The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer

Ascorbic Acid and the Glycosaminoglycans

Cameron, E., & Pauling, L. C. (2009) · Oncology · doi:10.1159/000224733 · Cited by 109 · see citing works

The orthomolecular treatment of cancer I. The role of ascorbic acid in host resistance

Cameron, E., & Pauling, L. C. (1974) · Chemico-Biological Interactions · doi:10.1016/0009-2797(74)90018-0 · Cited by 99 · see citing works

The Role of Ascorbic Acid in the Prevention of Bladder Tumor Formation

Sohlegel, J. U., Pipkin, G. E., Nishimura, R., & Shultz, G. N. (1970) · The Journal of Urology · doi:10.1016/s0022-5347(17)61912-8 · Cited by 70 · see citing works

URINARY OXALATE AND VITAMIN-C SUPPLEMENTS

Briggs, M. H., Garcia‐Webb, P., & Davies, P. (1973) · The Lancet · doi:10.1016/s0140-6736(73)93029-8 · Cited by 66 · see citing works

ASCORBIC ACID, CELL PROLIFERATION, AND CANCER

Cameron, E., & Rotman, D. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90215-2 · Cited by 62 · see citing works

Hyaluronidase and Cancer.

(1966) · Annals of Internal Medicine · doi:10.7326/0003-4819-65-4-875_4 · Cited by 44 · see citing works

THE NEED FOR HUMANISED SCIENCE IN EVALUATING MEDICATION

Feinstein, A. (1972) · The Lancet · doi:10.1016/s0140-6736(72)91814-4 · Cited by 41 · see citing works

Seromucoid in the Diagnosis of Cancer

Cameron, E. (1961) · Scottish Medical Journal · doi:10.1177/003693306100600702 · Cited by 16 · see citing works

TREATMENT OF BREAST CANCER

Edelstyn, G. A., & MacRae, K. D. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92672-4 · Cited by 11 · see citing works

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506390102 · Cited by 1,075 · see citing works

Ascorbic acid: Chemistry, biology and the treatment of cancer

Du, J., Cullen, J. J., & Buettner, G. R. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.06.003 · Cited by 1,071 · see citing works

Vitamin C pharmacokinetics: Implications for oral and intravenous use

Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992 · see citing works

Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.

Cameron, E., & Pauling, L. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3685 · Cited by 710 · see citing works

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid <i>in vivo</i>

Chen, Q., Espey, M. G., Sun, A. Y., Lee, J.-H., Krishna, M. C., Shacter, E., Choyke, P. L., Pooput, C., Kirk, K. L., Buettner, G. R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702854104 · Cited by 676 · see citing works

High-Dose Vitamin C versus Placebo in the Treatment of Patients with Advanced Cancer Who Have Had No Prior Chemotherapy: A Randomized Double-Blind Comparison

Moertel, C. G., Fleming, T. R., Creagan, E. T., Rubin, J., O'Connell, M. J., & Ames, M. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120301 · Cited by 637 · see citing works

Failure of High-Dose Vitamin C (Ascorbic Acid) Therapy to Benefit Patients with Advanced Cancer: A Controlled Trial

Creagan, E. T., Moertel, C. G., O'Fallon, J. R., Schutt, A. J., O'Connell, M. J., Rubin, J., & Frytak, S. (1979) · New England Journal of Medicine · doi:10.1056/nejm197909273011303 · Cited by 584 · see citing works

Vitamin C in Disease Prevention and Cure: An Overview

Chambial, S., Dwivedi, S., Shukla, K. K., John, P. J., & Sharma, P. (2013) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-013-0375-3 · Cited by 551 · see citing works

Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?

