., Morales, L. G. F., Correa‐Basurto, J., Valdez, M. O., Baez, E. V. G., Vázquez, D. G. R., García, A. P. A., & Cruz, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112945 · Cited by 17 · see citing works

Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery

Li, Y., Li, Y., Fang, X., Chen, D., Yu, W., & Zhu, Z. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1365448 · Cited by 17 · see citing works

Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders

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Multifunctional Anti-Alzheimer’s Disease Effects of Natural Xanthone Derivatives: A Primary Structure-Activity Evaluation

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Whole‐brain neural connectivity to cholinergic neurons in the nucleus basalis of Meynert

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Pharmacological implications of ipriflavone against environmental metal–induced neurodegeneration and dementia in rats

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Plexins: Navigating through the neural regulation and brain pathology

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The Potential Effect of Insulin on AChE and Its Interactions with Rivastigmine In Vitro

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Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer’s Diseases Pathways

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The therapeutic effect of Zhenbao pills on behavioral changes in zebrafish caused by aluminum chloride

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Unlocking the Potential of Oxymatrine: A Comprehensive Review of Its Neuroprotective Mechanisms and Therapeutic Prospects in Neurological Disorders

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Recent advances in potential enzymes and their therapeutic inhibitors for the treatment of Alzheimer's disease

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Evaluation of selected carotenoids of Lycopersicon esculentum variants as therapeutic targets for ‘Alzheimer’s disease: an in silico approach

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Multiadducts of C60 Modulate Amyloid-β Fibrillation with Dual Acetylcholinesterase Inhibition and Antioxidant Properties: In Vitro and In Silico Studies

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Multi-Target-Directed Ligand Approach in Anti-Alzheimer’s Drug Discovery

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Farnesyl Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking

Chen, T., Cai, C.-Y., Wang, L., Li, S., & Chen, L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.589780 · Cited by 7 · see citing works

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

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Homoplantaginin Antagonizes N -Methyl- d -aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity

Chen, T., Chen, Y., Hsu, M.-L., Liao, Y. J., Wu, C.-H., Yao, C., Yang, W., Lin, W., & Lin, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c07659 · Cited by 5 · see citing works

The photocatalytic journey of heteroatoms: Illuminating aza-Henry reactions in organic synthesis

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Co-Immobilized Capillary Enzyme Reactor Based on Beta-Secretase1 and Acetylcholinesterase: A Model for Dual-Ligand Screening

Vilela, A. F. L., dos Reis, V. E. N., & Cardoso, C. L. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.708374 · Cited by 5 · see citing works

Strategic Approaches to Target the Enzymes using Natural Compounds for the Management of Alzheimer’s Disease: A Review

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Molecular Characterization of Prunus lusitanica L. Fruit Extracts and Their Health-Promoting Potential in Inflammation, Diabetes, and Neurodegenerative Diseases

Abraão, A., Martins‐Gomes, C., Domínguez‐Perles, R., Barros, A., & Silva, A. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108830 · Cited by 4 · see citing works

A Novel Design of a Portable Birdcage via Meander Line Antenna (MLA) to Lower Beta Amyloid (Aβ) in Alzheimer’s Disease

Perez, F. P., Morisaki, J., Kanakri, H. M., Rizkalla, M., & Abdalla, A. (2025) · IEEE Journal of Translational Engineering in Health and Medicine · doi:10.1109/jtehm.2025.3559693 · Cited by 5 · see citing works

Enzyme inhibitory activity of marine alkaloid aaptamines for neurodegenerative diseases: an in silico study

Nguyen, T. L. A., Nguyen, H. L., Pham, T. M., Truong, D. H., Ngo, T. C., Li, M. S., & Dao, D. Q. (2025) · Royal Society Open Science · doi:10.1098/rsos.250697 · Cited by 3 · see citing works

Correlation of Neuroinflammation and Therapeutic Targets in Perioperative Neurocognitive Disorders

Khan, F., Verma, M., Rautela, I., Upadhye, V. J., Pandey, P., & Kumar, R. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010315764240920064245 · Cited by 3 · see citing works

Experimental and computational analyses of the anti-alzheimer and antidiabetic effects of flavonoid-rich extract of avocado seeds (Persea americana Mill.)

