Intravenous Vitamin C and Cancer: A Systematic Review
Open accessAbstract
Background. Intravenous vitamin C (IVC) is a contentious adjunctive cancer therapy, widely used in naturopathic and integrative oncology settings. We conducted a systematic review of human interventional and observational studies assessing IVC for use in cancer patients. Methods. We searched MEDLINE, EMBASE, The Cochrane Library, CINAHL, and AMED from inception to April 2013 for human studies examining the safety, effectiveness, or pharmacokinetics of IVC use in cancer patients. Results. Of 897 records, a total of 39 reports of 37 studies were included: 2 randomized controlled trials (RCTs), 15 uncontrolled trials, 6 observational studies, and 14 case reports. IVC dosing ranged from 1 g to more than 200 g ascorbic acid per infusion, typically administered 2 to 3 times weekly. IVC does not appear to increase toxicity or interfere with antitumor effects of gemcitabine/erlotinib therapy or paclitaxel and carboplatin. Based on 1 RCT and data from uncontrolled human trials, IVC may improve time to relapse and possibly enhance reductions in tumor mass and improve survival in combination with chemotherapy. IVC may improve quality of life, physical function, and toxicities associated with chemotherapy, including fatigue, nausea, insomnia, constipation, and depression. Case reports document several instances of tumor regression and long-term disease-free survival associated with use of IVC. Conclusion. There is limited high-quality clinical evidence on the safety and effectiveness of IVC. The existing evidence is preliminary and cannot be considered conclusive but is suggestive of a good safety profile and potentially important antitumor activity; however, more rigorous evidence is needed to conclusively demonstrate these effects. IVC may improve the quality of life and symptom severity of patients with cancer, and several cases of cancer remission have been reported. Well-designed, controlled studies of IVC therapy are needed.
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A significant number of clinical trials have indicated that vitamin C administered intravenously in high-doses (in most trials, 50-100 g twice or thrice weekly) as a treatment for various cancers including glioblastoma, ovarian, prostate, lung, or rectum cancer is well tolerated with minimal toxicity, improves the quality of life for patients, and has a synergistic therapeutic effect when combined
“A significant number of clinical trials have indicated that vitamin C administered intravenously in high-doses (in most trials, 50–100 g twice or thrice weekly) as a treatment for various cancers including glioblastoma, ovarian, prostate, lung, or rectum cancer is well tolerated with minimal toxicity, improves the quality of life for patients, and has a synergistic therapeutic effect when combined”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [182]
Most of these studies were not designed as large-scale randomized clinical trials and clear verifications of the clinical efficacy of vitamin C are currently rather limited.
“However, most of these studies were not designed as large-scale randomized clinical trials and clear verifications of the clinical efficacy of vitamin C are currently rather limited [177,182,183,184].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [182]
Vitamin C (ascorbic acid) is a powerful antioxidant that can have beneficial effects on delaying the aging process and age-related diseases through its action on redox oxidative and mitochondrial pathways, immune system, inflamm-aging, endothelial integrity, and lipoprotein metabolism.
“Vitamin C or ascorbic acid (AA) is a powerful antioxidant that can have beneficial effects on delaying the aging process and age-related diseases thorough its action on redox oxidative and mitochondrial pathways, on the immune system, on inflamm-aging, on endothelial integrity, and on lipoprotein metabolism [114,115,116,117,118,119,120,121].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [120]
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- Authors
- Fritz, H., Flower, G., Weeks, L., Cooley, K., Callachan, M., McGowan, J., Skidmore, B., Kirchner, L., & Seely, D.
- Affiliations
- Canadian College of Naturopathic Medicine (CA)
- Ottawa Integrative Cancer Centre, Ottawa, Ontario, Canada
- Carp Ridge Natural Health Clinic, Carp, Ontario, Canada
- Venue
- Integrative Cancer Therapies
- Publisher
- SAGE Publications
- Published
- 2014-05-26
- Volume
- 13
- Issue
- 4
- Pages
- 280-300
- ISSN
- 1534-7354 (ISSN-L)
- 1552-695X
- OpenAlex
- W2100763849
- Cited by
- 124
- References
- 111
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 15 · 2021: 15 · 2020: 12 · 2019: 15 · 2018: 13 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 1 · 2013: 1
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Integrative Cancer Therapies (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- intravenous vitamin C, vitamin C, cancer therapy, adjunctive therapy, integrative oncology, naturopathy, chemotherapy toxicity, tumor regression, quality of life, safety profile, anticancer activity
- MeSH terms
- Antineoplastic Combined Chemotherapy Protocols, Ascorbic Acid, Humans, Infusions, Intravenous, Neoplasms, Quality of Life, Survival Rate
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