Personality traits are differentially associated with patterns of reward and novelty processing in the human substantia nigra/ventral tegmental area
Abstract
Background The long-standing observation that the novelty-seeking personality trait is a predictor of drug use and other reinforcable risky behaviors raises the question as to how novelty and reward processing functionally interact in mesolimbic dopaminergic circuitry and how this interaction is modulated by the novelty-seeking personality trait.Methods Functional magnetic resonance imaging (fMRI) hemodynamic responses to novelty and reward (monetary incentive) from the substantia nigra/ventral tegmental area (SN/VTA), the nucleus accumbens (NAcc), and the hippocampus of 29 subjects were correlated with novelty-seeking scores. These correlations were compared with those obtained for scores of reward-dependence. The fMRI data were taken from two experiments in which the interaction of novelty and reward was manipulated as a within-subject variable, and long-term memory for the critical stimuli was assessed after 24 hours.Results Novelty-seeking was positively correlated with SN/VTA activation elicited by novel cues that did not predict reward, whereas reward-dependence was related to activations elicited by novel cues that predicted reward. The positive correlation between SN/VTA responses to novelty and novelty-seeking scores was accompanied by a negative correlation with reward-related SN/VTA activation and memory enhancement.Conclusions SN/VTA responses to novelty and reward are differentially affected by personality traits of novelty-seeking and reward-dependence. Importantly, novelty-seekers were more responsive to novel cues in the absence of reward and needed less reward to boost their memory for novel cues. These observations strongly suggest that for novelty-seekers, the motivational value of novelty is not necessarily based on actual reward-predicting stimulus properties.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The prospect of receiving reward improved long-term episodic memory for novel stimuli in incidental and intentional encoding paradigms.
“It was found that the prospect of receiving reward (e.g., monetary gain) improved long-term episodic memory for novel stimuli in incidental [47, 55–57] and intentional [46] encoding paradigms.”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [56]
The personality trait of novelty seeking is correlated with the magnitude of the SN/VTA novelty fMRI response even when novel stimuli predict the absence of reward.
“Interestingly, the personality trait of novelty seeking is correlated with the magnitude of the SN/VTA novelty fMRI response even when novel stimuli predict the absence of reward [56]”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [56]
Memory enhancement after long retention intervals (e.g. 24 hours) has been consistently found.
“Memory enhancement after long retention intervals (e.g. 24 hours) has been consistently found [56, 57].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [56]
Cites
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072 · see citing works
The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580 · see citing works
The temperament and character inventory (TCI) : a guide to its development and use
Cloninger, C. R. (1994) · Medical Entomology and Zoology · Cited by 2,319 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
Dopamine neuron systems in the brain: An update
Björklund, A., & Dunnett, S. B. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.006 · Cited by 1,777 · see citing works
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Factors That Predict Individual Vulnerability to Amphetamine Self-Administration
Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1989) · Science · doi:10.1126/science.2781295 · Cited by 1,355 · see citing works
Adaptive Coding of Reward Value by Dopamine Neurons
Tobler, P. N., Fiorillo, C. D., & Schultz, W. (2005) · Science · doi:10.1126/science.1105370 · Cited by 1,276 · see citing works
Personality and Risk‐Taking: Common Bisocial Factors
Zuckerman, M., & Kuhlman, D. M. (2000) · Journal of Personality · doi:10.1111/1467-6494.00124 · Cited by 1,260 · see citing works
A unified biosocial theory of personality and its role in the development of anxiety states.
