Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515

The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Weber, K., & Osborn, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94333-4 · Cited by 16,688

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028

The Metabolic Basis of Inherited Disease

(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-389_2 · Cited by 3,990

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355

Apolipoprotein E polymorphism and atherosclerosis.

Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes

Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

Hooper, M., Hardy, K., Handyside, A. H., Hunter, S., & Monk, M. (1987) · Nature · doi:10.1038/326292a0 · Cited by 1,218

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine

Powell, L. M., Wallis, S. C., Pease, R. J., Edwards, Y. H., Knott, T. J., & Scott, J. (1987) · Cell · doi:10.1016/0092-8674(87)90510-1 · Cited by 1,045

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI

Rubin, E. M., Krauss, R. M., Spangler, E. A., Verstuyft, J. G., & Clift, S. (1991) · Nature · doi:10.1038/353265a0 · Cited by 985

Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice

Wouters, K., Shiri-Sverdlov, R., van Gorp, P. J., van Bilsen, M., & Hofker, M. H. (2005) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2005.085 · Cited by 163

Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice

Trogan, E., Choudhury, R. P., Dansky, H. M., Rong, J. X., Breslow, J. L., & Fisher, E. A. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042683999 · Cited by 163

Vascular effects of a low-carbohydrate high-protein diet

Foo, S. Y., Heller, E. R., Wykrzykowska, J. J., Sullivan, C. J., Manning, J. J., Moore, K. J., Gerszten, R. E., & Rosenzweig, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907995106 · Cited by 161

Nrf2 and Cardiovascular Defense

Howden, R. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/104308 · Cited by 168

Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension.

Smithies, O., & Maeda, N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5266 · Cited by 162

Decoding Transcriptional Programs Regulated by PPARs and LXRs in the Macrophage

Ricote, M., Valledor, A. F., & Glass, C. K. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000103951.67680.b1 · Cited by 164

Induction of Atherosclerosis by Low-Fat, Semisynthetic Diets in LDL Receptor–Deficient C57BL/6J and FVB/NJ Mice

Teupser, D., Persky, A. D., & Breslow, J. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000090126.34881.b1 · Cited by 161

Vascular expression of extracellular superoxide dismutase in atherosclerosis.

Fukai, T., Galis, Z. S., Meng, X. P., Parthasarathy, S., & Harrison, D. G. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2105 · Cited by 156

Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing

Mahley, R. W., & Huang, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30889 · Cited by 159

Effects of sex and age on atherosclerosis and autoimmunity in apoE-deficient mice

Caligiuri, G., Nicoletti, A., Zhou, X., Törnberg, I., & Hansson, G. K. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00081-7 · Cited by 159

Mechanism of Endothelial Dysfunction in Apolipoprotein E–Deficient Mice

d’Uscio, L. V., Baker, T. A., Mantilla, C. B., Smith, L., Weiler, D. A., Sieck, G. C., & Katušić, Z. S. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.1017 · Cited by 159

Adoptive Transfer of CD4+T Cells Reactive to Modified Low-Density Lipoprotein Aggravates Atherosclerosis

Zhou, X., Robertson, A.-K. L., Hjerpe, C., & Hansson, G. K. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000206122.61591.ff · Cited by 157

Control of Vascular Cell Proliferation and Migration by PPAR-γ

Hsueh, W. A., Jackson, S. M., & Law, R. E. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.392 · Cited by 156

Supplementation of Diets with the Black Rice Pigment Fraction Attenuates Atherosclerotic Plaque Formation in Apolipoprotein E Deficient Mice

Xia, M., Ling, W. H., Ma, J., Kitts, D. D., & Zawistowski, J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.3.744 · Cited by 157

Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteins

Cohn, J. S., Marcoux, C., & Davignon, J. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.10.2474 · Cited by 156

Metabolism and Modification of Apolipoprotein B-Containing Lipoproteins Involved in Dyslipidemia and Atherosclerosis

Morita, S. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00716 · Cited by 161

Innate Immune Signaling and Porphyromonas gingivalis -accelerated Atherosclerosis

Gibson, F. C., Yumoto, H., Takahashi, Y., Chou, H.-H., & Genco, C. A. (2006) · Journal of Dental Research · doi:10.1177/154405910608500202 · Cited by 154

