Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515

The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Weber, K., & Osborn, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94333-4 · Cited by 16,688

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028

The Metabolic Basis of Inherited Disease

(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-389_2 · Cited by 3,990

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355

Apolipoprotein E polymorphism and atherosclerosis.

Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes

Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

Hooper, M., Hardy, K., Handyside, A. H., Hunter, S., & Monk, M. (1987) · Nature · doi:10.1038/326292a0 · Cited by 1,218

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine

Powell, L. M., Wallis, S. C., Pease, R. J., Edwards, Y. H., Knott, T. J., & Scott, J. (1987) · Cell · doi:10.1016/0092-8674(87)90510-1 · Cited by 1,045

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI

Rubin, E. M., Krauss, R. M., Spangler, E. A., Verstuyft, J. G., & Clift, S. (1991) · Nature · doi:10.1038/353265a0 · Cited by 985

Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis

von Scheidt, M., Zhao, Y., Kurt, Z., Pan, C., Zeng, L., Yang, X., Schunkert, H., & Lusis, A. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.11.001 · Cited by 230

Increased Atherosclerosis in ApoE and LDL Receptor Gene Knock-Out Mice as a Result of Human Cholesteryl Ester Transfer Protein Transgene Expression

Plump, A. S., Masucci-Magoulas, L., Bruce, C., Bisgaier, C. L., Breslow, J. L., & Tall, A. R. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.4.1105 · Cited by 222

MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice

Horie, T., Baba, O., Kuwabara, Y., Chujo, Y., Watanabe, S., Kinoshita, M., Horiguchi, M., Nakamura, T., Chonabayashi, K., Hishizawa, M., et al. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.003376 · Cited by 220

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

Stein, S., Lohmann, C., Schäfer, N., Hofmann, J., Rohrer, L., Besler, C., Rothgiesser, K. M., Becher, B., Hottiger, M. O., Borén, J., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq107 · Cited by 188

A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet

Powell-Braxton, L., Véniant, M., Latvala, R. D., Hirano, K.-I., Won, W. B., Ross, J., Dybdal, N., Zlot, C. H., Young, S. G., & Davidson, N. O. (1998) · Nature Medicine · doi:10.1038/nm0898-934 · Cited by 192

Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor

Hasty, A. H., Shimano, H., Osuga, J.-I., Namatame, I., Takahashi, A., Yahagi, N., Perrey, S., Iizuka, Y., Tamura, Y., Amemiya-Kudo, M., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010176200 · Cited by 219

Adhesion of Monocytes to Arterial Endothelium and Initiation of Atherosclerosis Are Critically Dependent on Vascular Cell Adhesion Molecule-1 Gene Dosage

Dansky, H. M., Barlow, C. B., Lominska, C. E., Sikes, J. L., Kao, C., Weinsaft, J. W., Cybulsky, M. I., & Smith, J. D. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.096625 · Cited by 219

Recipes for Creating Animal Models of Diabetic Cardiovascular Disease

Hsueh, W. A., Abel, E. D., Breslow, J. L., Maeda, N., Davis, R. C., Fisher, E. A. A., Dansky, H. M., McClain, D. A., McIndoe, R., Wassef, M. K., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000266449.37396.1f · Cited by 221

Mouse Models of Atherosclerosis

Daugherty, A. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200201000-00002 · Cited by 218

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

Wu, Y., Carballo‐Jane, E., McLaren, D. G., Mendoza, V., Gagen, K., Geoghagen, N. S. M., McNamara, L. A., Gorski, J. N., Eiermann, G. J., Petrov, A., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m019927 · Cited by 229

Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia

Gallagher, E. J., Zelenko, Z., Neel, B. A., Antoniou, I. M., Rajan, L., KASE, N. G., & LeRoith, D. (2017) · Oncogene · doi:10.1038/onc.2017.247 · Cited by 222

Cigarette Smoke Exposure and Hypercholesterolemia Increase Mitochondrial Damage in Cardiovascular Tissues

Knight-Lozano, C. A., Young, C. G., Burow, D. L., Hu, Z., Uyeminami, D. L., Pinkerton, K. E., Ischiropoulos, H., & Ballinger, S. W. (2002) · Circulation · doi:10.1161/hc0702.103977 · Cited by 217

Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury

Chen, Y., Lomnitski, L., Michaelson, D. M., & Shohami, E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00007-9 · Cited by 214

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice

Gordon, I., Grauer, E., Genis, I., Sehayek, E., & Michaelson, D. M. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12006-p · Cited by 172

Mammalian acyl-CoA:cholesterol acyltransferases

Buhman, K. K. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00144-x · Cited by 214

Aortic valve disease and treatment: The need for naturally engineered solutions

Butcher, J. T., Mahler, G. J., & Hockaday, L. A. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.01.008 · Cited by 220

Differential Effects of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein on Fatty-Streak Formation in Apolipoprotein E–Deficient Mice

Elhage, R., Maret, A., Pieraggi, M. T., Thiers, J., Arnal, J., & Bayard, F. (1998) · Circulation · doi:10.1161/01.cir.97.3.242 · Cited by 209

Role of Leukotriene B4Receptors in the Development of Atherosclerosis: Potential Mechanisms

Subbarao, K., Jala, V. R., Mathis, S., Suttles, J., Zacharias, W., Ahamed, J., Ali, H., Tseng, M. T., & Haribabu, B. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000110503.16605.15 · Cited by 210

Apolipoprotein E and atherosclerosis: insight from animal and human studies

Davignon, J., Cohn, J. S., Mabile, L., & Bernier, L. (1999) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00097-2 · Cited by 210

Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation.

Boisvert, W. A., Spangenberg, J., & Curtiss, L. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118098 · Cited by 207

The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity

Sag, D., Cekic, C., Wu, R., Linden, J., & Hedrick, C. C. (2015) · Nature Communications · doi:10.1038/ncomms7354 · Cited by 205

Regulation of cholesterol homeostasis

van der Wulp, M. Y. M., Verkade, H. J., & Groen, A. K. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.007 · Cited by 210

Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability

Lillis, A. P., MIKHAILENKO, I. A., & Strickland, D. K. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01371.x · Cited by 210

Overexpression and Accumulation of Apolipoprotein E as a Cause of Hypertriglyceridemia

Huang, Y., Liu, X. Q., Rall, S. C., Taylor, J. M., von Eckardstein, A., Assmann, G., & Mahley, R. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26388 · Cited by 204

Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant

Al-Mashhadi, R. H., Sørensen, C. B., Kragh, P. M., Christoffersen, C., Mortensen, M. B., Tolbod, L. P., Thim, T., Du, Y., Li, J., Liu, Y., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004853 · Cited by 207

Human Plasma Phospholipid Transfer Protein Increases the Antiatherogenic Potential of High Density Lipoproteins in Transgenic Mice

van Haperen, R., van Tol, A., Vermeulen, P. S., Jauhiainen, M., van Gent, T., van den Berg, P., Ehnholm, S., Grosveld, F. G., van der Kamp, A., & de Crom, R. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.4.1082 · Cited by 204

Uremia Accelerates both Atherosclerosis and Arterial Calcification in Apolipoprotein E Knockout Mice

Massy, Z. A., Ivanovski, O., Nguyen-Khoa, T., Angulo, J., Szumilak, D., Mothu, N., Phan, O., Daudon, M., Lacour, B., Dru[Combining Diaeresis]eke, T. B., et al. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004060495 · Cited by 203

Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice

Merhi‐Soussi, F., Kwak, B. R., Magne, D., Chadjichristos, C. E., Berti, M., Pelli, G., James, R. W., Mach, F., & Gabay, C. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.008 · Cited by 200

Do the Apoe −/− and Ldlr −/– Mice Yield the Same Insight on Atherogenesis?

Getz, G. S., & Reardon, C. A. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.306874 · Cited by 198

Chylomicron assembly and catabolism: role of apolipoproteins and receptors

Hussain, M. M., Kancha, R. K., Zhou, Z., Luchoomun, J., Zu, H. Y., & Bakillah, A. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00041-0 · Cited by 205

Cyclic AMP Induces Apolipoprotein E Binding Activity and Promotes Cholesterol Efflux from a Macrophage Cell Line to Apolipoprotein Acceptors

Smith, J. D., Miyata, M., Ginsberg, M. D., Grigaux, C., Shmookler, E., & Plump, A. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30647 · Cited by 197

Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.