Ojo, O. A., Maduakolam-Aniobi, T. C., Gyebi, G. A., Soyinka, T. O., Ejiogu, O. F., Ojo, A. B., Alruwaili, M., Ali, N. H., Alnaaim, S. A., Alsfouk, B. A. A., et al. (2025) · Nutrire · doi:10.1186/s41110-025-00335-5 · Cited by 3 · see citing works

Paeonol Derivative, 6′-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer’s Disease Mice Model

Chen, P., Yao, C., Chien, P., Tsai, H.-J., Chen, Y., Chuang, J.-H., Chou, P.-L., Lee, G.-C., Lin, W., & Lin, Y. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00633 · Cited by 3 · see citing works

Special Issue “Advances in Drug Discovery and Synthesis”

Ciccone, L., & Nencetti, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020584 · Cited by 3 · see citing works

Solid lipid nanoparticles enhance piracetam’s neuroprotective action in streptozotocin-induced cognitive dysfunction

Mishra, A., Satapathy, B. S., & Sahu, P. K. (2026) · Discover Nano · doi:10.1186/s11671-026-04528-3 · Cited by 2 · see citing works

Triterpenoid cholinesterase inhibitors that might improve gait disturbances in Parkinson's disease patients

Heise, N. V., Schüler, J., Orlamünde, T. E., Brandes, B., Deigner, H., Al‐Harrasi, A., & Csük, R. (2022) · Mediterranean Journal of Chemistry · doi:10.13171/mjc02211021650csuk · Cited by 2 · see citing works

The discovery of subunit-selective GluN1/GluN2B NMDAR antagonist via pharmacophere-based virtual screening

Tang, J., Jin, J., Huang, Z., An, F., Huang, C., & Jiang, W. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231220666 · Cited by 2 · see citing works

Drug repurposing for Alzheimer's disease integrating transcriptome-wide association study and biological network analysis

Wang, X., Wang, M., Wang, H., Yin, G., & Zhang, Y. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251360009 · Cited by 3 · see citing works

Positive Effects of Walnut Meal Extracts on Memory Impairment of Alzheimer's Disease Mice Induced by D-GalactosePreprint

Lv, H., Chen, D., Xu, C., Ma, Y., Yang, J., Chen, C., & Zhao, S. (2021) · Research Square · doi:10.21203/rs.3.rs-209172/v1 · Cited by 2 · see citing works

Effectiveness of DBS as a treatment for Alzheimer’s disease: Meta-analysis

Mello, J. S., Bechara, G. I., & de Aguiar, P. H. P. (2025) · Deep Brain Stimulation · doi:10.1016/j.jdbs.2025.01.001 · Cited by 1 · see citing works

Case Report: Acute Psychiatric Behavioral Disturbance in a Patient with Presenilin 1 Gene Mutation Associated with Familial Alzheimer’s Disease

Xia, Y., Liu, X., Cui, W., Zhi, Q., & Sun, Y. (2025) · Neurology and Therapy · doi:10.1007/s40120-025-00787-x · Cited by 1 · see citing works

Treatment of Alzheimer's Disease: Contemporary Perspectives in Medicinal Chemistry

de Oliveira, A. S. (2022) · Current Medicinal Chemistry · doi:10.2174/092986733006221208094952 · Cited by 1 · see citing works

Treatment for alzheimer's disease: The present and future

Wei, C. (2021) · E3S Web of Conferences · doi:10.1051/e3sconf/202127103018

Molecular Insights into the Role of ER Stress in Neurodegenerative Diseases

Kabir, M. T. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_9

Mendelian Randomization Identified CHRNE as a Potential Drug Target for Alzheimer’s diseasePreprint

Li, M.-L., Yang, Y., Song, B., Yang, J., Fan, L., & Xu, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1940818/v1

Two new natural products from Portulaca oleracea L. and their bioactivities

Song, M., Ying, Z., Ying, X., Jia, L., & Yang, G. (2023) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2022-0197

O-demethyl Galantamine Alters Protein Expression in Cerebellum of 5xFAD Mice

Kiris, İ., Karayel‐Basar, M., Gürel, B., Mroczek, T., & Baykal, A. T. (2024) · TURKISH JOURNAL OF BIOLOGY · doi:10.55730/1300-0152.2692

Functional Proteins/Peptides Targeting to Clear Amyloid‐β for Alzheimer's Disease Therapy