Vascular smooth muscle-specific progerin expression accelerates atherosclerosis and death in a mouse model of Hutchinson-Gilford progeria syndrome

Hamczyk, M. R., Villa-Bellosta, R., Gonzalo, P., Andrés-Manzano, M. J., Nogales, P., Bentzon, J. F., López-Otín, C., & Andrés, V. (2018) · Circulation · doi:10.1161/circulationaha.117.030856 · Cited by 153

Human Serum Paraoxonase 1 Decreases Macrophage Cholesterol Biosynthesis

Rozenberg, O., Shih, D. M., & Aviram, M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000060462.35946.b3 · Cited by 152

Animal models for the atherosclerosis research: a review

Li, X., Yuanwu, L., Zhang, H., Liming, R., Li, Q., & Li, N. (2011) · Protein & Cell · doi:10.1007/s13238-011-1016-3 · Cited by 147

Cystatin C Deficiency Increases Elastic Lamina Degradation and Aortic Dilatation in Apolipoprotein E–Null Mice

Sukhova, G. K., Wang, B., Libby, P., Pan, J., Zhang, Y., GRUBB, A. O., Fang, K., Chapman, H. A., & Shi, G. (2005) · Circulation Research · doi:10.1161/01.res.0000155964.34150.f7 · Cited by 151

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.

Shimada, M., Ishibashi, S., Inaba, T., Yagyu, H., Harada, K., Osuga, J.-I., Ohashi, K., Yazaki, Y., & Yamada, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7242 · Cited by 151

ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury

Methia, N., André, P., Hafezi-Moghadam, A., Economopoulos, M., Thomas, K. L., & Wagner, D. D. (2001) · Molecular Medicine · doi:10.1007/bf03401973 · Cited by 150

Role of Nrf2 in the pathogenesis of atherosclerosis

Mimura, J., & Itoh, K. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.019 · Cited by 156

Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids

Liu, X., Ukai, T., Yumoto, H., Davey, M., Goswami, S., Gibson, F. C., & Genco, C. A. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.03.025 · Cited by 149

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

Ming, X., Rajapakse, A. G., Yepuri, G., Xiong, Y., Carvas, J. M., Ruffieux, J., Scerri, I., Wu, Z., Popp, K., Li, J., et al. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.000992 · Cited by 155

Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: No accentuation by apolipoprotein(a)

Sanan, D. A., Newland, D., Tao, R., Marcovina, S. M., Wang, J., Mooser, V., Hammer, R. E., & Hobbs, H. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4544 · Cited by 150

Genetics of responsiveness to high-fat and high-cholesterol diets in the mouse

Paigen, B. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.2.458s · Cited by 150

Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI

Holm, T. M., Braun, A., Trigatti, B. L., Brugnara, C., Sakamoto, M., Krieger, M., & Andrews, N. C. (2002) · Blood · doi:10.1182/blood.v99.5.1817 · Cited by 149

Prevention of Atherosclerosis by Interference with the Vascular Nitric Oxide System

Li, H., & Förstermann, U. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789058002 · Cited by 154

ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage

Hafezi-Moghadam, A., Thomas, K. L., & Wagner, D. D. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00563.2005 · Cited by 149

Beyond the CNS: The many peripheral roles of APOE

Martínez-Martínez, A. B., Torres-Perez, E., Devanney, N., Del Moral, R., Johnson, L. A., & Arbones-Mainar, J. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104809 · Cited by 149

Lipoprotein Size and Atherosclerosis Susceptibility in Apoe −/− and Ldlr −/− Mice

Véniant, M. M., Withycombe, S. K., & Young, S. G. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.097780 · Cited by 149

Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors.

