Cited by 2,263Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthAtherosclerosis and Cardiovascular Diseases

The DOI matches its Crossref record; 42 of the 45 references it cites were found in a registry or an index.

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Plump, Andrew S., Smith, Jonathan D., Hayek, Tony, Aalto-Setälä, Katriina, Walsh, Annemarie, Verstuyft, Judy G., Rubin, Edward M., Breslow, Jan L.·1992·Cell

DOI 10.1016/0092-8674(92)90362-g

Open this paper in CoChat — free account

Abstract

apoE-deficient mice have been created by homologous recombination in ES cells. On a low fat, low cholesterol chow diet these animals have plasma cholesterol levels of 494 mg/dl compared with 60 mg/dl in control animals, and when challenged with a high fat Western-type diet, these animals have plasma cholesterol levels of 1821 mg/dl compared with 132 mg/dl in controls. This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and coronary and pulmonary arteries. apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(92)90362-g

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.
Weber, K., & Osborn, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94333-4 · Cited by 16,688
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
The Metabolic Basis of Inherited Disease
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-389_2 · Cited by 3,990
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells
Hooper, M., Hardy, K., Handyside, A. H., Hunter, S., & Monk, M. (1987) · Nature · doi:10.1038/326292a0 · Cited by 1,218
A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine
Powell, L. M., Wallis, S. C., Pease, R. J., Edwards, Y. H., Knott, T. J., & Scott, J. (1987) · Cell · doi:10.1016/0092-8674(87)90510-1 · Cited by 1,045
Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI
Rubin, E. M., Krauss, R. M., Spangler, E. A., Verstuyft, J. G., & Clift, S. (1991) · Nature · doi:10.1038/353265a0 · Cited by 985
Self-citation

