Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord
Open accessAbstract
Oxytocinergic neurons in the paraventricular nucleus of the hypothalamus that project to extrahypothalamic brain areas and the lumbar spinal cord play an important role in the control of erectile function and male sexual behavior in mammals. The gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord is an important component of the neural circuits that control penile reflexes in rats, circuits that are commonly referred to as the "spinal ejaculation generator (SEG)." We have examined the functional interaction between the SEG neurons and the hypothalamo-spinal oxytocin system in rats. Here, we show that SEG/GRP neurons express oxytocin receptors and are activated by oxytocin during male sexual behavior. Intrathecal injection of oxytocin receptor antagonist not only attenuates ejaculation but also affects pre-ejaculatory behavior during normal sexual activity. Electron microscopy of potassium-stimulated acute slices of the lumbar cord showed that oxytocin-neurophysin-immunoreactivity was detected in large numbers of neurosecretory dense-cored vesicles, many of which are located close to the plasmalemma of axonal varicosities in which no electron-lucent microvesicles or synaptic membrane thickenings were visible. These results suggested that, in rats, release of oxytocin in the lumbar spinal cord is not limited to conventional synapses but occurs by exocytosis of the dense-cored vesicles from axonal varicosities and acts by diffusion-a localized volume transmission-to reach oxytocin receptors on GRP neurons and facilitate male sexual function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The appetitive and consummatory aspects of sex are regulated by gonadal steroids (estrogen, progesterone, testosterone) as well as by OT, DA, and AVP.
“The appetitive and consummatory aspects of sex are regulated by gonadal steroids (estrogen, progesterone, testosterone) as well as by OT, DA, and AVP [51,119,120,121,122].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [122]
The Introduction (page unavailable) describes oxytocin’s role in male sexual function, including libido, erection and ejaculation, and says the spinal nuclei controlling erection and ejaculation are androgen-dependent. The Methods (page unavailable) use estradiol and progesterone to induce receptivity in stimulus females. These passages support parts of the broad claim, but the paper does not establish that dopamine or vasopressin regulate the appetitive and consummatory aspects of sex. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn rats, OT release from neurons in the PVN facilitates male sexual activity and ejaculation as well as mating-induced anxiolysis.
“In rats, OT release from neurons in the PVN facilitates male sexual activity and ejaculation as well as mating-induced anxiolysis [122,123].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [122]
The Introduction describes PVN oxytocin neurons projecting to the spinal cord and controlling erection and ejaculation in male rats. The Results report that blocking spinal oxytocin receptors reduced intromissions and ejaculations. Our copy does not report mating-induced anxiolysis; searches for anxiolysis, anxiety, and reduced anxiety after mating found no relevant passage. Page numbers were not available. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Self-citationThe neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · see citing works
Self-citationSwanson, L. W., & Kuypers, H. G. J. M. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901940306 · Cited by 1,413 · see citing works
Knobil and Neill's Physiology of Reproduction
(2015) · Elsevier eBooks · doi:10.1016/c2011-1-07288-0 · Cited by 1,276 · see citing works
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works
A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
Sun, Y.-G., & Chen, Z. (2007) · Nature · doi:10.1038/nature06029 · Cited by 792 · see citing works
Oxytocin-gaze positive loop and the coevolution of human-dog bonds
Nagasawa, M., Mitsui, S., En, S., Ohtani, N., Ohta, M., Sakuma, Y., Onaka, T., Mogi, K., & Kikusui, T. (2015) · Science · doi:10.1126/science.1261022 · Cited by 753 · see citing works
Oxytocin-dependent consolation behavior in rodents
Burkett, J. P., Andari, E., Johnson, Z. V., Curry, D. C., de Waal, F. B. M., & Young, L. J. (2016) · Science · doi:10.1126/science.aac4785 · Cited by 692 · see citing works
Self-citationCD38 is critical for social behaviour by regulating oxytocin secretion