Halliwell, B. (1996) · Free Radical Research · doi:10.3109/10715769609149066 · Cited by 531 · see citing works

New developments and novel therapeutic perspectives for vitamin C

Li, Y., & Schellhorn, H. E. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.10.2171 · Cited by 508 · see citing works

Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer

Cameron, E., & Pauling, L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4538 · Cited by 476 · see citing works

Vitamin C: Update on physiology and pharmacology

Mandl, J., Szarka, A., & Bánhegyi, G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00282.x · Cited by 451 · see citing works

Phase I clinical trial of i.v. ascorbic acid in advanced malignancy

Hoffer, L. J., Levine, M., Assouline, S., Melnychuk, D., Padayatty, S. J., Rosadiuk, K., Rousseau, C., Robitaille, L., & Miller, W. H. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn377 · Cited by 375 · see citing works

Vitamin C: A concentration-function approach yields pharmacology and therapeutic discoveries

Levine, M., Padayatty, S. J., & Espey, M. G. (2011) · Advances in Nutrition · doi:10.3945/an.110.000109 · Cited by 357 · see citing works

Drug Antioxidant Effects

Halliwell, B. B. (1991) · Drugs · doi:10.2165/00003495-199142040-00003 · Cited by 354 · see citing works

Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

Du, J., Martin, S. M., Levine, M., Wagner, B. A., Buettner, G. R., Wang, S.-H., Taghiyev, A. F., Du, C., Knudson, C. M., & Cullen, J. J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1713 · Cited by 316 · see citing works

Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer

Stephenson, C. M., Levin, R. D., Spector, T., & Lis, C. G. (2013) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-013-2179-9 · Cited by 265 · see citing works

Intravenously administered vitamin C as cancer therapy: three cases

Padayatty, S. J. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.050346 · Cited by 255 · see citing works

Antioxidants in cancer therapy; their actions and interactions with oncologic therapies.

Lamson, D. W., & Brignall, M. S. (1999) · PubMed · Cited by 241 · see citing works

Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms

Su, X., Shen, Z., Yang, Q., Sui, F., Pu, J., Ma, J., Ma, S., Yao, D., Ji, M., & Hou, P. (2019) · Theranostics · doi:10.7150/thno.35219 · Cited by 238 · see citing works

A Review of Natural and Synthetic Antioxidants Important for Health and Longevity

Wójcik, M., Burzyńska-Pędziwiatr, I., & Woźniak, L. A. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710792231950 · Cited by 235 · see citing works

The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration

Evans, R., Currie, L., & Campbell, A. (1982) · British Journal Of Nutrition · doi:10.1079/bjn19820059 · Cited by 226 · see citing works

Use of Antioxidants During Chemotherapy and Radiotherapy Should Be Avoided

D’Andrea, G. M. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.5.319 · Cited by 217 · see citing works

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

Böttger, F., Vallés‐Martí, A., Cahn, L., & Jiménez, C. R. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02134-y · Cited by 216 · see citing works

Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly

Shenoy, N. K., Creagan, E. T., Witzig, T. E., & Levine, M. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.07.014 · Cited by 207 · see citing works

Effects of Drugs on Glucose Measurements With Handheld Glucose Meters and a Portable Glucose Analyzer

Tang, Z., Du, X., Louie, R. F., & Kost, G. J. (2000) · American Journal of Clinical Pathology · doi:10.1309/qaw1-x5xw-bvrq-5lkq · Cited by 207 · see citing works

New insights into the physiology and pharmacology of vitamin C.

Padayatty, S. J., & Levine, M. (2001) · Europe PMC (PubMed Central) · Cited by 175 · see citing works

Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2

Lv, H., Wang, C., Fang, T., Li, T., Lv, G., Han, Q., Yang, W. K., & Wang, H. (2018) · npj Precision Oncology · doi:10.1038/s41698-017-0044-8 · Cited by 168 · see citing works

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

Boretti, A. A., & Banik, B. K. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100190 · Cited by 168 · see citing works

The role of vitamin C in the treatment of pain: new insights

Carr, A. C., & McCall, C. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1179-7 · Cited by 160 · see citing works

The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review

van Gorkom, G. N. Y., Lookermans, E. L., Van Elssen, C. H. M. J., & Bos, G. M. J. (2019) · Nutrients · doi:10.3390/nu11050977 · Cited by 159 · see citing works

The Role of Vitamins in Cancer: A Review

Mamede, A. C., Tavares, S. D., Abrantes, A. M., Trindade, J. R., Maia, J. M., & Botelho, M. F. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2011.539315 · Cited by 158 · see citing works

Genetic toxicology of ascorbic acid

Shamberger, R. J. (1984) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(84)90005-8 · Cited by 155 · see citing works

High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer.