Purcell-huynh, D. A., Farese, R. V., Johnson, D. F., Flynn, L. M., Pierotti, V., Newland, D., Linton, M. F., Sanan, D. A., & Young, S. G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117915 · Cited by 197

LIPOPROTEIN PHYSIOLOGY

Ginsberg, H. N. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70023-2 · Cited by 194

Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo

Roselaar, S. E., & Daugherty, A. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32160-x · Cited by 193

Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals

Takahashi, K. I., Takeya, M., & Sakashita, N. (2002) · Medical Molecular Morphology · doi:10.1007/s007950200023 · Cited by 192

Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)–deficient mice

Miettinen, H. E., Rayburn, H., & Krieger, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13288 · Cited by 192

Effects of sucrose, glucose and fructose on peripheral and central appetite signals

Lindqvist, A., Baelemans, A., & Erlanson‐Albertsson, C. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2008.06.008 · Cited by 201

Lymphocyte Populations in Atherosclerotic Lesions of ApoE −/− and LDL Receptor −/− Mice

Roselaar, S. E., Kakkanathu, P. X., & Daugherty, A. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.1013 · Cited by 191

Chylomicronemia due to apolipoprotein CIII overexpression in apolipoprotein E-null mice. Apolipoprotein CIII-induced hypertriglyceridemia is not mediated by effects on apolipoprotein E.

Ebara, T., Ramakrishnan, R., Steiner, G. A., & Shachter, N. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119456 · Cited by 195

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis

Terwel, D., Steffensen, K. R., Verghese, P. B., Kummer, M. P., Gustafsson, J.-Å., Holtzman, D. M., & Heneka, M. T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6546-10.2011 · Cited by 190

Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond

Fuior, E. V., & Gafencu, A. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235939 · Cited by 186

Innate and adaptive immunity in atherosclerosis

Packard, R. R. S., Lichtman, A. H., & Libby, P. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0153-8 · Cited by 191

Rapid regression of atherosclerosis: insights from the clinical and experimental literature

Williams, K. J., Feig, J. E., & Fisher, E. A. A. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1086 · Cited by 190

The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease

Beffert, U. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00008-3 · Cited by 190

Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice.

Li, H., Reddick, R. L., & Maeda, N. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.12.1814 · Cited by 189

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

Li, Z., Zhang, H., Liu, J., Liang, C.-P., Li, Y., Li, Y., Teitelman, G., Beyer, T. P., Bui, H. H., Peake, D. A., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05893-11 · Cited by 191

Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening

Kothapalli, D., Liu, S., Bae, Y., Monslow, J., Xu, T., Hawthorne, E. A., Byfield, F. J., Castagnino, P. A., Rao, S. J., Rader, D. J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.018 · Cited by 187

Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function

Battista, A. M. D., Heinsinger, N. M., & Rebeck, G. W. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160401115127 · Cited by 189

Reduction of Atherosclerosis by the Peroxisome Proliferator-activated Receptor α Agonist Fenofibrate in Mice*

Duez, H., Chao, Y., Hernandez, M., Torpier, G., Poulain, P., Mundt, S., Mallat, Z., Teissier, E., Burton, C. A., Tedgui, A., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206966200 · Cited by 201

Reduced Atherosclerotic Plaque but Enhanced Aneurysm Formation in Mice With Inactivation of the Tissue Inhibitor of Metalloproteinase-1 ( TIMP-1 ) Gene

Silence, J., Collen, D., & LIJNEN, H. R. (2002) · Circulation Research · doi:10.1161/01.res.0000016501.56641.83 · Cited by 185

Induction of Sustained Hypercholesterolemia by Single Adeno-Associated Virus–Mediated Gene Transfer of Mutant hPCSK9

Roche-Molina, M., Sanz‐Rosa, D., Cruz, F. M., García‐Prieto, J., López, S., Abia, R., Muriana, F. J. G., Fuster, V., Ibáñez, B., & Bernal, J. A. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303617 · Cited by 191

Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

Daugherty, A., Tall, A. R., Daemen, M. J. A. P., Falk, E., Fisher, E. A. A., García‐Cardeña, G., Lusis, A. J., Owens, A. P., Rosenfeld, M. E., & Virmani, R. (2017) · Circulation Research · doi:10.1161/res.0000000000000169 · Cited by 186

Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery

Eitzman, D. T., Westrick, R. J., Xu, Z., Tyson, J. A., & Ginsburg, D. (2000) · Blood · doi:10.1182/blood.v96.13.4212 · Cited by 182

LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice

Schreyer, S. A., Vick, C. M., Lystig, T., Mystkowski, P., & LeBoeuf, R. C. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e207 · Cited by 182

Inhibition of α 4 Integrin and ICAM-1 Markedly Attenuate Macrophage Homing to Atherosclerotic Plaques in ApoE-Deficient Mice

Patel, S. S., Thiagarajan, R., Willerson, J. T., & Yeh, E. T. H. (1998) · Circulation · doi:10.1161/01.cir.97.1.75 · Cited by 182

Phospholipid methylation in mammals: from biochemistry to physiological function

Vance, D. E. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.10.018 · Cited by 185

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice

Willner, E. L., Tow, B., Buhman, K. K., Wilson, M. D., Sanan, D. A., Rudel, L. L., & Farese, R. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336398100 · Cited by 181

Hyperhomocysteinemia accelerates atherosclerosis in cystathionine β-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation

Wang, H., Jiang, X., Yang, F., Gaubatz, J. W., Ma, L., Magera, M. J., Yang, X.-F., Berger, P. B., Durante, W., Pownall, H. J., et al. (2003) · Blood · doi:10.1182/blood-2002-08-2606 · Cited by 180

ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis

Lemaître, V., O’Byrne, T. K., Borczuk, A., Okada, Y., Tall, A. R., & D'Armiento, J. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci9626 · Cited by 180

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production.

Plump, A. S., Erickson, S. K., Weng, W., Partin, J. S., Breslow, J. L., & Williams, D. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118716 · Cited by 178

A plasma lipoprotein containing only apolipoprotein Eand with gamma mobility on electrophoresis releases cholesterol fromcells.

Huang, Y., von Eckardstein, A., Wu, S., Maeda, N., & Assmann, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1834 · Cited by 180

Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis

Tan, M. H., Sun, Z., Opitz, S. L., Schmidt, T. E., Peters, J. H., & George, E. L. (2004) · Blood · doi:10.1182/blood-2003-09-3363 · Cited by 177

PAI ‐1, progress in understanding the clinical problem and its aetiology

Iwaki, T., Urano, T., & Umemura, K. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09074.x · Cited by 177

Connexins in Vascular Physiology and Pathology

Brisset, A. C., Isakson, B. E., & Kwak, B. R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2115 · Cited by 177

Interaction of the Estrogen Receptors with the Fas Ligand Promoter in Human Monocytes

Mor, G., Sapi, E., Abrahams, V. M., Rutherford, T., Song, J. H., Hao, X.-Y., Muzaffar, S., & Kohen, F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.114 · Cited by 177

The atherogenic effect of excess methionine intake

Troen, A. M., Lutgens, E., Smith, D. E., Rosenberg, I. H., & Selhub, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436385100 · Cited by 180

Infectious Agents Are Not Necessary for Murine Atherogenesis

Wright, S. D., Burton, C., Hernandez, M., Hassing, H., Montenegro, J., Mundt, S., Patel, S., Card, D. J., Hermanowski-Vosatka, A., Bergstrom, J. D., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1437 · Cited by 176

Receptor for advanced glycation endproducts (RAGE) and vascular inflammation: Insights into the pathogenesis of macrovascular complications in diabetes

Wendt, T., Bucciarelli, L. G., Qu, W., Lu, Y., Yan, S. F., Stern, D. M., & Schmidt, A. M. (2002) · Current Atherosclerosis Reports · doi:10.1007/s11883-002-0024-4 · Cited by 176

LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease

Bieghs, V., van Gorp, P. J., Wouters, K., Hendrikx, T., Gijbels, M. J., van Bilsen, M., Bakker, J. A., Binder, C. J., Lütjohann, D., Staels, B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030668 · Cited by 175