Jin, D., Liu, H.-X., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Shnayder, N. A., Yamada, K., Noda, M., Seike, T., et al. (2007) · Nature · doi:10.1038/nature05526 · Cited by 665 · see citing works
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · see citing works
Cellular Basis of Itch Sensation
Sun, Y.-G., Zhao, Z.-Q., Meng, X.-L., Yin, J., Liu, X., & Chen, Z. (2009) · Science · doi:10.1126/science.1174868 · Cited by 612 · see citing works
Morgan, C. W., Nadelhaft, I., & de Groat, W. C. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902010308 · Cited by 466 · see citing works
Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis
Pow, D. V., & Morris, J. F. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90091-2 · Cited by 446 · see citing works
Self-citationRegulation of cortical microcircuits by unitary GABA-mediated volume transmission
Oláh, S., Füle, M., Komlósi, G., Varga, C., Báldi, R., Barzó, P., & Tamás, G. (2009) · Nature · doi:10.1038/nature08503 · Cited by 386 · see citing works
Identification of a Potential Ejaculation Generator in the Spinal Cord
Truitt, W. A., & Coolen, L. M. (2002) · Science · doi:10.1126/science.1073885 · Cited by 362 · see citing works
Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90478-x · Cited by 360 · see citing works
The neural mechanisms and circuitry of the pair bond
Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353 · see citing works
Self-citationIntracellular calcium stores regulate activity-dependent neuropeptide release from dendrites
Ludwig, M., Sabatier, N., Bull, P. M., Landgraf, R., Dayanithi, G., & Leng, G. (2002) · Nature · doi:10.1038/nature00822 · Cited by 346 · see citing works
Swanson, L. W., & McKellar, S. (1979) · Journal of Comparative Neurology · doi:10.1002/cne.901880108 · Cited by 336 · see citing works
Changes in oxytocin and vasopressin secretion during sexual activity in men
MURPHY, M. R., SECKL, J. R., BURTON, S., CHECKLEY, S. A., & LIGHTMAN, S. L. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-4-738 · Cited by 318 · see citing works
A distributed network for social cognition enriched for oxytocin receptors
Mitre, M., Marlin, B. J., Schiavo, J. K., Morina, E., Norden, S. E., Hackett, T. A., Aoki, C. J., Chao, M. V., & Froemke, R. C. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2409-15.2016 · Cited by 305 · see citing works
DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
Eisenstat, D. D., Liu, J. K., Mione, M., Zhong, W., Yu, G. K., Anderson, S. A., Ghattas, I. R., Puelles, L., & Rubenstein, J. L. R. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991115)414:2 · Cited by 286 · see citing works
Johnson, Z. V., & Young, L. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.034 · Cited by 242 · see citing works
Self-citationZoli, M., Torri, C., Ferrari, R., Jansson, A., Zini, I., Fuxé, K., & Agnati, L. F. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00048-9 · Cited by 235 · see citing works
Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus
Argiolas, A., & Melis, M. R. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.002 · Cited by 227 · see citing works
A model for the study of sexual function in anesthetized male and female rats
McKenna, K. E., Chung, S. K., & McVary, K. T. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.261.5.r1276 · Cited by 220 · see citing works
Young, L. J., & Barrett, C. E. (2015) · Science · doi:10.1126/science.aaa8120 · Cited by 200 · see citing works
Self-citationOxytocin-induced penile erection and yawning: site of action in the brain
Melis, M. R., Argiolas, A., & Gessa, G. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)91485-x · Cited by 190 · see citing works
Meister, B., Villar, M. J., Ceccatelli, S., & Hökfelt, T. G. M. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90094-k · Cited by 174 · see citing works
GnRH Neurons Elaborate a Long-Range Projection with Shared Axonal and Dendritic Functions
Herde, M. K., Iremonger, K. J., Constantin, S., & Herbison, A. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0579-13.2013 · Cited by 170 · see citing works
The acute effects of intranasal oxytocin administration on endocrine and sexual function in males
Burri, A., Heinrichs, M., Schedlowski, M., & Kruger, T. H. C. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.01.014 · Cited by 168 · see citing works
Ju, G., Melander, T., Ceccatelli, S., Hökfelt, T. G. M., & Frey, P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90103-5 · Cited by 168 · see citing works
Localization of oxytocin receptor messenger ribonucleic acid in the rat brain.