Ohno, S., Ohno, Y., Suzuki, N., Soma, G., & Inoue, M. (2009) · PubMed · Cited by 143 · see citing works

Nutritional issues in cancer management

Laviano, A., & Meguid, M. M. (1996) · Nutrition · doi:10.1016/s0899-9007(96)80061-x · Cited by 142 · see citing works

Ascorbic acid and its pro-oxidant activity as a therapy for tumours of oral cavity – A systematic review

Putchala, M. C., Ramani, P., Sherlin, H. J., Premkumar, P., & Natesan, A. (2013) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2013.01.016 · Cited by 139 · see citing works

Vitamin C and cancer revisited

Frei, B. B., & Lawson, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806433105 · Cited by 137 · see citing works

Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge

Carr, A. C., & Cook, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01182 · Cited by 133 · see citing works

Intravenous Vitamin C and Cancer: A Systematic Review

Fritz, H., Flower, G., Weeks, L., Cooley, K., Callachan, M., McGowan, J., Skidmore, B., Kirchner, L., & Seely, D. (2014) · Integrative Cancer Therapies · doi:10.1177/1534735414534463 · Cited by 124 · see citing works

The orthomolecular treatment of cancer

Cameron, E., Campbell, A., & Jack, T. (1975) · Chemico-Biological Interactions · doi:10.1016/0009-2797(75)90007-1 · Cited by 124 · see citing works

Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture.

Prasad, K. N., Sinha, P. K., Ramanujam, M., & Sakamoto, A. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.2.829 · Cited by 119 · see citing works

Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent

Riordan, N. H., Riordan, H. D., Meng, X., Li, Y., & Jackson, J. A. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90137-x · Cited by 116 · see citing works

Is There a Role for Oral or Intravenous Ascorbate (Vitamin C) in Treating Patients With Cancer? A Systematic Review

Jacobs, C. M., Hutton, B., Ng, T. L., Shorr, R., & Clemons, M. J. (2015) · The Oncologist · doi:10.1634/theoncologist.2014-0381 · Cited by 114 · see citing works

Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials

Nauman, G., Gray, J. C., Parkinson, R., Levine, M., & Paller, C. J. (2018) · Antioxidants · doi:10.3390/antiox7070089 · Cited by 107 · see citing works

An Overview of the Antioxidant Effects of Ascorbic Acid and Alpha Lipoic Acid (in Liposomal Forms) as Adjuvant in Cancer Treatment

Attia, M., Essa, E. A., Zaki, R. M., & Elkordy, A. (2020) · Antioxidants · doi:10.3390/antiox9050359 · Cited by 106 · see citing works

The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life

Carr, A. C., Vissers, M. C. M., & Cook, J. S. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00283 · Cited by 104 · see citing works

Parenteral Ascorbate As a Cancer Therapeutic: A Reassessment Based on Pharmacokinetics

Parrow, N. L., Leshin, J. A., & Levine, M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5372 · Cited by 101 · see citing works

Intravenous vitamin C in the supportive care of cancer patients: A review and rational approach

Klimant, E., Wright, H., Rubin, D., Seely, D., & Markman, M. (2018) · Current Oncology · doi:10.3747/co.25.3790 · Cited by 99 · see citing works

The orthomolecular treatment of cancer I. The role of ascorbic acid in host resistance

Cameron, E., & Pauling, L. C. (1974) · Chemico-Biological Interactions · doi:10.1016/0009-2797(74)90018-0 · Cited by 99 · see citing works

Effects of intake of L-ascorbic acid on the incidence of dermal neoplasms induced in mice by ultraviolet light.

