Cited by 83Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorAlcohol Consumption and Health Effects

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Pharmacological Approaches to Reducing Craving in Patients with Alcohol Use Disorders

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Haass-Koffler, Carolina L., Leggio, Lorenzo, Kenna, George A.·2014·CNS Drugs

DOI 10.1007/s40263-014-0149-3PMC PMC3990000

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Abstract

Research on the concept of craving may lead to better understanding of the biobehavioural circuitries that contribute to the complexity of alcohol use disorders (AUDs). The experiences described as craving or desire to drink are often associated with physical responses such as increased salivation and heart rate, and alteration of stress hormones, as well as psychological responses such as anxiety and depression. Greater craving has been associated with an increased probability of alcohol relapse. Reversal of craving, which is understood as a symptom of protracted abstinence, offers the possibility of preventing relapses and treating alcoholism. Various medications have been studied to establish whether they are able to reduce craving; however, the results obtained from clinical studies have been inconsistent. Here, we review the interdisciplinary models developed to evaluate craving, then the different approaches used to assess and measure craving and, finally, the medications utilized and tested to lessen craving in patients suffering from AUDs.

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The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
Prevalence and Co-occurrence of Substance Use Disorders and IndependentMood and Anxiety Disorders: Results From the National Epidemiologic Survey on Alcohol and RelatedConditions
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.807 · Cited by 2,889
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Executive functions and self-regulation
Hofmann, W., Schmeichel, B. J., & Baddeley, A. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.006 · Cited by 1,965
Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence: The COMBINE Study: A Randomized Controlled Trial
Anton, R. F., O’Malley, S. S., Ciraulo, D. A., Cisler, R. A., Couper, D., Donovan, D. M., Gastfriend, D. R., Hosking, J. D., Johnson, B. A., LoCastro, J. S., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2003 · Cited by 1,930
Naltrexone in the Treatment of Alcohol Dependence
Volpicelli, J. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820110040006 · Cited by 1,828
"A Controlled Study"
Davis, H. S. (1966) · JAMA · doi:10.1001/jama.1966.03100200106038 · Cited by 1,719
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615
A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes
Tiffany, S. T. (1990) · Psychological Review · doi:10.1037/0033-295x.97.2.147 · Cited by 1,554
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513
Naltrexone and Coping Skills Therapy for Alcohol Dependence
O’Malley, S. S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820110045007 · Cited by 1,476
Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons
Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,448
Bacchus by Caravaggio as the Visual Diagnosis of Alcohol Use Disorder from the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)
Haass-Koffler, C., & Kenna, G. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00086 · Cited by 1,126
Self-citation
Imaginary Relish and Exquisite Torture: The Elaborated Intrusion Theory of Desire.
Kavanagh, D. J., Andrade, J., & May, J. (2005) · Psychological Review · doi:10.1037/0033-295x.112.2.446 · Cited by 956
Types of Alcoholics, I
Babor, T. F. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080007002 · Cited by 903
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants
Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., & Van Tol, H. H. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031157.x · Cited by 858
Psychometric properties of the Penn Alcohol Craving Scale
Flannery, B. A., Volpicelli, J. R., & Pettinati, H. M. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04349.x · Cited by 852
Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice
Rhodes, J. S., Best, K., Belknap, J. K., Finn, D. A., & Crabbe, J. C. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.10.007 · Cited by 820
Drug Addiction as a Pathology of Staged Neuroplasticity
Kalivas, P. W., & O’Brien, C. P. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301564 · Cited by 761
Oral topiramate for treatment of alcohol dependence: A randomised controlled trial
Johnson, B. A., Ait-Daoud, N., Bowden, C. L., DiClemente, C. C., Roache, J. D., Lawson, K., Javors, M. A., & Ma, J. Z. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13370-3 · Cited by 743
Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study
Addolorato, G., Leggio, L., Ferrulli, A., Cardone, S., Vonghia, L., Mirijello, A., Abenavoli, L., D’Angelo, C., Caputo, F., Zambon, A., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61814-5 · Cited by 683
Self-citation
The Obsessive Compulsive Drinking Scale: A Self‐Rated Instrument for the Quantification of Thoughts about Alcohol and Drinking Behavior
Anton, R. F., Moak, D. H., & Latham, P. K. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01475.x · Cited by 679
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission
Kalivas, P. W., Volkow, N., & Seamans, J. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.005 · Cited by 657
Development and Initial Validation of a Measure of Drinking Urges in Abstinent Alcoholics
Bohn, M. J., Krahn, D. D., & Staehler, B. A. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01554.x · Cited by 641
Naltrexone in the Treatment of Alcohol Dependence
Krystal, J. H., Cramer, J. A., Krol, W. F., Kirk, G. F., & Rosenheck, R. A. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011127 · Cited by 618
Neural Mechanisms of Drug Reinforcementa
Koob, G. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25966.x · Cited by 607
Implicit cognition and addiction: a tool for explaining paradoxical behavior
Stacy, A. W., & Wiers, R. W. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131444 · Cited by 607
A meta-analytic investigation of the relationship between attentional bias and subjective craving in substance abuse
Field, M., Munafò, M. R., & Franken, I. H. A. (2009) · Psychological Bulletin · doi:10.1037/a0015843 · Cited by 602
Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics
Gr�sser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., Weber-Fahr, W., Flor, H., Mann, K., Braus, D. F., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1828-4 · Cited by 598
The neurobiology of craving: Implications for the understanding and treatment of addiction.
