Exocrine scent marking: coordinative role of arginine vasopressin in the systemic regulation of social signaling behaviors
Abstract
Arginine vasopressin (AVP) is a neurohypophysial hormone that coordinatively regulates central socio-emotional behavior and peripheral control of antidiuretic fluid homeostasis. Most mammals, including rodents, utilize exocrine or urine-contained scent marking as a social signaling tool that facilitates social adaptation. The exocrine scent marking behavior is postulated to fine-tune sensory and cognitive abilities to recognize key social features via exocrine/urinary olfactory cues and subsequently control exocrine deposition or urinary marking through the mediation of osmotic fluid balance. AVP is implicated as a major player in controlling both recognition and signaling responses. This review provides constructive hypotheses on the coordinative processes of the AVP neurohypophysial circuits in the systemic regulations of fluid control and social-communicative behavior, via the expression of exocrine scent marking, and further emphasizes a potential role of AVP in a common mechanism underlying social communication in rodents.
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Some behavioral effects of oxytocin and vasopressin are functionally linked to their peripheral function: oxytocin promotes birth and nursing but also parental nurturing, while vasopressin modulates urine production and also territorial behavior involving urine and scent marking.
“Some of the behavioral effects of OXT and AVP are functionally linked to their peripheral function, as OXT promotes birth and nursing but also parental nurturing, while AVP modulates urine production and also territorial behavior, which often involves urine and scent marking (17,18).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [17]
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Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
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- Authors
- Arakawa, H., & Higuchi, Y.
- Affiliations
- University of the Ryukyus (JP)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 136
- Pages
- 104597
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W4214812366
- Cited by
- 8
- References
- 189
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, urine marking, social signaling, social communication, osmoregulation, fluid homeostasis, olfactory cues, rodents, social recognition
- MeSH terms
- Animals, Arginine Vasopressin, Humans, Mammals, Odorants, Smell, Social Behavior
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