Yoshimura, R., Kiyama, H., Kimura, T., Araki, T., Maeno, H., Tanizawa, O., & Tohyama, M. (1993) · Endocrinology · doi:10.1210/endo.133.3.8396014 · Cited by 161 · see citing works
Oxytocin receptors on oxytocin neurones: histoautoradiographic detection in the lactating rat.
Freund‐Mercier, M. J., Stoeckel, M. E., & Klein, M. J. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020349 · Cited by 153 · see citing works
Sex, parturition and motherhood without oxytocin?
Russell, J., & Leng, G. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1570343 · Cited by 150 · see citing works
Neurobiology of Male Sexual Behavior
Hull, E. M., Wood, R. W., & MCKENNA, K. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50038-5 · Cited by 149 · see citing works
The action radius of oxytocin release in the mammalian CNS: from single vesicles to behavior
Chini, B., Verhage, M., & Grinevich, V. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.08.005 · Cited by 141 · see citing works
Oxytocin in the central nervous system and sexual behaviour in male rats
Hughes, A. M., Everitt, B. J., Lightman, S. L., & Todd, K. (1987) · Brain Research · doi:10.1016/0006-8993(87)91333-3 · Cited by 140 · see citing works
ULTRASTRUCTURAL EVIDENCE OF POLARIZED SYNAPSES IN THE NERVE NET OF HYDRA
Westfall, J. A., Yamataka, S., & Enos, P. D. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.51.1.318 · Cited by 125 · see citing works
Truitt, W. A., Shipley, M. T., Veening, J. G., & Coolen, L. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00325.2003 · Cited by 123 · see citing works
Wagner, C. K., & Clemens, L. G. (1991) · Brain Research · doi:10.1016/0006-8993(91)91629-f · Cited by 121 · see citing works
Sakamoto, H., Matsuda, K.-I., Zuloaga, D. G., Hongu, H., Wada, E., Wada, K., Jordan, C. L., Breedlove, S. M., & Kawata, M. (2008) · Nature Neuroscience · doi:10.1038/nn.2126 · Cited by 108 · see citing works
Self-citationWang, H., Ward, A., & Morris, J. F. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00186-m · Cited by 106 · see citing works
Self-citationIncreased Fos Expression in Oxytocin Neurons Following Masculine Sexual Behavior
Witt, D. M., & Insel, T. R. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00549.x · Cited by 102 · see citing works
Spinal pacemaker controlling sexual reflexes in male rats
Sachs, B. D., & Garinello, L. D. (1979) · Brain Research · doi:10.1016/0006-8993(79)90742-x · Cited by 93 · see citing works
The spinal pattern generator for ejaculation
Carro-Juárez, M., & Rodrı́guez–Manzo, G. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.12.002 · Cited by 88 · see citing works
Fisher, T. E., & Bourque, C. W. (2001) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(01)00017-7 · Cited by 85 · see citing works
Fuxe, K., Borroto-Escuela, D. O., Romero-Fernandez, W., Ciruela, F., Manger, P., Leo, G., Díaz-Cabiale, Z., & Agnati, L. F. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.062 · Cited by 81 · see citing works
Sequential Role of E2 and GnRH for the Expression of Estrous Behavior in Ewes
Caraty, A., Delaleu, B., Chesneau, D., & Fabre‐Nys, C. (2002) · Endocrinology · doi:10.1210/endo.143.1.8605 · Cited by 77 · see citing works
Coolen, L. M. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20784 · Cited by 77 · see citing works
SIRINATHSINGHJI, D. J. S. (1987) · Brain Research · doi:10.1016/0006-8993(87)91236-4 · Cited by 76 · see citing works
Male Anorgasmia Treated with Oxytocin
IsHak, W. W., Berman, D. S., & Peters, A. L. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00691.x · Cited by 75 · see citing works
Carro-Juárez, M., Cruz, S. L., & Rodrı́guez–Manzo, G. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02686-6 · Cited by 74 · see citing works
Wagner, C. K., & Clemens, L. G. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903360109 · Cited by 71 · see citing works
Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition
