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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Abstract
apoE-deficient mice have been created by homologous recombination in ES cells. On a low fat, low cholesterol chow diet these animals have plasma cholesterol levels of 494 mg/dl compared with 60 mg/dl in control animals, and when challenged with a high fat Western-type diet, these animals have plasma cholesterol levels of 1821 mg/dl compared with 132 mg/dl in controls. This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins. At 10 weeks of age, apoE-deficient mice have already developed atherosclerotic lesions in the aorta and coronary and pulmonary arteries. apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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In the citing paper
“The increased amounts of apoA-IV in VLDL and IDL we observed were seen in other reports of apoE deficiency4,5,9 and in apoE-deficient mice.31”
From Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function (2014) · cites this paper as [31]
In the citing paper
“Increased amounts of apoA-I were observed in LDL from an apoE-deficient patient9 and in VLDL from ApoE knockout mice.31”
From Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function (2014) · cites this paper as [31]
In the citing paper
“Disorders of apoE are associated with atherosclerosis, which causes dyslipidemia and myocardial infarction, and apoE-deficient mice are used as model animals for atherosclerosis2, 3).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [3]
In the citing paper
“Disorders of apoE are associated with atherosclerosis, which causes dyslipidemia and myocardial infarction, and apoE-deficient mice are used as model animals for atherosclerosis2, 3).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [3]
In the citing paper
“In vivo and in vitro studies have shown that mutations in apoE that diminish binding of apoE-containing lipoproteins to the LDL receptor are associated with high plasma cholesterol levels and cause premature atherosclerosis in humans and experimental animals ( 1-3, 7, 8 ).”
From Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4 (2011) · cites this paper as [1]
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Weber, K., & Osborn, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94333-4 · Cited by 16,688
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
The Metabolic Basis of Inherited Disease
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-389_2 · Cited by 3,990
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells
Hooper, M., Hardy, K., Handyside, A. H., Hunter, S., & Monk, M. (1987) · Nature · doi:10.1038/326292a0 · Cited by 1,218
A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine
Powell, L. M., Wallis, S. C., Pease, R. J., Edwards, Y. H., Knott, T. J., & Scott, J. (1987) · Cell · doi:10.1016/0092-8674(87)90510-1 · Cited by 1,045
Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI
Rubin, E. M., Krauss, R. M., Spangler, E. A., Verstuyft, J. G., & Clift, S. (1991) · Nature · doi:10.1038/353265a0 · Cited by 985
Self-citation
Cited by
Sorted by citations
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Chitosan Chemistry and Pharmaceutical Perspectives
Kumar, M. N. V. R., Müzzarelli, R. A. A., Muzzarelli, C., Sashiwa, H., & Domb, A. J. (2004) · Chemical Reviews · doi:10.1021/cr030441b · Cited by 2,945
The biochemistry and medical significance of the flavonoids
Havsteen, B. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00298-x · Cited by 2,702
Macrophages in atherosclerosis: a dynamic balance
Moore, K. J., Sheedy, F. J., & Fisher, E. A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3520 · Cited by 2,559
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Inflammasomes in health and disease
Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230
The immune response in atherosclerosis: a double-edged sword
Hansson, G. K., & Libby, P. (2006) · Nature reviews. Immunology · doi:10.1038/nri1882 · Cited by 2,220
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
