Interleukin-10-deficient mice develop chronic enterocolitis

IL-10 inhibits cytokine production by activated macrophages

Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D., & Paul, W. E. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.3.921 · Cited by 954

Interleukin-10 and the Interleukin-10 Receptor

Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 4,979

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173

Points of control in inflammation

Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738

Cytokines in inflammatory bowel disease

Neurath, M. F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3661 · Cited by 2,706

Commensal Host-Bacterial Relationships in the Gut

Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362

A microbial symbiosis factor prevents intestinal inflammatory disease

Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

Chassaing, B., Koren, O., Goodrich, J. K., Poole, A. C., Srinivasan, S., Ley, R. E., & Gewirtz, A. T. (2015) · Nature · doi:10.1038/nature14232 · Cited by 2,055

Microbial Influences in Inflammatory Bowel Diseases

Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927

RAGE Mediates a Novel Proinflammatory Axis

Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

Coutinho, A. E., & Chapman, K. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.04.005 · Cited by 1,815

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806

Intestinal barrier function: molecular regulation and disease pathogenesis

Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775

Anti-Inflammatory Cytokines

Opal, S. M., & DePalo, V. A. (2000) · Chest · doi:10.1378/chest.117.4.1162 · Cited by 1,752

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699

Radical causes of cancer

Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656

B cells regulate autoimmunity by provision of IL-10

Fillatreau, S., Sweenie, C. H., McGeachy, M. J., Gray, D., & Anderton, S. M. (2002) · Nature Immunology · doi:10.1038/ni833 · Cited by 1,647

Reciprocal interactions of the intestinal microbiota and immune system

Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586

Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10

Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo

Atreya, R., Mudter, J., Finotto, S., Müllberg, J., Jostock, T., Wirtz, S., Schütz, M., Bartsch, B., Holtmann, M., Becker, C., et al. (2000) · Nature Medicine · doi:10.1038/75068 · Cited by 1,293

The intestinal epithelial barrier: a therapeutic target?

Odenwald, M. A., & Turner, J. R. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.169 · Cited by 1,288

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils

Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

Powrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90045-0 · Cited by 1,146

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmén-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., et al. (2014) · Gut · doi:10.1136/gutjnl-2012-303207 · Cited by 1,004

Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota

Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048

Peripheral education of the immune system by colonic commensal microbiota

Lathrop, S. K., Bloom, S. M., Rao, S. M., Nutsch, K., Lio, C.-W., Santacruz, N., Peterson, D. A., Stappenbeck, T. S., & Hsieh, C.-S. (2011) · Nature · doi:10.1038/nature10434 · Cited by 1,034

Immunological aspects of intestinal mucus and mucins

Johansson, M. E. V., & Hansson, G. C. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.88 · Cited by 1,007

Biology of interleukin-10

Sabat, R., Grütz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K., & Geginat, J. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.09.002 · Cited by 977

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900

The microbiota regulates type 2 immunity through RORγt + T cells

Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., et al. (2015) · Science · doi:10.1126/science.aac4263 · Cited by 863

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

Bansal, T., Alaniz, R. C., Wood, T. K., & Jayaraman, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906112107 · Cited by 868

A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells

Awasthi, A., Carrier, Y., Peron, J. P. S., Bettelli, E., Kamanaka, M., Flavell, R. A., Kuchroo, V. K., Oukka, M., & Weiner, H. L. (2007) · Nature Immunology · doi:10.1038/ni1541 · Cited by 804

A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease

Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., & Steidler, L. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.028 · Cited by 786

The microbiome in infectious disease and inflammation

Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

Shechter, R., London, A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000113 · Cited by 770

STAT3 signaling in immunity

Hillmer, E. J., Zhang, H., Li, H. S., & Watowich, S. S. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.05.001 · Cited by 740

Role of cytokines in inflammatory bowel disease

Sanchez-Muñoz, F., Dominguez-Lopez, A., & Yamamoto-Furusho, J. K. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.4280 · Cited by 699