Cr, C. (1986) · PubMed · Cited by 1,090 · see citing works
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034 · see citing works
THE TRIDIMENSIONAL PERSONALITY QUESTIONNAIRE: U.S. NORMATIVE DATA
Cloninger, C. R., Przybeck, T. R., & Švrakić, D. M. (1991) · Psychological Reports · doi:10.2466/pr0.1991.69.3.1047 · Cited by 1,034 · see citing works
Responses of monkey dopamine neurons during learning of behavioral reactions
Ljungberg, T., Apicella, P., & Schultz, W. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.1.145 · Cited by 987 · see citing works
Reward-motivated learning: mesolimbic activation precedes memory formation
Adcock, R. A., Thangavel, A., Whitfield-Gabrieli, S., Knutson, B., & Gabrieli, J. D. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.036 · Cited by 977 · see citing works
Computational roles for dopamine in behavioural control
Montague, P. R., Hyman, S. E., & Cohen, J. D. (2004) · Nature · doi:10.1038/nature03015 · Cited by 966 · see citing works
The neural basis of the blood–oxygen–level–dependent functional magnetic resonance imaging signal
Logothetis, N. K. (2002) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1114 · Cited by 952 · see citing works
Contribution of human hippocampal region to novelty detection
Knight, R. T. (1996) · Nature · doi:10.1038/383256a0 · Cited by 834 · see citing works
Neural mechanisms for detecting and remembering novel events
Ranganath, C., & Rainer, G. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1052 · Cited by 779 · see citing works
Functional magnetic resonance imaging of reward prediction
Knutson, B., & Cooper, J. C. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000173463.24758.f6 · Cited by 736 · see citing works
When zero is not zero: the problem of ambiguous baseline conditions in fMRI
Stark, C. E. L., & Squire, L. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221462998 · Cited by 724 · see citing works
Wittmann, B. C., Schott, B. H., Guderian, S., Frey, J. U., Heinze, H.-J., & Düzel, E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.010 · Cited by 698 · see citing works
BOLD responses reflecting dopaminergic signals in the human ventral tegmental area
D'Ardenne, K., McClure, S. M., Nystrom, L. E., & Cohen, J. D. (2008) · Science · doi:10.1126/science.1150605 · Cited by 661 · see citing works
Ventral Tegmental Area Neurons in Learned Appetitive Behavior and Positive Reinforcement
Fields, H. L., Hjelmstad, G. O., Margolis, E. B., & Nicola, S. M. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094341 · Cited by 611 · see citing works
Aghajanian, G. K., & Bunney, B. S. (1977) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00508803 · Cited by 548 · see citing works
Margolis, E. B., Lock, H., Hjelmstad, G. O., & Fields, H. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117069 · Cited by 527 · see citing works
Absolute Coding of Stimulus Novelty in the Human Substantia Nigra/VTA
Bunzeck, N., & Düzel, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.021 · Cited by 503 · see citing works
Wills, T. A., Vaccaro, D., & McNamara, G. (1994) · Journal of Substance Abuse · doi:10.1016/s0899-3289(94)90039-6 · Cited by 480 · see citing works
Dopamine: generalization and bonuses
Kakade, S. M., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00048-5 · Cited by 477 · see citing works
Morris, R. G. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04888.x · Cited by 398 · see citing works
Weiner, I. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1313-x · Cited by 387 · see citing works
The Yin and Yang of dopamine release: a new perspective
GOTO, Y., OTANI, S., & GRACE, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.007 · Cited by 342 · see citing works
Piazza, P. V., Rougé‐Pont, F., Deminière, J. M., Kharouby, M., Moal, M. L., & Simon, H. (1991) · Brain Research · doi:10.1016/0006-8993(91)91452-7 · Cited by 326 · see citing works
Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder
Ströhle, A., Stoy, M., Wrase, J., Schwarzer, S., Schlagenhauf, F., Huss, M., Hein, J., Nedderhut, A., Neumann, B., Gregor, A., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.044 · Cited by 323 · see citing works
Anatomy of the dopamine system in the basal ganglia
Smith, Y., & Kieval, J. Z. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00023-9 · Cited by 320 · see citing works
Coding of Predicted Reward Omission by Dopamine Neurons in a Conditioned Inhibition Paradigm
Tobler, P. N., Dickinson, A., & Schultz, W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10402.2003 · Cited by 300 · see citing works
The dopaminergic mesencephalic projections to the hippocampal formation in the rat
Gasbarri, A., Sulli, A., & Packard, M. G. (1997) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(96)00157-1 · Cited by 285 · see citing works
Anckarsäter, H., Stahlberg, O., Larson, T., Hakansson, C., Jutblad, S.-B., Niklasson, L., Nydén, A., Wentz, E., Westergren, S., Cloninger, C. R., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.7.1239 · Cited by 271 · see citing works
