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Cited by 253

The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.

Advanced glycation End-products (AGEs): an emerging concern for processed food industries

Open access
Sharma, Chetan, Kaur, Amarjeet, Thind, S S, Singh, Baljit, Raina, Shiveta·2015·Journal of Food Science and Technology

Abstract

The global food industry is expected to increase more than US $ 7 trillion by 2014. This rise in processed food sector shows that more and more people are diverging towards modern processed foods. As modern diets are largely heat processed, they are more prone to contain high levels of advanced glycation end products (AGEs). AGEs are a group of complex and heterogeneous compounds which are known as brown and fluorescent cross-linking substances such as pentosidine, non-fluorescent cross-linking products such as methylglyoxal-lysine dimers (MOLD), or non-fluorescent, non-cross linking adducts such as carboxymethyllysine (CML) and pyrraline (a pyrrole aldehyde). The chemistry of the AGEs formation, absorption and bioavailability and their patho-biochemistry particularly in relation to different complications like diabetes and ageing discussed. The concept of AGEs receptor - RAGE is mentioned. AGEs contribute to a variety of microvascular and macrovascular complications through the formation of cross-links between molecules in the basement membrane of the extracellular matrix and by engaging the receptor for advanced glycation end products (RAGE). Different methods of detection and quantification along with types of agents used for the treatment of AGEs are reviewed. Generally, ELISA or LC-MS methods are used for analysis of foods and body fluids, however lack of universally established method highlighted. The inhibitory effect of bioactive components on AGEs by trapping variety of chemical moieties discussed. The emerging evidence about the adverse effects of AGEs makes it necessary to investigate the different therapies to inhibit AGEs.

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Metadata

Authors
Sharma, C., Kaur, A., Thind, S. S., Singh, B., & Raina, S.
Venue
Journal of Food Science and Technology
Published
2015-08-01
Volume
52
Issue
12
Pages
7561-7576
ISSN
  • 0022-1155 (ISSN-L)
  • 0975-8402
OpenAlex
W1087960405
Cited by
253
References
144
FWCI
5.47
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Advanced glycation End-products (AGEs): an emerging concern for processed food industries. https://app.cochat.ai/papers/10.1007/s13197-015-1851-y
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Sharma, C., Kaur, A., Thind, S. S., Singh, B., & Raina, S. (2015). Advanced glycation End-products (AGEs): an emerging concern for processed food industries. Journal of Food Science and Technology. https://doi.org/10.1007/s13197-015-1851-y

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