Effects of Exercise on Gene Expression of Inflammatory Markers in Human Peripheral Blood Cells: A Systematic Review

Gjevestad, Gyrd O.; Holven, Kirsten B.; Ulven, Stine M.

doi:10.1007/s12170-015-0463-4

Cited by 102Exercise and Physiological ResponsesPhysical Activity and HealthCardiovascular and exercise physiology

Effects of Exercise on Gene Expression of Inflammatory Markers in Human Peripheral Blood Cells: A Systematic Review

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Gjevestad, Gyrd O., Holven, Kirsten B., Ulven, Stine M.·2015·Current Cardiovascular Risk Reports

DOI 10.1007/s12170-015-0463-4PMC PMC4439514

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Abstract

Regular physical activity seems to be one of the most important contributors to prevent disease and promote health. Being physically active reduces the risk of developing chronic diseases such as cardiovascular disease, diabetes, and some types of cancers. The molecular mechanisms are however not fully elucidated. Depending on duration and intensity, exercise will cause disruption of muscle fibers triggering a temporary inflammatory response. This response may not only involve the muscle tissue, but also peripheral tissues such as white blood cells, which are important components of the immune system. The immune system plays a vital role in the development of atherosclerosis, thereby making white blood cells relevant to study when looking at molecular mechanisms induced by physical activity. In this review, we summarize the existing literature on exercise and gene expression in human white blood cells, and discuss these results in relation to inflammation and atherosclerosis.

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Some forms of exercise are anti-inflammatory.
“Moreover, some forms of exercise are anti-inflammatory, and if repeated regularly over the lifespan, there is a lower morbidity and mortality from diseases with an immunological and inflammatory aetiology.”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Gjevestad et al. 2015
Data from chronic exercise training interventions in the young and elderly show an anti-inflammatory effect of exercise, but long-term changes to immune cell function and phenotype are less consistent.
“Data from these studies in the young and elderly show an anti-inflammatory effect of exercise, but long-term changes to immune cell function and phenotype are less consistent (Gjevestad et al. 2015; Gleeson et al. 2011; Kohut and Senchina 2004; Simpson et al. 2012).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Gjevestad et al. 2015

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Authors: Gjevestad, G. O., Holven, K. B., & Ulven, S. M.
Affiliations: University of Oslo (NO)
Oslo University Hospital (NO)
OsloMet – Oslo Metropolitan University (NO)
Corresponding author: Ulven, Stine M.
ORCID: Holven, Kirsten B.
Ulven, Stine M.
Venue: Current Cardiovascular Risk Reports
Publisher: Springer Science and Business Media LLC
Published: 2015-05-21
Volume: 9
Issue: 7
Pages: 34-34
ISSN: 1932-9520 (ISSN-L)
1932-9563
DOI: 10.1007/s12170-015-0463-4
PMC: PMC4439514
OpenAlex: W252343246
Cited by: 102
References: 79
Citations by year: 2026: 3 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 14 · 2019: 16 · 2018: 4 · 2017: 14 · 2016: 8 · 2015: 5
FWCI: 1.43
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Current Cardiovascular Risk Reports (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: physical activity, gene expression, inflammatory markers, leukocytes, peripheral blood cells, inflammation, atherosclerosis, chronic disease prevention, immune system

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Effects of Exercise on Gene Expression of Inflammatory Markers in Human Peripheral Blood Cells: A Systematic Review

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