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Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder

Yehuda, Rachel, Giller, Earl L., Southwick, Steven M., Lowy, Martin T., Mason, John W.·1991·Biological Psychiatry

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Research works printed but not linked: 102

  1. Ader, 1970, The effects of early experience on the adrenocortical response to different magnitude stimulation., Physiol. Behav, 5, 837, 10.1016/0031-9384(70)90168-X · DOI
  2. Amir, 1979, The pituitary gland mediates acute and chronic pain responsiveness in stressed and nonstressed rats., Life Sci, 24, 439, 10.1016/0024-3205(79)90216-9 · DOI · Paper page
  3. Armario, 1985, Dissociation between adrenocorticotropin and corticosterone response to restrain after previous chronic exposure to stress., Life Sci, 36, 2085, 10.1016/0024-3205(85)90304-2 · DOI
  4. Armario, 1988, Evidence that the pituitary-adrenal axis does not cross-adapt to stressors: Comparison to other physiological variables., Neuroendocrinology, 47, 263, 10.1159/000124921 · DOI
  5. Banki, 1987, CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia., Am J Psychiatry, 144, 873, 10.1176/ajp.144.7.873 · DOI · Paper page
  6. von Bardeleben, 1985, Combined administration of human corticotropin-releasing factor and lysine vasopressin induces cortisol escape from dexamethasone suppression in healthy subjects., Life Sci, 37, 1613, 10.1016/0024-3205(85)90480-1 · DOI
  7. Bohus, 1973, Pituitary-adrenal influences on avoidance and approach behavior of the rat., Prog Brain Res, 39, 407, 10.1016/S0079-6123(08)64096-0 · DOI
  8. Bohus, 1977, Analysis of the individual variations of adaptation in the rat, on the basis of conditioned reflex and endocrine studies, J Endocrinol, 72, 64P
  9. Bourne, 1967, Urinary 17-OHCA levels. Data on seven helicopter ambulance medics in combat, Arch Gen Psychiatry, 17, 104, 10.1001/archpsyc.1967.01730250106015 · DOI
  10. Bourne, 1968, 17-OHCS levels in combat: Special forces “A” team under threat of attack, Arch Gen Psychiatry, 19, 135, 10.1001/archpsyc.1968.01740080007002 · DOI
  11. Carroll, 1982, The dexamethasone suppression test for melancholia, Br J Psychiatry, 140, 292, 10.1192/bjp.140.3.292 · DOI · Paper page
  12. Carroll, 1981, A specific laboratory test for the diagnosis of melancholia, Arch Gen Psychiatry, 38, 15, 10.1001/archpsyc.1981.01780260017001 · DOI · Paper page
  13. Dallman, 1973, Diminishing corticotrope capacity to release ACTH during sustained stimulation: The twenty four hours after bilateral adrenalectomy in the rat, Endocrinology, 95, 65, 10.1210/endo-95-1-65 · DOI
  14. Daniels-Severs, 1973, Effect of chronic crowding and cold on the pituitary-adrenal system: Responsiveness to an acute stimulus during chronic stress, Pharmacology, 9, 348, 10.1159/000136408 · DOI
  15. Davidson, 1985, A diagnostic and family study of posttraumatic stress disorder, Am J Psychiatry, 142, 90, 10.1176/ajp.142.1.90 · DOI · Paper page
  16. DeKloet, 1987, Feedback action and tonic influence on corticosteroids on brain function: A concept arising from the heterogeneity of brain receptor systems, Psychoneuroendocrinology, 12, 83, 10.1016/0306-4530(87)90040-0 · DOI · Paper page
  17. Endroczi, 1957, Analysis of the individual variations of adaptation in the rat, on the basis of conditioned reflex and endocrine studies, Acta Physiol Hung, 11, 393
  18. Frenkl, 1969, A study of the stress reaction elicited by muscular exertion in trained and untrained man and rats, Acta Physiol Hung, 36, 365
  19. Friedman, 1963, Urinary 17-hydroxycorticosteroid levels in parents of children with neoplastic disease: A study of chronic psychological stress, Psychosom Med, 25, 364, 10.1097/00006842-196307000-00007 · DOI