Takayanagi, Y., Yoshida, M., Takashima, A., Takanami, K., Yoshida, S., Nishimori, K., Nishijima, I., Sakamoto, H., Yamagata, T., & Onaka, T. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.021 · Cited by 66 · see citing works
Self-citationNon-synaptic and dendritic exocytosis from dense-cored vesicles in the suprachiasmatic nucleus
Castel, M., Morris, J., & Belenky, M. (1996) · NeuroReport · doi:10.1097/00001756-199601310-00040 · Cited by 61 · see citing works
Self-citationNicholas, A. P., Zhang, X., & Hökfelt, T. G. M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00446-2 · Cited by 60 · see citing works
Effects of Paraventricular Lesions on Sex Behavior and Seminal Emission in Male Rats
Ackerman, A. E., Lange, G. M., & Clemens, L. G. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00386-7 · Cited by 60 · see citing works
Dramatic Improvement in Sexual Function Induced by Intranasal Oxytocin
MacDonald, K. S., & Feifel, D. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02703.x · Cited by 59 · see citing works
Wegrzyn, J., Bark, S. J., Funkelstein, L., Mosier, C., Yap, A., Kazemi‐Esfarjani, P., Spada, A. R. L., Sigurdson, C. J., O’Connor, D. T., & HOOK, V. Y. H. (2010) · Journal of Proteome Research · doi:10.1021/pr1003104 · Cited by 57 · see citing works
Morris, J. F. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0680225 · Cited by 55 · see citing works
Self-citationClément, P., Peeters, M., Bernabé, J., Denys, P., Alexandre, L., & Giuliano, F. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.176 · Cited by 53 · see citing works
Ludwig, M., Callahan, M. F., & Morris, M. (2008) · Neuroendocrinology · doi:10.1159/000127058 · Cited by 52 · see citing works
Circuits for social learning: a unified model and application to autism spectrum disorder
DeMayo, M. M., Young, L. J., Hickie, I. B., Song, Y. J. C., & Guastella, A. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.034 · Cited by 52 · see citing works
Self-citationMeeker, R. B., Swanson, D. J., Greenwood, R., & Hayward, J. N. (1991) · Brain Research · doi:10.1016/0006-8993(91)91454-9 · Cited by 51 · see citing works
Higashida, H. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0425-0 · Cited by 49 · see citing works
Sakamoto, H., Takanami, K., Zuloaga, D. G., Matsuda, K.-I., Jordan, C. L., Breedlove, S. M., & Kawata, M. (2009) · Endocrinology · doi:10.1210/en.2008-1791 · Cited by 48 · see citing works
Self-citationCastel, M., Morris, J. F., Whitnall, M. H., & Sivan, N. (1986) · Cell and Tissue Research · doi:10.1007/bf00221868 · Cited by 46 · see citing works
Self-citationDistribution of gastrin‐releasing peptide in the rat trigeminal and spinal somatosensory systems
Takanami, K., Sakamoto, H., Matsuda, K., Satoh, K., Tanida, T., Yamada, S., Inoue, K., Oti, T., Sakamoto, T., & Kawata, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23506 · Cited by 45 · see citing works
Self-citationNewton, B. W. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90312-u · Cited by 40 · see citing works
Westberry, J. M., & Meredith, M. J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02535-6 · Cited by 38 · see citing works
Abe, K., Hazama, M., KATOH, H., Yamamura, K., & Suzuki, M. (2004) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.53.311 · Cited by 32 · see citing works
Brain–spinal cord neural circuits controlling male sexual function and behavior
Sakamoto, H. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.11.002 · Cited by 29 · see citing works
Self-citationAndoh, T., Uta, D., Kato, M., Toume, K., Komatsu, K., & Kuraishi, Y. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00899 · Cited by 29 · see citing works
Self-citationGnRH in the spinal subarachnoid space potentiates lordosis behavior in the female rat
Sirinathsinghji, D. J. S. (1983) · Physiology & Behavior · doi:10.1016/s0031-9384(83)80009-2 · Cited by 27 · see citing works
