Cited by 142Musculoskeletal pain and rehabilitationOsteoarthritis Treatment and MechanismsResilience and Mental Health

Adaptation to Early Knee Osteoarthritis: The Role of Risk, Resilience, and Disease Severity on Pain and Physical Functioning

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Wright, Lisa Johnson, Zautra, Alex J., Going, Scott·2008·Annals of Behavioral Medicine

Abstract

BACKGROUND: Radiographic joint changes are used to diagnose osteoarthritis; however, they alone do not adequately predict who experiences symptoms. PURPOSE: To examine psychological risk and resilience factors in combination with an objective indicator of disease severity (knee X-rays) to determine what factors best account for pain and physical functioning in an early knee osteoarthritis (KOA) population. METHODS: Structural equation modeling was used to analyze data from 275 men and women with early KOA. RESULTS: Structural equation modeling yielded a fair to good fit of the data, suggesting that both risk and resilience were important in predicting pain and physical functioning over and above disease severity in the expected directions. Resilience's effect on pain was mediated through self-efficacy, suggesting that higher self-efficacy was linked to lower pain and better physical functioning. CONCLUSIONS: Results provide an integrative model of adjustment to early KOA and may be important to the prevention of disability in this population.

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  • Higher catastrophizing is related to enhanced fMRI responses to calibrated noxious stimuli in areas such as anterior insular cortex in both fibromyalgia patients and pain-free adults.

    “Higher levels of catastrophizing are related to enhanced fMRI responses to calibrated noxious stimuli in areas such as anterior insular cortex among both fibromyalgia patients 396, and pain-free adults 397.”
  • Other neuroimaging work has highlighted maladaptive activity or connectivity in the amygdala.

    “Other neuroimaging work has highlighted maladaptive activity or connectivity in the amygdala 396, 398, 399.”

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Authors
Wright, L. J., Zautra, A. J., & Going, S.
Affiliations
  • University of California San Diego (US)
  • Arizona State University (US)
  • University of Arizona (US)
Corresponding author
Wright, Lisa Johnson
Venue
Annals of Behavioral Medicine
Published
2008-08
Volume
36
Issue
1
Pages
70-80
ISSN
  • 0742-5554 (ISSN-L)
  • 0883-6612
  • 1532-4796
OpenAlex
W2169351650
Cited by
141
References
65
Citations by year
2026: 1 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 12 · 2016: 15 · 2015: 5 · 2014: 14 · 2013: 12 · 2012: 7
FWCI
2.81
Type
journal article
Language
en
Open access
Locations
  • Annals of Behavioral Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR047595)
Topics
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Keywords
knee osteoarthritis, early osteoarthritis, psychological adjustment, resilience, psychological risk factors, self-efficacy, pain, physical function, disease severity, knee radiographs, disability prevention
MeSH terms
Adaptation, Psychological, Adult, Affect, Depressive Disorder, Factor Analysis, Statistical, Female, Humans, Knee Joint, Male, Middle Aged, Models, Psychological, Radiography, Self-Assessment, Severity of Illness Index, Chi-Square Distribution, Cost of Illness, Pain Threshold, Risk Assessment, Osteoarthritis, Knee, Self Efficacy

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