Wise, R. A. (1988) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.97.2.118 · Cited by 577
A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients
Oslin, D. W., Berrettini, W., Kranzler, H. R., Pettinati, H., Gelernter, J., Volpicelli, J. R., & O'Brien, C. P. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300219 · Cited by 571
Topiramate for Treating Alcohol Dependence<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Johnson, B. A. (2007) · JAMA · doi:10.1001/jama.298.14.1641 · Cited by 542
Differential Brain Activity in Alcoholics and Social Drinkers to Alcohol Cues: Relationship to Craving
Myrick, H., Anton, R. F., Li, X., Henderson, S., Drobes, D., Voronin, K., & George, M. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300295 · Cited by 521
The Obsessive Compulsive Drinking Scale
Anton, R. F. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830030047008 · Cited by 514
Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications
SINHA, R., & LI, C. ‐. R. (2007) · Drug and Alcohol Review · doi:10.1080/09595230601036960 · Cited by 497
Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis
O’Malley, S. S., Krishnan‐Sarin, S., Farren, C. K., Sinha, R., & Kreek, M. J. (2002) · Psychopharmacology · doi:10.1007/s002130100919 · Cited by 492
Extending the Treatment Options in Alcohol Dependence: A Randomized Controlled Study of As-Needed Nalmefene
Mann, K. F., Bladström, A., Torup, L., Gual, A., & van den Brink, W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.020 · Cited by 486
Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & al, E. (1997) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.106.2.243 · Cited by 479
BACLOFEN EFFICACY IN REDUCING ALCOHOL CRAVING AND INTAKE: A PRELIMINARY DOUBLE-BLIND RANDOMIZED CONTROLLED STUDY
Addolorato, G. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.5.504 · Cited by 479
Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & Gaupp, L. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.2.243 · Cited by 479
Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals
Sinha, R., Fox, H. C., Hong, K. A., Bergquist, K., Bhagwagar, Z., & Siedlarz, K. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.78 · Cited by 466
An Evaluation of μ-Opioid Receptor (OPRM1) as a Predictor of Naltrexone Response in the Treatment of Alcohol Dependence: Results From the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study
Anton, R. F., Oroszi, G., O’Malley, S., Couper, D., Swift, R., Pettinati, H., & Goldman, D. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.2.135 · Cited by 451
The dopamine D4 receptor: one decade of research
Oak, J. N., Oldenhof, J., & Tol, H. H. M. V. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00562-8 · Cited by 421
Naltrexone and Cognitive Behavioral Therapy for the Treatment of Outpatient Alcoholics: Results of a Placebo-Controlled Trial
Anton, R. F., Moak, D. H., Waid, L. R., Latham, P. K., Malcolm, R. J., & Dias, J. K. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1758 · Cited by 421
A three-pathway psychobiological model of craving for alcohol.
Verheul, R., van den Brink, W., & Geerlings, P. J. (1999) · Alcohol and Alcoholism · doi:10.1093/alcalc/34.2.197 · Cited by 415
Ondansetron for Reduction of Drinking Among Biologically Predisposed Alcoholic Patients
Johnson, B. A., Roache, J. D., Javors, M. A., DiClemente, C. C., Cloninger, C. R., Prihoda, T. J., Bordnick, P. S., Ait‐Daoud, N., & Hensler, J. (2000) · JAMA · doi:10.1001/jama.284.8.963 · Cited by 415
Correlation Between Dopamine D2 Receptors in the Ventral Striatum and Central Processing of Alcohol Cues and Craving
Heinz, A., Siessmeier, T., Wrase, J., Hermann, D., Klein, S., Grüsser-Sinopoli, S. M., Flor, H., Braus, D. F., Buchholz, H. G., Gründer, G., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1783 · Cited by 408
The Status of Disulfiram: A Half of a Century Later
Suh, J. J., Pettinati, H. M., Kampman, K. M., & O'Brien, C. P. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000222512.25649.08 · Cited by 382
Pharmacological treatment of alcohol dependence: Target symptoms and target mechanisms
Heilig, M. A., & Egli, M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.02.001 · Cited by 382
Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking
Steensland, P., Simms, J. A., Holgate, J. Y., Richards, J. K., & Bartlett, S. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705368104 · Cited by 368
The Efficacy of Acamprosate in the Maintenance of Abstinence in Alcohol‐Dependent Individuals: Results of a Meta‐Analysis
Mann, K. F., Lehert, P., & Morgan, M. Y. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000108656.81563.05 · Cited by 363
A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use
Chiara, G. D. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200108 · Cited by 352
Serotonin and alcohol intake, abuse, and dependence: Clinical evidence
LeMarquand, D. G., Pihl, R. O., & Benkelfat, C. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90630-0 · Cited by 331
Identifying the neural circuitry of alcohol craving and relapse vulnerability
Heinz, A., Beck, A., Grüsser, S. M., Grace, A. A., & Wrase, J. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00136.x · Cited by 326
How placebo responses are formed: a learning perspective
Colloca, L., & Miller, F. G. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0398 · Cited by 323
Stress‐Induced and Alcohol Cue‐Induced Craving in Recently Abstinent Alcohol‐Dependent Individuals
Fox, H. C., Bergquist, K. L., Hong, K., & Sinha, R. (2007) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00320.x · Cited by 315
A MULTICENTRE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF NALTREXONE IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ABUSE
Chick, J. (2000) · Alcohol and Alcoholism · doi:10.1093/alcalc/35.6.587 · Cited by 310
Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers
McKee, S. A., Harrison, E. L. R., O’Malley, S. S., Krishnan‐Sarin, S., Shi, J. M., Tetrault, J. M., Picciotto, M. R., Petrakis, I. L., Estevez, N., & Balchunas, E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.029 · Cited by 307
Efficacy and Safety of Baclofen for Alcohol Dependence: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Garbutt, J. C., Kampov‐Polevoy, A. B., Gallop, R., Kalka-Juhl, L. S., & Flannery, B. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01273.x · Cited by 290
What is craving? Models and implications for treatment.