Phan, D. C., & Newton, B. W. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00819-8 · Cited by 26 · see citing works
Sakamoto, H., Arii, T., & Kawata, M. (2009) · Endocrinology · doi:10.1210/en.2009-0485 · Cited by 25 · see citing works
Self-citationDobberfuhl, A. D., Oti, T., Sakamoto, H., & Marson, L. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12418 · Cited by 25 · see citing works
Self-citationSexually dimorphic nuclei in the spinal cord control male sexual functions
Sakamoto, H. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00184 · Cited by 24 · see citing works
Self-citationSatoh, K., Oti, T., Katoh, A., Ueta, Y., Morris, J. F., Sakamoto, T., & Sakamoto, H. (2015) · FEBS Journal · doi:10.1111/febs.13291 · Cited by 21 · see citing works
Self-citationActivation of MAP Kinase in Lumbar Spinothalamic Cells Is Required for Ejaculation
Staudt, M. D., de Oliveira, C. V. R., Lehman, M. N., McKenna, K. E., & Coolen, L. M. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01741.x · Cited by 19 · see citing works
Oti, T., Takanami, K., Katayama, N., Edey, T., Satoh, K., Sakamoto, T., & Sakamoto, H. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0058-x · Cited by 13 · see citing works
Self-citationKatayama, N., Oti, T., Takanami, K., Sakamoto, T., & Sakamoto, H. (2016) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.92.69 · Cited by 9 · see citing works
Self-citationNeurosecretory Vesicles: Structure, Distribution, Release and Breakdown
Morris, J. F. (2020) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-22989-4_5 · Cited by 9 · see citing works
Self-citationOti, T., Takanami, K., Ito, S., Ueda, T., Matsuda, K., Kawata, M., Soh, J., Ukimura, O., Sakamoto, T., & Sakamoto, H. (2018) · Endocrinology · doi:10.1210/en.2018-00043 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
1 of the 86 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The emergence and influence of internal states
Flavell, S. W., Gogolla, N., Lovett-Barron, M., & Zelikowsky, M. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.030 · Cited by 234 · see citing works
Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191 · see citing works
Self-citationA genetically encoded sensor measures temporal oxytocin release from different neuronal compartments
Qian, T., Wang, H., Wang, P., Geng, L., Mei, L., Osakada, T., Wang, L. A., Tang, Y., Kania, A., Grinevich, V., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-022-01561-2 · Cited by 145 · see citing works
Whole-brain wiring diagram of oxytocin system in adult mice
Son, S., Manjila, S. B., Newmaster, K. T., Wu, Y.-T., Vanselow, D. J., Ciarletta, M., Anthony, T. E., Cheng, K. C., & Kim, Y. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.0307-22.2022 · Cited by 125 · see citing works
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100 · see citing works
Loth, M. K., & Donaldson, Z. R. (2020) · Endocrinology · doi:10.1210/endocr/bqaa223 · Cited by 74 · see citing works
The multiple faces of the oxytocin and vasopressin systems in the brain
Grinevich, V., & Ludwig, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13004 · Cited by 74 · see citing works
The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives
Blumenthal, S. A., & Young, L. J. (2023) · Biology · doi:10.3390/biology12060844 · Cited by 59 · see citing works
Self-citationThe oxytocin system and early‐life experience‐dependent plastic changes
Onaka, T., & Takayanagi, Y. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13049 · Cited by 60 · see citing works
Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms
Liu, C. M., Spaulding, M. O., Rea, J. J., Noble, E. E., & Kanoski, S. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910859 · Cited by 53 · see citing works
Understanding and treating ejaculatory dysfunction in men with diabetes mellitus
Desai, A., Chen, R., Cayetano-Alcaráz, A. A., Jayasena, C. N., & Minhas, S. (2022) · Andrology · doi:10.1111/andr.13262 · Cited by 51 · see citing works