Gasbarri, A., Packard, M. G., Campana, E., & Pacitti, C. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90288-7 · Cited by 266 · see citing works
Anticipation of novelty recruits reward system and hippocampus while promoting recollection
Wittmann, B. C., Bunzeck, N., Dolan, R. J., & Düzel, E. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.038 · Cited by 265 · see citing works
Marinelli, M., & White, F. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08876.2000 · Cited by 254 · see citing works
Howard, M. O., Kivlahan, D. R., & Walker, R. D. (1997) · Journal of Studies on Alcohol · doi:10.15288/jsa.1997.58.48 · Cited by 244 · see citing works
Schott, B. H., Seidenbecher, C. I., Fenker, D. B., Lauer, C. J., Bunzeck, N., Bernstein, H.-G., Tischmeyer, W., Gundelfinger, E. D., Heinze, H.-J., & Düzel, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3463-05.2006 · Cited by 214 · see citing works
White, F. J., & Wang, R. Y. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90088-2 · Cited by 200 · see citing works
Mercuri, N. B., Saiardi, A., Bonci, A., Picetti, R., Calabresi, P., Bernardi, G., & Borrelli, E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00135-8 · Cited by 198 · see citing works
Schott, B. H., Niehaus, L., Wittmann, B. C., Schütze, H., Seidenbecher, C. I., Heinze, H. –., & Düzel, E. (2007) · Brain · doi:10.1093/brain/awm147 · Cited by 193 · see citing works
Adell, A., & Artigas, F. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.05.001 · Cited by 190 · see citing works
The phasic reward signal of primate dopamine neurons
Schultz, W. (1997) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)60841-8 · Cited by 169 · see citing works
Individual differences in amphetamine sensitization: Dose-dependent effects
Hooks, M. S., Jones, G. H., Neill, D. B., & Justice, J. B. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90083-r · Cited by 138 · see citing works
Excitability of Dopamine Neurons: Modulation and Physiological Consequences
White, F., Hu, X., Marinelli, M., & Rudick, C. N. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706784111542 · Cited by 136 · see citing works
Reward-Spatial View Representations and Learning in the Primate Hippocampus
Rolls, E. T., & Xiang, J.-Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1481-05.2005 · Cited by 129 · see citing works
Responses of monkey midbrain dopamine neurons during delayed alternation performance
Ljungberg, T., Apicella, P., & Schultz, W. (1991) · Brain Research · doi:10.1016/0006-8993(91)90816-e · Cited by 128 · see citing works
Reproducibility of BOLD-based functional MRI obtained at 4 T
Tegeler, C., Strother, S. C., Anderson, J. R., & Kim, S. (1999) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1999)7:4 · Cited by 121 · see citing works
Hernández, G., Hamdani, S., Rajabi, H., Conover, K. L., Stewart, J., Arvanitogiannis, A., & Shizgal, P. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.4.888 · Cited by 105 · see citing works
Volumes, spatial extents and a probabilistic atlas of the human basal ganglia and thalamus
Ahsan, R. L., Allom, R. J., Gousias, I. S., Habib, H., Turkheimer, F., Free, S. L., Lemieux, L., Myers, R., Duncan, J. S., & Brooks, D. J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.004 · Cited by 102 · see citing works
Pélissolo, A., Mallet, L., Baleyte, J., Michel, G., Cloninger, C. R., Allilaire, J., & Jouvent, R. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00551.x · Cited by 101 · see citing works
Loss of autoreceptor function in dopaminergic neurons from dopamine D-2 receptor deficient mice
Mercuri, N., Saiardi, A., Bonci, A., Picetti, R., Calabresi, P., Bernardi, G., & Borrelli, E. (1997) · UCL Discovery (University College London) · Cited by 101 · see citing works
Reward modulates neuronal activity in the hippocampus of the rat
Hölscher, C., Jacob, W., & Mallot, H. A. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00422-9 · Cited by 90 · see citing works
Bradberry, C. W., Gruen, R. J., Berridge, C. W., & Roth, R. H. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90047-6 · Cited by 78 · see citing works
Aghajanian, G. K., & Bs, B. (1977) · PubMed · Cited by 42 · see citing works
Inter-correlations between Cloninger's temperament dimensions — A meta-analysis
Miettunen, J., Lauronen, E., Kantojärvi, L., Veijola, J. M., & Joukamaa, M. I. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.05.003 · Cited by 37 · see citing works
Regional brain cerebral glucose metabolism and temperament: A positron emission tomography study
Hakamata, Y., Iwase, M., Iwata, H., Kobayashi, T., Tamaki, T., Nishio, M., Kawahara, K., Matsuda, H., Ozaki, N., Honjo, S., et al. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.017 · Cited by 30 · see citing works
Pharmacological characterization of dopamine-4-O-sulfate.
