Cited by 124Probiotics and Fermented FoodsGut microbiota and healthSteroid Chemistry and Biochemistry

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Bile Salt Hydrolase (Bsh) Activity Screening of Lactobacilli: In Vitro Selection of Indigenous Lactobacillus Strains with Potential Bile Salt Hydrolysing and Cholesterol-Lowering Ability

Kumar, Rajesh, Grover, Sunita, Batish, Virender Kumar·2012·Probiotics and Antimicrobial Proteins

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Abstract

The bile salt hydrolase (Bsh) activity of probiotic bacterium residing in gastrointestinal tract has often being associated with its cholesterol-lowering effects. Hence, Bsh activity was explored in this study as the criterion for the selection of most potential Bsh-active and cholesterol-lowering indigenous Lactobacillus strains. Forty lactobacilli were adjudged Bsh active after a preliminary screening of 102 lactobacilli and occurrence of Bsh activity correlated well with their natural habitats. Of the 40 shortlisted lactobacilli, fifteen putative Lactobacillus strains were selected and further tested for their comparative Bsh activity. In the end, indigenous Lactobacillus plantarum strains Lp91 and Lp21 were emerged as the promising Bsh-active lactobacilli with their substrate preference inclined more towards glycocholate than other bile acid amino conjugates. In addition, strains Lp91 and Lp21 also exhibited significantly high bile salt deconjugation, cholesterol assimilation and cholesterol co-precipitation ability in vitro. In conclusion, indigenous L. plantarum strains Lp91 and Lp21 may be the promising candidate probiotics to elucidate the ecological significance of probiotic Bsh activity in vivo.

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Authors: Kumar, R., Grover, S., & Batish, V. K.
Affiliations: National Dairy Research Institute (IN)
Corresponding author: Kumar, Rajesh
Batish, Virender Kumar
ORCID: Kumar, Rajesh
Grover, Sunita
Batish, Virender Kumar
Venue: Probiotics and Antimicrobial Proteins
Publisher: Springer Science and Business Media LLC
Published: 2012-04-21
Volume: 4
Issue: 3
Pages: 162-172
ISSN: 1867-1306 (ISSN-L)
1867-1314
DOI: 10.1007/s12602-012-9101-3
OpenAlex: W2081706251
Cited by: 123
References: 41
Citations by year: 2026: 16 · 2025: 17 · 2024: 15 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 1
FWCI: 9.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Probiotics and Antimicrobial Proteins (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Keywords: bile salt hydrolase, Lactobacillus plantarum, cholesterol-lowering effect, bile acid deconjugation, glycocholate, cholesterol assimilation, probiotic strain selection, indigenous lactic acid bacteria

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Bile Salt Hydrolase (Bsh) Activity Screening of Lactobacilli: In Vitro Selection of Indigenous Lactobacillus Strains with Potential Bile Salt Hydrolysing and Cholesterol-Lowering Ability

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