Hyperinsulinemia: A cause of obesity?

Erion, Karel A.; Corkey, Barbara E.

doi:10.1007/s13679-017-0261-z

Cited by 161Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Hyperinsulinemia: A cause of obesity?

Open access

Erion, Karel A., Corkey, Barbara E.·2017·Current Obesity Reports

DOI 10.1007/s13679-017-0261-zPMC PMC5487935

Open this paper in CoChat — free account Open PDF

Abstract

PURPOSE OF REVIEW: This perspective is motivated by the need to question dogma that does not work: that the problem is insulin resistance (IR). We highlight the need to investigate potential environmental obesogens and toxins. RECENT FINDINGS: The prequel to severe metabolic disease includes three interacting components that are abnormal: (a) IR, (b) elevated lipids and (c) elevated basal insulin (HI). HI is more common than IR and is a significant independent predictor of diabetes. We hypothesize that (1) the initiating defect is HI that increases nutrient consumption and hyperlipidemia (HL); (2) the cause of HI may include food additives, environmental obesogens or toxins that have entered our food supply since 1980; and (3) HI is sustained by HL derived from increased adipose mass and leads to IR. We suggest that HI and HL are early indicators of metabolic dysfunction and treating and reversing these abnormalities may prevent the development of more serious metabolic disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s13679-017-0261-z

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hyperinsulinemia has been proposed to be an early crucial driver in the progression of adiposity.
“In this regard, hyperinsulinemia has been proposed to be an early crucial driver in the progression of adiposity [265,266,267,268].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [267]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