Luo, G., Ducy, P. F., McKee, M. D., Pinero, G. J., Loyer, E. M., Behringer, R. R., & Karsenty, G. (1997) · Nature · doi:10.1038/386078a0 · Cited by 2,118
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
NF-κB, Inflammation, and Metabolic Disease
Baker, R. G., Hayden, M. S., & Ghosh, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.008 · Cited by 1,952
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Tedgui, A., & Mallat, Z. (2006) · Physiological Reviews · doi:10.1152/physrev.00024.2005 · Cited by 1,751
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693
Self-citationIshibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., & Herz, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116663 · Cited by 1,354
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448
Metabolic Syndrome: Updates on Pathophysiology and Management in 2021
Fahed, G., Aoun, L., Bou Zerdan, M., Allam, S., Bou Zerdan, M., Bouferraa, Y., & Assi, H. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020786 · Cited by 1,441
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice
Daugherty, A., Manning, M. W., & Cassis, L. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7818 · Cited by 1,371
Swirski, F. K., Libby, P., Aikawa, E., Alcaide, P., Luscinskas, F. W., Weissleder, R., & Pittet, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29950 · Cited by 1,148
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Suzuki, H. I., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997) · Nature · doi:10.1038/386292a0 · Cited by 1,226
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
Sha, W. C., Liou, H.-C., TUOMANEN, E. I., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90415-8 · Cited by 1,158
Sata, M., Saiura, A., Kunisato, A., Tojo, A., Okada, S., Tokuhisa, T., Hirai, H., Makuuchi, M., Hirata, Y., & Nagai, R. (2002) · Nature Medicine · doi:10.1038/nm0402-403 · Cited by 1,154
Park, L., Raman, K. G., Lee, K. J., Lu, Y., Ferran, L. J., Chow, W. S., Stern, D. M., & Schmidt, A. M. (1998) · Nature Medicine · doi:10.1038/2012 · Cited by 1,103
Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., & Silverstein, R. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9259 · Cited by 1,037
Self-citationAdiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice
Okamoto, Y., Kihara, S., Ouchi, N., Nishida, M., Arita, Y., Kumada, M., Ohashi, K., Sakai, N., Shimomura, I., Kobayashi, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000042707.50032.19 · Cited by 1,036
Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis
Goldberg, I. J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37569-6 · Cited by 1,029
Blood-brain barrier dysfunction and recovery after ischemic stroke
Jiang, X., Andjelkovic, A. V., Zhu, L., Yang, T., Bennett, M. V. L., Chen, J., Keep, R. F., & Shi, Y. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.001 · Cited by 967
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J.-C., Krauss, R. M., & Rubin, E. M. (2001) · Science · doi:10.1126/science.1064852 · Cited by 921
Self-citationNakashima, Y., Raines, E. W., Plump, A. S., Breslow, J. L., & Ross, R. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.5.842 · Cited by 917
Self-citationGlobular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209033200 · Cited by 911
Mouse Models of Diabetic Nephropathy
Brosius, F. C., Alpers, C. E., Böttinger, E. P., Breyer, M. D., Coffman, T. M., Gurley, S. B., Harris, R. C., Kakoki, M., Kretzler, M., Leiter, E. H., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009070721 · Cited by 901
Role of Caveolae and Caveolins in Health and Disease
Cohen, A. W., Hnasko, R. M., Schubert, W., & Lisanti, M. P. (2004) · Physiological Reviews · doi:10.1152/physrev.00046.2003 · Cited by 894
Miyata, M., & Smith, J. D. (1996) · Nature Genetics · doi:10.1038/ng0996-55 · Cited by 735
Self-citationThe endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
Feng, B., Yao, P. M., Li, Y., Devlin, C. M., Zhang, D., Harding, H. P., Sweeney, M., Rong, J. X., Kuriakose, G., Fisher, E. A. A., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb1035 · Cited by 902
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.
