Fronto‐temporal alterations within the first 200 ms during an attentional task distinguish major depression, non‐clinical participants with depressed mood and healthy controls: A potential biomarker?
Open accessAbstract
Attentional impairment in depression is a cardinal feature of depression and has been proposed as a candidate endophenotype for major depressive disorder. Event‐related potentials (ERPs) elicited by oddball signal detection tasks provide objective markers of selective stimulus processing, and are pertinent endophenotypic markers for depression. While previous studies have sought to determine objective markers for attentional impairment in depression, evidence is inconsistent and may involve heterogeneity in relatively small samples. Here, we brought together oddball ERP recording with source localization of neural correlates of selective attention in outpatients with major depressive disorder (MDD; n = 78) and participants with depressed mood (PDM; n = 127) relative to healthy controls (CTL; n = 116). The key finding was a dimensional exaggeration of the P200 (140–270 ms) to both target (signal) and non‐target (noise) stimuli, most pronounced in MDD, followed by PDM, relative to CTL. This exaggeration was coupled with slower and more variable response times, suggesting that neural systems are attempting to compensate for a difficulty in discriminating signal from noise. P200 alterations were localised to limbic (hippocampal), temporal and ventral prefrontal regions, key components of the signal detection network. A subsequent reduction and delay in the P300 was also revealed for MDD indicating that the pronounced lack of discrimination in clinical depression may also lead to impaired stimulus evaluation. This P200 increase in depression could provide a potential mechanism for the attentional impairment frequently observed in depression and consequent alterations in the P300 may differentiate clinically significant depression. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc.
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Studies comparing oddball task performance often find that unmedicated major depressive disorder patients respond more slowly than healthy controls.
“Studies comparing oddball task performance by unmedicated MDD patients versus healthy controls often find that MDD patients respond more slowly than controls23–25, suggesting that even in the absence of overt distraction attentional focus is impaired.”
From Paying attention to attention in depression (2019) · cites this paper as [23]
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- Authors
- Kemp, A. H., Hopkinson, P. J., Hermens, D. F., Rowe, D. L., Sumich, A. L., Clark, C. R., Drinkenburg, W., Abdi, N., Penrose, R., McFarlane, A., Boyce, P., Gordon, E., & Williams, L. M.
- Affiliations
- Westmead Hospital (AU)
- The University of Sydney (AU)
- King's College London (GB)
- Flinders University (AU)
- Janssen Research & Development (United States) (US)
- The University of Adelaide (AU)
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2009-01-19
- Volume
- 30
- Issue
- 2
- Pages
- 602-614
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6870851
- OpenAlex
- W2112724572
- Cited by
- 66
- References
- 80
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
- Funders
- Pfizer
- National Health and Medical Research Council (358770)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, attentional impairment, P200, P300, event-related potentials, endophenotypes, depressive mood, source localization, hippocampus, ventral prefrontal cortex, response latency, biomarkers
- MeSH terms
- Attention, Cerebral Cortex, Depression, Major Depressive Disorder, Diagnosis, Differential, Hippocampus, Neuropsychological Tests, Predictive Value of Tests, Psychomotor Performance, Reaction Time, Temporal Lobe, Time Factors, Biomarkers, Prefrontal Cortex
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