Kashyap, V. S., Santamarina-Fojo, S., Brown, D. R., Parrott, C. L., Applebaum-Bowden, D. M., Meyn, S. M., Talley, G. D., Paigen, B. J., Maeda, N., & Brewer, H. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118200 · Cited by 147

Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility

Weng, W., & Breslow, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14788 · Cited by 148

Apolipoprotein E and the Apolipoprotein E-Deficient Mouse

Plump, A. S., & Breslow, J. L. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.002431 · Cited by 154

Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice

van Ree, J. H., van den Broek, W. J. A. A., Dahlmans, V. E. H., Groot, P. H. E., Vidgeon-Hart, M., Frants, R. R., Wieringa, B., Havekes, L. M., & Hofker, M. H. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90188-0 · Cited by 147

Somatic Gene Transfer of Human ApoA-I Inhibits Atherosclerosis Progression in Mouse Models

Benoit, P., Emmanuel, F., Caillaud, J. M., Bassinet, L., Castro, G. R., Gallix, P., Fruchart, J., Branellec, D., Denèfle, P., & Duverger, N. (1999) · Circulation · doi:10.1161/01.cir.99.1.105 · Cited by 147

Atherosclerotic lesions in mouse and man: is it the same disease?

Bentzon, J. F., & Falk, E. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833ded6a · Cited by 147

Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice

Rozenberg, O., Shih, D. M., & Aviram, M. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.12.030 · Cited by 147

Age-Associated Aortic Stenosis in Apolipoprotein E-Deficient Mice

Tanaka, K., Sata, M., Fukuda, D., Suematsu, Y., Motomura, N., Takamoto, S., Hirata, Y., & Nagai, R. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.03.058 · Cited by 147

Altered immune responses in apolipoprotein E-deficient mice

Laskowitz, D. T., Lee, D. M., Schmechel, D. E., & Staats, H. F. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32409-3 · Cited by 148

Coronary atherosclerosis in transplanted mouse hearts. I. Time course and immunogenetic and immunopathological considerations.

Russell, P. S., Chase, C. M., Winn, H. J., & Colvin, R. B. (1994) · PubMed Central · Cited by 147

Transgenesis in rats: Technical aspects and models

Charreau, B. L., Tesson, L., Soulillou, J., Pourcel, C., & Anegón, I. (1996) · Transgenic Research · doi:10.1007/bf01972876 · Cited by 146

Cytomegalovirus infection increases development of atherosclerosis in Apolipoprotein-E knockout mice

Hsich, E., Zhou, Y. F., Paigen, B. J., Johnson, T. M., Burnett, M. S., & Epstein, S. E. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00608-0 · Cited by 146

The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice

Hayek, T. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00239-4 · Cited by 146

Hepatic and Extrahepatic Scavenger Receptors

Terpstra, V., van Amersfoort, E. S., van Velzen, A. G., Kuiper, J., & van Berkel, T. J. C. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.8.1860 · Cited by 145

Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis

Chuang, G. C., Yang, Z., Westbrook, D. G., Pompilius, M., Ballinger, C. A., White, C. R., Krzywanski, D. M., Postlethwait, E. M., & Ballinger, S. W. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00102.2009 · Cited by 145

RPGR mutation associated with retinitis pigmentosa, impaired hearing, and sinorespiratory infections

Zito, I., Downes, S. M., Patel, R. J., Cheetham, M. E., Ebenezer, N. D., Jenkins, S. A., Bhattacharya, S. S., Webster, A. R., Holder, G. E., Bird, A. C., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.609 · Cited by 145

Apolipoprotein E Inhibits Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration and Proliferation by Suppressing Signal Transduction and Preventing Cell Entry to G1 Phase

Ishigami, M., Swertfeger, D. K., Granholm, N. A., & Hui, D. Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20156 · Cited by 144

Stabilisation of atherosclerotic plaques

Bentzon, J. F., Daemen, M. J. A. P., Falk, E., Garcia-Garcia, H., Herrmann, J., Hoefer, I. E., Jukema, J. W., Krams, R., Kwak, B. R., Marx, N., et al. (2011) · Thrombosis and Haemostasis · doi:10.1160/th10-12-0784 · Cited by 150

Apolipoprotein E Isoform-Specific Differences in Outcome from Focal Ischemia in Transgenic Mice

Sheng, H., Laskowitz, D. T., Bennett, E. R., Schmechel, D. E., Bart, R. D., Saunders, A. M., Pearlstein, R. D., Roses, A. D., & Warner, D. S. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199804000-00003 · Cited by 143

MRI and Characterization of Atherosclerotic Plaque

Choudhury, R. P., Fuster, V., Badimón, J. J., Fisher, E. A. A., & Fayad, Z. A. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000019735.54479.2f · Cited by 142