‘Small Changes' to Diet and Physical Activity Behaviors for Weight Management
Hills, A. P., Byrne, N. M., Lindstrom, R. C., & Hill, J. O. (2013) · Obesity Facts · doi:10.1159/000345030 · Cited by 9,526 · see citing works
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works
Glycemic index of foods: a physiological basis for carbohydrate exchange
Jenkins, D. J., Wolever, T. M., Taylor, R. H., Barker, H., Fielden, H., Baldwin, J. M., Bowling, A. C., Newman, H. C., Jenkins, A. L., & Goff, D. V. (1981) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.3.362 · Cited by 3,857 · see citing works
Obesity and the Environment: Where Do We Go from Here?
Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180 · see citing works
Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans
Levine, J. A., Eberhardt, N. L., & Jensen, M. D. (1999) · Science · doi:10.1126/science.283.5399.212 · Cited by 997 · see citing works
β-Cell Glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes.
Robertson, R. P., Harmon, J., Tran, P. O. T., & Poitout, V. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s119 · Cited by 914 · see citing works
Insulin resistance and hypersecretion in obesity: European Group for the Study of Insulin Resistance (EGIR)
Ferrannini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N., & Mingrone, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119628 · Cited by 898 · see citing works
Fatty acids, obesity, and insulin resistance: Time for a reevaluation
Karpe, F., Dickmann, J. R., & Frayn, K. N. (2011) · Diabetes · doi:10.2337/db11-0425 · Cited by 896 · see citing works
Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance
Blüher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B., & Kahn, C. R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00199-5 · Cited by 806 · see citing works
Untitled work
(1922) · PubMed · Cited by 753 · see citing works
Persistent metabolic adaptation 6 years after “The Biggest Loser” competition
Fothergill, E., Guo, J., Howard, L., Kerns, J. C., Knuth, N. D., Brychta, R., Chen, K. Y., Skarulis, M. C., Walter, M., Walter, P. J., et al. (2016) · Obesity · doi:10.1002/oby.21538 · Cited by 672 · see citing works
What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes
McGarry, J. D. (1992) · Science · doi:10.1126/science.1439783 · Cited by 657 · see citing works
DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.
Ahrens, M., Ammerpohl, O., von Schönfels, W., Kolarova, J., Bens, S., Itzel, T., Teufel, A., Herrmann, A., Brosch, M., Hinrichsen, H., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.004 · Cited by 528 · see citing works
Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production
Mehran, A. E., Templeman, N. M., Brigidi, G. S., Lim, G. E., Chu, K.-Y., Hu, X., Botezelli, J. D., Asadi, A., Hoffman, B. G., Kieffer, T. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.019 · Cited by 498 · see citing works
Insulin resistance: the link between obesity and cardiovascular disease.
Reaven, G. (2011) · The Medical clinics of North America · doi:10.1016/j.mcna.2011.06.002 · Cited by 458 · see citing works
Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K+ Channels in Pancreatic β-Cells
Kieffer, T. J., Heller, R. S., Leech, C. A., Holz, G. G., & Habener, J. F. (1997) · Diabetes · doi:10.2337/diab.46.6.1087 · Cited by 392 · see citing works
EXTRACELLULAR THIOLS AND THIOL/DISULFIDE REDOX IN METABOLISM
Moriarty-Craige, S. E., & Jones, D. P. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132208 · Cited by 390 · see citing works
Decreased food intake does not completely account for adiposity reduction after ob protein infusion.
Levin, N. W., Nelson, C., Gurney, A., VANDLEN, R. L., & de Sauvage, F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1726 · Cited by 372 · see citing works
Pancreatic Extracts in The Treatment of Diabetes Mellitus
Banting, F., BEST, C. H., Collip, J. B., Campbell, W. R., & Fletcher, A. A. (1956) · Diabetes · doi:10.2337/diab.5.1.69 · Cited by 347 · see citing works
Role for neuronal insulin resistance in neurodegenerative diseases
Schubert, M., Gautam, D., Surjo, D., Ueki, K., Baudler, S., Schubert, D., Kondo, T., Alber, J., Galldiks, N., Kustermann, E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308724101 · Cited by 339 · see citing works
Insulin Signaling in the Central Nervous System
Porte, D., Baskin, D. G., & Schwartz, M. W. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1264 · Cited by 334 · see citing works
Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota
Pallejá, A., Kashani, A., Allin, K. H., Nielsen, T., Zhang, C., Li, Y., Brach, T., Liang, S., Feng, Q., Jørgensen, N. B., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0312-1 · Cited by 312 · see citing works
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