Anton, R. F. (1999) · PubMed Central · Cited by 289
A Double-Blind, Placebo-Controlled Trial Assessing the Efficacy of Varenicline Tartrate for Alcohol Dependence
Litten, R. Z., Ryan, M. L., Fertig, J. B., Falk, D. E., Johnson, B., Dunn, K. E., Green, A. I., Pettinati, H. M., Ciraulo, D. A., Sarid-Segal, O., et al. (2013) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e31829623f4 · Cited by 287
Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving rats
Chiara, G. D., & Impérato, A. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90598-9 · Cited by 287
Assessing the Clinical Significance of Single Items Relative to Summated Scores
Sloan, J. A., Aaronson, N. K., Cappelleri, J. C., Fairclough, D. L., & Varricchio, C. G. (2002) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)62218-0 · Cited by 275
Induction of smoking urge through imaginal and in vivo procedures: Physiological and self-report manifestations.
Drobes, D. J., & Tiffany, S. T. (1997) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.106.1.15 · Cited by 275
DOUBLE-BLIND RANDOMIZED MULTICENTRE TRIAL OF ACAMPROSATE IN MAINTAINING ABSTINENCE FROM ALCOHOL
Paillé, F., Guelfi, J., Perkins, A. C., Royer, R., Stéru, L., & Parot, P. (1995) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045720 · Cited by 274
The validity of the reinstatement model of craving and relapse to drug use
Katz, J. L., & Higgins, S. T. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1441-y · Cited by 273
Effect of naltrexone and ondansetron on alcohol cue–induced activation of the ventral striatum in alcohol-dependent people
Myrick, H., Anton, R. F., Li, X., Henderson, S., Randall, P. K., & Voronin, K. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.466 · Cited by 258
Effects of Naltrexone on Alcohol Sensitivity and Genetic Moderators of Medication Response: A Double-blind Placebo-Controlled Study
Ray, L. A., & Hutchison, K. E. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.9.1069 · Cited by 258
The Effects of Clozapine on Alcohol and Drug Use Disorders Among Patients With Schizophrenia
Drake, R. E., Xie, H., McHugo, G. J., & Green, A. I. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033464 · Cited by 253
Stress Enhancement of Craving During Sobriety: A Risk for Relapse
Breese, G. R., Chu, K., Dayas, C. V., Funk, D. R., Knapp, D. J., Koob, G. F., Lê, A. D., Dell, L. E. O., Overstreet, D. H., Roberts, A. J., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000153544.83656.3c · Cited by 251
Neuroscience, Clinical Evidence, and the Future of Psychiatric Classification in DSM-5
Kupfer, D. J., & Regier, D. A. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020219 · Cited by 245
A controlled trial of cue exposure treatment in alcohol dependence
Drummond, D. C., & Glautier, S. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.62.4.809 · Cited by 244
Correlation of Stable Elevations in Striatal μ-Opioid Receptor Availability in Detoxified Alcoholic Patients With Alcohol Craving
Heinz, A., Reimold, M., Wrase, J., Hermann, D., Croissant, B., Mundle, G., Dohmen, B. M., Braus, D. H., Schumann, G., Machulla, H., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.1.57 · Cited by 241
Gamma‐Hydroxybutyric Acid in the Treatment of Alcohol Dependence: A Double‐Blind Study
Gallimberti, L., Ferri, M., Ferrara, S. D., Fadda, F., & Gessa, G. L. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb00658.x · Cited by 240
3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism
Gehlert, D. R., Cippitelli, A., Thorsell, A., Lê, A. D., Hipskind, P. A., Hamdouchi, C., Lu, J., Hembre, E. J., Cramer, J. W., Song, M., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4985-06.2007 · Cited by 239
Olanzapine Increases Weight and Serum Triglyceride Levels
Osser, D. N., Najarian, D. M., & Dufresne, R. L. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n1109 · Cited by 231
Metabolic Syndrome in Patients With Schizophrenia
Heiskanen, T. H., NISKANEN, L. K., Lyytikäinen, R., Saarinen, P., & Hintikka, J. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0513 · Cited by 229
Targeted Use of Naltrexone Without Prior Detoxification in the Treatment of Alcohol Dependence: A Factorial Double-Blind, Placebo-Controlled Trial
Heinälä, P., Alho, H., Kiianmaa, K., Lönnqvist, J. K., Kuoppasalmi, K. I., & Sinclair, J. D. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200106000-00006 · Cited by 226
Craving research: future directions
Drummond, C., Litten, R. Z., Lowman, C., & Hunt, W. A. (2000) · Addiction · doi:10.1080/09652140050111816 · Cited by 226
Sertraline Treatment for Alcohol Dependence: Interactive Effects of Medication and Alcoholic Subtype
Pettinati, H. M., Volpicelli, J. R., Kranzler, H. R., Lück, G., Rukstalis, M. R., & Cnaan, A. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04648.x · Cited by 225
Reactivity to alcohol‐related stimuli in the laboratory and in the field: predictors of craving in treated alcoholics
Litt, M. D., Cooney, N. L., & Morse, P. A. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.9568896.x · Cited by 225
A controlled trial of cue exposure treatment in alcohol dependence.
Drummond, C., & Glautier, S. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.62.4.809 · Cited by 218
Cue exposure with coping skills treatment for male alcoholics: A preliminary investigation.