Dm, A., Hieble, J. P., Sarau, H. M., & Tc, J. (1984) · PubMed · Cited by 23 · see citing works
Flagged first, then by citations
1 of the 64 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
States of Curiosity Modulate Hippocampus-Dependent Learning via the Dopaminergic Circuit
Gruber, M. J., Gelman, B. D., & Charan Ranganath, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.060 · Cited by 742 · see citing works
A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
Lisman, J., Grace, A. A., & Duzel, E. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.006 · Cited by 465 · see citing works
Induction of Empathy by the Smell of Anxiety
Prehn‐Kristensen, A., Wiesner, C. D., Bergmann, T. O., Wolff, S., Jansen, O., Mehdorn, H. M., Ferstl, R., & Pause, B. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005987 · Cited by 255 · see citing works
Düzel, E., Bunzeck, N., Guitart-Masip, M., & Düzel, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.006 · Cited by 249 · see citing works
Neural correlates of personality: An integrative review
Kennis, M., Rademaker, A. R., & Geuze, E. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.10.012 · Cited by 243 · see citing works
Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218 · see citing works
Functional imaging of the human dopaminergic midbrain
Düzel, E., Bunzeck, N., Guitart-Masip, M., Wittmann, B., Schott, B. H., & Tobler, P. N. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.02.005 · Cited by 216 · see citing works
Gaining while giving: An fMRI study of the rewards of family assistance among White and Latino youth
Telzer, E. H., Masten, C. L., Berkman, E. T., Lieberman, M. D., & Fuligni, A. J. (2010) · Social Neuroscience · doi:10.1080/17470911003687913 · Cited by 189 · see citing works
Dopamine Modulates Episodic Memory Persistence in Old Age
Chowdhury, R., Guitart‐Masip, M., Bunzeck, N., Dolan, R. J., & Düzel, E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1278-12.2012 · Cited by 179 · see citing works
Influence of reward motivation on human declarative memory
Lombard, E., Bavelier, D., & Schwartz, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.015 · Cited by 174 · see citing works
Wolosin, S. M., Zeithamová, D., & Preston, A. R. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00237 · Cited by 151 · see citing works
Revisiting the Role of Rewards in Motivation and Learning: Implications of Neuroscientific Research
Hidi, S. E. (2015) · Educational Psychology Review · doi:10.1007/s10648-015-9307-5 · Cited by 146 · see citing works
Krebs, R. M., Heipertz, D., Schuetze, H., & Duzel, E. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.038 · Cited by 135 · see citing works
Cloninger, C. R., Cloninger, K. M., Zwir, I. J. S., & Keltikangas‐Järvinen, L. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0621-4 · Cited by 141 · see citing works
Curiosity in old age: A possible key to achieving adaptive aging
Sakaki, M., Yagi, A., & Murayama, K. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.007 · Cited by 139 · see citing works
The novelty exploration bonus and its attentional modulation☆
Krebs, R. M., Schott, B. H., Schütze, H., & Düzel, E. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.01.015 · Cited by 127 · see citing works
Uncovering the complex genetics of human temperament
Zwir, I. J. S., Arnedo, J., del Val, C., Pulkki-Råbäck, L., Konte, B., Yang, S. S., Romero‐Zaliz, R., Hintsanen, M., Cloninger, K. M., Garcia, D., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0264-5 · Cited by 123 · see citing works
Gatzke‐Kopp, L. M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.013 · Cited by 115 · see citing works
Reward Processing in Healthy Offspring of Parents With Bipolar Disorder
Singh, M. K., Kelley, R. G., Howe, M. E., Reiss, A. L., Gotlib, I. H., & Chang, K. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1031 · Cited by 107 · see citing works
The Big Five default brain: functional evidence
Sampaio, A., Soares, J. M., Coutinho, J. F. P., Sousa, N., & Gonçalves, Ó. F. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0610-y · Cited by 102 · see citing works
A common mechanism for adaptive scaling of reward and novelty