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Ehrhart-Bornstein, M., O’shea, J. J., Chrousos, G. P., & Bornstein, S. R. (2002) · The FASEB Journal · doi:10.1096/fj.01-0245com · Cited by 606

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.589 · Cited by 613

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

Maynard, C. L., Harrington, L. E., Janowski, K. M., Oliver, J. R., Zindl, C. L., Rudensky, A. Y., & Weaver, C. T. (2007) · Nature Immunology · doi:10.1038/ni1504 · Cited by 599

A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes

Scharschmidt, T. C., Vasquez, K. S., Truong, H.-A., Gearty, S. V., Pauli, M. L., Nosbaum, A., Gratz, I. K., Otto, M., Moon, J. J., Liese, J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.016 · Cited by 586

Large-scale plasma proteomics comparisons through genetics and disease associations

Eldjarn, G. H., Ferkingstad, E., Lund, S. H., Helgason, H., Magnusson, O. T., Gunnarsdottir, K., Olafsdottir, T. A., Halldorsson, B. V., Olason, P. I., Zink, F., et al. (2023) · Nature · doi:10.1038/s41586-023-06563-x · Cited by 583

The Disease Spectrum of Helicobacter Pylori: The Immunopathogenesis of Gastroduodenal Ulcer and Gastric Cancer

Ernst, P. B., & Gold, B. D. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.615 · Cited by 554

Understanding the role of gut microbiome–host metabolic signal disruption in health and disease

Holmes, E., Li, J. V., Athanasiou, T., Ashrafian, H., & Nicholson, J. K. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.05.006 · Cited by 541

Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications

Natividad, J. M. M., & Verdu, E. F. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.007 · Cited by 525

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

Alexeev, E. E., Lanis, J. M., Kao, D. J., Campbell, E. L., Kelly, C. J., Battista, K. D., Gerich, M. E., Jenkins, B. R., Walk, S. T., Kominsky, D. J., et al. (2018) · The American Journal of Pathology · doi:10.1016/j.ajpath.2018.01.011 · Cited by 532

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

Li, M. O., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.003 · Cited by 501

Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models

Seril, D. N. (2003) · Carcinogenesis · doi:10.1093/carcin/24.3.353 · Cited by 467

Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers

Vulevic, J., Drakoularakou, A., Yaqoob, P., Tzortzis, G., & Gibson, G. R. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26242 · Cited by 451

The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases

Chassaing, B., & Darfeuille–Michaud, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.054 · Cited by 443

Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response

MURRAY, P. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.01.010 · Cited by 436

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

Uronis, J. M., Mühlbauer, M., Herfarth, H. H., Rubinas, T. C., Jones, G. S., & Jobin, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006026 · Cited by 425

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

Mumm, J. B., Emmerich, J., Zhang, X., Chan, I., Wu, L., Mauze, S., Blaisdell, S., Basham, B., Dai, J., Grein, J., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.11.003 · Cited by 418

B cells responses and cytokine production are regulated by their immune microenvironment

Vazquez, M. I., Catalan-Dibene, J., & Zlotnik, A. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.007 · Cited by 421

Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa

Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice

Screpanti, I., Romani, L., Musiani, P., Modesti, A., Fattori, E., Lazzaro, D., Sellitto, C., Scarpa, S., Bellavia, D., & Lattanzio, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07185.x · Cited by 407

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

Davidson, N. J., Leach, M. W., Fort, M. M., Thompson-Snipes, L., Kühn, R., Müller, W., Berg, D. J., & Rennick, D. M. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.1.241 · Cited by 402

Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response

Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., Wu, Q., You, L., Wang, Y., Lin, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720696115 · Cited by 400

Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis

Matsushita, T., Horikawa, M., Iwata, Y., & Tedder, T. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001307 · Cited by 394

Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice

Schultz, M., Veltkamp, C., Dieleman, L. A., Grenther, W. B., Wyrick, P. B., Tonkonogy, S. L., & Sartor, R. B. (2002) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200203000-00001 · Cited by 375

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

Guillot-Sestier, M.-V., Doty, K. R., Gate, D., Rodriguez, J., Leung, B. P., Rezai-Zadeh, K., & Town, T. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.068 · Cited by 363

The enteric nervous system relays psychological stress to intestinal inflammation

Schneider, K. M., Blank, N., Alvarez, Y., Thum, K., Lundgren, P., Litichevskiy, L., Sleeman, M., Bahnsen, K., Kim, J., Kardo, S., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.001 · Cited by 344

The development and function of regulatory T cells

Workman, C. J., Szymczak-Workman, A. L., Collison, L. W., Pillai, M. R., & Vignali, D. A. A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0026-2 · Cited by 344

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314

Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

Leclercq, S., Cani, P. D., Neyrinck, A. M., Stärkel, P., Jamar, F., Mikolajczak, M., Delzenne, N. M., & de Timary, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.04.001 · Cited by 310

RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F., Yan, S. D., Stern, D. M., et al. (2002) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-002-8491-x · Cited by 304

Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice

Vandenbroucke, K., Hans, W., Van Huysse, J., Neirynck, S., Demetter, P., Remaut, E., Rottiers, P., & Steidler, L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.020 · Cited by 277

Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

Deriu, E., Boxx, G. M., He, X., Pan, C., Benavidez, S. D., Cen, L., Rozengurt, N., Shi, W., & Cheng, G. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005572 · Cited by 280

Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome

Ohland, C. L., Kish, L., Bell, H., Thiesen, A., Hotte, N., Pankiv, E., & Madsen, K. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.008 · Cited by 273

Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?: Table 1

Gonsalkorale, W. M., Perrey, C., Pravica, V, Whorwell, P. J., & Hutchinson, I. V. (2003) · Gut · doi:10.1136/gut.52.1.91 · Cited by 273

Developmental and Functional Control of Natural Killer Cells by Cytokines

Wu, Y., Tian, Z., & Wei, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00930 · Cited by 269

Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis

Rana, N., Braun, D. P., House, R., Gebel, H., Rotman, C., & Dmowski, W. P. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58262-4 · Cited by 264

IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

Greenhill, C. J., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P. J., Mansell, A., & Jenkins, B. J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002971 · Cited by 264

The Protooncogene c-Maf Is an Essential Transcription Factor for IL-10 Gene Expression in Macrophages

Cao, S., Liu, J., Song, L., & Ma, X. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3484 · Cited by 244

Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function

Melillo, J. A., Song, L., Bhagat, G., Blazquez, A. B., Plumlee, C. R., Lee, C., Berin, C., Reizis, B., & Schindler, C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902960 · Cited by 225

Role of Tumor Necrosis Factor-alpha and Interleukin-10 Gene Polymorphisms in Irritable Bowel Syndrome

van der Veek, P. P. J., van den Berg, M., de Kroon, Y. E., Verspaget, H. W., & Masclee, A. A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00257.x · Cited by 217

To respond or not to respond — a personal perspective of intestinal tolerance

Mowat, A. M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0002-x · Cited by 206

Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation

Riedel, C. U. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i23.3729 · Cited by 210

Dietary Inulin Improves Distal Colitis Induced by Dextran Sodium Sulfate in the Rat

Videla, S., Vilaseca, J., Antolín, M., García-Lafuente, A., Guarner, F., Crespo, E., Casalots, J., Salas, A., & Malagelada, J. R. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03802.x · Cited by 209

SAMP1/YitFc mouse strain: A spontaneous model of Crohnʼs disease-like ileitis

Pizarro, T. T., Pastorelli, L., Bamias, G., Garg, R. R., Reuter, B. K., Mercado, J. R., Chieppa, M., Arseneau, K. O., Ley, K., & Cominelli, F. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21638 · Cited by 192

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Graham, W. V., He, W., Marchiando, A. M., Zha, J., Singh, G., Li, H.-S., Biswas, A., Ong, M. L. D. M., Jiang, Z.-H., Choi, W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0393-7 · Cited by 176

Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

Shemer, A., Scheyltjens, I., Frumer, G. R., Kim, J.-S., Grozovski, J., Ayanaw, S., Dassa, B., Van Hove, H., Chappell-Maor, L., Boura-Halfon, S., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.09.018 · Cited by 175

Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways

Murray, P. J., & Smale, S. T. (2012) · Nature Immunology · doi:10.1038/ni.2391 · Cited by 170

GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte response

Cohen, N., Mouly, E., Hamdi, H., Maillot, M.-C., Pallardy, M., Godot, V., Capel, F., Balian, A., Naveau, S., Galanaud, P., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2760 · Cited by 170

The Nuclear IκB Protein IκBNS Selectively Inhibits Lipopolysaccharide-Induced IL-6 Production in Macrophages of the Colonic Lamina Propria

Hirotani, T., Lee, P. Y., Kuwata, H., Yamamoto, M., Matsumoto, M., Kawase, I., Akira, S., & Takeda, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3650 · Cited by 167

Polystyrene micro-/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines

Jing, J., Zhang, L., Han, L., Wang, J., Zhang, W., Liu, Z., & Gao, A. (2022) · Environment International · doi:10.1016/j.envint.2022.107131 · Cited by 167

Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate IFN-γ+CD4+ T Cell Numbers during Colitis Development in Mice

Maseda, D., Candando, K. M., Smith, S. H., Kalampokis, I., Weaver, C. T., Plevy, S. E., Poe, J. C., & Tedder, T. F. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300649 · Cited by 144

Dual biological effects of the cytokines interleukin-10 and interferon-γ

Wilke, C. M., Wei, S., Wang, L., Kryczek, I., Kao, J., & Zou, W. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1104-5 · Cited by 138

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

Rieder, F., Kessler, S., Sans, M., & Fiocchi, C. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00059.2012 · Cited by 135

Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice

Froicu, M., Zhu, Y., & Cantorna, M. T. (2006) · Immunology · doi:10.1111/j.1365-2567.2005.02290.x · Cited by 128

miR-27a regulates inflammatory response of macrophages by targeting IL-10

Xie, N., Cui, H., Banerjee, S., Tan, Z., Salomao, R., Fu, M., Abraham, E., Thannickal, V. J., & Liu, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400203 · Cited by 128

Gut microbiome and anticancer immune response: really hot Sh*t!

Viaud, S., Daillère, R., Boneca, I. G., Lepage, P., Langella, P., Chamaillard, M., Pittet, M. J., Ghiringhelli, F., Trinchieri, G., Goldszmid, R., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.56 · Cited by 123

Mouse models of ageing and their relevance to disease

Kõks, S., Dogan, S., Tuna, B. G., González-Navarro, H., Potter, P., & Vandenbroucke, R. E. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.10.001 · Cited by 125

Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype

Laffer, B., Bauer, D., Wasmuth, S., Busch, M., Jalilvand, T. V., Thanos, S., Meyer zu Hörste, G., Loser, K., Langmann, T., Heiligenhaus, A., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00430 · Cited by 120

Interleukin-10 potential benefits and possible risks in clinical infectious diseases

Opal, S. M., Wherry, J. C., & Grint, P. (1998) · Clinical Infectious Diseases · doi:10.1086/515032 · Cited by 114

Mast cells and nerves tickle in the tummy

Rijnierse, A., Nijkamp, F. P., & Kraneveld, A. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.008 · Cited by 105

Anxiety- and depressive-like behaviors are associated with altered hippocampal energy and inflammatory status in a mouse model of Crohn's disease

Haj-Mirzaian, A., Amiri, S., Amini-Khoei, H., Hosseini, M.-J., Haj-Mirzaian, A., Momeny, M., Rahimi-Balaei, M., & Dehpour, A. R. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.10.023 · Cited by 100