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

Bennett, B. J., Davis, R. C., Civelek, M., Orozco, L. D., Wu, J., Qi, H., Pan, C., Packard, R. R. S., Eskin, E., Yan, M., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005711 · Cited by 138

Inhibition of Atherogenesis in BLT1-Deficient Mice Reveals a Role for LTB4 and BLT1 in Smooth Muscle Cell Recruitment

Heller, E. A., Liu, E. H., Tager, A. M., Sinha, S., Roberts, J. D., Koehn, S. L., Libby, P., Aikawa, E. R., Chen, J. Q., Huang, P. L., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.545616 · Cited by 141

Hydrogen Sulfide and the Pathogenesis of Atherosclerosis

Mani, S., Untereiner, A. A., Wu, L., & Wang, R. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5324 · Cited by 141

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

Huynh, T.-P. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0337-1 · Cited by 139

Genetics of Variation in HDL Cholesterol in Humans and Mice

Wang, X., & Paigen, B. J. (2005) · Circulation Research · doi:10.1161/01.res.0000151332.39871.13 · Cited by 137

Dietary chitosan inhibits hypercholesterolaemia and atherogenesis in the apolipoprotein E-deficient mouse model of atherosclerosis

Ormrod, D. J., Holmes, C. C., & Miller, T. E. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00045-8 · Cited by 139

Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice.

Shachter, N. S., Hayek, T., Leff, T., Smith, J. D., Rosenberg, D. W., Walsh, A., Ramakrishnan, R., Goldberg, I. J., Ginsberg, H. N., & Breslow, J. L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117151 · Cited by 143

Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia.

Ji, Z. S., Fazio, S., & Mahley, R. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36849-7 · Cited by 138

RAGE Axis

Naka, Y., Bucciarelli, L. G., Wendt, T., Lee, L. K., Rong, L., Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000133191.71196.90 · Cited by 138

Genetic Deletion of Pregnancy-Associated Plasma Protein-A Is Associated With Resistance to Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice Challenged With a High-Fat Diet

Harrington, S. C., Simari, R. D., & Conover, C. A. (2007) · Circulation Research · doi:10.1161/circresaha.106.146183 · Cited by 138

Determinants of Atherosclerosis Susceptibility in the C3H and C57BL/6 Mouse Model

Shi, W., Wang, N. J., Shih, D. M., Sun, V. Z., Wang, X., & Lusis, A. J. (2000) · Circulation Research · doi:10.1161/01.res.86.10.1078 · Cited by 138

The Angiotensin-II Receptor Antagonist, Losartan, Inhibits LDL Lipid Peroxidation and Atherosclerosis in Apolipoprotein E-Deficient Mice

Keidar, S., Attias, J., Smith, J. D., Breslow, J. L., & Hayek, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6844 · Cited by 138

Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond

Pendse, A. A., Arbones-Mainar, J. M., Johnson, L. A., Altenburg, M. K., & Maeda, N. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800070-jlr200 · Cited by 155

Small rodent models of atherosclerosis

Zhao, Y., Qu, H., Wang, Y., Xiao, W., Zhang, Y., & Shi, D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110426 · Cited by 149

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

Berbée, J. F. P., van der Hoogt, C. C., Sundararaman, D., Havekes, L. M., & Rensen, P. C. N. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400301-jlr200 · Cited by 140

“Tall Oil”–Derived Phytosterols Reduce Atherosclerosis in ApoE-Deficient Mice

Moghadasian, M. H., McManus, B. M., Pritchard, P. H., & Frohlich, J. J. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.1.119 · Cited by 137

Tamoxifen elevates transforming growth factor–β and suppresses diet–induced formation of lipid lesions in mouse aorta

Grainger, D. J., Witchell, C., & Metcalfe, J. C. (1995) · Nature Medicine · doi:10.1038/nm1095-1067 · Cited by 136

Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture.