Bunzeck, N., Dayan, P., Dolan, R. J., & Düzel, E. (2010) · Human Brain Mapping · doi:10.1002/hbm.20939 · Cited by 99 · see citing works
Generation and the subjective feeling of “aha!” are independently related to learning from insight
Kizilirmak, J. M., da Silva, J. G. G., Imamoglu, F., & Richardson‐Klavehn, A. (2015) · Psychological Research · doi:10.1007/s00426-015-0697-2 · Cited by 87 · see citing works
Functional neuroanatomical review of the ventral tegmental area
Trutti, A. C., Mulder, M., Hommel, B., & Forstmann, B. U. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.01.062 · Cited by 90 · see citing works
Neural Correlates of Learning from Induced Insight: A Case for Reward-Based Episodic Encoding
Kizilirmak, J. M., Thuerich, H., Folta-Schoofs, K., Schott, B. H., & Richardson‐Klavehn, A. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01693 · Cited by 78 · see citing works
Connectome-based individualized prediction of temperament trait scores
Jiang, R., Calhoun, V. D., Zuo, N., Lin, D., Li, J., Fan, L., Qi, S., Sun, H., Fu, Z., Song, M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.038 · Cited by 81 · see citing works
Behavioral endophenotypes of drug addiction: Etiological insights from neuroimaging studies
Jupp, B., & Dalley, J. W. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.041 · Cited by 77 · see citing works
The Subcortical Cocktail Problem; Mixed Signals from the Subthalamic Nucleus and Substantia Nigra
de Hollander, G., Keuken, M. C., & Forstmann, B. U. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120572 · Cited by 67 · see citing works
Brain activity in near-death experiencers during a meditative state
Beauregard, M., Courtemanche, J., & Paquette, V. (2009) · Resuscitation · doi:10.1016/j.resuscitation.2009.05.006 · Cited by 65 · see citing works
Behavioral specifications of reward-associated long-term memory enhancement in humans
Wittmann, B. C., Dolan, R. J., & Düzel, E. (2011) · Learning & Memory · doi:10.1101/lm.1996811 · Cited by 62 · see citing works
Novelty Enhances Visual Salience Independently of Reward in the Parietal Lobe
Foley, N. C., Jangraw, D. C., Peck, C., & Gottlieb, J. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4171-13.2014 · Cited by 63 · see citing works
Montag, C., Markett, S. A., Basten, U., Stelzel, C., Fiebach, C. J., Canli, T., & Reuter, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.55 · Cited by 59 · see citing works
The Mesolimbic Dopamine Pathway and Romantic Love
Xu, X., Weng, X., & Aron, A. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00057-9 · Cited by 57 · see citing works
Otmakhova, N. A., Düzel, E., Deutch, A. Y., & Lisman, J. E. (2012) · Springer eBooks · doi:10.1007/978-3-642-32375-1_10 · Cited by 57 · see citing works
Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway
Kesner, A. J., Calva, C. B., & Ikemoto, S. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102252 · Cited by 56 · see citing works
Functional Connectome of the Five-Factor Model of Personality
Toschi, N., Riccelli, R., Indovina, I., Terracciano, A., & Passamonti, L. (2018) · Personality Neuroscience · doi:10.1017/pen.2017.2 · Cited by 52 · see citing works
Distinct Medial Temporal Lobe Network States as Neural Contexts for Motivated Memory Formation
Murty, V. P., & Adcock, R. (2017) · Springer eBooks · doi:10.1007/978-3-319-50406-3_15 · Cited by 41 · see citing works
Novelty Manipulations, Memory Performance, and Predictive Coding: the Role of Unexpectedness
Reichardt, R., Polner, B., & Simor, P. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00152 · Cited by 48 · see citing works
Adrián‐Ventura, J., Costumero, V., Parcet, M. A., & Ávila, C. (2019) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-019-00688-1 · Cited by 48 · see citing works
Differential effects of white noise in cognitive and perceptual tasks
Herweg, N. A., & Bunzeck, N. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01639 · Cited by 50 · see citing works
Kizilirmak, J. M., Schott, B. H., Thuerich, H., Sweeney‐Reed, C. M., Richter, A., Folta-Schoofs, K., & Richardson‐Klavehn, A. (2019) · Consciousness and Cognition · doi:10.1016/j.concog.2019.01.005 · Cited by 41 · see citing works
Approach–withdrawal and the role of the striatum in the temperament of behavioral inhibition.
