The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Increase of plasma IL-6 concentration with age in healthy subjects
Abstract
The present study demonstrated that plasma IL-6 concentration was higher in older subjects than in younger ones and significantly in the male group (P = 0.02); Spearman rank correlation showed that plasma IL-6 concentration was positively correlated with age (r = 0.28, N = 55, P < 0.05); there was a highly significant correlation between the concentrations in plasma IL-6 and IL-1 alpha (r = 0.51, N = 52, P < 0.001). These findings suggest the possibility that age-related changes of plasma IL-6 and IL-1 alpha may provide a pathological basis for the susceptibility to such illness as commonly occurs in elderly people, especially Alzheimer's disease as the two interleukins can induce the production of alpha 1-antichymotrypsin and beta-amyloid protein precursor.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In vitro, vitamin D modulates the pro-inflammatory profile of monocytes/macrophages from type 2 diabetic patients (733) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [733]
Citations
Cites
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES
Arai, K., Lee, F., Miyajima, A., Miyatake, S., Arai, N., & Yokota, T. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.004031 · Cited by 1,318
Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 900
Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847
Frei, K., Malipiero, U., Leist, T. P., Zinkernagel, R. M., Schwab, M. E., & Fontana, A. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190418 · Cited by 690
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder
George‐Hyslop, P. S., Haines, J. L., Farrer, L. A., Polinsky, R. J., Broeckhoven, C. V., Goate, A., McLachlan, D. R. C., Orr, H. T., Bruni, A. C., Sorbi, S., et al. (1990) · Nature · doi:10.1038/347194a0 · Cited by 396
Hama, T., Kushima, Y., Miyamoto, M., Kubota, M., Takei, N., & Hatanaka, H. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90132-8 · Cited by 301
Vandenabeele, P., & Fiers, W. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90032-o · Cited by 265
Blood to brain transport of interleukin links the immune and central nervous systems
Banks, W. A., & Kastin, A. J. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90385-o · Cited by 177
Age-associated increase in interleukin 6 in MRL/lpr mice
Tang, B., Matsuda, T., Akira, S., Nagata, N., Ikehara, S., Hirano, T., & Kishimoto, T. (1991) · International Immunology · doi:10.1093/intimm/3.3.273 · Cited by 159
Research works printed but not linked: 3
- Yankner, 1990, 87, 9020
- Goldgaber, 1989, 86, 7606
- Griffin, 1989, 86, 7611
Cited by
Sorted by citations
Items 101–107 of 107
Baune, B. T., Rothermundt, M., Ladwig, K. H., Meisinger, C., & Berger, K. (2011) · AGE · doi:10.1007/s11357-010-9165-5 · Cited by 95
Adipose–Muscle Crosstalk in Age-Related Metabolic Disorders: The Emerging Roles of Adipo-Myokines
Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101829 · Cited by 62
Preanalytical factors and the measurement of cytokines in human subjects
Dugué, B., Leppänen, E., & Gräsbeck, R. (1996) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02592351 · Cited by 35
Implications of inflammatory states on dysfunctional immune responses in aging and obesity
Thomas, A. L., Alarcon, P. C., Divanovic, S., Chougnet, C. A., Hildeman, D. A., & Moreno-Fernandez, M. E. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.732414 · Cited by 35
Bonfante, H. D. L., Almeida, C. D. S., Abramo, C., Grunewald, S. T. F., Levy, R. A., & Teixeira, H. C. (2017) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12589 · Cited by 33
Immune senescence and biomarkers profile of Bambuí aged population-based cohort
Torres, K. C. L., Rezende, V. B. D., Lima-Silva, M. L., Santos, L. J. D. S., Costa, C. G., Mambrini, J. V. D. M., Peixoto, S. V., Tarazona-Santos, E., Martins Filho, O. A., Lima-Costa, M. F., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.006 · Cited by 30
Inflammaging and Cardiovascular Risk in Old Women
Moscucci, F., Baratta, F., Bucciarelli, V., Mattioli, A. V., Pinti, M., Zanini, G., Sciomer, S., Gallina, S., Piccirillo, G., & Desideri, G. (2025) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-025-00758-1 · Cited by 8
Metadata
- Authors
- Wei, J., Xu, H., Davies, J. L., & Hemmings, G. P.
- ORCID
- Wei, Jun
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 51
- Issue
- 25
- Pages
- 1953-1956
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2040015087
- Cited by
- 402
- References
- 13
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 17 · 2023: 20 · 2022: 15 · 2021: 19 · 2020: 18 · 2019: 16 · 2018: 6 · 2017: 13 · 2016: 11 · 2015: 13 · 2014: 13 · 2013: 21 · 2012: 12
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- History & Philosophy of the Life Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- interleukin-6, interleukin-1 alpha, aging, plasma cytokine concentrations, sex differences, Alzheimer's disease, alpha-1-antichymotrypsin
- MeSH terms
- Adult, Aged, Aging, Female, Humans, Interleukin-1, Male, Middle Aged, Radioimmunoassay, Sex Factors, Interleukin-6
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