Show all 45 references

Sorted by citations

Items 701–800 of 1,010

Mouse model of heterotopic aortic arch transplantation
Chereshnev, I., Trogan, E., Omerhodzic, S., Itskovich, V. V., Aguinaldo, J.-G., Fayad, Z. A., Fisher, E. A. A., & Reis, E. D. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00039-8 · Cited by 69
Selective Reduction in the Sphingomyelin Content of Atherogenic Lipoproteins Inhibits Their Retention in Murine Aortas and the Subsequent Development of Atherosclerosis
Fan, Y., Shi, F., Liu, J., Dong, J., Bui, H. H., Peake, D. A., Kuo, M., Cao, G., & Jiang, X. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.213363 · Cited by 68
Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice?
Krause, B. R., & Princen, H. M. G. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00141-5 · Cited by 67
Receptor-mediated mechanisms of lipoprotein remnant catabolism
Chappell, D. A., & Medh, J. D. (1998) · Progress in Lipid Research · doi:10.1016/s0163-7827(98)00017-4 · Cited by 70
Apolipoprotein E regulates dietary cholesterol absorption and biliary cholesterol excretion: Studies in C57BL/6 apolipoprotein E knockout mice
Sehayek, E., Shefer, S., Nguyen, L. B., Ono, J. G., Merkel, M., & Breslow, J. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050016197 · Cited by 69
Self-citation
Molecular Advances in Cardiovascular Biology
Chien, K. R. (1993) · Science · doi:10.1126/science.8493528 · Cited by 69
Role of Heparan Sulfate Proteoglycans and the LDL Receptor‐Related Protein in Remnant Lipoprotein Metabolisma
Mahley, R. W., JI, Z., Brecht, W. J., Miranda, R. D., & He, D. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44300.x · Cited by 69
Apolipoprotein E localization in human coronary atherosclerotic plaques by in situ hybridization and immunohistochemistry and comparison with lipoprotein lipase.
O’Brien, K. D., Deeb, S. S., Ferguson, M. S., McDonald, T. O., Allen, M. D., Alpers, C. E., & Chait, A. (1994) · PubMed Central · Cited by 69
Sphingolipid Metabolism and Obesity-Induced Inflammation
Kang, S. C., Kim, B.-R., Lee, S., & Park, T. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00067 · Cited by 70
Distinct Characteristics of Circulating Vascular Endothelial Growth Factor-A and C Levels in Human Subjects
Wada, H., Ura, S., Kitaoka, S., Satoh‐Asahara, N., Horie, T., Ono, K., Takaya, T., Takanabe‐Mori, R., Akao, M., Abe, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029351 · Cited by 67
Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility
Tian, J., Pei, H., James, J. C., Li, Y., Matsumoto, A. H., Helm, G. A., & Shi, W. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.090 · Cited by 68
Role of macrophage‐expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice
Layne, M. D., Patel, A. P., Chen, Y., Rebel, V. I., Carvajal, I. M., Pellacani, A. U. E., Ith, B., Zhao, D., Schreiber, B. M., Yet, S., et al. (2001) · The FASEB Journal · doi:10.1096/fj.01-0374fje · Cited by 68
Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance
Hasty, A. H., Linton, M. F., Swift, L. L., & Fazio, S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33397-6 · Cited by 68
Apolipoprotein A-I Stimulates Secretion of Apolipoprotein E by Foam Cell Macrophages
Rees, D., Sloane, T., Jessup, W., Dean, R. T., & Kritharides, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27925 · Cited by 68
The results in rodent models of atherosclerosis are not interchangeable
Joven, J., Rull, A., Ferré, N., Escolá‐Gil, J. C., Marsillach, J., Coll, B., Alonso‐Villaverde, C., Aragonès, G., Clària, J., & Camps, J. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.06.012 · Cited by 67
The helix bundle: A reversible lipid binding motif
Narayanaswami, V., Kiss, R. S., & Weers, P. M. M. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.09.009 · Cited by 69
The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches
Simmons, R. D., Kumar, S., & Jo, H. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.005 · Cited by 71
Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake
Trigatti, B. L. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00154-2 · Cited by 66
Hypomorphic Apolipoprotein E Mice
Raffaı̈, R. L., & Weisgraber, K. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111222200 · Cited by 67
Transgenic mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans.
Grass, D., Saini, U., Felkner, R. H., Wallace, R., Lago, W., Young, S. G., & Swanson, M. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39866-7 · Cited by 66
Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia
Escolá‐Gil, J. C., Julve, J., Marzal-Casacuberta, À., Ordóñez‐Llanos, J., González‐Sastre, F., & Blanco‐Vaca, F. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33441-6 · Cited by 67
