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Cited by 49Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorCognitive Abilities and Testing

A functional magnetic resonance imaging study of the effects of pergolide, a dopamine receptor agonist, on component processes of working memory

Gibbs, S.E.B., D’Esposito, M.·2006·Neuroscience
DOI 10.1016/j.neuroscience.2005.11.055
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Abstract

Working memory is an important cognitive process dependent on a network of prefrontal and posterior cortical regions. In this study we tested the effects of the mixed D1-D2 dopamine receptor agonist pergolide on component processes of human working memory using functional magnetic resonance imaging (fMRI). An event-related trial design allowed separation of the effects on encoding, maintenance, and retrieval processes. Subjects were tested with spatial and object memoranda to investigate modality-specific effects of dopaminergic stimulation. We also measured baseline working memory capacity as previous studies have shown that effects of dopamine agonists vary with working memory span. Pergolide improved reaction time for high-span subjects and impaired reaction time for low-span subjects. This span-dependent change in behavior was accompanied by span-dependent changes in delay-related activity in the premotor cortex. We also found evidence for modality-specific effects of pergolide only during the response period. Pergolide increased activity for spatial memoranda and decreased activity for object memoranda in task-related regions including the prefrontal and parietal cortices.

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Crossref · 10.1016/j.neuroscience.2005.11.055

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  • Dopamine has an inverted U-shaped influence on working memory abilities via actions at the D1 receptor family in both animals and humans.

    “Dopamine has an inverted U-shaped influence on working memory abilities via actions at the D1 receptor family in both animals (100) and humans (105).”

    From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [105]

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Authors
Gibbs, S. E. B., & D’Esposito, M.
Affiliations
University of California, Berkeley (US)
Corresponding author
Gibbs, S.E.B.
ORCID
D’Esposito, M.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2006-04
Volume
139
Issue
1
Pages
359-371
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2005.11.055
OpenAlex
W2007581462
Cited by
49
References
80
Citations by year
2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 2
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01da011754-04)
  • National Institute of Mental Health (R01MH063901, MH 63901)
  • National Institute on Drug Abuse (DA11754)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
pergolide, dopamine agonists, working memory, working memory span, memory encoding, memory maintenance, memory retrieval, premotor cortex, prefrontal cortex, parietal cortex, spatial memory, object memory, reaction time
MeSH terms
Adult, Brain Mapping, Dopamine, Evoked Potentials, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Parietal Lobe, Pattern Recognition, Visual, Pergolide, Reaction Time, Receptors, Dopamine, Space Perception, Observer Variation, Prefrontal Cortex, Dopamine Agonists

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