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Cited by 371Thyroid Disorders and TreatmentsCardiovascular Function and Risk FactorsHormonal and reproductive studies

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Thyroid hormone and the cardiovascular system

Klein, Irwin·1990·The American Journal of Medicine
DOI 10.1016/0002-9343(90)90531-h
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Abstract

To understand the pathophysiology of thyroid heart disease, it is necessary to recognize that thyroid hormone has effects on both the peripheral circulation and the myocardium. One of the earliest responses to thyroid hormone administration is a decline in systemic vascular resistance and an increase in cardiac output and cardiac contractility. In many ways, this response is similar to the cardiovascular response to exercise and is associated with increased left ventricular work. The majority of cardiac adaptations to changes in thyroid function are physiologic; however, certain patients do demonstrate clinical evidence of cardiac disease. Atrial arrhythmias, limitations in exercise tolerance, and congestive heart failure are reported to occur as a result of hyperthyroidism and are more common in older patients. Thyroid hormone also plays an important role in the regulation of blood pressure. Diastolic hypertension is a common accompaniment of hypothyroidism. By understanding the mechanisms by which thyroid hormone affects both the peripheral circulation as well as the myocardium, it is possible to predict the clinical response to the treatment of various thyroid disease states.

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Citations

Cites

Research works printed but not linked: 5

  1. Parry, 1825, Collections from the unpublished papers of the late Caleb Hilliel Parry, Dis Heart, 2, 111
  2. Goetsch, 1918, Adrenaline hypersensitiveness in clinical states of hyperthyroidism, NY State J Med, 18, 259
  3. Mintz, 1989, Cardiac diastolic function in hyperthyroidism: response to therapy, Clin Res, 37, 520A
  4. Klein, 1985, Acute effects of propranolol on the thyrotoxic myopathy, Clin Res, 33, 284A
  5. Fuller, 1965, Myxedema: a cause of reversible hypertension, Circulation, 31, 91

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Metadata

Authors
Klein, I.
Affiliations
Cornell University (US)
Corresponding author
Klein, Irwin
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
1990-06
Volume
88
Issue
6
Pages
631-637
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/0002-9343(90)90531-h
OpenAlex
W2073919574
Cited by
370
References
57
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 4
FWCI
2.52
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r01hl041304-01)
  • National Heart, Lung, and Blood Institute (HL-41304)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
thyroid hormones, hyperthyroidism, hypothyroidism, systemic vascular resistance, cardiac output, cardiac contractility, left ventricular work, atrial arrhythmias, exercise intolerance, congestive heart failure, diastolic hypertension, blood pressure regulation, myocardium
MeSH terms
Heart, Heart Diseases, Hemodynamics, Humans, Myocardial Contraction, Thyroid Diseases, Thyroxine, Triiodothyronine

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