Helfinstein, S. M., Fox, N. A., & Pine, D. S. (2011) · Developmental Psychology · doi:10.1037/a0026402 · Cited by 43 · see citing works
Wang, Y., Liu, Y., Yang, L., Gu, F., Li, X., Zha, R., Wei, Z., Pei, Y., Zhang, P., Zhou, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep10534 · Cited by 42 · see citing works
Lei, X., Chen, C., Xue, F., He, Q., Chen, C., Liu, Q., Moyzis, R. K., Xue, G., Cao, Z., Li, J., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.043 · Cited by 39 · see citing works
The effect of novelty on reinforcement learning
Houillon, A., Lorenz, R. C., Böhmer, W., Rapp, M. A., Heinz, A., Gallinat, J., & Obermayer, K. (2013) · Progress in brain research · doi:10.1016/b978-0-444-62604-2.00021-6 · Cited by 41 · see citing works
Ninaus, M., Kiili, K. J. M., Wood, G. M. D. O., Moeller, K., & Kober, S. E. (2020) · IEEE Transactions on Learning Technologies · doi:10.1109/tlt.2020.3031644 · Cited by 35 · see citing works
Krauel, K., Feldhaus, H. C., Simon, A., Rehe, C., Glaser, M. B., Flechtner, H., Heinze, H., & Niehaus, L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.013 · Cited by 33 · see citing works
Konok, V., Marx, A., & Faragó, T. (2019) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2019.02.014 · Cited by 33 · see citing works
Oxytocin and Facial Emotion Recognition
Ellenbogen, M. A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_20 · Cited by 33 · see citing works
Edmiston, E. K., Fournier, J. C. J., Chase, H. W., Bertocci, M. A., Greenberg, T., Aslam, H. A., Lockovich, J., Graur, S., Bebko, G. M., Forbes, E. E., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.10.012 · Cited by 32 · see citing works
Constraints on decision making: Implications from genetics, personality, and addiction
Baker, T. E., Stockwell, T. R., & Holroyd, C. B. (2013) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-013-0164-8 · Cited by 31 · see citing works
Social rank-associated stress vulnerability predisposes individuals to cocaine attraction
Yanovich, C., Kirby, M. L., Michaelevski, I., Yadid, G., & Pinhasov, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-19816-x · Cited by 31 · see citing works
Exploration of a novel virtual environment improves memory consolidation in ADHD
Baumann, V., Birnbaum, T., Breitling-Ziegler, C., Tegelbeckers, J., Dambacher, J., Edelmann, E., Bergado-Acosta, J. R., Flechtner, H., & Krauel, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-78222-4 · Cited by 30 · see citing works
Disentangling the personality pathways to well-being
Moreira, P. A. S., Inman, R. A., & Cloninger, C. R. (2023) · Scientific Reports · doi:10.1038/s41598-023-29642-5 · Cited by 27 · see citing works
Effects of active exploration on novelty-related declarative memory enhancement
Schomaker, J., & Wittmann, B. C. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107403 · Cited by 29 · see citing works
Schindler, A. G., Meabon, J. S., Pagulayan, K. F., Hendrickson, R. C., Meeker, K. D., Cline, M. M., Li, G., Sikkema, C. L., Wilkinson, C. W., Perl, D. P., et al. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.06.004 · Cited by 28 · see citing works
Neurochemical modulation of repetition suppression and novelty signals in the human brain
Bunzeck, N., & Thiel, C. M. (2015) · Cortex · doi:10.1016/j.cortex.2015.10.013 · Cited by 28 · see citing works
Zweynert, S. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00144 · Cited by 28 · see citing works
Perceptual, Cognitive, and Personality Rigidity in Parkinson’s Disease
Díaz-Santos, M., Cao, B., Yazdanbakhsh, A., Norton, D. J., Neargarder, S., & Cronin-Golomb, A. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.01.044 · Cited by 27 · see citing works
Neural Correlates of Motor Vigour and Motor Urgency During Exercise
Rauch, L., Schönbächler, G., & Noakes, T. D. (2013) · Sports Medicine · doi:10.1007/s40279-013-0025-1 · Cited by 25 · see citing works
Li, S., Demenescu, L. R., Sweeney‐Reed, C. M., Krause, A. L., Metzger, C. D., & Walter, M. (2017) · Human Brain Mapping · doi:10.1002/hbm.23648 · Cited by 25 · see citing works
Keck, T. M., Suchland, K. L., Jimenez, C. C., & Grandy, D. K. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.006 · Cited by 26 · see citing works
Perogamvros, L., Aberg, K., Gex-Fabry, M., Perrig, S., Cloninger, C. R., & Schwartz, S. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134504 · Cited by 25 · see citing works
Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory
Barman, A., Assmann, A., Richter, S., Soch, J., Schuetze, H., Wüstenberg, T., Deibele, A., Klein, M., Richter, A., Behnisch, G., et al. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00260 · Cited by 25 · see citing works
Variables influencing the neural correlates of perceived risk of physical harm
Coaster, M., Rogers, B. P., Jones, O. D., Viscusi, W. K., Merkle, K. L., Zald, D. H., & Gore, J. C. (2011) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-011-0047-9 · Cited by 24 · see citing works
“The midbrain has been previously reported for processing novel salient stimuli ( Krebs, Schott, & Duzel, 2009 ) and for voluntary risk-taking choice behavior in the balloon assessment risk task (Rao, Korczykowski, Pluta, Hoang, & Detre, 2008).”