Inflammation and diabetes-accelerated atherosclerosis: myeloid cell mediators
Kanter, J. E., & Bornfeldt, K. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.10.002 · Cited by 66
Implitapide, a Microsomal Triglyceride Transfer Protein Inhibitor, Reduces Progression of Atherosclerosis in Apolipoprotein E Knockout Mice Fed a Western-Type Diet: Involvement of the Inhibition of Postprandial Triglyceride Elevation
Ueshima, K., Akihisa-Umeno, H., Nagayoshi, A., Takakura, S., Matsuo, M., & Mutoh, S. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.247 · Cited by 66
Sildenafil restores endothelial function in the apolipoprotein E knockout mouse
Balarini, C. M., Leal, M. A. S., Gomes, I. B., Pereira, T. M. C., Gava, A. L., Meyrelles, S. S., & Vasquez, E. C. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-3 · Cited by 66
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging
Senders, M. L., Meerwaldt, A. E., van Leent, M. M. T., Sánchez-Gaytán, B. L., van de Voort, J. C., Toner, Y. C., Maier, A., Klein, E. D., Sullivan, N. A. T., Sofias, A. M., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0642-4 · Cited by 65
High density lipoprotein, apolipoprotein A-1, and coronary artery disease
Srivastava, R., & Srivastava, N. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007111830472 · Cited by 65
Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter.
Roux, D. T., Roullot, V., Schweitzer, A., Berthier, R., & Marguerie, G. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2141 · Cited by 67
Metabonomic Changes Associated with Atherosclerosis Progression for LDLR–/– Mice
Li, D., Zhang, L., Dong, F., Liu, Y., Li, N., Li, H., Lei, H., Hao, F., Wang, Y., Zhu, Y., et al. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00032 · Cited by 65
Detection of vulnerable plaque in a murine model of atherosclerosis with optical coherence tomography
Çilingiroğlu, M., Oh, J., Sugunan, B., Kemp, N. J., Kim, J., Lee, S., Zaatari, H. N., Escobedo, D., Thomsen, S., Milner, T. E., et al. (2006) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.20717 · Cited by 65
Immune-inflammatory responses in atherosclerosis: Role of an adaptive immunity mainly driven by T and B cells
Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.05.010 · Cited by 66
Complete Atherosclerosis Regression After Human ApoE Gene Transfer in ApoE-Deficient/Nude Mice
Desurmont, C., Caillaud, J., Emmanuel, F., Benoit, P., Fruchart, J., Castro, G. R., Branellec, D., Heard, J., & Duverger, N. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.435 · Cited by 65
Hyperlipidemia Disrupts Cerebrovascular Reflexes and Worsens Ischemic Perfusion Defect
Ayata, C., Shin, H. K., Dileköz, E., Atochin, D. N., Kashiwagi, S., Eikermann‐Haerter, K., & Huang, P. L. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.38 · Cited by 64
Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy
Milad, N., White, Z. R., Tehrani, A. Y., Sellers, S., Rossi, F. M. V., & Bernatchez, P. N. (2017) · Skeletal Muscle · doi:10.1186/s13395-017-0135-9 · Cited by 60
Monocyte Chemoattractant Protein-1 but Not Tumor Necrosis Factor-α Is Correlated With Monocyte Infiltration in Mouse Lipid Lesions
Reckless, J., Rubin, E. M., Verstuyft, J. B., Metcalfe, J. C., & Grainger, D. J. (1999) · Circulation · doi:10.1161/01.cir.99.17.2310 · Cited by 64
Self-citation
Effects of Apoprotein E on Intracellular Metabolism of Model Triglyceride-rich Particles Are Distinct from Effects on Cell Particle Uptake
Schwiegelshohn, B., Presley, J. F., Gorecki, M., Vogel, T., Carpentier, Y., Maxfield, F. R., & Deckelbaum, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1761 · Cited by 64
Beyond vascular inflammation—recent advances in understanding atherosclerosis
Wolf, D., Zirlik, A., & Ley, K. F. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1971-6 · Cited by 62
Genetically modified pigs to model human diseases
Flisikowska, T., Kind, A., & Schnieke, A. (2013) · Journal of Applied Genetics · doi:10.1007/s13353-013-0182-9 · Cited by 63
Sphingomyelinase Converts Lipoproteins From Apolipoprotein E Knockout Mice Into Potent Inducers of Macrophage Foam Cell Formation
Marathe, S. V., Choi, Y., Leventhal, A. R., & Tabas, I. A. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.12.2607 · Cited by 63
The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis
Oguro, H. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00204 · Cited by 73
Peripheral versus central nervous system APOE in Alzheimer’s disease: Interplay across the blood-brain barrier
Chernick, D., Ortiz‐Valle, S., Jeong, A., Qu, W., & Li, L. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134306 · Cited by 64
