Regulation of the specific DNA binding function of p53

p53 Mutations in Human Cancers

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p53, guardian of the genome

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Definition of a consensus binding site for p53

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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Wild-type p53 activates transcription in vitro

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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Cell cycle, CDKs and cancer: a changing paradigm

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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Modes of p53 regulation.

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DNA damage activates p53 through a phosphorylation–acetylation cascade

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The multiple mechanisms that regulate p53 activity and cell fate

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

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Regulation of p53 in response to DNA damage

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

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Targeting mutant p53 for efficient cancer therapy

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Awakening guardian angels: drugging the p53 pathway

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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DNA damage induces phosphorylation of the amino terminus of p53

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p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

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Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

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Role of p53 in Cell Death and Human Cancers

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MDM2 — master regulator of the p53 tumor suppressor protein

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

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Regulation of p53 function and stability by phosphorylation.

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Regulating tumor suppressor genes: post-translational modifications

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p53 modifications: exquisite decorations of the powerful guardian

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Specificity within the ets Family of Transcription Factors

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Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

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Multiple roles of the tumor suppressor p53

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Increased activity of p53 in senescing fibroblasts

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A polymorphic microsatellite that mediates induction of PIG3 by p53

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Repression of p53-mediated transcription by MDM2: a dual mechanism

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DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation

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Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening

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p21/CDKN1A Mediates Negative Regulation of Transcription by p53

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

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Inhibition of p53 DNA binding by human papillomavirus E6 proteins

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Modulation of Transcription Factor Ets-1 DNA Binding: DNA-Induced Unfolding of an α Helix

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p53 Binds and Activates the Xeroderma Pigmentosum DDB2 Gene in Humans but Not Mice

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DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

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Characterization of the Cooperative Function of Inhibitory Sequences in Ets-1

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Deciphering the acetylation code of p53 in transcription regulation and tumor suppression

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Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukemia cell line

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What do we need to know and understand about p53 to improve its clinical value?

Salomao, N., Karakostis, K., Hupp, T., Vollrath, F., Vojtesek, B., & Fahraeus, R. (2021) · The Journal of Pathology · doi:10.1002/path.5677 · Cited by 15