Gao, Z., Hou, R., & Qian, C. (2025) · ChemBioChem · doi:10.1002/cbic.202400912

Combined Aluminum Chloride and Lead Acetate Exposure Induces Anxiety-like Behavior, Cognitive Impairment, and Cholinergic–Oxidative Dysregulation in Adult Zebrafish: Optimization of a Dementia-like Model

POPOVICI, L.-F., Rusu, A. S., Oancea, S., TĂUȘAN, I., Brinza, I., & Hriţcu, L. (2026) · Applied Sciences · doi:10.3390/app16042058

Zebrafish study provides evidence for Porphyromonas gingivalis outer membrane vesicles eliciting Alzheimer’s disease-like pathologies

Guo, J., Lin, K., Liang, R., Jiang, L., He, X., Chen, J., & Zheng, M. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1761068

Computationally driven design and validation of piperazine-bridged phthalimide derivatives as multifunctional agents against Alzheimer's disease

Devi, B., Jangid, K., Temgire, P., Kumar, N., Thareja, S., Kumar, P., & Kumar, V. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119417

Synthesis and Evaluation of Novel Cinnamic Acid Hybrids With Antiacetylcholinesterase, Antioxidant, and Anti‐Inflammatory Properties

Sdougkou, K., Rekka, E. A., & Papagiannopoulou, D. (2026) · ChemMedChem · doi:10.1002/cmdc.70343

Expanding Ayurvedic Pharmacology: Ecological, Quality Standards, and Environmental Health Implications of Medicinal Plant Drug Discovery

Dani, M., Khare, D. M. S., Namboothiri, K. P., Kulkarni, S. G., Pathan, S. Y., Kulkarni, V. G., & Patel, A. (2026) · Cureus · doi:10.7759/cureus.110701

Dual Cholinesterase Inhibition and Antimicrobial Activity of 4-Aminoantipyrine-Derived Schiff Bases for the Management of Alzheimer’s Disease and Microbial Infections

Dhiwar, P. S., Das, P. K., Panda, S., Prasad, P., Zambre, V. P., & Zanchi, F. B. (2026) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162025603726

Rational Design of Multifunctional Tacrine Derivatives as Candidates for the Treatment of Alzheimer and Parkinson Diseases

Dzib, E., Hernández‐Ayala, L. F., Silva‐Aguirre, S., & Galano, A. (2026) · ChemMedChem · doi:10.1002/cmdc.70429

Recent advances and future perspectives of fluorescent probes for serine hydrolases

Liu, C., Shi, R., Wu, M., Jiang, L., Yan, J., Zhang, H., Sun, Y., & Zhang, R. (2026) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2026.119101

Chinese herbal medicines in the treatment of noninfectious inflammatory diseases: Cholinergic mechanisms and therapeutic potential

Ming, S., Guo, P., Chen, F., Zhang, W., & Liu, X. (2026) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2026.08.003

Targeting the BACE1–GSK-3β Signaling Axis in Alzheimer’s Disease: From Molecular Crosstalk to Nanotechnology-Based Translational Strategies

Marimuthu, A., Singh, M. T., Balasubramanian, S., & Krishnamurthy, P. T. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06203-1

Neuroprotection Across Cerebellar and Nigrostriatal Degeneration: Translational Insights from Parkinson’s Disease to Spinocerebellar Ataxia Type 2

Fonseca-Fonseca, L. A., Fuentes, N. P., Outeiro, T. F., da Silva, V. D. A., Costa, S. L., Velázquez‐Pérez, L., & Núñez-Figueredo, Y. (2026) · The Cerebellum · doi:10.1007/s12311-026-02086-z

Garcinol-loaded PLGA nanoparticle-embedded chitosan–poloxamer-based thermoresponsive gel administered through nose-to-brain delivery ameliorated diabetes-induced cognitive dysfunction in rats: development, characterization, and efficacy validation

Mishra, A., Satapathy, B. S., & Sahu, P. K. (2026) · RSC Pharmaceutics · doi:10.1039/d6pm00478d

BindingDB Entry 50022427: Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties.

BindingDB (2025) · UC San Diego · doi:10.7270/q2g44w0m

BindingDB Entry 50017421: Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020).

BindingDB (2023) · UC San Diego · doi:10.7270/q2tb1bzk

Multi-target Design Strategies in the Context of Alzheimer’s Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces

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Designing Multi-Targeted Therapeutics for the Treatment of Alzheimer's Disease

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A molecular approach in drug development for Alzheimer’s disease

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