Attenuation of Atherosclerosis in Apolipoprotein E-Deficient Mice by Ramipril is Dissociated from Its Antihypertensive Effect and from Potentiation of Bradykinin
Keidar, S., Attias, J., Coleman, R., WIRTH, K. J., Schölkens, B. A., & Hayek, T. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200001000-00008 · Cited by 63
Self-citation
Localization, physiology, and modulation of a molluskan dopaminergic synapse
Magoski, N. S., & Bulloch, A. G. M. (1997) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199709)33:3 · Cited by 19
Lipid and apolipoprotein B48 transport in mesenteric lymph and the effect of hyperphagia on the clearance of chylomicron-like emulsions in insulin-deficient rats
Martins, I. J., Sainsbury, A., Mamo, J. C. L., & Redgrave, T. G. (1994) · Diabetologia · doi:10.1007/bf00398049 · Cited by 63
Oral Insulin Supplementation Attenuates Atherosclerosis Progression in Apolipoprotein E-Deficient Mice
Shamir, R., Shehadeh, N., Rosenblat, M., Eshach‐Adiv, O., Coleman, R., Kaplan, M., Hamoud, S., Lischinsky, S., & Hayek, T. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000042232.42883.56 · Cited by 63
Self-citation
Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice
Hiebert, P., Wu, D., & Granville, D. J. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.96 · Cited by 62
From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound
Hung, M., Zhang, Z. J., Li, S., Lei, B., Yuan, S., Cui, G., Hoi, M. P. M., Chan, K., & Lee, S. M. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/605303 · Cited by 63
Apolipoprotein E knockout mice display procedural deficits in the Morris water maze: analysis of learning strategies in three versions of the task
Champagne, D. L., Dupuy, J.-B., Rochford, J. M., & Poirier, J. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00313-5 · Cited by 64
New insights into immunological aspects of atherosclerosis
Jawień, J. (2008) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.332 · Cited by 62
Lecithin:Cholesterol Acyltransferase Deficiency Protects against Cholesterol-induced Hepatic Endoplasmic Reticulum Stress in Mice
Hager, L., Li, L., Pun, H., Liu, L., Hossain, M. A., Maguire, G. F., Naples, M., Baker, C., Magomedova, L., Tam, J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.340919 · Cited by 63
Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
Pereira, T. D. M. C., Nogueira, B. V., Freitas‐Lima, L. C., Porto, M. L., Arruda, J. A., Vasquez, E. C., & Meyrelles, S. S. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-87 · Cited by 61
Diabetes and Arterial Extracellular Matrix Changes in a Porcine Model of Atherosclerosis
McDonald, T. O., Gerrity, R. G., Jen, C., Chen, H.-J., Wark, K., Wight, T. N., Chait, A., & O’Brien, K. D. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.7a7221.2007 · Cited by 61
Macrophage fatty acid oxidation inhibits atherosclerosis progression
Nomura, M., Liu, J., Yu, Z., Yamazaki, T., Yan, Y., Kawagishi, H., Rovira, I. I., Liu, C., Wolfgang, M. J., Mukouyama, Y., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.01.003 · Cited by 61
CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ
Fan, J. J., Liu, L., Liu, Q., Cui, Y., Yao, B., Zhang, M., Gao, Y., Fu, Y., Dai, H., Pan, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07895-3 · Cited by 62
Targeting cellular cholesterol for anticancer therapy
Gu, L., Saha, S. T., Thomas, J., & Kaur, M. (2019) · FEBS Journal · doi:10.1111/febs.15018 · Cited by 63
Apolipoprotein E Inhibits Neointimal Hyperplasia after Arterial Injury in Mice
Zhu, B., Kuhel, D. G., Witte, D. P., & Hui, D. Y. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64823-7 · Cited by 61
Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping
Knopp, E. A., Arndt, T. L., Eng, K., Caldwell, M., LeBoeuf, R. C., Deeb, S. S., & O’Brien, K. D. (1999) · Mammalian Genome · doi:10.1007/s003359901053 · Cited by 61
Expression of lipoprotein receptors in atherosclerotic lesions
Hiltunen, T. P., & Ylä‐Herttuala, S. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00307-9 · Cited by 60
Effects of Isoflurane on Coronary Blood Flow Velocity in Young, Old and ApoE−/− Mice Measured by Doppler Ultrasound
Hartley, C. J., Reddy, A. K., Madala, S., Michael, L. H., Entman, M. L., & Taffet, G. E. (2007) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.11.002 · Cited by 60
Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice
Glaros, E. N., Kim, W. S., Quinn, C. M., Jessup, W., Rye, K., & Garner, B. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700261-jlr200 · Cited by 60
Apolipoprotein E and its role in aging and survival
Bonomini, F., Filippini, F., Hayek, T., Aviram, M., Keidar, S., Rodella, L. F., Coleman, R., & Rezzani, R. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.006 · Cited by 60
Self-citation