Oxytocin—a social peptide? Deconstructing the evidence
Leng, G., Leng, R., & Ludwig, M. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0055 · Cited by 48 · see citing works
Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances
Melis, M. R., & Argiolas, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910376 · Cited by 44 · see citing works
Oxytocin signaling in the posterior hypothalamus prevents hyperphagic obesity in mice
Inada, K., Tsujimoto, K., Yoshida, M., Nishimori, K., & Miyamichi, K. (2022) · eLife · doi:10.7554/elife.75718 · Cited by 39 · see citing works
Hypothalamic–Pituitary Diseases and Erectile Dysfunction
Salvio, G., Martino, M., Giancola, G., Arnaldi, G., & Balercia, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10122551 · Cited by 29 · see citing works
Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders
Zhang, S., Zhang, Y., Shi, D., & Wang, Z. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01173-6 · Cited by 28 · see citing works
Buijs, R. M., Hurtado‐Alvarado, G., & Soto‐Tinoco, E. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12998 · Cited by 23 · see citing works
Brainwide input-output architecture of paraventricular oxytocin and vasopressin neuronsPreprint
Freda, S. N., Priest, M. F., Badong, D., Xiao, L., Liu, Y., & Kozorovitskiy, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.17.476652 · Cited by 22 · see citing works
Boender, A. J., Boon, M., Albers, H. E., Eck, S. R., Fricker, B. A., Kelly, A. M., LeDoux, J. E., Motta, S. C., Shrestha, P., Taylor, J. H., et al. (2023) · Science Advances · doi:10.1126/sciadv.adf4950 · Cited by 19 · see citing works
Self-citationNeural cell-types and circuits linking thermoregulation and social behavior
Rogers, J. F., Vandendoren, M., Prather, J. F., Landen, J. G., Bedford, N. L., & Nelson, A. C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105667 · Cited by 20 · see citing works
Kobayashi, A., Hamada, M., Yoshida, M., Kobayashi, Y., Tsutsui, N., Sekiguchi, T., Matsukawa, Y., Maejima, S., Gingell, J. J., Sekiguchi, S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abk0331 · Cited by 15 · see citing works
Self-citationLiang, T., Jin, Z., Lin, Y., Chen, Z., Li, Y., Xu, J., Yang, F., & Qin, L. (2025) · Military Medical Research · doi:10.1186/s40779-025-00600-8 · Cited by 15 · see citing works
Uta, D., Oti, T., Sakamoto, T., & Sakamoto, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073400 · Cited by 11 · see citing works
Self-citationHorii, K., Sawamura, T., Onishi, A., Yuki, N., Naitou, K., Shiina, T., & Shimizu, Y. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00033.2022 · Cited by 10 · see citing works
Oti, T., & Sakamoto, H. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13324 · Cited by 9 · see citing works
Self-citationBeyond the HPA axis: Synaptic circuits of PVNCRH neurons in stress-related psychiatric disorders
Zheng, J., Yue, N., Tian, Z., Yu, J., & Li, B. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108179 · Cited by 8 · see citing works
Huang, S., Zeng, J., Sun, R., Yu, H. Y., Zhang, H., Su, X., & Yao, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.840398 · Cited by 8 · see citing works
Lenschow, C., Mendes, A. R., Ferreira, L., Lacoste, B., Marques, H. G., Quilgars, C., Bertrand, S. S., & Lima, S. Q. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.04.510783 · Cited by 8 · see citing works
Projectome-defined subtypes and modular intra-hypothalamic subnetworks of peptidergic neuronsPreprint
Jiao, Z., Gao, T., Wang, X., Zhang, W., Biglari, N., Boxer, E. E., Steuernagel, L., Ding, X., Yu, Z., Li, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.25.542241 · Cited by 10 · see citing works
Luan, J., Zhang, Q., Zhou, X., Zhou, X., Gu, Q., Xia, J., & Song, N. (2023) · Andrology · doi:10.1111/andr.13444 · Cited by 7 · see citing works