Development and Disease in Proteinase-Deficient Mice

Carmeliet, P., & Collen, D. (1998) · Thrombosis Research · doi:10.1016/s0049-3848(98)00122-4 · Cited by 174

Hyperlipidemia and Atherosclerotic Lesion Development in LDL Receptor–Deficient Mice Fed Defined Semipurified Diets With and Without Cholate

Lichtman, A. H., Clinton, S. K., Iiyama, K., Connelly, P. W., Libby, P., & Cybulsky, M. I. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.8.1938 · Cited by 174

Interleukin-1 Receptor Signaling Mediates Atherosclerosis Associated With Bacterial Exposure and/or a High-Fat Diet in a Murine Apolipoprotein E Heterozygote Model

Chi, H.-H., Messas, E., Levine, R. A., Graves, D. T., & Amar, S. (2004) · Circulation · doi:10.1161/01.cir.0000142085.39015.31 · Cited by 176

Proteomic and Metabolomic Analyses of Atherosclerotic Vessels From Apolipoprotein E-Deficient Mice Reveal Alterations in Inflammation, Oxidative Stress, and Energy Metabolism

Mayr, M., Chung, Y., Mayr, U., Yin, X., Ly, L., Troy, H., Fredericks, S., Hu, Y., Griffiths, J. R., & Xu, Q. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000183928.25844.f6 · Cited by 173

Macrophage scavenger receptors and foam cell formation

de Villiers, W. J. S., & Smart, E. J. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.5.740 · Cited by 173

Adipocyte Fatty Acid–Binding Protein, aP2, Alters Late Atherosclerotic Lesion Formation in Severe Hypercholesterolemia

Boord, J. B., Maeda, K., Makowski, L., Babaev, V. R., Fazio, S., Linton, M. F., & Hotamışlıgil, G. S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000033090.81345.e6 · Cited by 172

Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis

Skoura, A., Michaud, J. E., Im, D., Thangada, S., Xiong, Y., Smith, J. D., & Hla, T. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.213496 · Cited by 171

Endothelial C-type natriuretic peptide maintains vascular homeostasis

Moyes, A. J., Khambata, R. S., Villar, I. C., Bubb, K. J., Baliga, R. S., Lumsden, N. G., Xiao, F., Gane, P. J., Rebstock, A., Worthington, R. J., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74281 · Cited by 175

Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice.

Dithmar, S., Curcio, C. A., Le, N., Brown, S., & Grossniklaus, H. E. (2000) · PubMed · Cited by 171

Genetic Modifiers of Atherosclerosis in Mice

Knowles, J. W., & Maeda, N. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.11.2336 · Cited by 176

Dietary glycotoxins promote diabetic atherosclerosis in apolipoprotein E-deficient mice

Lin, R.-Y., Choudhury, R. P., Cai, W., Lu, M. M., Fallon, J. T., Fisher, E. A. A., & Vlassara, H. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00050-9 · Cited by 169

Atherosclerosis, Vascular Remodeling, and Impairment of Endothelium-Dependent Relaxation in Genetically Altered Hyperlipidemic Mice

Bonthu, S., Heistad, D. D., Chappell, D. A., Lamping, K. G., & Faraci, F. M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2333 · Cited by 171

Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice

Caligiuri, G., Levy, B. I., Pernow, J., Thorén, P., & Hansson, G. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6920 · Cited by 171

Chronic Renal Failure Accelerates Atherogenesis in Apolipoprotein E–Deficient Mice

Bro, S., Bentzon, J. F., Falk, E., Andersen, C. B., Ølgaard, K., & Nielsen, L. B. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000088024.72216.2e · Cited by 170

Proatherogenic and Antiatherogenic Effects of Probucol and Phytosterols in Apolipoprotein E–Deficient Mice

Moghadasian, M. H., McManus, B. M., Godin, D. V., Rodrigues, B. B., & Frohlich, J. J. (1999) · Circulation · doi:10.1161/01.cir.99.13.1733 · Cited by 169

Functional Blockade of Platelet-Derived Growth Factor Receptor-β but Not of Receptor-α Prevents Vascular Smooth Muscle Cell Accumulation in Fibrous Cap Lesions in Apolipoprotein E–Deficient Mice