  20. Funkenstein, 1954, The direction of anger during a laboratory stress-inducing situation, Psychosom Med, 16, 404, 10.1097/00006842-195409000-00006 · DOI · Paper page
  21. Gibbons, 1962, Plasma cortisol in depressive illness, J Psychiatr Res, 1, 162, 10.1016/0022-3956(62)90006-7 · DOI · Paper page
  22. Gold, 1985, Clinical studies with corticotropin releasing factor: Implications for the diagnosis and pathophysiology of depression, Cushing's disease and adrenal insufficiency, Psychoneuroendocrinology, 10, 401, 10.1016/0306-4530(85)90080-0 · DOI
  23. Gold, 1986, Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease, N Engl J Med, 314, 1329, 10.1056/NEJM198605223142101 · DOI · Paper page
  24. Gold, 1988, Clinical and biochemical manifestations of depression, N Engl J Med, 319, 413, 10.1056/NEJM198808183190706 · DOI · Paper page
  25. Gormley, 1985, Glucocorticoid receptors in depression: Relationship to the dexamethasone suppression test, Am J Psychiatry, 142, 1278, 10.1176/ajp.142.11.1278 · DOI
  26. Halbreich, 1989, Hypothalamo-pituitary-adrenal activity in endogenously depressed post-traumatic stress disorder patients, Psychoneuroendocrinology, 14, 365, 10.1016/0306-4530(89)90006-1 · DOI
  27. Haltmeyer, 1967, Modification of the plasma corticosterone response as a function of infantile stimulation and electric shock parameters, Physiol Behav, 2, 61, 10.1016/0031-9384(67)90012-1 · DOI
  28. Helzer, 1979, Depression in Vietnam veterans and civilian controls, Am J Psychiatry, 135, 526, 10.1176/ajp.1979.136.4b.526 · DOI
  29. Hess, 1969, Modification of the corticosterone response curve as a function of handling in infancy, Physiol Behav, 4, 109, 10.1016/0031-9384(69)90023-7 · DOI · Paper page
  30. Holsboer, 1985, ACTH, cortisol and corticosterone output after ovine corticotropin-releasing factor challenge during depression and after recovery, Biol Psychiatry, 20, 276, 10.1016/0006-3223(85)90057-5 · DOI
  31. Holsboer, 1986, Human corticotropin-releasing hormone in depression—Correlation with thyrotropin secretion following thyrotropin-releasing hormone, Biol Psychiatry, 21, 601, 10.1016/0006-3223(86)90121-6 · DOI
  32. Junker, 1983, Glucocorticoid receptors of human mononuclear leukocytes in vitro, J Clin Endocrinol Metab, 57, 506, 10.1210/jcem-57-3-506 · doi:10.1210/jcem-57-3-506
  33. Kathol, 1985, Etiologic implications of corticosteroid changes in affective disorder, Psychiat Med, 3, 135
  34. Kathol, 1989, Pathophysiology of HPA axis abnormalities in patients with major depression: An update, Am J Psychiatry, 146, 311, 10.1176/ajp.146.3.311 · DOI
  35. Katz, 1981, Animal model of depression: effects of electroconvulsive shock therapy, Neurosci Behav Rev, 5, 273, 10.1016/0149-7634(81)90009-9 · DOI
  36. Katz, 1984, Effects of zometrapine, a structurally novel antidepressant, in an animal model of depression, Pharmacol Biochem Behav, 21, 487, 10.1016/S0091-3057(84)80027-1 · DOI
  37. Katz, 1982, Animal model of depression: Tests of three structurally and pharmacologically novel antidepressant compounds, Pharmacol Biochem Behav, 16, 973, 10.1016/0091-3057(82)90055-7 · DOI
  38. Kawakami, 1972, Influence of repeated immobilization stress upon the circadian rhythmicity of adrenocorticoid biosynthesis, Neuroendocrinology, 9, 207, 10.1159/000122051 · doi:10.1159/000122051
  39. Kling, 1991, Cerebrospinal fluid immunoreactive corticotropin-releasing hormone and adrenocorticotropin secretion in Cushing's disease and major depression: Potential implications, J Clin Endocrin Metab, 72, 260, 10.1210/jcem-72-2-260 · DOI
  40. Knight, 1979, Psychological stress, ego defenses and cortisol production in children hospitalized for elective surgery, Psychosom Med, 41, 40, 10.1097/00006842-197902000-00005 · DOI