DUNHAM, W. B., Zuckerkandl, E., Reynolds, R., Willoughby, R., Marcuson, R., Barth, R., & Pauling, L. C. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7532 · Cited by 98 · see citing works

Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours

Casciari, J. J., Riordan, N. H., Schmidt, T. L., Meng, X., Jackson, J. A., & Riordan, H. D. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1814 · Cited by 96 · see citing works

Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia

Mingay, M., Chaturvedi, A., Bilenky, M., Cao, Q., Jackson, L., Hui, T., Moksa, M., Heravi-Moussavi, A., Humphries, R. K., Heuser, M., et al. (2018) · Leukemia · doi:10.1038/leu.2017.171 · Cited by 94 · see citing works

Reevaluation of Ascorbate in Cancer Treatment: Emerging Evidence, Open Minds and Serendipity

Padayatty, S. J., & Levine, M. (2000) · Journal of the American College of Nutrition · doi:10.1080/07315724.2000.10718941 · Cited by 94 · see citing works

Hepatoprotective Effect of Vitamin C (Ascorbic Acid)

Adikwu, E. B., & Oputiri, D. (2013) · Pharmacology &amp Pharmacy · doi:10.4236/pp.2013.41012 · Cited by 93 · see citing works

Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy

Chen, P., Yu, J., Chalmers, B., Drisko, J., Yang, J., Li, B., & Chen, Q. (2011) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32834fd01f · Cited by 92 · see citing works

Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies

Berretta, M., Quagliariello, V., Maurea, N., Francia, R. D., Sharifi, S., Facchini, G., Rinaldi, L., Piezzo, M., Manuela, C., Nunnari, G., et al. (2020) · Antioxidants · doi:10.3390/antiox9121182 · Cited by 91 · see citing works

Review of high‐dose intravenous vitamin C as an anticancer agent

Wilson, M. K., Baguley, B. C., Wall, C. R., Jameson, M. B., & Findlay, M. P. N. (2014) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.12173 · Cited by 90 · see citing works

Enhancement of the chromosome-damaging action of ascorbate by transition metals.

STICH, H. F., Wei, L., & Whiting, R. F. (1979) · PubMed · Cited by 87 · see citing works

Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest

Herst, P. M., Broadley, K. W. R., Harper, J. L., & McConnell, M. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.021 · Cited by 85 · see citing works

Vitamin C and Cancer

Wittes, R. E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120310 · Cited by 85 · see citing works

Vitamin C: Sources, Functions, Sensing and Analysis

Devaki, S. J., & Raveendran, R. L. (2017) · InTech eBooks · doi:10.5772/intechopen.70162 · Cited by 84 · see citing works

Therapeutic Use of Vitamin C in Cancer: Physiological Considerations

Roa, F. J., Peña, E., Gatica, M., Escobar‐Acuña, K., Saavedra, P., Maldonado, M., Cuevas, M. E., Moraga‐Cid, G., Rivas, C. I., & Muñoz-Montesino, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00211 · Cited by 81 · see citing works

Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression

Belin, S., Kaya, F., Duisit, G., Giacometti, S., Ciccolini, J., & Fontés, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004409 · Cited by 80 · see citing works

Harm of IV High-Dose Vitamin C Therapy in Adult Patients: A Scoping Review

Yanase, F., Fujii, T., Naorungroj, T., Belletti, A., Luethi, N., Carr, A. C., Young, P. J., & Bellomo, R. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004396 · Cited by 81 · see citing works

High-Dose Vitamin C for Cancer Therapy

Mussa, A., Idris, R. A. M., Ahmed, N., Ahmad, S., Murtadha, A. H., Din, T. A. D. A. T., Yean, C. Y., Rahman, W. F. W. A., Lazim, N. M., Uskoković, V., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15060711 · Cited by 81 · see citing works

SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment

Hong, S.-W., Lee, S.-H., Moon, J.-H., Hwang, J. J., Kim, D. E., Ko, E., Kim, H.-S., Cho, I. J., Kang, J.-I., Kim, D. J., et al. (2012) · Oncogene · doi:10.1038/onc.2012.176 · Cited by 78 · see citing works

The potential role of vitamin C in empowering cancer immunotherapy

Bedhiafi, T., Inchakalody, V. P., Fernandes, Q., Mestiri, S., Billa, N., Shahab Uddin, M. S., Merhi, M., & Dermime, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112553 · Cited by 77 · see citing works

The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review

Villagrán, M., Ferreira, J. L., Martorell, M., & Mardones, L. (2021) · Antioxidants · doi:10.3390/antiox10121894 · Cited by 73 · see citing works

Sodium Ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake

Carosio, R., Zuccari, G., Orienti, I., Mangraviti, S., & Montaldo, P. G. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-55 · Cited by 71 · see citing works