Systemic effects of oxytocin on male sexual activity via the spinal ejaculation generator in rats
Oti, T., Sakamoto, T., & Sakamoto, H. (2021) · Communicative & Integrative Biology · doi:10.1080/19420889.2021.1902056 · Cited by 7 · see citing works
Self-citationOxytocin facilitates human touch-induced play behavior in rats
Hayashi, H., Tateishi, S., Inutsuka, A., Maejima, S., Hagiwara, D., Sakuma, Y., Onaka, T., Grinevich, V., & Sakamoto, H. (2025) · Current Biology · doi:10.1016/j.cub.2025.05.034 · Cited by 6 · see citing works
Self-citationOti, T., Ueda, R., Kumagai, R., Nagafuchi, J., Ito, T., Sakamoto, T., Kondo, Y., & Sakamoto, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910362 · Cited by 6 · see citing works
Self-citationTakanami, K., Oti, T., Kobayashi, Y., Hasegawa, K., Ito, T., Tsutsui, N., Ueda, Y., Carstens, E. E., Sakamoto, T., & Sakamoto, H. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25376 · Cited by 6 · see citing works
Self-citationRaghuraman, R., Bhuyan, A. K., Baro, A., & Saikia, U. K. (2024) · Journal of Human Reproductive Sciences · doi:10.4103/jhrs.jhrs_60_24 · Cited by 5 · see citing works
Involvement of Histamine H3 Receptor Agonism in Premature Ejaculation Found by Studies in Rats
Kiyohara, K., Uta, D., Nagaoka, Y., Kino, Y., Nonaka, H., Ninomiya, M., & Fujita, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042291 · Cited by 5 · see citing works
Self-citationFootedness for scratching itchy eyes in rodents
Katayama, Y., Miura, A., Sakamoto, T., Takanami, K., & Sakamoto, H. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2022.1126 · Cited by 5 · see citing works
Self-citationThe central oxytocinergic system of the prairie vole
Ramos, E., Jiron, G. M., Danoff, J. S., Anderson, Z., Carter, C. S., Perkeybile, A. M., Connelly, J. J., & Erişir, A. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02832-1 · Cited by 4 · see citing works
Yamamoto, S., Kashimoto, R., Furukawa, S., Sakamoto, H., & Satoh, A. (2021) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.23093 · Cited by 4 · see citing works
Self-citationOxytocin Release: A Remedy for Cerebral Inflammaging
Buemann, B. (2022) · Current Aging Science · doi:10.2174/1874609815666220414104832 · Cited by 4 · see citing works
Liao, K., & Lou, Q. (2024) · PLoS ONE · doi:10.1371/journal.pone.0303338 · Cited by 4 · see citing works
Woszczyło, M., Szumny, A. J., Knap, P., Jezierski, T. A., Niżański, W., Kokocińska, A., Skwark, M. J., & Dzięcioł, M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0278524 · Cited by 4 · see citing works
Takanami, K., Morishita, M., Sakamoto, T., & Sakamoto, H. (2023) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2023.114289 · Cited by 5 · see citing works
Self-citationLenschow, C., Mendes, A. R., Ferreira, L., Lacoste, B., Marques, H. G., Gutiérrez‐Castellanos, N., Quilgars, C., Bertrand, S. S., & Lima, S. Q. (2025) · Nature Communications · doi:10.1038/s41467-025-63877-2 · Cited by 10 · see citing works
A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types
Li, Y., Butler, T. C., Nardone, S., Jacobs, C. L., Douglass, A. M., Madara, J. C., McDonough, M. C., Tao, J., Lowenstein, E. D., Wang, L., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116904 · Cited by 4 · see citing works
Ohashi, N., Uta, D., Ohashi, M., & Baba, H. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.03.023 · Cited by 4 · see citing works
Self-citationReduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms
Hassan, M., Flanagan, T. W., Eshaq, A. M., Altamimi, O. K., Altalag, H., Alsharif, M., Alshammari, N., Alkhalidi, T., Boulifa, A., Jamal, S. M. E., et al. (2025) · Cancers · doi:10.3390/cancers17050843 · Cited by 3 · see citing works
Sakamoto, H., & Inutsuka, A. (2024) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.24-00001 · Cited by 2 · see citing works
Self-citationDoes activation of oxytocinergic reward circuits postpone the decline of the aging brain?