Increased Atherosclerotic Lesion Calcification in a Novel Mouse Model Combining Insulin Resistance, Hyperglycemia, and Hypercholesterolemia
Heinonen, S. E., Leppänen, P., Kholová, I., Lumivuori, H., Häkkinen, S.-K., Bosch, F., Laakso, M., & Ylä‐Herttuala, S. (2007) · Circulation Research · doi:10.1161/circresaha.107.154401 · Cited by 60
Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity
Kypreos, K. E., Karagiannides, I., Fotiadou, E. H., Karavia, E. A., Brinkmeier, M. S., Giakoumi, S. M., & Tsompanidi, E. M. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07301.x · Cited by 61
Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice
Garner, B., Priestman, D. A., Stocker, R., Harvey, D. J., Butters, T. D., & Platt, F. M. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30162-0 · Cited by 60
Dietary cholic acid lowers plasma levels of mouse and human apolipoprotein A-I primarily via a transcriptional mechanism
Srivastava, R. A. K., Srivastava, N., & Averna, M. R. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2000.01473.x · Cited by 60
Apolipoprotein E and Alzheimer's Disease: A Review of Recent Studies
Higgins, G. A., Large, C. H., Rupniak, H. T., & Barnes, J. C. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00420-0 · Cited by 58
Molecular and cellular concepts in atherosclerosis
Sanders, M. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)90060-4 · Cited by 60
Uptake of type III hypertriglyceridemic VLDL by macrophages is enhanced by oxidation, especially after remnant formation
Whitman, S. C., Miller, D. B., Wolfe, B. M., Hegele, R. A., & Huff, M. W. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.9.1707 · Cited by 59
Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition
Zhu, Z., Hua, B., Shang, Z., Yuan, G., Xu, L., Li, E., Li, X., Sun, N., Yan, Z., Qian, R., et al. (2016) · BioMed Research International · doi:10.1155/2016/5438589 · Cited by 60
Quantitative Assay for Mouse Atherosclerosis in the Aortic Root
Baglione, J., & Smith, J. D. (2006) · Humana Press eBooks · doi:10.1385/1-59745-213-0:83 · Cited by 59
Self-citation
Chronic Stress Accelerates Atherosclerosis in the Apolipoprotein E Deficient Mouse
Meena Kumari, B., Grahame-Clarke, C. N., Shanks, N. M., Marmot, M. G., Lightman, S. L., & Vallance, P. J. (2003) · Stress · doi:10.1080/10253890310001619461 · Cited by 59
Diabetes‐mediated myelopoiesis and the relationship to cardiovascular risk
Barrett, T. J., Murphy, A. J., Goldberg, I. J., & Fisher, E. A. A. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13462 · Cited by 60
Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis
Centa, M., Prokopec, K. E., Garimella, M. G., Habir, K., Hofste, L., Stark, J. M., Dahdah, A., Tibbitt, C. A., Polyzos, K. A., Gisterå, A., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310802 · Cited by 59
Promoting the Delivery of Nanoparticles to Atherosclerotic Plaques by DNA Coating
Zhang, L., Tian, X. Y., Chan, C. K. W., Bai, Q., Cheng, C. K., Chen, F. M., Cheung, M. S. H., Yin, B., Yang, H., Yung, W., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b17928 · Cited by 59
Apolipoprotein E Receptor Binding VersusHeparan Sulfate Proteoglycan Binding in Its Regulation of Smooth Muscle Cell Migration and Proliferation
Swertfeger, D. K., & Hui, D. Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102357200 · Cited by 59
Genetically modified mice for the study of apolipoprotein B
Kim, E. J.-H., & Young, S. G. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32560-8 · Cited by 59
Homozygous Familial Defective Apolipoprotein B-100
Schaefer, J. R., Scharnagl, H., Baumstark, M. W., Schweer, H., Zech, L. A., Seyberth, H. J., Winkler, K., Steinmetz, A., & März, W. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.2.348 · Cited by 59
Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E–Deficient mice fed a high-cholesterol diet
Amigo, L., Quiñones, V., Mardones, P., Zanlungo, S., Miquel, J. F., Nervi, F. O., & Rigotti, A. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70147-8 · Cited by 59
Low-Density Lipoprotein Receptor Knockout Mice Exhibit Exaggerated Microvascular Responses to Inflammatory Stimuli
Henninger, D. D., Gerritsen, M. E., & Granger, D. N. (1997) · Circulation Research · doi:10.1161/01.res.81.2.274 · Cited by 59
Phenotypic Correction of Hypercholesterolemia in ApoE-Deficient Mice by Adenovirus-Mediated In Vivo Gene Transfer
Stevenson, S. C., Marshall-Neff, J., Teng, B., Lee, C. B., Roy, S., & McClelland, A. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.4.479 · Cited by 59
Virus-mediated Transduction of Apolipoprotein E (ApoE)-Sendai Develops Lipoprotein Glomerulopathy in ApoE-deficient Mice