  41. Kontula, 1980, Glucocorticoid receptors in adrenocorticoid disorders, J Clin Endocrinol Metab, 51, 654, 10.1210/jcem-51-3-654 · DOI
  42. Kosten, 1984, Psychological correlates of growth hormone response to stress, Psychosom Med, 46, 49, 10.1097/00006842-198401000-00007 · doi:10.1097/00006842-198401000-00007
  43. Kosten, 1990, The dexamethasone test and TRH stimulation test in post-traumatic stress disorder, Biol Psychiatry, 28, 657, 10.1016/0006-3223(90)90452-8 · DOI
  44. Kudler, 1987, The DST and post-traumatic stress disorder, Am J Psychiatry, 144, 1068, 10.1176/ajp.144.8.1068 · DOI
  45. LeMevel, 1979, Temporal changes in plamsma adrenocorticotropin concentration after repeated neurotropic stress in male and female rats, Endocrinology, 105, 812, 10.1210/endo-105-3-812 · DOI · Paper page
  46. Levine, 1967, Physiological and behavioral effects of infantile stimulation, Physiol Behav, 2, 55, 10.1016/0031-9384(67)90011-X · DOI · Paper page
  47. Levine, 1970, Urinary 17-OHCS response of high and low aggressive rhesus monkeys to shock avoidance, Physiol Behav, 5, 919, 10.1016/0031-9384(70)90183-6 · doi:10.1016/0031-9384(70)90183-6
  48. Ling, 1981, Side effects of corticosteroid therapy, Arch Gen Psychiatry, 38, 471, 10.1001/archpsyc.1981.01780290105011 · DOI · Paper page
  49. Lissak, 1957, Somatisches Verhalten und Nebennierenrindentatigkeit, Pflugers Arch, 265, 117, 10.1007/BF00364562 · DOI
  50. Lowy, 1989, Quantification of Type I and II adrenal steroid receptors in neuronal, lymphoid, and pituitary tissues, Brain Res, 503, 191, 10.1016/0006-8993(89)91663-6 · DOI
  51. Lowy, 1990, Reserpine induced decrease in Type I and II corticosteroid receptors in neuronal and lymphoid tissue of adrenalectomized rats, Neuroendocrinology, 51, 190, 10.1159/000125336 · DOI
  52. Lowy, 1987, Dexamethasone bioavailability: Implications for DST research, Biol Psychiatry, 22, 373, 10.1016/0006-3223(87)90155-7 · DOI
  53. Lowy, 1984, Glucocorticoid resistance in depression: The dexamethasone suppression test and lymphocyte sensitivity to dexamethasone, Am J Psychiatry, 141, 1365, 10.1176/ajp.141.11.1365 · DOI
  54. Mason, 1968, A review of psychoendocrine research on the sympathetic-adrenal medullary system, Psychosom Med, 30, 631, 10.1097/00006842-196809000-00022 · DOI · Paper page
  55. Mason, 1968, Plasma and urinary 17-hydroxycorticosteroid responses to 72-hr avoidance sessions in the monkey, Psychosom Med, 30, 608, 10.1097/00006842-196809000-00021 · DOI
  56. Mason, 1986, Urinary free-cortisol levels in posttraumatic stress disorder patients, J Nerv Ment Dis, 174, 145, 10.1097/00005053-198603000-00003 · DOI · Paper page
  57. McEwen, 1977, Adrenal steroid feedback on neuroendocrine tissues, NY Acad Sci, 297, 567, 10.1111/j.1749-6632.1977.tb41883.x · DOI
  58. McEwen, 1975, Corticosterone binding to hippocampus: Immediate and delayed influences of the absence of adrenal secretion, Brain Res, 70, 321, 10.1016/0006-8993(74)90321-7 · DOI
  59. McEwen, 1976, Interactions in vivo and in vitro of corticoids and progesterone with cell nuclei and soluble macromolecules from the rat brain regions and pituitary, Brain Res, 105, 129, 10.1016/0006-8993(76)90928-8 · DOI
  60. McEwen, 1986, Adrenal steroid receptors and actions in the nervous system, Physiol Rev, 66, 1121, 10.1152/physrev.1986.66.4.1121 · DOI · Paper page
  61. Meany, 1985, 3H Dexamethasone binding in rat frontal cortex, Brain Res, 328, 176, 10.1016/0006-8993(85)91340-X · DOI
  62. Meany, 1985, The effects of postnatal handling on the development of the glucocorticoid receptor systems and stress recovery in the rat, Prog Neuropsychopharmacol Biol Psychiatry, 9, 731, 10.1016/0278-5846(85)90050-8 · DOI · Paper page