BackgroundCollins, H. R., Corbly, C. R., Liu, X., Kelly, T. H., Lynam, D. R., & Joseph, J. E. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.004 · Cited by 24 · see citing works
Reinforcement Sensitivity Theory, Research, Applications, and Future
Smillie, L. D., Loxton, N. J., & Avery, R. E. (2011) · Wiley eBooks · doi:10.1002/9781444343120.ch4 · Cited by 24 · see citing works
Ren, J., Huang, F., Gao, C., Gott, J., Schoch, S. F., Qin, S., Dresler, M., & Luo, J. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac129 · Cited by 23 · see citing works
Schott, B. H., Voss, M., Wagner, B., Wüstenberg, T., Düzel, E., & Behr, J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00144 · Cited by 23 · see citing works
Guran, C.-N. A., Lehmann-Grube, J., & Bunzeck, N. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02997 · Cited by 19 · see citing works
The Intricacies of Dopamine Neuron Modulation
Heinz, A., Grace, A. A., & Beck, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.003 · Cited by 20 · see citing works
The influence of genes on “positive valence systems” constructs: A systematic review
Hess, J., Kawaguchi, D. M., Wagner, K. E., Faraone, S. V., & Glatt, S. J. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32382 · Cited by 18 · see citing works
Levodopa effects on [11C]raclopride binding in the resting human brain
BLACK, K. J., Piccirillo, M. L., Koller, J. M., Hseih, T., Wang, L., & Mintun, M. A. (2015) · F1000Research · doi:10.12688/f1000research.5672.1 · Cited by 18 · see citing works
Effects of valence and arousal on implicit approach/ avoidance tendencies: A fMRI study
Ascheid, S., Wessa, M., & Linke, J. O. (2019) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2019.05.028 · Cited by 18 · see citing works
“Wanting” versus “needing” related value: An fMRI meta‐analysis
Bosulu, J., Allaire, M., Tremblay‐Grénier, L., Luo, Y., Eickhoff, S. B., & Hétu, S. (2022) · Brain and Behavior · doi:10.1002/brb3.2713 · Cited by 16 · see citing works
Midbrain fMRI: Applications, Limitations and Challenges
Düzel, E., Guitart-Masip, M., Maass, A., Hämmerer, D., Betts, M. J., Speck, O., Weiskopf, N., & Kanowski, M. (2015) · Biological Magnetic Resonance · doi:10.1007/978-1-4899-7591-1_20 · Cited by 16 · see citing works
Active Reward Processing during Human Sleep: Insights from Sleep-Related Eating Disorder
Perogamvros, L., Baud, P., Hasler, R., Cloninger, C. R., Schwartz, S., & Perrig, S. H. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00168 · Cited by 17 · see citing works
The striatum and beyond: contributions of the hippocampus to decision making
Wimmer, G. E., & Daphna Shohamy, A. (2011) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199600434.003.0013 · Cited by 14 · see citing works
Ludwig, M., Richter, M. F., Goltermann, J., Redlich, R., Repple, J., Flint, C., Grotegerd, D., Koch, K., Leehr, E. J., Meinert, S. L., et al. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105148 · Cited by 13 · see citing works
Pérez, E. J. P., de León, J. M. R. S., Arroyo, Á. O., Mota, G. R., Luque, M. L., & García, C. P. (2011) · PubMed · Cited by 11 · see citing works
Adaptive scaling of reward in episodic memory: a replication study
Mason, A., Ludwig, C. J. H., & Farrell, S. (2016) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470218.2016.1233439 · Cited by 11 · see citing works
Ramm, M., Urbanek, A., Failing, A., Young, P., Scherfler, C., Högl, B., & Heidbreder, A. (2020) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8688 · Cited by 11 · see citing works
Dickerson, K. C., & Adcock, R. A. (2018) · Wiley eBooks · doi:10.1002/9781119170174.epcn107 · Cited by 1 · see citing works
Schaub, A.-C., Vogel, M., Lang, U. E., Kaiser, S., Walter, M., Herdener, M., Wrege, J. S., Kirschner, M., & Schmidt, A. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103423 · Cited by 9 · see citing works
Brancato, A., Cavallaro, A., Lavanco, G., Plescia, F., & Cannizzaro, C. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725683 · Cited by 9 · see citing works
Do Event-Related Evoked Potentials Reflect Apathy Tendency and Motivation?