Wang, R.-H., Kim, H., Xiao, C., Xu, X., Gavrilova, O., & Deng, C. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46243 · Cited by 311 · see citing works
Plasma glucose, non-esterified fatty acid and insulin concentrations in hypothalamic-hyperphagic rats
Hales, C. N., & Gc, K. (1964) · Biochemical Journal · doi:10.1042/bj0900620 · Cited by 308 · see citing works
Octreotide Therapy of Pediatric Hypothalamic Obesity: A Double-Blind, Placebo-Controlled Trial
Lustig, R. H., Hinds, P. S., Ringwald-Smith, K., Christensen, R. K., Kaste, S. C., Schreiber, R. E., Rai, S. N., Lensing, S., Wu, S., & Xiong, X. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-030003 · Cited by 299 · see citing works
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.
Weyer, C., Hanson, R. L., Tataranni, P. A., Bogardus, C., & Pratley, R. E. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2094 · Cited by 296 · see citing works
Effects of a Low–Glycemic Load vs Low-Fat Diet in Obese Young Adults: A Randomized Trial
Ebbeling, C. B., Leidig, M. M., Feldman, H. A., Lovesky, M. M., & Ludwig, D. S. (2007) · JAMA · doi:10.1001/jama.297.19.2092 · Cited by 284 · see citing works
Mechanisms of Insulin Resistance in Humans and Possible Links With Inflammation
Savage, D. B., Petersen, K. F., & Shulman, G. I. (2005) · Hypertension · doi:10.1161/01.hyp.0000163475.04421.e4 · Cited by 284 · see citing works
Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children.
Odeleye, O. E., de Courten, M., Pettitt, D. J., & Ravussin, E. (1997) · Diabetes · doi:10.2337/diab.46.8.1341 · Cited by 273 · see citing works
Long-term effects of low glycemic index/load vs. high glycemic index/load diets on parameters of obesity and obesity-associated risks: a systematic review and meta-analysis
Schwingshackl, L., & Hoffmann, G. (2013) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.04.008 · Cited by 271 · see citing works
Central insulin action regulates peripheral glucose and fat metabolism in mice
Koch, L., Wunderlich, F. T., Seibler, J., Könner, A. C., Hampel, B., Irlenbusch, S., Brabant, G. E., Kahn, C. R., Schwenk, F., & Brüning, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31073 · Cited by 270 · see citing works
Insulin Receptor Knockout Mice
Kitamura, T., Kahn, C. R., & Accili, D. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142540 · Cited by 259 · see citing works
Hyperinsulinemia in african-american children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity.
Arslanian, S., Saad, R. J., Lewy, V., Danadian, K., & Janosky, J. (2002) · Diabetes · doi:10.2337/diabetes.51.10.3014 · Cited by 250 · see citing works
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
Klöckener, T., Heß, S., Belgardt, B., Paeger, L., Verhagen, L. A. W., Husch, A., Sohn, J., Hampel, B., Dhillon, H., Zigman, J. M., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2847 · Cited by 239 · see citing works
Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome
Gallagher, E. J., LeRoith, D., & Karnieli, E. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20212 · Cited by 236 · see citing works
Hedonic Hunger is Increased in Severely Obese Patients and is Reduced After Gastric Bypass Surgery
Schultes, B., Ernst, B., Wilms, B., Thurnheer, M., & Hallschmid, M. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29007 · Cited by 219 · see citing works
Increased Brain Fatty Acid Uptake in Metabolic Syndrome
Karmi, A., Iozzo, P., Viljanen, A. P. M., Hirvonen, J., Fielding, B. A., Virtanen, K. A., Oikonen, V., Kemppainen, J., Viljanen, T., Guiducci, L., et al. (2010) · Diabetes · doi:10.2337/db09-0138 · Cited by 204 · see citing works
Effect of liver fat on insulin clearance
Kotronen, A., Vehkavaara, S., Seppälä-Lindroos, A., Bergholm, R., & Yki-Järvinen, H. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00444.2007 · Cited by 202 · see citing works
Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes
Camastra, S., Gastaldelli, A., Mari, A., Bonuccelli, S., Scartabelli, G., Frascerra, S., Baldi, S., Nannipieri, M., Rebelos, E., Anselmino, M., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2193-6 · Cited by 196 · see citing works
CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age
Vogt, M. C., & Brüning, J. C. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.004 · Cited by 188 · see citing works
A causal role for hyperinsulinemia in obesity
Templeman, N. M., Skovsø, S., Page, M. M., Lim, G. E., & Johnson, J. D. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0449 · Cited by 168 · see citing works
ACTION OF INSULIN ON DEPOSITION OF GLYCOGEN AND STORAGE OF FAT IN ADIPOSE TISSUE
Renold, A. E., Marble, A., & Fawcett, D. W. (1950) · Endocrinology · doi:10.1210/endo-46-1-55 · Cited by 165 · see citing works