Ji, Z. S., Lauer, S. J., Fazio, S., Bensadoun, A., Taylor, J. M., & Mahley, R. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36850-3 · Cited by 136

Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease

Chaudhary, R. K., Likidlilid, A., Peerapatdit, T., Tresukosol, D., Srisuma, S., Ratanamaneechat, S., & Sriratanasathavorn, C. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-36 · Cited by 137

Animal Models of Calcific Aortic Valve Disease

Sider, K. L., Blaser, M. C., & Simmons, C. A. (2011) · International Journal of Inflammation · doi:10.4061/2011/364310 · Cited by 146

A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice

Jahagirdar, R., Zhang, H., Azhar, S., Tobin, J., Attwell, S., Yu, R., Wu, J., McLure, K. G., Hansen, H. C., Wagner, G. S., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.06.008 · Cited by 134

Interleukin-4 Does Not Influence Development of Hypercholesterolemia or Angiotensin II-Induced Atherosclerotic Lesions in Mice

King, V. L., Cassis, L. A., & Daugherty, A. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060857 · Cited by 134

Diet-Induced Occlusive Coronary Atherosclerosis, Myocardial Infarction, Cardiac Dysfunction, and Premature Death in Scavenger Receptor Class B Type I-Deficient, Hypomorphic Apolipoprotein ER61 Mice

Zhang, S., Picard, M. H., Vasile, E., Zhu, Y. Y., Raffaı̈, R. L., Weisgraber, K. H., & Krieger, M. (2005) · Circulation · doi:10.1161/circulationaha.104.523563 · Cited by 134

Biomechanics of the cardiovascular system: the aorta as an illustratory example

Kassab, G. S. (2006) · Journal of The Royal Society Interface · doi:10.1098/rsif.2006.0138 · Cited by 134

Hemodynamic changes in apolipoprotein E-knockout mice

Hartley, C. J., Reddy, A. K., Madala, S., Martin-McNulty, B., Vergona, R. A., Sullivan, M. E., Halks‐Miller, M., Taffet, G. E., Michael, L. H., Entman, M. L., et al. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.5.h2326 · Cited by 134

Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut

Crook, N., Ferreiro, A. L., Gasparrini, A. J., Pesesky, M. W., Gibson, M. K., Wang, B., Sun, X., Condiotte, Z. J., Dobrowolski, S., Peterson, D. A., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.005 · Cited by 134

Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase.

Jeong, T., Schissel, S. L., Tabas, I. A., Pownall, H. J., Tall, A. R., & Jiang, X. (1998) · Journal of Clinical Investigation · doi:10.1172/jci870 · Cited by 133

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

Kruit, J. K., Kremer, P. H. C., Dai, L., Tang, R., Ruddle, P., de Haan, W., Brunham, L. R., Verchere, C. B., & Hayden, M. R. (2010) · Diabetologia · doi:10.1007/s00125-010-1691-2 · Cited by 133

Local Monocyte Chemoattractant Protein-1 Therapy Increases Collateral Artery Formation in Apolipoprotein E–Deficient Mice but Induces Systemic Monocytic CD11b Expression, Neointimal Formation, and Plaque Progression

van Royen, N., Hoefer, I. E., Böttinger, M., Hua, J., Grundmann, S., Voskuil, M., Bode, C., Schaper, W. K. A., Buschmann, I. R., & Piek, J. J. (2003) · Circulation Research · doi:10.1161/01.res.0000052313.23087.3f · Cited by 133

Angiogenesis Is Impaired by Hypercholesterolemia

Jang, J. J., Ho, H. –. V., Kwan, H. H., Fajardo, L. F., & Cooke, J. P. (2000) · Circulation · doi:10.1161/01.cir.102.12.1414 · Cited by 133

17β-Estradiol Prevents Fatty Streak Formation in Apolipoprotein E–Deficient Mice

Elhage, R., Arnal, J., Pieraggi, M. T., Duverger, N., Fiévet, C., Faye, J., & Bayard, F. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2679 · Cited by 132

Hypothalamic–Pituitary–Adrenal Dysfunction inApoe−/−Mice: Possible Role in Behavioral and Metabolic Alterations

Raber, J., Akana, S. F., Bhatnagar, S., Dallman, M. F., Wong, D. T., & Mucke, L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-02064.2000 · Cited by 131

Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.

Shimano, H., Ohsuga, J.-I., Shimada, M., Namba, Y., Gotoda, T., Harada, K., Katsuki, M., Yazaki, Y., & Yamada, N. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117687 · Cited by 132

Dioxin Exposure Is an Environmental Risk Factor for Ischemic Heart Disease

Dalton, T. P., Kerzee, J. K., Wang, B., Miller, M. L., Dieter, M. Z., Lorenz, J. N., Shertzer, H. G., Nebert, D. W., & Puga, A. (2001) · Cardiovascular Toxicology · doi:10.1385/ct:1:4:285 · Cited by 131

Apolipoproteins and aging: emerging mechanisms

Smith, J. D. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00005-3 · Cited by 133

Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice.