Buemann, B. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1250745 · Cited by 2 · see citing works
Whole-brain mapping of spinal-projecting neurons in larval zebrafishPreprint
Tano, M. C., Fidelin, K., Welch, T., Narayan, S., Ahrens, M. B., Dubuc, R., & Wyart, C. (2026) · eLife · doi:10.7554/elife.112062 · Cited by 2 · see citing works
Comparative Perspectives on the Function of Oxytocin in Fish and Mammals
Yokoi, S., Young, L. J., & Takeuchi, H. (2022) · Springer eBooks · doi:10.1007/978-981-19-5359-0_8 · Cited by 1 · see citing works
Self-citationAdenosine signaling: a potential therapeutic target for psychogenic erectile dysfunction
Xue, K. (2024) · American Journal of Translational Research · doi:10.62347/yzdz1428 · Cited by 1 · see citing works
102 高速衝撃ねじり試験機の試作(加工, 日本鉄鋼協会第 67 回(春季)講演大会講演論文集 (II))
作井, 誠., & 中村, 正. (1964) · 鐵と鋼 : 日本鐡鋼協會々誌
Althammer, F., Stern, J. E., & Grinevich, V. (2021) · Masterclass in neuroendocrinology · doi:10.1007/978-3-030-86630-3_6
Nasukawa, D., Matsushima, S., Yamada, K., Ujihara, Y., Hirakata, H., Tamura, R., Yatagai, S., Hayashi, K., & Toda, K. (2026) · Pharmacology Biochemistry and Behavior · doi:10.1101/2022.07.23.501222 · Cited by 2 · see citing works
Masugi-Tokita, M., Kubota, S., KOBAYASHI, K. P., Yoshida, T., Kageyama, S., Sakamoto, H., & Kawauchi, A. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.11.012
Self-citationCabral, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-818872-9.00167-9 · Cited by 1 · see citing works
Neuroendocrinology of reproductive behavior
Chiang, V. S., & Park, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15986-2.00015-0
Rae, R. J., Alberhasky, J. M. H., Baillet, M., Bangasser, D. A., Belloy, M. E., Berry, A. S., Berteotti, C., Bow, H., Buckley, R. F., Caldwell, J. K., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71291 · Cited by 1 · see citing works
Effets de l’exposition aux phtalates sur les comportements de reproduction de la souris femelle
Adam, N. (2022) · theses.fr (ABES) · doi:10.70675/f8535eb9z782dz40b8zb1d0z583132d3fd1b
Hu, Z., Luo, J., Lou, J., Deng, J., Gong, Z. T., & Chen, J. M. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03911-2
Hypothalamic supraoptic and paraventricular nuclei
Krabichler, Q., & Grinevich, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-24078-2.00012-7
Whole brain mapping of spinal-projecting neurons in larval zebrafishPreprint
Tano, M. C., Fidelin, K., Welch, T., Narayan, S., Ahrens, M. B., Dubuc, R., & Wyart, C. (2026) · eLife · doi:10.7554/elife.112062.2
- Authors
- Oti, T., Satoh, K., Uta, D., Nagafuchi, J., Tateishi, S., Ueda, R., Takanami, K., Young, L. J., Galione, A., Morris, J. F., Sakamoto, T., & Sakamoto, H.
- Affiliations
- Okayama University (JP)
- University of Toyama (JP)
- National Institute of Genetics (JP)
- University of Tsukuba (JP)
- University of Oxford (GB)
- Corresponding author
- Sakamoto, Hirotaka
- ORCID
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 31
- Issue
- 1
- Pages
- 103-114.e5
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC7855431
- OpenAlex
- W3096327674
- Cited by
- 63
- References
- 86
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 21 · 2021: 11 · 2020: 1
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Okayama University Scientific Achievement Repository (Okayama University) (submittedVersion)
- Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Foundation for the National Institutes of Health
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, male sexual behavior, lumbar spinal cord, volume transmission, dense core vesicles, axonal varicosities, oxytocin receptor, paraventricular nucleus, erectile function, neurosecretion
- MeSH terms
- Animals, Axons, Diffusion, Ejaculation, Exocytosis, Female, Hypothalamus, Injections, Spinal, Lumbar Vertebrae, Male, Oxytocin, Penile Erection, Penis, Spinal Cord, Receptors, Oxytocin, Gastrin-Releasing Peptide, Rats, Rats, Transgenic, Heparin-binding EGF-like Growth Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review