Elimination of Ascorbic Acid After High‐Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation

Nielsen, T. K., Højgaard, M., Andersen, J. T., Poulsen, H. E., Lykkesfeldt, J., & Mikines, K. J. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12323 · Cited by 71 · see citing works

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment

Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A. J., Warrick, J. I., Timmins, P. F., III, Kesterson, J. P., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.11.009 · Cited by 68 · see citing works

The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer

Ullah, M. F., Khan, H. Y., Zubair, H., Shamim, U., & Hadi, S. M. (2011) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1290-4 · Cited by 70 · see citing works

Phthalocyanine-based fluorescence probes for detecting ascorbic acid: phthalocyaninatosilicon covalently linked to TEMPO radicals

Ishii, K., Kubo, K., Sakurada, T., Komori, K., & Sakai, Y. (2011) · Chemical Communications · doi:10.1039/c1cc10817d · Cited by 70 · see citing works

High-Dose Vitamin C in Advanced-Stage Cancer Patients

Zasowska‐Nowak, A., Nowak, P. J., & Ciałkowska-Rysz, A. D. (2021) · Nutrients · doi:10.3390/nu13030735 · Cited by 69 · see citing works

Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma

Hemachandra, L. P. M. P., Shin, D., Dier, U., Iuliano, J. N., Engelberth, S. A., Uusitalo, L. M., Murphy, S. K., & Hempel, N. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3799 · Cited by 69 · see citing works

A battery of translational biomarkers for the assessment of the in vitro and in vivo antioxidant action of plant polyphenolic compounds: The biomarker issue

Veskoukis, A. S., Kerasioti, E., Priftis, A., Kouka, P., Spanidis, Y., Makri, S., & Kouretas, D. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.10.001 · Cited by 66 · see citing works

Depletion of Ascorbic Acid Restricts Angiogenesis and Retards Tumor Growth in a Mouse Model

Telang, S., Clem, A. L., Eaton, J. W., & Chesney, J. A. (2007) · Neoplasia · doi:10.1593/neo.06664 · Cited by 65 · see citing works

Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism

Petronek, M. S., Spitz, D. R., Buettner, G. R., & Allen, B. G. (2019) · Cancers · doi:10.3390/cancers11081077 · Cited by 61 · see citing works

Expected and Unexpected Effects of Pharmacological Antioxidants

Tyuryaeva, I. I., & Lyublinskaya, O. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119303 · Cited by 66 · see citing works

Treatment of Pancreatic Cancer with Pharmacological Ascorbate

Cieslak, J. A., & Cullen, J. J. (2015) · Current Pharmaceutical Biotechnology · doi:10.2174/138920101609150715135921 · Cited by 60 · see citing works

Vitamin C Promotes Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma

Zhou, J., Chen, C., Chen, X., Fei, Y., Jiang, L., & Wang, G. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00976 · Cited by 59 · see citing works

An insight and update on the analgesic properties of vitamin C

Chaitanya, N. C., Muthukrishnan, A., Krishnaprasad, C. M. S., Sanjuprasanna, G., Pillay, P., & Mounika, B. (2018) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/jpbs.jpbs_12_18 · Cited by 57 · see citing works

Vitamin C Intake and Cancers: An Umbrella Review

Chen, Z., Huang, Y. C., Cao, D., Qiu, S., Chen, B., Li, J., Bao, Y., Wei, Q., Han, P., & Liu, L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.812394 · Cited by 55 · see citing works

Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models

Chen, P., Stone, J., Sullivan, G., Drisko, J., & Chen, Q. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.031 · Cited by 55 · see citing works

Weekly ascorbic acid infusion in castration-resistant prostate cancer patients: a single-arm phase II trial

Nielsen, T. K., Højgaard, M., Andersen, J. T., Jørgensen, N. R., Zerahn, B., Kristensen, B., & Henriksen, T. (2017) · Translational Andrology and Urology · doi:10.21037/tau.2017.04.42 · Cited by 55 · see citing works

Effect of supplemental antioxidants vitamin C, vitamin E, and coenzyme Q10 for the prevention and treatment of cardiovascular disease.