Gupta, S. K. S., Pablo, A. M., Jiang, X., Wang, N., Tall, A. R., & Schindler, C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119465 · Cited by 885
Aviram, M., Dornfeld, L., Rosenblat, M., Volkova, N., Kaplan, M., Coleman, R., Hayek, T., Presser, D., & Fuhrman, B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1062 · Cited by 866
Self-citationDunn, W. B., Broadhurst, D., Atherton, H. J., Goodacre, R., & Griffin, J. L. (2010) · Chemical Society Reviews · doi:10.1039/b906712b · Cited by 909
Ramasamy, R., Vannucci, S. J., Yan, S. S. D., Herold, K., Yan, S. F., & Schmidt, A. M. (2005) · Glycobiology · doi:10.1093/glycob/cwi053 · Cited by 834
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
The IL-33/ST2 pathway: therapeutic target and novel biomarker
Kakkar, R. K., & Lee, R. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2660 · Cited by 831
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
Calkin, A. C., & Tontonoz, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3312 · Cited by 779
Ishibashi, S., Goldstein, J. L., Brown, M. S., Herz, J., & Burns, D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117179 · Cited by 731
Smith, J. D., Trogan, E., Ginsberg, M., Grigaux, C., Tian, J., & Miyata, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8264 · Cited by 721
Self-citationLaursen, J. B., Somers, M., Kurz, S., McCann, L., Warnholtz, A., Freeman, B. A., Tarpey, M., Fukai, T., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.9.1282 · Cited by 721
Mouse Models of Atherosclerosis
Breslow, J. L. (1996) · Science · doi:10.1126/science.272.5262.685 · Cited by 549
Self-citationScavenger Receptor BI Promotes High Density Lipoprotein-mediated Cellular Cholesterol Efflux
Ji, Y. I., Jian, B., Wang, N., Sun, Y., Moya, M. D. L. L., Phillips, M. C., Rothblat, G. H., Swaney, J. B., & Tall, A. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20982 · Cited by 694
Mahley, R. W., & Ji, Z.-S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33334-4 · Cited by 693
Cholesterol metabolism and homeostasis in the brain
Zhang, J., & Liu, Q. (2015) · Protein & Cell · doi:10.1007/s13238-014-0131-3 · Cited by 686
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
Laffitte, B. A., Repa, J. J., Joseph, S. B., Wilpitz, D. C., Kast, H. R., Mangelsdorf, D. J., & Tontonoz, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.507 · Cited by 683
Atherogenesis in perspective: Hypercholesterolemia and inflammation as partners in crime
Steinberg, D. H. (2002) · Nature Medicine · doi:10.1038/nm1102-1211 · Cited by 687
Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
Carmeliet, P., Moons, L., Lijnen, R. H., Baes, M. I., Lemaı̂tre, V., Tipping, P. G., Drew, A. F., Eeckhout, Y., Shapiro, S. D., Lupu, F., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-439 · Cited by 660
Gosling, J., Slaymaker, S., Gu, L., Tseng, S., Zlot, C. H., Young, S. G., Rollins, B. J., & Charo, I. F. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5624 · Cited by 657
Animal Models of Atherosclerosis
Getz, G. S., & Reardon, C. A. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.237693 · Cited by 668
Iiyama, K., Hajra, L., Iiyama, M., Li, H., DiChiara, M. R., Medoff, B. D., & Cybulsky, M. I. (1999) · Circulation Research · doi:10.1161/01.res.85.2.199 · Cited by 639
Periodontal disease and systemic conditions: a bidirectional relationship
Kim, J., & Amar, S. (2006) · Odontology · doi:10.1007/s10266-006-0060-6 · Cited by 619
Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia.
Watanabe, M., Osada, J., Aratani, Y., Kluckman, K. D., Reddick, R. L., Malinow, M. R., & Maeda, N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1585 · Cited by 569
Plump, A. S., Scott, C., & Breslow, J. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9607 · Cited by 569
Self-citationPalinski, W., Hörkkö, S., Miller, E., Steinbrecher, U., Powell, H., Curtiss, L., & Witztum, J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118853 · Cited by 593
Chen, W. S., Manova, K., Weinstein, D. C., Duncan, S. A., Plump, A. S., Prezioso, V. R., Bachvarova, R. F., & Darnell, J. E., Jr. (1994) · Genes & Development · doi:10.1101/gad.8.20.2466 · Cited by 553
Self-citationTargeting phosphoinositide 3-kinase—Moving towards therapy
Marone, R., Cmiljanović, V., Giese, B., & Wymann, M. P. (2007) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2007.10.003 · Cited by 560