Ishigaki, Y., Oikawa, S., Suzuki, T., Usui, S., Magoori, K., Kim, D.-H., Suzuki, H., Sasaki, J., Sasano, H., Okazaki, M., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005906200 · Cited by 58
Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E
Fazio, S., Lee, Y. L., Ji, Z. S., & Rall, S. C. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116728 · Cited by 71
Domains of Apolipoprotein E Contributing to Triglyceride and Cholesterol Homeostasis in Vivo
Kypreos, K. E., van Dijk, K. W., van der Zee, A., Havekes, L. M., & Zannis, V. I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100418200 · Cited by 62
Remodeling of the Neurovascular Unit Following Cerebral Ischemia and Hemorrhage
Satō, Y., Falcone-Juengert, J., Tominaga, T., Su, H., & Liu, J. (2022) · Cells · doi:10.3390/cells11182823 · Cited by 60
Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells
Hasanov, Z., Ruckdeschel, T., König, C., Mogler, C., Kapel, S. S., Korn, C., Spegg, C., Eichwald, V., Wieland, M. J., Appak‐Baskoy, S., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308455 · Cited by 58
A20, a regulator of NFκB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains
Idel, S., Dansky, H. M., & Breslow, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1835672100 · Cited by 58
Self-citation
Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer
Zannis, V. I., Chroni, A., Kypreos, K. E., Kan, H.-Y., Cesar, T. B., Zanni, E. E., & Kardassis, D. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200404000-00008 · Cited by 74
Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice
Slätis, K., Gåfvels, M. E., Kannisto, K., Овчинникова, О. А., Paulsson‐Berne, G., Parini, P., Jiang, Z., & Eggertsen, G. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009308 · Cited by 57
Regulation of cholesterol homeostasis by liver X receptors
Hu, Y., Zheng, L., & Wang, Q. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.12.027 · Cited by 57
In vitro models of aortic valve calcification: solidifying a system
Bowler, M. A., & Merryman, W. D. (2014) · Cardiovascular Pathology · doi:10.1016/j.carpath.2014.08.003 · Cited by 60
Endogenous Renovascular Hypertension Combined With Low Shear Stress Induces Plaque Rupture in Apolipoprotein E–Deficient Mice
Jin, S., Shen, L., Nie, P., Yuan, W., Hu, L., Li, D., Chen, X., Zhang, X.-K., & He, B. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.236158 · Cited by 57
Endothelial dysfunction and atherosclerosis: Endothelin receptor antagonists as novel therapeutics
Barton, M. (2000) · Current Hypertension Reports · doi:10.1007/s11906-000-0064-5 · Cited by 57
Reconstituted Discoidal ApoE-Phospholipid Particles Are Ligands for the Scavenger Receptor BI
Li, X., Kan, H.-Y., Lavrentiadou, S. N., Krieger, M., & Zannis, V. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200658200 · Cited by 57
Autoimmunity in atherosclerosis: lessons from experimental models
George, J., Afek, A. B., Gilburd, B., Harats, D., & Shoenfeld, Y. (2000) · Lupus · doi:10.1191/096120300678828190 · Cited by 57
Arterial Injury Increases Expression of Inflammatory Adhesion Molecules in the Carotid Arteries of Apolipoprotein-E-Deficient Mice 1
Manka, D. R., Wiegman, P., Din, S., Sanders, J. M., Green, S. A., Gimple, L. W., Ragosta, M., Powers, E. R., Ley, K. F., & Sarembock, I. J. (1999) · Journal of Vascular Research · doi:10.1159/000025676 · Cited by 57
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.
Calingasan, N. Y., Gandy, S., Baker, H., Sheu, K. R., Smith, J. D., Lamb, B. T., Gearhart, J. D., Buxbaum, J. D., Harper, C. C., Selkoe, D. J., et al. (1996) · Europe PMC (PubMed Central) · Cited by 56
Self-citation
Increased 3-nitrotyrosine in brains of Apo E-deficient mice
Matthews, R. T., & Beal, M. F. (1996) · Brain Research · doi:10.1016/0006-8993(95)01576-0 · Cited by 57
IRF5 Deficiency Ameliorates Lupus but Promotes Atherosclerosis and Metabolic Dysfunction in a Mouse Model of Lupus-Associated Atherosclerosis
Watkins, A. A., Yasuda, K., Wilson, G. E., Aprahamian, T. R., Xie, Y., Maganto-García, E., Shukla, P., Oberlander, L., Laskow, B., Menn‐Josephy, H., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402807 · Cited by 57
The F11 receptor (F11R/JAM-A) in atherothrombosis: Overexpression of F11R in atherosclerotic plaques
Babińska, A., Azari, B. M., Salifu, M., Liu, R., Jiang, X., Sobocka, M. B., Boo, D., Khoury, G., Deitch, J. S., Marmur, J. D., et al. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-08-0454 · Cited by 56
Characterization of Nuclear Sirtuins: Molecular Mechanisms and Physiological Relevance
Toiber, D., Sebastián, C., & Mostoslavsky, R. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_9 · Cited by 57
Sphingolipids and atherosclerosis
Hornemann, T., & Worgall, T. S. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.08.041 · Cited by 60