Monti, P. M., Rohsenow, D. J., Rubonis, A. V., NIAURA, R. S., Sirota, A. D., Colby, S. M., Goddard, P., & Abrams, D. B. (1993) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.61.6.1011 · Cited by 216
Fluoxetine Treatment Seems to Reduce the Beneficial Effects of Cognitive‐Behavioral Therapy in Type B Alcoholics
Kranzler, H. R., Burleson, J. A., Brown, J., & Babor, T. F. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01696.x · Cited by 212
REWARD CRAVING AND WITHDRAWAL RELIEF CRAVING: ASSESSMENT OF DIFFERENT MOTIVATIONAL PATHWAYS TO ALCOHOL INTAKE
Heinz, A., Löber, S., Georgi, A., Wrase, J., Hermann, D., Rey, E.-R., Wellek, S., & Mann, K. (2003) · Alcohol and Alcoholism · doi:10.1093/alcalc/agg005 · Cited by 210
Predicting Treatment Response to Naltrexone: The Influence of Craving and Family History
Monterosso, J. R., Flannery, B., Pettinati, H. M., Oslin, D. W., Rukstalis, M. R., O’Brien, C. P., & Volpicelli, J. R. (2001) · American Journal on Addictions · doi:10.1080/105504901750532148 · Cited by 208
Cognitive concepts of craving.
Tiffany, S. T. (1999) · PubMed Central · Cited by 206
Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative Study
Gelernter, J. E., Gueorguieva, R. V., Kranzler, H. R., Zhang, H., Cramer, J. A., Rosenheck, R. A., Krystal, J. H., & the VA Cooperative Study #425 Study Group (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00339.x · Cited by 204
Ability of Baclofen in Reducing Alcohol Craving and Intake: II???Preliminary Clinical Evidence
Addolorato, G., Caputo, F., Capristo, E., G., C., Gessa, G. L., & Gasbarrini, A. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04555.x · Cited by 203
Baclofen in the Treatment of Alcohol Withdrawal Syndrome: A Comparative Study vs Diazepam
Addolorato, G., Leggio, L., Abenavoli, L., Agabio, R., Caputo, F., Capristo, E., Colombo, G., Gessa, G. L., & Gasbarrini, G. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.08.042 · Cited by 203
Self-citation
Neuroprotective and Abstinence-Promoting Effects of Acamprosate: Elucidating the Mechanism of Action
De Witte, P., Littleton, J., Parot, P., & Koob, G. (2005) · CNS Drugs · doi:10.2165/00023210-200519060-00004 · Cited by 201 · cited 1×
“In vitro studies have shown that acamprosate may attenuate excessive glutamatergic activity by blocking the toxicity produced by abrupt ethanol withdrawal [218].”
Induction of smoking urge through imaginal and in vivo procedures: Physiological and self-report manifestations.
Drobes, D. J., & Tiffany, S. T. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.1.15 · Cited by 196
Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism.
Gianoulakis, C. (2001) · PubMed Central · Cited by 193
Specific forms of facial EMG response index emotions during an interview: From Darwin to the continuous flow hypothesis of affect-laden information processing.
Cacioppo, J. T., Martzke, J. S., Petty, R. E., & Tassinary, L. G. (1988) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.54.4.592 · Cited by 188
Naltrexone's Effect on Cue‐Elicited Craving Among Alcoholics in Treatment
Monti, P. M., Rohsenow, D. J., Hutchison, K. E., Swift, R. M., Mueller, T. I., Colby, S. M., Brown, R. A., Gulliver, S. B., Gordon, A. A., & Abrams, D. B. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04361.x · Cited by 188
Obsessive–compulsive aspects of craving: development of the Obsessive Compulsive Drinking Scale
Anton, R. F. (2000) · Addiction · doi:10.1080/09652140050111771 · Cited by 185
5-HT3 receptors and the neural actions of alcohols: an increasingly exciting topic
Lovinger, D. M. (1999) · Neurochemistry International · doi:10.1016/s0197-0186(99)00054-6 · Cited by 182
Types Of Alcoholics
Kunitz, S. J., & Gabriel, K. R. (2000) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195136159.003.0005 · Cited by 182
Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients
Pelc, I., Verbanck, P., Bon, O. L., Gavrilovic, M., Lion, K., & Lehert, P. (1997) · The British Journal of Psychiatry · doi:10.1192/bjp.171.1.73 · Cited by 180
Clinical Pharmacology and Mechanism of Action of Zonisamide
Biton, V. (2007) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3180413d7d · Cited by 180
Varenicline decreases alcohol consumption in heavy-drinking smokers
Mitchell, J., Teague, C. H., Kayser, A. S., Bartlett, S. E., & Fields, H. L. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2717-x · Cited by 179
Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders
Petrakis, I. L., Poling, J., Levinson, C., Nich, C., Carroll, K., & Rounsaville, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.016 · Cited by 177
α1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol
Walker, B. M., Rasmussen, D. D., Raskind, M. A., & Koob, G. F. (2008) · Alcohol · doi:10.1016/j.alcohol.2007.12.002 · Cited by 170
Obsessive–compulsive aspects of craving: development of the Obsessive Compulsive Drinking Scale
Anton, R. F. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.9.x · Cited by 170
Tests of the elaborated intrusion theory of craving and desire: Features of alcohol craving during treatment for an alcohol disorder
Kavanagh, D. J., May, J., & Andrade, J. (2009) · British Journal of Clinical Psychology · doi:10.1348/014466508x387071 · Cited by 169
Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics
Krystal, J. H., Petrakis, I. L., Webb, E., Cooney, N. L., Karper, L. P., Namanworth, S. N., Stetson, P. L., Trevisan, L. A., & Charney, D. S. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.4.354 · Cited by 166
Pharmacokinetics of gamma‐hydroxybutyric acid in alcohol dependent patients after single and repeated oral doses.