Zhou, X., Nicoletti, A., Elhage, R., & Hansson, G. K. (2000) · Circulation · doi:10.1161/01.cir.102.24.2919 · Cited by 559
Animal models of atherosclerosis
Emini Veseli, B., Perrotta, P., De Meyer, G. R. A., Roth, L., Van der Donckt, C., Martinet, W., & De Meyer, G. R. Y. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.010 · Cited by 548
Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice
Caligiuri, G., Nicoletti, A., Poirier, B., & Hansson, G. K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci7272 · Cited by 544
Hofmann, M. A., Lalla, E., Lu, Y., Gleason, M. R., Wolf, B. M., Tanji, N., Ferran, L. J., Kohl, B., Rao, V., Kisiel, W., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10588 · Cited by 529
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
Cyrus, T., Witztum, J. L., Rader, D. J., Tangirala, R., Fazio, S., Linton, M. F., & Funk, C. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5897 · Cited by 523
Krieger, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.523 · Cited by 517
Tangirala, R. K., Rubin, E. M., & Palinski, W. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39713-3 · Cited by 514
Self-citationYan, S. F., Ramasamy, R., Naka, Y., & Schmidt, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000103862.26506.3d · Cited by 513
Trigatti, B. L., Rayburn, H., Viñals, M., Braun, A., Miettinen, H. E., Penman, M., Hertz, M., Schrenzel, M. D., Amigo, L., Rigotti, A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9322 · Cited by 504
Praticò, D., Tangirala, R. K., Rader, D. J., Rokach, J., & FitzGerald, G. A. (1998) · Nature Medicine · doi:10.1038/2685 · Cited by 501
Cholesterol metabolism in neurons and astrocytes
Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500
Atherosclerosis in the Apolipoprotein E–Deficient Mouse
Meir, K. S., & Leitersdorf, E. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000128849.12617.f4 · Cited by 498
Collins, R. G., Velji, R., Guevara, J., Hicks, J. M., Chan, L., & Beaudet, A. L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.189 · Cited by 507
Braun, A., Trigatti, B. L., Post, M. J., Sato, K., Simons, M., Edelberg, J. M., ROSENBERG, R. D., Schrenzel, M. D., & Krieger, M. (2002) · Circulation Research · doi:10.1161/hh0302.104462 · Cited by 497
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival
Landsman, L., Bar‐On, L., Zernecke, A., Kim, K.-W., Krauthgamer, R., Shagdarsuren, E., Lira, S. A., Weissman, I. L., Weber, C., & Jung, S. (2008) · Blood · doi:10.1182/blood-2008-07-170787 · Cited by 505
Mouse Models of Abdominal Aortic Aneurysms
Daugherty, A., & Cassis, L. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000118013.72016.ea · Cited by 489
Palinski, W., Ord, V. A., Plump, A. S., Breslow, J. L., Steinberg, D. H., & Witztum, J. L. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.4.605 · Cited by 488
Self-citationDecreased atherosclerosis in CX3CR1–/– mice reveals a role for fractalkine in atherogenesis
Lesnik, P., Haskell, C. A., & Charo, I. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15555 · Cited by 487
Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation
Linton, M. F., Atkinson, J. B., & Fazio, S. (1995) · Science · doi:10.1126/science.7863332 · Cited by 478
Mitochondrial Integrity and Function in Atherogenesis
Ballinger, S. W., Patterson, C., Knight-Lozano, C. A., Burow, D. L., Conklin, C. A., Hu, Z., Reuf, J., Horaist, C., Lebovitz, R. M., Hunter, G. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000023921.93743.89 · Cited by 476
Mouse Models of Diabetic Nephropathy
Breyer, M. D., Böttinger, E. P., Brosius, F. C., Coffman, T. M., Harris, R. C., Heilig, C. W., & Sharma, K. (2004) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004080648 · Cited by 475
Monocyte Chemoattractant Protein-1 Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice
Aiello, R. J., Bourassa, P.-A. K., Lindsey, S., Weng, W., Natoli, E. J., Rollins, B. J., & Milos, P. M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.6.1518 · Cited by 465
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice
Visel, A., Zhu, Y., May, D., Afzal, V., Gong, E., Attanasio, C., Blow, M. J., Cohen, J. C., Rubin, E. M., & Pennacchio, L. A. (2010) · Nature · doi:10.1038/nature08801 · Cited by 472
Self-citationRohlmann, A., Gotthardt, M., Hammer, R. E., & Herz, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1240 · Cited by 455
Plasmin and Matrix Metalloproteinases in Vascular Remodeling
LIJNEN, H. R. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616230 · Cited by 474
Mahley, R. W., Huang, Y., & Rall, S. C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32417-2 · Cited by 447
Davenport, P., & Tipping, P. G. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63471-2 · Cited by 442
Rigotti, A., Miettinen, H. E., & Krieger, M. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0037 · Cited by 435
Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.Preprint
Bugge, T. H., Flick, M. J., Daugherty, C. C., & Degen, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.7.794 · Cited by 432
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7356 · Cited by 440
Ishibashi, S., Herz, J., Maeda, N., Goldstein, J. L., & Brown, M. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4431 · Cited by 430
Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
Reddick, R. L., Zhang, S. H., & Maeda, N. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.141 · Cited by 633
Shih, D. M., Xia, Y.-R., Wang, X.-P., Miller, E. R., Castellani, L. W., Subbanagounder, G., Cheroutre, H., Faull, K. F., Berliner, J. A., Witztum, J. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910376199 · Cited by 423
Li, L., Messas, E., Júnior, E. L. B., Levine, R. A., & Amar, S. (2002) · Circulation · doi:10.1161/hc0702.104178 · Cited by 436
Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.Preprint
Suh, T. T., Holmbäck, K., Jensen, N. J., Daugherty, C. C., Small, K. M., Simon, D. I., Potter, S., & Degen, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.16.2020 · Cited by 421
Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency
Bugge, T. H., Kombrinck, K. W., Flick, M. J., Daugherty, C. C., Danton, M. J. S., & Degen, J. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81390-2 · Cited by 422
Liver X receptor in cholesterol metabolism
Zhao, C., & Dahlman‐Wright, K. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0271 · Cited by 425
Zhou, X., Paulsson, G. B., Stemme, S., & Hansson, G. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1216 · Cited by 414
Role of Inflammation in Atherosclerosis Associated with Rheumatoid Arthritis
Libby, P. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.06.014 · Cited by 413
Sparrow, C. P., Burton, C. A., Hernandez, M., Mundt, S. S., Hassing, H., Patel, S., Rosa, R., Hermanowski‐Vosatka, A., Wang, P.-R., Zhang, D., et al. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.1.115 · Cited by 407
Animal Models of Cardiovascular Diseases
Zaragoza, C., Gómez‐Guerrero, C., Martı́n-Ventura, J. L., Blanco‐Colio, L. M., Lavín, B., Mallavia, B., Tarín, C., Mas, S., Ortíz, A., & Egido, J. (2011) · BioMed Research International · doi:10.1155/2011/497841 · Cited by 411
Metadata
- Authors
- Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L.
- Affiliations
- Rockefeller University (US)
- Lawrence Berkeley National Laboratory (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1992-10
- Volume
- 71
- Issue
- 2
- Pages
- 343-353
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2048890665
- Cited by
- 2,263
- References
- 45
- Citations by year
- 2026: 23 · 2025: 41 · 2024: 28 · 2023: 32 · 2022: 52 · 2021: 39 · 2020: 60 · 2019: 69 · 2018: 57 · 2017: 66 · 2016: 57 · 2015: 71 · 2014: 71 · 2013: 82 · 2012: 75
- FWCI
- 72.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl033714-17)
- National Heart, Lung, and Blood Institute (HL 33714, R01HL032435, HL32435)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- apolipoprotein E deficiency, hypercholesterolemia, atherosclerosis, ApoE-deficient mice, homologous recombination, embryonic stem cells, serum cholesterol, VLDL, intermediate density lipoprotein, high-fat diet, aortic atherosclerotic lesions, coronary arteries, pulmonary artery, animal models of atherosclerosis
- MeSH terms
- Animals, Aorta, Apolipoproteins E, Arteriosclerosis, Cholesterol, Coronary Vessels, Disease Models, Animal, Hypercholesterolemia, Lipoproteins, Lipoproteins, VLDL, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Pulmonary Artery, Stem Cells, Mice, Lipoproteins, IDL
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