Zhang, S. H., Reddick, R. L., Avdievich, E., Surles, L., Jones, R. G., Reynolds, J. B., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119479 · Cited by 131

ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age

Mooijaart, S. P., Berbée, J. F. P., van Heemst, D., Havekes, L. M., de Craen, A. J. M., Slagboom, P. E., Rensen, P. C. N., & Westendorp, R. G. J. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030176 · Cited by 129

Effect of Eplerenone, a Selective Aldosterone Blocker, on Blood Pressure, Serum and Macrophage Oxidative Stress, and Atherosclerosis in Apolipoprotein E–Deficient Mice

Keidar, S., Hayek, T., Kaplan, M., Pavlotzky, E., Hamoud, S., Coleman, R., & Aviram, M. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200306000-00019 · Cited by 128

Endothelial Lipase Modulates Susceptibility to Atherosclerosis in Apolipoprotein-E-deficient Mice

Ishida, T., Choi, S. Y., Kundu, R. K., Spin, J. M., Yamashita, T., Hirata, K., Kojima, Y., Yokoyama, M., Cooper, A. D., & Quertermous, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406360200 · Cited by 129

Role of the Low Density Lipoprotein (LDL) Receptor Pathway in the Metabolism of Chylomicron Remnants

Ishibashi, S., Perrey, S., Chen, Z., Osuga, J.-I., Shimada, M., Ohashi, K., Harada, K., Yazaki, Y., & Yamada, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22422 · Cited by 106

Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis

Xiao, Q., Danton, M. J. S., Witte, D. P., Kowala, M. C., Valentine, M. T., Bugge, T. H., & Degen, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10335 · Cited by 129

Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice.

Homanics, G. E., Smith, T. J., Zhang, S. H., Lee, D., Young, S. G., & Maeda, N. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2389 · Cited by 128

Lipoprotein receptors – an evolutionarily ancient multifunctional receptor family

Dieckmann, M., Dietrich, M. F., & Herz, J. (2010) · Biological Chemistry · doi:10.1515/bc.2010.129 · Cited by 135

Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis

Carmeliet, P. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00108-4 · Cited by 129

Affinity-Driven Design of Cargo-Switching Nanoparticles to Leverage a Cholesterol-Rich Microenvironment for Atherosclerosis Therapy

Kim, H., Kumar, S., Kang, D. W., Jo, H., & Park, J. (2020) · ACS Nano · doi:10.1021/acsnano.9b08216 · Cited by 127

Inhibition of atherosclerosis in CD4 T-cell-ablated and nude (nu/nu) C57BL/6 hyperlipidemic mice.

Emeson, E. E., Shen, M. L., Bell, C., & Qureshi, A. R. (1996) · Europe PMC (PubMed Central) · Cited by 126

Protective Effect of the Immunosuppressant Sirolimus Against Aortic Atherosclerosis In Apo E-Deficient Mice

Elloso, M. M., Azrolan, N., Sehgal, S. N., Hsu, P.-L., Phiel, K. L., Kopec, C. A., Basso, M., & Adelman, S. J. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00094.x · Cited by 126

The Microcirulation in Hypercholesterolemic Mice

Constantinescu, A. A., & Vink, H. (2004) · Basic science for the cardiologist · doi:10.1007/978-1-4615-0483-2_13

Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice

Ree, J. H. V., Broek, W. J. A. A. V. D., Dahlmans, V. E. H., Groot, P. H. E., Vidgeon-Hart, M., Frants, R. R., Wieringa, B., Havekes, L. M., & Hofker, M. H. (1994) · TNO Repository

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693

Cholesterol Levels and Atherosclerosis in ApoE-Deficient Mice

Groot, P. H. E., van Berkel, T. J. C., Eck, A. V., Herijgers, N., Willems, K., Dijk, V., Havekes, L. M., Marten, H., Biol, A. T. V., Eck, A. V., et al. (2014)