Ferrara, S., Zotti, S., Tedeschi, L., et al. (1992) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1992.tb04129.x · Cited by 165
Effects of Naltrexone on Alcohol Self-Administration in Heavy Drinkers
Davidson, D., Palfai, T. P., Bird, C., & Swift, R. M. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04099.x · Cited by 165
ABILITY OF CALCIUM BIS ACETYL HOMOTAURINE, A GABA AGONIST, TO PREVENT RELAPSE IN WEANED ALCOHOLICS
Lhuintre, J. P., Moore, N., Saligaut, C., BOISMARE, F., Daoust, M., Chrétien, P., Tran, G., & Hillemand, B. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91615-0 · Cited by 164
CONGENITAL LYSINE INTOLERANCE WITH PERIODIC AMMONIA INTOXICATION
Colombo, J. P., Richterich, R., Spahr, A., Donath, A., & Rossi, E. (1964) · The Lancet · doi:10.1016/s0140-6736(64)91924-5 · Cited by 162
Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings
Fox, H. C., Anderson, G. M., Tuit, K. L., Hansen, J., Kimmerling, A., Siedlarz, K. M., MORGAN, P. T., & Sinha, R. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01628.x · Cited by 159
A Pilot Trial of the Alpha‐1 Adrenergic Antagonist, Prazosin, for Alcohol Dependence
Simpson, T. L., Saxon, A. J., Meredith, C. W., Malte, C. A., McBride, B., Ferguson, L. C., Gross, C., Hart, K. L., & Raskind, M. A. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00807.x · Cited by 159
Measurement of alcohol craving
Kavanagh, D. J., Statham, D. J., Feeney, G. F. X., Young, R. M., May, J., Andrade, J., & Connor, J. P. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.08.004 · Cited by 153
Baclofen for Alcohol Dependence: A Preliminary Open‐Label Study
Flannery, B., Garbutt, J. C., Cody, M. W., Renn, W., Grace, K., Osborne, M., Crosby, K., Morreale, M. K., & Trivette, A. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000141640.48924.14 · Cited by 152
Naltrexone, relapse prevention, and supportive therapy with alcoholics: An analysis of patient treatment matching.
Jaffe, A. J., Rounsaville, B. J., Chang, G., Schottenfeld, R. S., Meyer, R. E., & O'Malley, S. S. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.64.5.1044 · Cited by 149
Reactivity to alcohol cues and induced moods in alcoholics
Litt, M. D., Cooney, N. L., Kadden, R. M., & Gaupp, L. A. (1990) · Addictive Behaviors · doi:10.1016/0306-4603(90)90017-r · Cited by 148
Alcohol and cannabis use in schizophrenia: effects of clozapine vs. risperidone
Green, A. I., Burgess, E. S., Dawson, R., Zimmet, S. V., & Strous, R. D. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00231-1 · Cited by 146
Toward bridging the gap between biological, psychobiological and psychosocial models of alcohol craving
Monti, P. M., Rohsenow, D. J., & Hutchison, K. E. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.11.x · Cited by 142
Toward bridging the gap between biological, psychobiological and psychosocial models of alcohol craving
Monti, P. M., Rohsenow, D. J., & Hutchison, K. E. (2000) · Addiction · doi:10.1080/09652140050111799 · Cited by 141
Developmental decrease in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: relation to the actions of ifenprodil.
Lovinger, D. M. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10532-6 · Cited by 141
Obsessive and Compulsive Characteristics of Craving for Alcohol in Alcohol Abuse and Dependence
Modell, J. G., Glaser, F. B., Cyr, L., & Mountz, J. M. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb01375.x · Cited by 139
AN OPEN MULTICENTRIC STUDY EVALUATING 4-HYDROXYBUTYRIC ACID SODIUM SALT IN THE MEDIUM-TERM TREATMENT OF 179 ALCOHOL DEPENDENT SUBJECTS
Addolorato, G., Castelli, E., Stefanini, G. F., CASELLA, G., Caputo, F., Marsigli, L., Bernardi, M., GASBARRIN, G., & GHB STUDY GROUP (1996) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008160 · Cited by 138
Severity of psychosocial stress and outcome of alcoholism treatment.
Brown, S. A., Vik, P. W., McQuaid, J. R., Patterson, T. L., Irwin, M. R., & Grant, I. (1990) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.99.4.344 · Cited by 135
Microdialysis of Dopamine in the Nucleus Accumbens of Alcohol-Preferring (P) Rats During Anticipation and Operant Self-Administration of Ethanol
Meléndez, R. I., Rodd, Z. A., Engleman, E. A., Li, T., McBride, W. J., & Murphy, J. M. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02540.x · Cited by 135
Cognitive changes after alcohol cue exposure.
Cooney, N. L., Gillespie, R. A., Baker, L. H., & Kaplan, R. F. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.55.2.150 · Cited by 134
Discriminative stimulus effects of ethanol: effect of training dose on the substitution of N-methyl-D-aspartate antagonists.