Sano, H., Sudo, T., Yokode, M., Murayama, T., Kataoka, H., Takakura, N., Nishikawa, S., Nishikawa, S.-I., & Kita, T. (2001) · Circulation · doi:10.1161/01.cir.103.24.2955 · Cited by 169

Atherosclerosis—An immune disease

Hansson, G. K. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.08.039 · Cited by 169

Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease

Pasterkamp, G., den Ruijter, H. M., & Libby, P. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.166 · Cited by 178

Mouse models of atherosclerosis: a historical perspective and recent advances

Lee, Y. T., Lin, H. Y., Chan, Y. W. F., Li, K. H. C., To, O. T. L., Yan, B. P., Liu, T., Li, G., Wong, W. T., Keung, W., et al. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-016-0402-5 · Cited by 183

LIPOPROTEINS AND ATHEROGENESIS

Hoeg, J. M. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70026-8 · Cited by 166

Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes.

Kuipers, F., Jong, M. C., Lin, Y., Eck, M. V., Havinga, R., Bloks, V. W., Verkade, H. J., Hofker, M. H., Moshage, H. J., van Berkel, T. J. C., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119841 · Cited by 167

Genetic Background Determines the Extent of Atherosclerosis in ApoE-Deficient Mice

Dansky, H. M., Charlton, S. A., Sikes, J. L., Heath, S. C., Simantov, R., Levin, L. F., Shu, P., Moore, K. J., Breslow, J. L., & Smith, J. D. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.8.1960 · Cited by 167

Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia

Laskowitz, D. T., Sheng, H., Bart, R. D., Joyner, K. A., Roses, A. D., & Warner, D. S. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199707000-00005 · Cited by 166

Embryonic stem cells in drug discovery

McNeish, J. D. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1281 · Cited by 171

Mouse Macrophage Paraoxonase 2 Activity Is Increased Whereas Cellular Paraoxonase 3 Activity Is Decreased Under Oxidative Stress

Rosenblat, M., Draganov, D. I., Watson, C. E., Bisgaier, C. L., Du, B. N. L., & Aviram, M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000059385.95664.4d · Cited by 166

Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.

Cohen, R. D., Castellani, L. W., Qiao, J. H., Lenten, B. J. V., Lusis, A. J., & Reue, K. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119358 · Cited by 165

Adenovirus-Mediated Overexpression of Tissue Inhibitor of Metalloproteinase-1 Reduces Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice

Rouis, M., Adamy, C., Duverger, N., Lesnik, P., Horellou, P., Moreau, M., Emmanuel, F., Caillaud, J., Laplaud, P. M., Dachet, C., et al. (1999) · Circulation · doi:10.1161/01.cir.100.5.533 · Cited by 166

Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease

Aprahamian, T. R., Rifkin, I. R., Bonegio, R. G. B., Hugel, B., Freyssinet, J., Sato, K., Castellot, J. J., & Walsh, K. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031557 · Cited by 163

CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice

Kuziel, W. A., Dawson, T. C., Quinones, M. P., Garavito, É., Chenaux, G., Ahuja, S. S., Reddick, R. L., & Maeda, N. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00382-9 · Cited by 164

Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease

Manning, M. W., Cassis, L. A., Huang, J., Szilvassy, S. J., & Daugherty, A. (2002) · Vascular Medicine · doi:10.1191/1358863x02vm413ra · Cited by 163

Molecular analysis of blood vessel formation and disease

Carmeliet, P., & Collen, D. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.5.h2091 · Cited by 161

The Microcirulation in Hypercholesterolemic Mice

Constantinescu, A. A., & Vink, H. (2004) · Basic science for the cardiologist · doi:10.1007/978-1-4615-0483-2_13

Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice

Ree, J. H. V., Broek, W. J. A. A. V. D., Dahlmans, V. E. H., Groot, P. H. E., Vidgeon-Hart, M., Frants, R. R., Wieringa, B., Havekes, L. M., & Hofker, M. H. (1994) · TNO Repository

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693

Cholesterol Levels and Atherosclerosis in ApoE-Deficient Mice

Groot, P. H. E., van Berkel, T. J. C., Eck, A. V., Herijgers, N., Willems, K., Dijk, V., Havekes, L. M., Marten, H., Biol, A. T. V., Eck, A. V., et al. (2014)