Takayoshi, H., Onoda, K., & Yamaguchi, S. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00011 · Cited by 9 · see citing works
Time-resolved connectome of the five-factor model of personality
Passamonti, L., Riccelli, R., Indovina, I., Duggento, A., Terracciano, A., & Toschi, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-51469-2 · Cited by 9 · see citing works
A bias toward the unknown: individual and environmental factors influencing exploratory behavior
Petzke, T. M., & Schomaker, J. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14757 · Cited by 8 · see citing works
Paganini, C., Peterson, G. M., & Andrews, K. (2021) · The Journal of Genetic Psychology · doi:10.1080/00221325.2021.1940822 · Cited by 8 · see citing works
Basile, G. A., Bramanti, A., Bertino, S., Cutroneo, G., Bruno, A., Tisano, A., Paladina, G., Milardi, D., & Anastasi, G. (2020) · Medicina · doi:10.3390/medicina56120686 · Cited by 8 · see citing works
Švrakić, D. M., & Jovanovic, M. D. (2018) · doi:10.1093/med/9780190884574.001.0001 · Cited by 6 · see citing works
The Ratio of Second and Fourth Digit Length: A Biomarker for Methamphetamine Dependence?
Kim, Y., Won, S.-D., Kwon, H., & Han, C. (2022) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2022.20.4.694 · Cited by 6 · see citing works
Genes and Human Decision-Making
Reuter, M., & Montag, C. (2016) · Studies in neuroscience, psychology and behavioral economics · doi:10.1007/978-3-642-35923-1_4 · Cited by 6 · see citing works
The Cortico-basal-cerebellar Neurocircuit is Linked to Personality Trait of Novelty Seeking
Wei, L., Weng, T., Dong, H., Baeken, C., Jiang, T., & Wu, G. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.02.027 · Cited by 5 · see citing works
Personality Traits Induce Different Brain Patterns When Processing Social and Valence Information
Hevia-Orozco, J. C., Reyes-Aguilar, A., Hernández-Pérez, R., González-Santos, L., Pasaye, E. H., & Barrios, F. A. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.782754 · Cited by 5 · see citing works
Hall, J. M., Shahnazian, D., & Krebs, R. M. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00336 · Cited by 4 · see citing works
Psychobiological personality traits of children and adolescents with disorders of arousal
Turner, K., Castelnovo, A., Perogamvros, L., Cloninger, R. C., Galbiati, A., Bertolotti, A., Proserpio, P., Terzaghi, M., Manni, R., Ferini Strambi, L., et al. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.12.035 · Cited by 4 · see citing works
Galinowski, A., Miranda, R., Lemaître, H., Artiges, É., Martinot, M. P., Filippi, I., Penttilä, J., Grimmer, Y., van Noort, B. M., Stringaris, A. K., et al. (2019) · Addiction Biology · doi:10.1111/adb.12781 · Cited by 4 · see citing works
Moreira, P., Inman, R. A., & Cloninger, C. R. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1193441 · Cited by 3 · see citing works
Genetics, drugs, and cognitive control: uncovering individual differences in substance dependence
Baker, T. E. (2012) · UVic’s Research and Learning Repository (University of Victoria) · Cited by 3 · see citing works
Aron, C., Schomaker, J., & Bastin, C. (2025) · Applied Cognitive Psychology · doi:10.1002/acp.70109 · Cited by 3 · see citing works
- Authors
- Krebs, R. M., Schott, B. H., & Düzel, E.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- Charité – Universitätsmedizin Berlin (DE)
- University College London (GB)
- Corresponding author
- Düzel, Emrah
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 65
- Issue
- 2
- Pages
- 103-110
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2034607657
- Cited by
- 129
- References
- 64
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 18 · 2017: 5 · 2016: 3 · 2015: 14 · 2014: 4 · 2013: 8 · 2012: 10
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Keywords
- novelty seeking, reward dependence, personality traits, substantia nigra/ventral tegmental area, novelty processing, reward processing, nucleus accumbens, hippocampus, memory enhancement, financial incentives
- MeSH terms
- Arousal, Brain Mapping, Cerebrovascular Circulation, Dopamine, Exploratory Behavior, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Neural Pathways, Nucleus Accumbens, Personality, Probability Learning, Reaction Time, Mental Recall, Reference Values, Regression Analysis, Reward, Substantia Nigra, Ventral Tegmental Area, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