Hypothalamic obesity caused by cranial insult in children: Altered glucose and insulin dynamics and reversal by a somatostatin agonist
Lustig, R. H., Rose, S. R., Burghen, G. A., Velasquez‐Mieyer, P., Broome, D. C., Smith, K., Li, H., Hudson, M. M., Heideman, R. L., & Kun, L. E. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70017-x · Cited by 162 · see citing works
Fasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 diabetes.
Pfützner, A., Kunt, T., Hohberg, C., Mondok, A., Pahler, S., Konrad, T., Lübben, G., & Forst, T. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.682 · Cited by 162 · see citing works
Plasma insulin and triglyceride levels after hypothalamic lesions in weanling rats
Frohman, L. A., Bernardis, L. L., Schnatz, J. D., & BUREK, L. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.216.6.1496 · Cited by 160 · see citing works
Acute Postchallenge Hyperinsulinemia Predicts Weight Gain: A Prospective Study
Sigal, R. J., El-Hashimy, M., Martin, B. C., Soeldner, J. S., Królewski, A. S., & Warram, J. H. (1997) · Diabetes · doi:10.2337/diab.46.6.1025 · Cited by 153 · see citing works
Diabetes: Have We Got It All Wrong?
Pories, W. J., & Dohm, G. L. (2012) · Diabetes Care · doi:10.2337/dc12-0684 · Cited by 142 · see citing works
Dependence of Hypothalamic Obesity on Insulin, the Pituitary and the Adrenal Gland11
York, D. A., & Bray, G. A. (1972) · Endocrinology · doi:10.1210/endo-90-4-885 · Cited by 141 · see citing works
Effect of Obesity on Insulin Resistance in Normal Subjects and Patients With NIDDM
Ludvik, B. H., Nolan, J. J., Baloga, J., Sacks, D. A., & Olefsky, J. M. (1995) · Diabetes · doi:10.2337/diab.44.9.1121 · Cited by 138 · see citing works
Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.
Leroux, L., Desbois, P., Lamotte, L., Duvillié, B., Cordonnier, N., Jackerott, M., Jami, J., Bucchini, D., & Joshi, R. L. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s150 · Cited by 137 · see citing works
Correlation between Hyperinsulinemia and Hyperphagia in Rats with Ventromedial Hypothalamic Lesions
Hustvedt, B. E., & Lövö, A. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05152.x · Cited by 134 · see citing works
Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes
Laedtke, T., Kjems, L., Pørksen, N. K., Schmitz, O., Veldhuis, J. D., Kao, P. C., & Butler, P. C. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e520 · Cited by 133 · see citing works
Diabetes: Have We Got It All Wrong?
Corkey, B. E. (2012) · Diabetes Care · doi:10.2337/dc12-0825 · Cited by 130 · see citing works
Self-citation
Hyperinsulinemia in tube-fed hypophysectomized rats bearing hypothalamic lesions
Han, P., & La, F. (1970) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1970.219.6.1632 · Cited by 128 · see citing works
Effect of Insulin and Cortisone on Weight Gain, Protein and Fat Content of Rats
Hausberger, F. X., & Hausberger, B. C. (1958) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1958.193.3.455 · Cited by 128 · see citing works
Roux-en-Y Gastric Bypass Corrects Hyperinsulinemia Implications for the Remission of Type 2 Diabetes
Reed, M. A., Pories, W. J., Chapman, W. H. H., Pender, J. R., Bowden, R., Barakat, H. A., Gavin, T. P., Green, T., Tapscott, E., Zheng, D., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0165 · Cited by 114 · see citing works
Beneficial Effect of Diazoxide in Obese Hyperinsulinemic Adults1
Alemzadeh, R., Langley, G., Upchurch, L., Smith, P., & Slonim, A. E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4852 · Cited by 112 · see citing works
Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistance
Liu, H.-Y., Hong, T., Wen, G.-B., Han, J., Zuo, D., Liu, Z., & Cao, W. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00374.2009 · Cited by 111 · see citing works
A COMPARISON OF THE EFFECTS OF GROWTH HORMONE AND OF INSULIN ADMINISTRATION
Beaton, G. H., & CURRY, D. M. (1956) · Endocrinology · doi:10.1210/endo-58-6-797 · Cited by 104 · see citing works
Pharmacological Inhibition of PI3K Reduces Adiposity and Metabolic Syndrome in Obese Mice and Rhesus Monkeys
Ortega-Molina, A., Lopez-Guadamillas, E., Mattison, J. A., Mitchell, S. J., Muñoz‐Martín, M., Iglesias, G., Gutierrez, V. M., Vaughan, K. L., Szarowicz, M. D., González‐García, I., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.017 · Cited by 99 · see citing works
Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults
Velasquez‐Mieyer, P., Cowan, P. A., Arheart, K. L., Buffington, C. K., Spencer, K., Connelly, B. E., Cowan, G., & Lustig, R. H. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.802227 · Cited by 98 · see citing works
Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity
Templeman, N. M., Clee, S. M., & Johnson, J. D. (2015) · Diabetologia · doi:10.1007/s00125-015-3676-7 · Cited by 94 · see citing works
Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling
Gray, S. L., Donald, C., Jetha, A., Covey, S. D., & Kieffer, T. J. (2010) · Endocrinology · doi:10.1210/en.2010-0102 · Cited by 92 · see citing works
Predictors of weight change in a bi-ethnic population. The San Antonio Heart Study.
Valdez, R. A., Mitchell, B. D., Haffner, S. M., Hazuda, H. P., Morales, P. A., Monterrosa, A., & D, M. P. S. M. (1994) · PubMed · Cited by 88 · see citing works
Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells
Laubner, K., Kieffer, T. J., Lam, N. T., Niu, X., Jakob, F., & Seufert, J. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3410 · Cited by 85 · see citing works
Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward
Williams, K. J., & Wu, X. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.004 · Cited by 81 · see citing works
Metabolic differences between Caucasian and African-American children and the relationship to type 2 diabetes mellitus.
Arslanian, S. A. (2002) · PubMed · Cited by 76 · see citing works
Energy Expenditure Responses to Fasting and Overfeeding Identify Phenotypes Associated With Weight Change
Schlögl, M., Piaggi, P., Pannacciulli, N., Bonfiglio, S. M., Krakoff, J. A., & Thearle, M. S. (2015) · Diabetes · doi:10.2337/db15-0382 · Cited by 73 · see citing works
Modification of insulin resistance by diazoxide in obese Zucker rats
Alemzadeh, R., Slonim, A. E., Zdanowicz, M. M., & Maturo, J. M. (1993) · Endocrinology · doi:10.1210/endo.133.2.8344209 · Cited by 72 · see citing works
Antiobesity effect of diazoxide in obese zucker rats
Alemzadeh, R., Jacobs, W., & Pitukcheewanont, P. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90287-5 · Cited by 70 · see citing works
Long-term effects of dietary glycemic index on adiposity, energy metabolism, and physical activity in mice
Scribner, K. B., Pawlak, D. B., Aubin, C. M., Majzoub, J. A., & Ludwig, D. S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90487.2008 · Cited by 66 · see citing works
Insulinemia in Children at Low and High Risk of NIDDM
Pettitt, D. J., Moll, P. P., Knowler, W. C., et al. (1993) · Diabetes Care · doi:10.2337/diacare.16.4.608 · Cited by 63 · see citing works
Redox-regulating role of insulin: The essence of insulin effect
Wang, X., Tao, L., & Hai, C. X. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.019 · Cited by 60 · see citing works
Reprogramming of defended body weight after R oux‐En‐ Y gastric bypass surgery in diet‐induced obese mice
Zheng, H., Mumphrey, M. B., Townsend, R. L., Morrison, C. D., Münzberg, H., Ye, J., & Berthoud, H. (2016) · Obesity · doi:10.1002/oby.21400 · Cited by 57 · see citing works
Hypertriglyceridemia is associated with increased insulin resistance in subjects with normal glucose tolerance: Evaluation in a large cohort of subjects assessed with the 1999 World Health Organization criteria for the classification of diabetes
Moro, E., Gallina, P., Pais, M., Cazzolato, G., Alessandrini, P., & Bittolo-Bon, G. (2003) · Metabolism · doi:10.1053/meta.2003.50102 · Cited by 53 · see citing works
Dietary Fat Is Shunted Away from Oxidation, Toward Storage in Obese Zucker Rats
Bessesen, D. H., Rupp, C. L., & Eckel, R. H. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00134.x · Cited by 52 · see citing works
Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells
Erion, K., Berdan, C. A., Burritt, N. E., Corkey, B. E., & Deeney, J. T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.620351 · Cited by 52 · see citing works
Self-citation
Food intake in hypothalamic obesity
Goldman, J. K., Bernardis, L. L., & La, F. (1974) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1974.227.1.88 · Cited by 49 · see citing works
Both Fasting and Glucose-Stimulated Proinsulin Levels Predict Hyperglycemia and Incident Type 2 Diabetes: A Population-Based Study of 9,396 Finnish Men
Vangipurapu, J., Stančáková, A., Kuulasmaa, T., Kuusisto, J., & Laakso, M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124028 · Cited by 46 · see citing works
The Extracellular Redox State Modulates Mitochondrial Function, Gluconeogenesis, and Glycogen Synthesis in Murine Hepatocytes
Nocito, L., Kleckner, A. S., Yoo, E. J., Jones, A. R., Liesa, M., & Corkey, B. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122818 · Cited by 44 · see citing works
Self-citation
Relationship of insulin dynamics to body composition and resting energy expenditure following weight loss: Insulin, Body Composition, and Energy Expenditure
Hron, B. M., Ebbeling, C. B., Feldman, H. A., & Ludwig, D. S. (2015) · Obesity · doi:10.1002/oby.21213 · Cited by 42 · see citing works
EFFECT OF INSULIN ON GROWTH IN FORCE-FED HYPOPHYSECTOMIZED RATS
Wagner, E. M., & Scow, R. O. (1957) · Endocrinology · doi:10.1210/endo-61-4-419 · Cited by 41 · see citing works