Authors: Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L.
Affiliations: Rockefeller University (US)
Lawrence Berkeley National Laboratory (US)
ORCID: Smith, Jonathan D.
Rubin, Edward M.
Breslow, Jan L.
Venue: Cell
Publisher: Elsevier BV
Published: 1992-10
Volume: 71
Issue: 2
Pages: 343-353
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(92)90362-g
OpenAlex: W2048890665
Cited by: 2,263
References: 45
Citations by year: 2026: 23 · 2025: 41 · 2024: 28 · 2023: 32 · 2022: 52 · 2021: 39 · 2020: 60 · 2019: 69 · 2018: 57 · 2017: 66 · 2016: 57 · 2015: 71 · 2014: 71 · 2013: 82 · 2012: 75
FWCI: 72.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hl033714-17)
National Heart, Lung, and Blood Institute (HL 33714, R01HL032435, HL32435)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: apolipoprotein E deficiency, hypercholesterolemia, atherosclerosis, ApoE-deficient mice, homologous recombination, embryonic stem cells, serum cholesterol, VLDL, intermediate density lipoprotein, high-fat diet, aortic atherosclerotic lesions, coronary arteries, pulmonary artery, animal models of atherosclerosis
MeSH terms: Animals, Aorta, Apolipoproteins E, Arteriosclerosis, Cholesterol, Coronary Vessels, Disease Models, Animal, Hypercholesterolemia, Lipoproteins, Lipoproteins, VLDL, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Pulmonary Artery, Stem Cells, Mice, Lipoproteins, IDL

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks