Interleukin-10-deficient mice develop chronic enterocolitis

IL-10 inhibits cytokine production by activated macrophages

Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D., & Paul, W. E. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.3.921 · Cited by 954

The Role of Ets2 Transcription Factor in the Induction of MicroRNA-155 (miR-155) by Lipopolysaccharide and Its Targeting by Interleukin-10

Quinn, S. R., Mangan, N. E., Caffrey, B. E., Gantier, M. P., Williams, B. R. G., Hertzog, P. J., McCoy, C. E., & O'Neill, L. A. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.522730 · Cited by 100

IL-10-Deficient B10.Q Mice Develop More Severe Collagen-Induced Arthritis, but Are Protected from Arthritis Induced with Anti-Type II Collagen Antibodies

Johansson, A. C. M., Hansson, A.-S., Nandakumar, K. S., Bäcklund, J., & Holmdahl, R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3505 · Cited by 96

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Zhang, H., Madi, A., Yosef, N., Chihara, N., Awasthi, A., Pot, C., Lambden, C., Srivastava, A., Burkett, P. R., Nyman, J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108433 · Cited by 91

Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis?

Shields, A. M., Panayi, G. S., & Corrigall, V. M. (2011) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2011.04433.x · Cited by 90

TLR9 is important for protection against intestinal damage and for intestinal repair

II, W. A. R., Sakamoto, K., & Leifer, C. A. (2012) · Scientific Reports · doi:10.1038/srep00574 · Cited by 84

Time to include the gut microbiota in the hygienic standardisation of laboratory rodents

Bleich, A., & Hansen, A. K. (2012) · Comparative Immunology, Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2011.12.006 · Cited by 82

Engineering microphysiological immune system responses on chips

Miller, C. P., Shin, W., Ahn, E. H., Kim, H. J., & Kim, D.-H. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.01.003 · Cited by 74

Psychological stress suppresses innate IFN-γ production via glucocorticoid receptor activation: Reversal by the anxiolytic chlordiazepoxide

Curtin, N. M., Boyle, N. T., Mills, K. H. G., & Connor, T. J. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.02.003 · Cited by 72

Interleukin-10 deficiency exacerbates inflammation-induced tau pathology

Weston, L. L., Jiang, S., Chisholm, D., Jantzie, L. L., & Bhaskar, K. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02211-1 · Cited by 69

Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5

Peng, L., Zhang, H., Hao, Y., Xu, F., Yang, J., Zhang, R., Lu, G., Zheng, Z., Cui, M., Qi, C.-F., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.041 · Cited by 67

Lipocalin‐2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response

Nairz, M., Schroll, A., Haschka, D., Dichtl, S., Sonnweber, T., Theurl, I., Theurl, M., Lindner, E., Demetz, E., Aßhoff, M., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545569 · Cited by 67

The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts

Hov, J., & Karlsen, T. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1608801 · Cited by 65

Rules of Engagement: Epithelial-Microbe Interactions and Inflammatory Bowel Disease

Jergens, A. E., Parvinroo, S., Kopper, J., & Wannemuehler, M. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.669913 · Cited by 63

Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells

Pender, S. L. F., Quinn, J. J., Sanderson, I. R., & MacDonald, T. T. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.5.g918 · Cited by 55

Recycling endosome-dependent and -independent mechanisms for IL-10 secretion in LPS-activated macrophages

Stanley, A. C., Lieu, Z. Z., Wall, A. A., Venturato, J., Khromykh, T., Hamilton, N. A., Gleeson, P. A., & Stow, J. L. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0412191 · Cited by 55

Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice

Ring, C., Klopfleisch, R., Dahlke, K., Basic, M., Bleich, A., & Blaut, M. (2019) · Gut Microbes · doi:10.1080/19490976.2018.1511663 · Cited by 52

Interleukin-10 Inhibits Lipopolysaccharide-induced Tumor Necrosis Factor-α Translation through a SHIP1-dependent Pathway

Chan, C. S., Ming-Lum, A., Golds, G. B., Lee, S. J., Anderson, R. J., & Mui, A. L.-F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.348599 · Cited by 52

NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis

Jie, Z., Yang, J.-Y., Gu, M., Wang, H., Xie, X., Li, Y., Liu, T., Zhu, L., Shi, J., Zhang, L., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0206-z · Cited by 50

Selective Encapsulation of Therapeutic mRNA in Engineered Extracellular Vesicles by DNA Aptamer

Zhang, S., Dong, Y., Wang, Y., Sun, W., Wei, M., Yuan, L., & Yang, G. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01817 · Cited by 50

Early Growth Response Gene 2‐Expressing CD4+LAG3+ Regulatory T Cells: The Therapeutic Potential for Treating Autoimmune Diseases

Okamura, T., Yamamoto, K., & Fujio, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00340 · Cited by 41

Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice

van der Sluis, M., Bouma, J., Vincent, A., Velcich, A., Carraway, K. L., Büller, H. A., Einerhand, A. W. C., van Goudoever, J. B., Van Seuningen, I., & Renes, I. B. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.28 · Cited by 44

Early‐onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)

Nagarajan, P., Agudelo Garcia, P. A., Iyer, C. C., Popova, L. V., Arnold, W. D., & Parthun, M. R. (2019) · Aging Cell · doi:10.1111/acel.12992 · Cited by 43

Stress-related peripheral neuroendocrine–immune interactions in women with ulcerative colitis

Langhorst, J., Cobelens, P. M., Kavelaars, A., Heijnen, C. J., Benson, S., Rifaie, N., Dobos, G. J., Schedlowski, M., & Elsenbruch, S. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.09.003 · Cited by 35

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

Duque-Correa, M. A., Karp, N. A., McCarthy, C., Forman, S., Goulding, D., Sankaranarayanan, G., Jenkins, T. P., Reid, A. J., Cambridge, E. L., Ballesteros Reviriego, C., et al. (2019) · PLOS Pathogens · doi:10.1371/journal.ppat.1007265 · Cited by 35

Interferon-alpha and its effects on the cytokine cascade: a pro- and anti-inflammatory cytokine

Tilg, H., & Peschel, C. (1996) · Leukemia & Lymphoma · doi:10.3109/10428199609054802 · Cited by 34

Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes

Chamberlain, T. C., Cheung, S. T., Yoon, J. S. J., Ming-Lum, A., Gardill, B. R., Shakibakho, S., Dzananovic, E., Ban, F., Samiea, A., Jawanda, K., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101433 · Cited by 32

Genomic and computational approaches to dissect the mechanisms of STAT3’s universal and cell type-specific functions

Hutchins, A. P., Diez, D., & Miranda-Saavedra, D. (2013) · JAK-STAT · doi:10.4161/jkst.25097 · Cited by 31

Epithelial-specific Toll-like receptor (TLR)5 activation mediates barrier dysfunction in experimental ileitis

Lopetuso, L. R., Jia, R., Wang, X.-M., Jia, L.-G., Petito, V., Goodman, W. A., Meddings, J. B., Cominelli, F., Reuter, B. K., & Pizarro, T. T. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001035 · Cited by 28

Plasmacytoid Dendritic Cells Are Largely Dispensable for the Pathogenesis of Experimental Inflammatory Bowel Disease

Sawai, C. M., Serpas, L., Neto, A. G., Jang, G., Rashidfarrokhi, A., Kolbeck, R., Sanjuan, M. A., Reizis, B., & Sisirak, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02475 · Cited by 20

Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen

Timmann, C., Fuchs, S., Thoma, C., Lepping, B., Brattig, N. W., Sievertsen, J., Thye, T., Müller-Myhsok, B., & Horstmann, R. D. (2004) · Genes & Immunity · doi:10.1038/sj.gene.6364094 · Cited by 17

Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice

Koh, S.-J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i28.8580 · Cited by 14