  63. Meaney, 1989, Neonatal handling alters adrenocortical negative feedback sensitivity and hippocampal Type II glucocorticoid binding in the rat, Neuroendocrinology, 50, 597, 10.1159/000125287 · DOI · Paper page
  64. Meltzer, 1982, Effect of dexamethasone on plasma prolactin and cortisol levels in psychiatric patients, Am J Psychiatry, 139, 763, 10.1176/ajp.139.6.763 · DOI
  65. Natelson, 1988, Effect of stressor intensity on habituation of the adrenocortical stress response, Physiol Behav, 43, 41, 10.1016/0031-9384(88)90096-0 · DOI · Paper page
  66. Nemeroff, 1984, Elevated concentration of CSF corticotropin releasing factor like immunoreactivity in depressed patients, Science, 226, 1342, 10.1126/science.6334362 · DOI · Paper page
  67. Nemeroff, 1988, Reduced corticotropin binding sites in the frontal cortex of suicide victims, Arch Gen Psych, 45, 577, 10.1001/archpsyc.1988.01800300075009 · DOI · Paper page
  68. Nesse, 1984, Endocrine and physiologic responses to phobic anxiety (abstract), Psychosom Med, 46, 86
  69. Olivera, 1990, Affective disorders, DST, and treatment in PTSD patients: Clinical observations, J Traumatic Stress, 3, 407, 10.1002/jts.2490030309 · DOI
  70. Olpe, 1976, Glucocorticoid binding to receptor-like proteins in rat brain and pituitary: Ontogenetic and experimentally induced changes, Brain Res, 105, 121, 10.1016/0006-8993(76)90927-6 · DOI
  71. Ottenweller, 1989, Adrenocortical and behavioral responses to repeated stressors: Toward an animal model of chronic stress and stress-related mental illness, Biol Psychiatry, 26, 829, 10.1016/0006-3223(89)90123-6 · DOI
  72. Pitman, 1990, Twenty-four urinary cortisol and catecholamine excretion in combat-related posttraumatic stress disorder, Biol Psychiatry, 27, 245, 10.1016/0006-3223(90)90654-K · DOI · Paper page
  73. Pitman, 1990, Effect of stressor intensity on habituation and sensitization of glucocorticoid responses in rats, Behav Neurosci, 104, 28, 10.1037/0735-7044.104.1.28 · doi:10.1037/0735-7044.104.1.28
  74. Pitts, 1985, Special section: Posttraumatic stress disorder: Editorial, J Clin Psychiatry, 46, 373
  75. Poe, 1970, Multiple determinants of 17-OHCS excretion in recruits during basic training, Psychosom Med, 32, 369, 10.1097/00006842-197007000-00005 · doi:10.1097/00006842-197007000-00005
  76. Riegle, 1973, Chronic stress effects on adrenocortical responsiveness in young and aged rats, Neuroendocrinology, 11, 1, 10.1159/000122114 · DOI
  77. Rivier, 1987, Diminished responsiveness of the hypothalamic pituitary adrenal axis of the rat during exposure to prolonged stress: A pituitary-mediated mechanism, Endocrinology, 121, 1320, 10.1210/endo-121-4-1320 · DOI
  78. Rose, 1968, Psychological state and body size as determinants of 17-OHCS excretion, Arch Intern Med, 121, 406, 10.1001/archinte.121.5.406 · DOI
  79. Roy, 1987, CSF corticotropin-releasing hormone in depressed patients and normal control subjects, Am J Psychiatry, 144, 641, 10.1176/ajp.144.5.641 · DOI · Paper page
  80. Sachar, 1973, Disrupted 24-hour patterns of cortisol secretion in psychotic depression, Arch Gen Psychiatry, 28, 19, 10.1001/archpsyc.1973.01750310011002 · DOI · Paper page
  81. Sakellaris, 1975, Increased rate of response of the pituitary-adrenal system in rats adapted to chronic stress, Endocrinology, 97, 597, 10.1210/endo-97-3-597 · DOI · Paper page
  82. Saplosky, 1984, Stress down regulates corticosterone receptors in a site specific manner in the brain, Endocrinology, 114, 287, 10.1210/endo-114-1-287 · DOI · Paper page
  83. Sapolsky, 1985, Prolonged glucocorticoid exposure reduces hippocampal neuron number. Implications for aging, J Neurosci, 5, 1221, 10.1523/JNEUROSCI.05-05-01222.1985 · DOI · Paper page