Shekelle, P., Morton, S. C., & Hardy, M. L. (2003) · PubMed Central · Cited by 51 · see citing works

Effect of ascorbic acid on incidence of spontaneous mammary tumors and UV-light-induced skin tumors in mice

Pauling, L. C. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1252s · Cited by 50 · see citing works

High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients

Giansanti, M., Karimi, T., Faraoni, I., & Graziani, G. (2021) · Cancers · doi:10.3390/cancers13061428 · Cited by 50 · see citing works

Vitamin C: From nutrition to oxygen sensing and epigenetics

Kietzmann, T. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102753 · Cited by 51 · see citing works

Ascorbyl palmitate-incorporated paclitaxel-loaded composite nanoparticles for synergistic anti-tumoral therapy

Zhou, M., Li, X., Li, Y., Yao, Q., Ming, Y., Li, Z., Lu, L., & Shi, S. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1370619 · Cited by 47 · see citing works

Citrus and health

Ma, G., Zhang, L., Sugiura, M., & Kato, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-812163-4.00024-3 · Cited by 47 · see citing works

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells

Brandt, K. E., Falls, K. C., Schoenfeld, J. D., Rodman, S. N., Gu, Z., Zhan, F., Cullen, J. J., Wagner, B. A., Buettner, G. R., Allen, B. G., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.017 · Cited by 46 · see citing works

Vitamin C in the critically ill - indications and controversies

Nabzdyk, C. S., & Bittner, E. A. (2018) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v7.i5.52 · Cited by 45 · see citing works

Vitamin C Therapy of Advanced Cancer

Pauling, L. C. (1980) · New England Journal of Medicine · doi:10.1056/nejm198003203021219 · Cited by 45 · see citing works

A radioprotective effect of vitamin C observed in Chinese hamster ovary cells

O’Connor, M. K., Malone, J. F., Moriarty, M. J., & Mulgrew, S. (1977) · British Journal of Radiology · doi:10.1259/0007-1285-50-596-587 · Cited by 45 · see citing works

SVCT-2 determines the sensitivity to ascorbate-induced cell death in cholangiocarcinoma cell lines and patient derived xenografts

Wang, C., Lv, H., Yang, W. K., Li, T., Fang, T., Lv, G., Han, Q., Dong, L., Jiang, T., Jiang, B., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.03.039 · Cited by 42 · see citing works

An overview of interactions between micronutrients and of micronutrients with drugs, genes and immune mechanisms

Thurnham, D. I. (2004) · Nutrition Research Reviews · doi:10.1079/nrr200486 · Cited by 42 · see citing works

Inhibition of benzo(a)pyrene Carcinogenesis in rats with vitamin C

Kallistratos, G., & Fasske, E. (1980) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf00411283 · Cited by 42 · see citing works

The effect of ascorbic acid on the photophysical properties and photodynamic therapy activities of zinc phthalocyanine-single walled carbon nanotube conjugate on MCF-7 cancer cells

Ogbodu, R. O., & Nyokong, T. (2015) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2015.06.063 · Cited by 41 · see citing works

Vitamin Therapy in the Absence of Obvious Deficiency

Ovesen, L. (1984) · Drugs · doi:10.2165/00003495-198427020-00003 · Cited by 41 · see citing works

Ascorbic acid as an effective agent in cancer therapy

Khurshid, A., Khurshid, A., Anwar, Z., Arsalan, A., & Ahmad, I. (2015)

High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer.

Ohno, S., Ohno, Y., Suzuki, N., Soma, G., & Inoue, M. (2009) · PubMed · Cited by 143 · see citing works

The orthomolecular treatment of cancer

Cameron, E., Campbell, A., & Jack, T. (1975) · Chemico-Biological Interactions · doi:10.1016/0009-2797(75)90007-1 · Cited by 124 · see citing works

Clinical Attestation and Redox Mechanism of Ascorbic Acid in the Treatment of Cancer

Bhattacharya, S. (2021) · Free Radicals and Antioxidants · doi:10.5530/fra.2021.1.1 · Cited by 2 · see citing works

[Role of ascorbic acid in the palliative treatment of neoplasms].

Krzakowski, M. J. (1978) · PubMed