Grant, K. A., & Colombo, G. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10137-7 · Cited by 134
Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats
Lê, A. D., Funk, D. R., Juzytsch, W., Coen, K. M., Navarre, B. M., Cifani, C., & Shaham, Y. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2178-7 · Cited by 132
The ICD-10 Symptom Checklist: a companion to the ICD-10 Classification of Mental and Behavioural Disorders
Janča, A., Üstün, T. B., Early, T., & Sartorius, N. (1993) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/bf00788743 · Cited by 128
Double-Blind Clinical Trial of Sertraline Treatment for Alcohol Dependence
Pettinati, H. M., Volpicelli, J. R., Lück, G., Kranzler, H. R., Rukstalis, M. R., & Cnaan, A. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200104000-00005 · Cited by 127
Naltrexone in the treatment of alcoholism: predicting response to naltrexone.
Volpicelli, J. R., Clay, K. L., Watson, N. T., & O'Brien, C. P. (1995) · PubMed · Cited by 126
Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Post-Traumatic Stress Disorder
Petrakis, I. L., Poling, J. C., Levinson, C. M., Nich, C., Carroll, K. M., Ralevski, E., & Rounsaville, B. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.074 · Cited by 125
A preliminary investigation of varenicline for heavy drinking smokers
Fucito, L. M., Toll, B. A., Wu, R., Romano, D. M., Tek, E., & O’Malley, S. S. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2160-9 · Cited by 124
Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: Relationship to acamprosate actions
Blednov, Y. A., & Adron Harris, R. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008584 · Cited by 123
Rapid suppression of alcohol withdrawal syndrome by baclofen
Addolorato, G., Caputo, F., Capristo, E., Janiri, L., Bernardi, M., Agabio, R., Colombo, G., Gessa, G. L., & Gasbarrini, A. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)01088-9 · Cited by 123
Obsessive and Compulsive Characteristics of Alcohol Abuse and Dependence: Quantification by a Newly Developed Questionnaire
Modell, J. G., Glaser, F. B., Mountz, J. M., Schmaltz, S. P., & Cyr, L. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb01374.x · Cited by 122
Predictive validity of the extinction/reinstatement model of drug craving
Fuchs, R. A., Tran-Nguyen, L. T. L., Specio, S. E., Groff, R. S., & Neisewander, J. L. (1998) · Psychopharmacology · doi:10.1007/s002130050496 · Cited by 121
Naltrexone combined with either cognitive behavioral or motivational enhancement therapy for alcohol dependence
Anton, R. F., Moak, D. H., Latham, P., Waid, L. R., Myrick, H., Voronin, K., Thevos, A., Wang, W., & Woolson, R. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000172071.81258.04 · Cited by 121
The Effect of Olanzapine on Craving and Alcohol Consumption
Hutchison, K. E., Ray, L. A., Sandman, E., Goodworth, M.-C. R., Peters, A., Davidson, D., & Swift, R. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300917 · Cited by 118
Olanzapine Reduces Craving for Alcohol: A DRD4 VNTR Polymorphism by Pharmacotherapy Interaction
Hutchison, K. E., Wooden, A., Swift, R. M., Smolen, A., McGeary, J. E., Adler, L. E., & Paris, L. L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300264 · Cited by 118
Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell
Tizabi, Y., Bai, L., Copeland, R., & Taylor, R. E. (2007) · Alcohol and Alcoholism · doi:10.1093/alcalc/agm057 · Cited by 118
Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist
Breese, G. R., Knapp, D. J., & Overstreet, D. H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300282 · Cited by 117
Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues
Heilig, M., Thorsell, A., Sommer, W. H., Hansson, A. C., Ramchandani, V. A., George, D. T., Hommer, D., & Barr, C. S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.018 · Cited by 117
Effectiveness and Safety of Baclofen in the Treatment of Alcohol Dependent Patients
Leggio, L., Garbutt, J. C., & Addolorato, G. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710790966614 · Cited by 116
Self-citation
NALTREXONE VERSUS ACAMPROSATE: ONE YEAR FOLLOW-UP OF ALCOHOL DEPENDENCE TREATMENT
Rubio, G. (2001) · Alcohol and Alcoholism · doi:10.1093/alcalc/36.5.419 · Cited by 116
Effect of Memantine on Cue-Induced Alcohol Craving in Recovering Alcohol-Dependent Patients
Krupitsky, E. M., Neznanova, O., Masalov, D. V., Burakov, A. M., Didenko, T., Romanova, T. N., Tsoy, M., Bespalov, A., Slavina, T. Y., Grinenko, A. Y., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.519 · Cited by 116
Assessing craving for alcohol.
Drobes, D. J., & Thomas, S. E. (1999) · PubMed Central · Cited by 116
Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin
Mason, B. J., Light, J. M., Williams, L. D., & Drobes, D. J. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00133.x · Cited by 115
SUPPRESSION OF SYMPTOMS OF ALCOHOL DEPENDENCE AND CRAVING USING HIGH-DOSE BACLOFEN
Bucknam, W. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl091 · Cited by 115
Effects of Topiramate on Urge to Drink and the Subjective Effects of Alcohol: A Preliminary Laboratory Study
Miranda, R., MacKillop, J. M., Monti, P. M., Rohsenow, D. J., Tidey, J. W., Gwaltney, C. J., Swift, R. M., Ray, L. A., & McGeary, J. E. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00592.x · Cited by 115
Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats
Bito‐Onon, J. J., Simms, J. A., Chatterjee, S., Holgate, J. Y., & Bartlett, S. E. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00309.x · Cited by 114
Behavioral, biological, and chemical perspectives on targeting CRF1 receptor antagonists to treat alcoholism
Zorrilla, E. P., Heilig, M. A., de Wit, H., & Shaham, Y. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.12.017 · Cited by 113
Factor Structure and Predictive Validity of the Obsessive Compulsive Drinking Scale
Roberts, J. S., Anton, R. F., Latham, P. K., & Moak, D. H. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04671.x · Cited by 112
Ondansetron reduces the craving of biologically predisposed alcoholics
Johnson, B. A., Roache, J. D., Ait‐Daoud, N., Zanca, N. A., & Velázquez, M. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1002-9 · Cited by 109
A Randomized, Multicenter, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Aripiprazole for the Treatment of Alcohol Dependence
Anton, R. F., Kranzler, H. R., Breder, C. D., Marcus, R. N., Carson, W. H., & Han, J. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181602fd4 · Cited by 109
The Smoking Cessation Medication Varenicline Attenuates Alcohol and Nicotine Interactions in the Rat Mesolimbic Dopamine System
Ericson, M., Löf, E., Stomberg, R., & Söderpalm, B. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.147058 · Cited by 109
A one-year pragmatic trial of naltrexone vs disulfiram in the treatment of alcohol dependence
DE SOUSA, A., & DE SOUSA, A. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh104 · Cited by 108
Naltrexone, relapse prevention, and supportive therapy with alcoholics: An analysis of patient treatment matching.