Metabolic master regulators: sharing information among multiple systems
Corkey, B. E., & Shirihai, O. S. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.07.006 · Cited by 38 · see citing works
Self-citation
Insulin and insulin signaling play a critical role in fat induction of insulin resistance in mouse
Ning, J., Hong, T., Yang, X., Mei, S., Liu, Z., Liu, H.-Y., & Cao, W. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00164.2011 · Cited by 37 · see citing works
Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lepob/ob mice
D'souza, A. M., Johnson, J. D., Clee, S. M., & Kieffer, T. J. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.09.007 · Cited by 37 · see citing works
Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice
Isken, F., Weickert, M. O., Tschöp, M. H., Nogueiras, R., Möhlig, M., Abdelrahman, A., Klaus, S., Thorens, B., & Pfeiffer, A. F. (2009) · Diabetologia · doi:10.1007/s00125-009-1466-9 · Cited by 36 · see citing works
Can Weight Gain in Healthy, Nonobese Volunteers Be Predicted by Differences in Baseline Plasma Insulin Concentration?1
Zavaroni, I., Zuccarelli, A., Gasparini, P., Massironi, P., Barilli, A. L., & Reaven, G. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5178 · Cited by 33 · see citing works
Fasting Plasma Insulin at 5 Years of Age Predicted Subsequent Weight Increase in Early Childhood over a 5-Year Period—The Da Qing Children Cohort Study
Chen, Y., Wang, J. P., Jiang, Y. Y., Li, H., Hu, Y., Lee, K., & Li, G. W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127389 · Cited by 30 · see citing works
Extracellular Redox Regulation of Intracellular Reactive Oxygen Generation, Mitochondrial Function and Lipid Turnover in Cultured Human Adipocytes
Jones, A. R., Meshulam, T., de Oliveira, M. F., Burritt, N. E., & Corkey, B. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164011 · Cited by 30 · see citing works
Self-citation
DIABETES MELLITUS AMONG INDIANS OF THE AMERICAN SOUTHWEST: ITS PREVALENCE AND CLINICAL CHARACTERISTICS IN A HOSPITALIZED POPULATION
COHEN, B. M. (1954) · Annals of Internal Medicine · doi:10.7326/0003-4819-40-3-588 · Cited by 28 · see citing works
Regulation of body weight: What is the regulated parameter?
Bessesen, D. H. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.05.006 · Cited by 27 · see citing works
Twenty-four hour insulin secretion and beta cell NEFA oxidation in type 2 diabetic, morbidly obese patients before and after bariatric surgery
Salinari, S., BERTUZZI, A., Iaconelli, A., Manco, M., & Mingrone, G. (2008) · Diabetologia · doi:10.1007/s00125-008-1007-y · Cited by 26 · see citing works
Hyperinsulinism in obese diabetic Pima Indians
GENUTH, S. M., Bennett, P. H., Miller, M., & Burch, T. A. (1967) · Metabolism · doi:10.1016/0026-0495(67)90094-7 · Cited by 26 · see citing works
The LoxP/CRE System and Genome Modification
Wilson, T. J., & Kola, I. (2003) · Humana Press eBooks · doi:10.1385/1-59259-220-1:83 · Cited by 25 · see citing works
No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8‐week weight‐loss diet
Due, A., Flint, A., Eriksen, G., Møller, B., Raben, A., Hansen, J. B., & Astrup, A. V. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00645.x · Cited by 25 · see citing works
Hyperproinsulinemia and Proinsulin-to-Insulin Ratios in Swedish Middle-aged Men: Association with Glycemia and Insulin Resistance but Not with Family History of Diabetes
Grill, V. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.9.834 · Cited by 22 · see citing works
The Obese Brain—Effects of Bariatric Surgery on Energy Balance Neurocircuitry
Júnior, J. C. D. L., Velloso, L. A., & Geloneze, B. (2015) · Current Atherosclerosis Reports · doi:10.1007/s11883-015-0536-3 · Cited by 21 · see citing works
Hyperinsulinemia and its role in maintaining the hypothalamic hyperphagia in chickens
Sonoda, T. (1983) · Physiology & Behavior · doi:10.1016/0031-9384(83)90133-6 · Cited by 21 · see citing works
Effect of vagotomy on hyperinsulinemia in obese rats with hypothalamic lesions.
CHIKAMORI, K., Masuda, A., IZUMI, H., ISAKA, K., & TEZUKA, U. (1977) · Endocrinologia Japonica · doi:10.1507/endocrj1954.24.251 · Cited by 20 · see citing works
Early development of lipogenesis in genetically obese (ob/ob) mice
Godbole, V. Y., Grundleger, M. L., & Thenen, S. W. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.239.4.e265 · Cited by 18 · see citing works
Hyperalimentation in Normal Animals Produced by Protamine Insulin
MacKay, E. M., & Callaway, J. W. (1937) · Experimental Biology and Medicine · doi:10.3181/00379727-36-9248p · Cited by 6 · see citing works
Effects of a Diazoxide inhibition of insulin release on food intake of normal and hyperphagic hypothalamic rats
Larue‐Achagiotis, C., & Magnen, J. L. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90345-3 · Cited by 5 · see citing works