  84. Schelchte, 1982, Decreased glucocorticoid receptor binding in adrenal insufficiency, J Clin Endocrinol Metab, 54, 145, 10.1210/jcem-54-1-145 · doi:10.1210/jcem-54-1-145
  85. Schlechte, 1985, Lymphocyte glucocorticoid receptor binding in depressed patients with hypercortisolemia, Psychoneuroendocrinology, 10, 469, 10.1016/0306-4530(85)90086-1 · DOI
  86. Schlechte, 1987, The effect of glucocorticoid on corticosteroid binding globulin, Clin Endocrinol, 27, 197, 10.1111/j.1365-2265.1987.tb01145.x · DOI
  87. Schlechte, 1982, Regulation of the glucocorticoid receptor in human lymphocytes, J Steroid Biochem, 16, 69, 10.1016/0022-4731(82)90145-5 · DOI
  88. Selye, 1936, Thymus and adrenals in the response of the organisms to injuries and intoxications, Br J Exp Pathol, 17, 234
  89. Sierles, 1983, Post-traumatic stress disorder and concurrent psychiatric illness: A preliminary report, Am J Psychiatry, 140, 1177, 10.1176/ajp.140.9.1177 · DOI · Paper page
  90. Smith, 1989, The corticotropin releasing hormone test in patients with posttraumatic stress disorder, Biol Psychiatry, 26, 349, 10.1016/0006-3223(89)90050-4 · DOI · Paper page
  91. Southwick, 1991, Characterization of depression in war-related posttraumatic stress disorder, Am J Psychiatry, 148, 179, 10.1176/ajp.148.2.179 · DOI
  92. Stark, 1968, An attempt to explain differences in the hypophyseal-adrenocortical response to repeated stressful stimuli by their dependence of differences in pathways, Acta Med Hung, 25, 251
  93. Vernikos, 1972, Pituitary-adrenal function in rats chronically exposed to cold, Endocrinology, 110, 413, 10.1210/endo-110-2-413 · DOI
  94. Vernikos Danellis, 1975, The physiological cost of flight stress and flight fatigue, US Navy Med J, 66, 12
  95. Wassef, 1990, Mononuclear leukocyte glucocorticoid receptor binding characteristics and down-regulation in major depression, Psychoneuroendocrinology, 15, 59, 10.1016/0306-4530(90)90047-D · DOI
  96. Whalley, 1986, Glucocorticoid receptors and depression, Br Med J, 292, 859, 10.1136/bmj.292.6524.859 · DOI
  97. Wolff, 1964, Relationship between psychological defenses and mean urinary 17-OHCS excretion rates: A predictive study of parents of fatally ill children, Psychosom Med, 26, 576, 10.1097/00006842-196409000-00002 · DOI · Paper page
  98. Wolkowitz, 1990, Cognitive effects of corticosteroids, Am J Psychiatry, 147, 1297, 10.1176/ajp.147.10.1297 · DOI · Paper page
  99. Yehuda, 1990, Low urinary cortisol excretion in PTSD, J Nerv Ment Dis, 178, 366, 10.1097/00005053-199006000-00004 · DOI · Paper page
  100. Yehuda, 1991, Increased number of glucocorticoid receptor number in post-traumatic stress disorder, Am J Psychiatry, 149, 499
  101. Young, 1985, Corticotropin-releasing factor stimulation of adrenocorticotropin and β-endorphin release: Effects of acute and chronic stress, Endocrinology, 117, 23, 10.1210/endo-117-1-23 · DOI
  102. Young, 1985, Changes in releasability of ACTH and beta-endorphin with chronic stress, Neuropeptides, 5, 545, 10.1016/0143-4179(85)90075-7 · DOI

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Metadata

Authors
Yehuda, R., Giller, E. L., Southwick, S. M., Lowy, M. T., & Mason, J. W.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1991-11
Volume
30
Issue
10
Pages
1031-1048
ISSN
0006-3223 (ISSN-L)
OpenAlex
W1992582497
Cited by
389
References
7
FWCI
3.16
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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Yehuda, R., Giller, E. L., Southwick, S. M., Lowy, M. T., & Mason, J. W. (1991). Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder. Biological Psychiatry. https://doi.org/10.1016/0006-3223(91)90123-4

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