Jaffé, A., Rounsaville, B. J., Chang, G., et al. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.64.5.1044 · Cited by 108
Pharmacotherapy for alcohol dependence: status of current treatments
Franck, J., & Jayaram-Lindström, N. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.05.005 · Cited by 107
An open randomized study comparing disulfiram and acamprosate in the treatment of alcohol dependence
DE SOUSA, A., & DE SOUSA, A. (2005) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh187 · Cited by 107
The α1‐Adrenergic Receptor Antagonist, Prazosin, Reduces Alcohol Drinking in Alcohol‐Preferring (P) Rats
Rasmussen, D. D., Alexander, L., Raskind, M. A., & Froehlich, J. C. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00829.x · Cited by 106
Alcohol craving and the dimensionality of alcohol disorders
Keyes, K. M., Krueger, R. F., Grant, B. F., & Hasin, D. S. (2010) · Psychological Medicine · doi:10.1017/s003329171000053x · Cited by 105
Family History of Alcoholism Influences Naltrexone-Induced Reduction in Alcohol Drinking
Krishnan‐Sarin, S., Krystal, J. H., Shi, J. M., Pittman, B. P., & O’Malley, S. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.018 · Cited by 105
Genetic Moderators of Naltrexone's Effects on Alcohol Cue Reactivity
McGeary, J. E., Monti, P. M., Rohsenow, D. J., Tidey, J. W., Swift, R. M., & Miranda, R. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00156.x · Cited by 105
Cognitive changes after alcohol cue exposure.
Cooney, N. L., Gillespie, R. A., Baker, L. H., et al. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.55.2.150 · Cited by 104
Effects of naltrexone on adolescent alcohol cue reactivity and sensitivity: an initial randomized trial
Miranda, R., Ray, L. A., Blanchard, A., Reynolds, E. K., Monti, P. M., Chun, T. H., Justus, A. N., Swift, R. M., Tidey, J. W., Gwaltney, C. J., et al. (2013) · Addiction Biology · doi:10.1111/adb.12050 · Cited by 102
Aripiprazole in the treatment of patients with alcohol dependence: a double-blind, comparison trial vs. Naltrexone
Martinotti, G., Nicola, M. D., Giannantonio, M. D., & Janiri, L. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108089596 · Cited by 102
A Double-Blind, Randomized Trial of Sertraline for Alcohol Dependence
Kranzler, H. R., Armeli, S., Tennen, H. A., Covault, J., Feinn, R., Arias, A. J., Pettinati, H. M., & Oncken, C. A. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31820465fa · Cited by 101
Supervised Disulfiram as Adjunct to Psychotherapy in Alcoholism Treatment
Krampe, H., & Ehrenreich, H. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791516431 · Cited by 101
A Pilot Double‐Blind Treatment Trial of Memantine for Alcohol Dependence
Evans, S. M., LEVIN, F. R., Brooks, D. J., & Garawi, F. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00360.x · Cited by 101
Olanzapine reduces urge to drink after drinking cues and a priming dose of alcohol
Hutchison, K. E., Swift, R. M., Rohsenow, D. J., Monti, P. M., Davidson, D., & Almeida, A. B. (2001) · Psychopharmacology · doi:10.1007/s002130000629 · Cited by 101
Neuronal Nicotinic Acetylcholine Receptors as Pharmacotherapeutic Targets for the Treatment of Alcohol Use Disorders
Chatterjee, S., & Bartlett, S. E. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710790966597 · Cited by 100
Naltrexone in the treatment of alcohol dependence
Mangado, E. O. (1994) · Alcohol · doi:10.1016/0741-8329(94)90014-0 · Cited by 100
Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control
Wouda, J. A., Riga, D., de Vries, W., Stegeman, M., van Mourik, Y., Schetters, D., Schoffelmeer, A. N. M., Pattij, T., & Vries, T. J. D. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2213-8 · Cited by 99
Serotonin's role in alcohol's effects on the brain.
Lovinger, D. M. (1997) · PubMed · Cited by 98
Sleep Abnormalities During Abstinence in Alcohol-Dependent Patients
Landolt, H., & Gillin, J. C. (2001) · CNS Drugs · doi:10.2165/00023210-200115050-00006 · Cited by 97
Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking
Simms, J. A., Haass-Koffler, C. L., Bito-Onon, J., Li, R., & Bartlett, S. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.268 · Cited by 97
Self-citation
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Mewton, L. R., Slade, T. N., McBride, O., Grove, R., & Teesson, M. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.03340.x · Cited by 95
Measuring Craving: An Attempt to Connect Subjective Craving with Cue Reactivity
Ooteman, W., Koeter, M. W. J., Vserheul, R., Schippers, G. M., & van den Brink, W. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00019.x · Cited by 94
Quetiapine for Treatment of Alcohol Dependence
Monnelly, E. P., Ciraulo, D. A., Knapp, C. M., LoCastro, J. S., & Sepulveda, I. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000138763.23482.2a · Cited by 94
A Double‐Blind, Placebo‐Controlled Trial to Assess the Efficacy of Quetiapine Fumarate XR in Very Heavy‐Drinking Alcohol‐Dependent Patients
Litten, R. Z., Fertig, J. B., Falk, D. E., Ryan, M. L., Mattson, M. E., Collins, J. F., Murtaugh, C., Ciraulo, D. A., Green, A. I., Johnson, B. A., et al. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01649.x · Cited by 94
Focal cerebral blood flow change during craving for alcohol measured by SPECT
Modell, J. G., & Mountz, J. M. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.1.15 · Cited by 91
Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate
Kiefer, F., Witt, S. H., Frank, J., Richter, A., Treutlein, J., Leménager, T., Nöthen, M. M., Cichon, S., Batra, A., Berner, M., et al. (2010) · The Pharmacogenomics Journal · doi:10.1038/tpj.2010.51 · Cited by 91
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Noaín, D., Avale, M. E., Wedemeyer, C., Calvo, D. J., Peper, M., & Rubinstein, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05148.x · Cited by 91
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A Double-Blind, Placebo-Controlled Pilot Trial of Quetiapine for the Treatment of Type A and Type B Alcoholism
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Martinotti, G., Andreoli, S., Nicola, M. D., Giannantonio, M. D., Sarchiapone, M., & Janiri, L. (2008) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.944 · Cited by 89
Effect of Haloperidol on Measures of Craving and Impaired Control in Alcoholic* Subjects
Modell, J. G., Mountz, J. M., Glaser, F. B., & Lee, J. Y. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00755.x · Cited by 89
A Placebo‐Controlled, Double‐Blind Study of Fluoxetine in Severe Alcohol Dependence: Adjunctive Pharmacotherapy During and After Inpatient Treatment
Kabel, D., & Petty, F. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01686.x · Cited by 88
Ethanol and N -methyl- D -aspartate receptor complex interactions: a detailed drug discrimination study in the rat
Hundt, W., Danysz, W., Hölter, S. M., & Spanagel, R. (1998) · Psychopharmacology · doi:10.1007/s002130050484 · Cited by 87
Measuring alcohol craving: development of the Alcohol Craving Experience questionnaire
Statham, D. J., Connor, J. P., Kavanagh, D. J., Feeney, G. F. X., Young, R. M., May, J., & Andrade, J. (2011) · Addiction · doi:10.1111/j.1360-0443.2011.03442.x · Cited by 86
Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence
Bencherif, B., Wand, G. S., McCaul, M. E., Kim, Y. K., Ilgìn, N., Dannals, R. F., & Frost, J. J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.07.007 · Cited by 86
Neurochemical Characteristics Associated With Ethanol Preference in Selected Alcohol-Preferring and -Nonpreferring Rats: A Quantitative Microdialysis Study
Katner, S. N., & Weiss, F. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02199.x · Cited by 85
Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (The COMBINE Study): Examination of Posttreatment Drinking Outcomes
Donovan, D. M., Anton, R. F., Miller, W. R., Longabaugh, R., Hosking, J. D., & Youngblood, M. (2008) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2008.69.5 · Cited by 83
Serotonergic Agents and Alcoholism Treatment: Rebirth of the Subtype Concept???An Hypothesis
Johnson, B. A. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04581.x · Cited by 83
Ethanol inhibition of N-methyl-d-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine
Peoples, R. W., & Weight, F. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)90674-x · Cited by 82

Research works printed but not linked: 2

Verheul R, van den Brink W, Geerlings P. A three-pathway psychobiological model of craving for alcohol. Alcohol Alcohol. 1999;34(2):197–222. · DOI
Anton RF, Moak DH, Waid LR, Latham PK, Malcolm RJ, Dias JK. Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial. Am J Psychiatry. 1999;156(11):1758–64. · DOI

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Authors: Haass-Koffler, C. L., Leggio, L., & Kenna, G. A.
Affiliations: National Institutes of Health (US)
Brown University (US)
Corresponding author: Kenna, George A.
ORCID: Leggio, Lorenzo
Venue: CNS Drugs
Publisher: Springer Science and Business Media LLC
Published: 2014-02-27
Volume: 28
Issue: 4
Pages: 343-360
ISSN: 1172-7047 (ISSN-L)
1179-1934
DOI: 10.1007/s40263-014-0149-3
PMC: PMC3990000
OpenAlex: W2078816211
Cited by: 83
References: 269
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 10 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 2
FWCI: 0.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: CNS Drugs (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA015753, K01AA023867, R03AA020169, R21AA019994, R01AA016079, R21AA021128, R21AA019709, T32AA007459)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: alcohol craving, alcoholism, craving measurement, alcohol relapse prevention, protracted abstinence, stress hormones, anxiety and depression
MeSH terms: Animals, Humans, Serotonin Antagonists, Receptors, N-Methyl-D-Aspartate, Behavior, Addictive, Excitatory Amino Acid Antagonists, Alcohol-Related Disorders, Craving

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Pharmacological Approaches to Reducing Craving in Patients with Alcohol Use Disorders

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