Flagged first, then by citations

Sorted by citations

The carbohydrate-insulin model: A physiological perspective on the obesity pandemic
Ludwig, D. S., Aronne, L. J., Astrup, A., de Cabo, R., Cantley, L. C., Friedman, M. I., Heymsfield, S. B., Johnson, J. D., King, J. C., Krauss, R. M., et al. (2021) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab270 · Cited by 292 · see citing works
The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
Mild suppression of hyperinsulinemia to treat obesity and insulin resistance
Page, M. M., & Johnson, J. D. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.03.018 · Cited by 99 · see citing works
Towards a comprehensive theory of obesity and a healthy diet: The causal role of oxidative stress in food addiction and obesity
Tobore, T. O. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112560 · Cited by 73 · see citing works
Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
Zhang, F., Chen, Z., Wu, D., Tian, L., Chen, Q., Ye, Y., Chen, W., Wu, X., Wu, P., Yuan, W., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103382 · Cited by 54 · see citing works

Authors: Erion, K. A., & Corkey, B. E.
Affiliations: Boston University (US)
Corresponding author: Corkey, Barbara E.
ORCID: Erion, Karel A.
Corkey, Barbara E.
Venue: Current Obesity Reports
Publisher: Springer Science and Business Media LLC
Published: 2017-05-02
Volume: 6
Issue: 2
Pages: 178-186
ISSN: 2162-4968 (ISSN-L)
DOI: 10.1007/s13679-017-0261-z
PMC: PMC5487935
OpenAlex: W2611024481
Cited by: 161
References: 102
Citations by year: 2026: 8 · 2025: 14 · 2024: 10 · 2023: 27 · 2022: 26 · 2021: 27 · 2020: 23 · 2019: 15 · 2018: 9 · 2017: 2
FWCI: 1.78
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Current Obesity Reports (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: hyperinsulinemia, obesity, insulin resistance, hyperlipidemia, obesogens, food additives, environmental toxins, metabolic dysfunction, diabetes mellitus, adipose tissue, lipid metabolism
MeSH terms: Animals, Energy Intake, Eating, Humans, Hyperinsulinism, Hyperlipidemias, Insulin, Insulin Resistance, Lipids, Obesity, Risk Factors, Time Factors, Biomarkers, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hyperinsulinemia: A cause of obesity?

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks